The blood labyrinthine barrier in the human normal and Meniere's disease macula utricle.

The ultrastructural organization of the blood labyrinthine barrier (BLB) was investigated in the human vestibular endorgan, the utricular macula, using postmortem specimens from individuals with documented normal auditory and vestibular function and surgical specimens from patients with intractable Meniere's disease. Transmission electron microscopic analysis of capillaries located in the normal human utricular stroma showed vascular endothelial cells with few pinocytotic vesicles, covered by a smooth and uniform basement membrane surrounded by pericyte processes. Meniere's disease specimens revealed differential ultrastructural pathological changes in the cellular elements of the microvasculature. With moderate degeneration of the BLB, there were numerous vesicles within the vascular endothelial cells (VECs), with increased numbers at the abluminal face, pericyte process detachment and disruption of the perivascular basement membrane surrounding the VECs. With severe degeneration of the BLB, there was severe vacuolization or frank apparent necrosis of VECs and loss of subcellular organelles. A higher severity of BLB degenerative changes was associated with a higher degree of basement membrane thickening and edematous changes within the vestibular stroma. This study presents the first ultrastructural analysis of the capillaries constituting the BLB in the human vestibular macula utricle from normal and Meniere's disease

Imprints of the super-Eddington accretion on the quasar clustering

Super-Eddington mass accretion has been suggested as an efficient mechanism to grow supermassive black holes (SMBHs). We investigate the imprint left by the radiative efficiency of the super-Eddington accretion process on the clustering of quasars using a new semi-analytic model of galaxy and quasar formation based on large-volume cosmological $N$-body simulations. Our model includes a simple model for the radiative efficiency of a quasar, which imitates the effect of photon trapping for a high mass accretion rate. We find that the model of radiative efficiency affects the relation between the quasar luminosity and the quasar host halo mass. The quasar host halo mass has only weak dependence on quasar luminosity when there is no upper limit for quasar luminosity. On the other hand, it has significant dependence on quasar luminosity when the quasar luminosity is limited by its Eddington luminosity. In the latter case, the quasar bias also depends on the quasar luminosity, and the quasar bias of bright quasars is in agreement with observations. Our results suggest that the quasar clustering studies can provide a constraint on the accretion disc model.Comment: 6 pages, 4 figures, to appear in MNRAS Letter

4f-shell configuration of Yb in InP studied by electron spin resonance

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