141 research outputs found
Controlling orbital moment and spin orientation in CoO layers by strain
We have observed that CoO films grown on different substrates show dramatic
differences in their magnetic properties. Using polarization dependent x-ray
absorption spectroscopy at the Co L edges, we revealed that the
magnitude and orientation of the magnetic moments strongly depend on the strain
in the films induced by the substrate. We presented a quantitative model to
explain how strain together with the spin-orbit interaction determine the 3d
orbital occupation, the magnetic anisotropy, as well as the spin and orbital
contributions to the magnetic moments. Control over the sign and direction of
the strain may therefore open new opportunities for applications in the field
of exchange bias in multilayered magnetic films
Human papillomavirus 16 L2 inhibits the transcriptional activation function, but not the DNA replication function, of HPV-16 E2
In this study we analysed the outcome of the interaction between HPV-16 L2 and E2 on the transactivation and DNA replication functions of E2. When E2 was expressed on its own, it transactivated a number of E2-responsive promoters but co-expression of L2 led to the down-regulation of the transcription transactivation activity of the E2 protein. This repression is not mediated by an increased degradation of the E2 protein. In contrast, the expression of L2 had no effect on the ability of E2 to activate DNA replication in association with the viral replication factor E1. Deletion mutagenesis identified L2 domains responsible for binding to E2 (first 50 N-terminus amino acid residues) and down-regulating its transactivation function (residues 301–400). The results demonstrate that L2 selectively inhibits the transcriptional activation property of E2 and that there is a direct interaction between the two proteins, although this is not sufficient to mediate the transcriptional repression. The consequences of the L2–E2 interaction for the viral life cycle are discussed
Charge injection instability in perfect insulators
We show that in a macroscopic perfect insulator, charge injection at a
field-enhancing defect is associated with an instability of the insulating
state or with bistability of the insulating and the charged state. The effect
of a nonlinear carrier mobility is emphasized. The formation of the charged
state is governed by two different processes with clearly separated time
scales. First, due to a fast growth of a charge-injection mode, a localized
charge cloud forms near the injecting defect (or contact). Charge injection
stops when the field enhancement is screened below criticality. Secondly, the
charge slowly redistributes in the bulk. The linear instability mechanism and
the final charged steady state are discussed for a simple model and for
cylindrical and spherical geometries. The theory explains an experimentally
observed increase of the critical electric field with decreasing size of the
injecting contact. Numerical results are presented for dc and ac biased
insulators.Comment: Revtex, 7pages, 4 ps figure
Magnetic versus crystal field linear dichroism in NiO thin films
We have detected strong dichroism in the Ni x-ray absorption
spectra of monolayer NiO films. The dichroic signal appears to be very similar
to the magnetic linear dichroism observed for thicker antiferromagnetic NiO
films. A detailed experimental and theoretical analysis reveals, however, that
the dichroism is caused by crystal field effects in the monolayer films, which
is a non trivial effect because the high spin Ni ground state is not
split by low symmetry crystal fields. We present a practical experimental
method for identifying the independent magnetic and crystal field contributions
to the linear dichroic signal in spectra of NiO films with arbitrary
thicknesses and lattice strains. Our findings are also directly relevant for
high spin and systems such as LaFeO, FeO,
VO, LaCrO, CrO, and Mn manganate thin films
Giant positive magnetoresistance in metallic VOx thin films
We report on giant positive magnetoresistance effect observed in VOx thin
films, epitaxially grown on SrTiO3 substrate. The MR effect depends strongly on
temperature and oxygen content and is anisotropic. At low temperatures its
magnitude reaches 70% in a magnetic field of 5 T. Strong electron-electron
interactions in the presence of strong disorder may qualitatively explain the
results. An alternative explanation, related to a possible magnetic
instability, is also discussed.Comment: 4 pages, 5 figures included in the text, references update
Rifapentine Population Pharmacokinetics and Dosing Recommendations for Latent Tuberculosis Infection.
RATIONALE: Rifapentine has been investigated at various doses, frequencies, and dosing algorithms but clarity on the optimal dosing approach is lacking. OBJECTIVES: In this individual participant data meta-analysis of rifapentine pharmacokinetics, we characterize rifapentine population pharmacokinetics, including autoinduction, and determine optimal dosing strategies for short-course rifapentine-based regimens for latent tuberculosis infection. METHODS: Rifapentine pharmacokinetic studies were identified though a systematic review of literature. Individual plasma concentrations were pooled, and non-linear mixed effects modeling was performed. A subset of data was reserved for external validation. Simulations were performed under various dosing conditions including current weight-based methods and alternative methods driven by identified covariates. MEASUREMENTS AND MAIN RESULTS: We identified 9 clinical studies with a total of 863 participants with pharmacokinetic data (n=4301 plasma samples). Rifapentine population pharmacokinetics were described successfully with a one-compartment distribution model. Autoinduction of clearance was driven by rifapentine plasma concentration. The maximum effect was a 72% increase in clearance and was reached after 21 days. Drug bioavailability decreased by 27% with HIV infection, decreased by 28% with fasting, and increased by 49% with a high-fat meal. Body weight was not a clinically relevant predictor of clearance. Pharmacokinetic simulations showed that current weight-based dosing leads to lower exposures in low weight individuals, which can be overcome with flat dosing. In HIV-positive patients, 30% higher doses are required to match drug exposure in HIV-negative patients. CONCLUSIONS: Weight-based dosing of rifapentine should be removed from clinical guidelines and higher doses for HIV-positive patients should be considered to provide equivalent efficacy
Electronic structure of Co_xTiSe_2 and Cr_xTiSe_2
The results of investigations of intercalated compounds Cr_xTiSe_2 and
Co_xTiSe_2 by X-ray photoelectron spectroscopy (XPS) and X-ray emission
spectroscopy (XES) are presented. The data obtained are compared with
theoretical results of spin-polarized band structure calculations. A good
agreement between theoretical and experimental data for the electronic
structure of the investigated materials has been observed. The interplay
between the M3d--Ti3d hybridization (M=Cr, Co) and the magnetic moment at the M
site is discussed. A 0.9 eV large splitting of the core Cr2p{3/2} level was
observed, which reveals a strong exchange magnetic interaction of 3d-2p
electrons of Cr. In the case of a strong localization of the Cr3d electrons
(for x<0.25), the broadening of the CrL spectra into the region of the states
above the nominal Fermi level was observed and attributed to X-ray re-emission.
The measured kinetic properties are in good accordance with spectral
investigations and band calculation results.Comment: 14 pages, 11 figures, submitted to Phys.Rev.
- …