767 research outputs found

    A preliminary review of the existing literature investigating ethnic and gender differences in early childhood development

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    There exist well documented inequalities in earnings by gender, race and ethnicity. Those disadvantaged groups are usually referred to together as minorities, where the majority is usually "White-male". Empirical research often attributes the lower earnings of minorities to their lower human capital endowments. One view is that minorities choose to invest less in human capital due to expected labour market discrimination. An alternative view is that lower human capital acquisition among the minorities could be determined by pre-labour market factors, such as their adverse socio-economic status. However, the age at which these ability gaps set in is not clear: one could argue that trajectory of these inequalities is established early on in childhood, and just gets accentuated by the adverse socio-economic status. This paper reports on the findings of a preliminary review of the existing literature investigating ethnic and gender differences in early childhood development

    On well-covered triangulations: Part I

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    AbstractA graph G is said to be well-covered if every maximal independent set of vertices has the same cardinality. A planar (simple) graph in which each face is a triangle is called a triangulation. It is the aim of this paper to prove that there are no 5-connected planar well-covered triangulations

    The Firefighter Problem: A Structural Analysis

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    We consider the complexity of the firefighter problem where b>=1 firefighters are available at each time step. This problem is proved NP-complete even on trees of degree at most three and budget one (Finbow et al.,2007) and on trees of bounded degree b+3 for any fixed budget b>=2 (Bazgan et al.,2012). In this paper, we provide further insight into the complexity landscape of the problem by showing that the pathwidth and the maximum degree of the input graph govern its complexity. More precisely, we first prove that the problem is NP-complete even on trees of pathwidth at most three for any fixed budget b>=1. We then show that the problem turns out to be fixed parameter-tractable with respect to the combined parameter "pathwidth" and "maximum degree" of the input graph

    Search for the disappearance of muon antineutrinos in the NuMI neutrino beam

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    We report constraints on muon antineutrino oscillation parameters that were obtained by using the two MINOS detectors to measure the 7% antineutrino component of the NuMI neutrino beam. In the Far Detector, we select 130 events in the charged-current muon antineutrino sample, compared to a prediction of 136.4 +/- 11.7(stat) ^{+10.2}_{-8.9}(syst) events under the assumption |dm2bar|=2.32x10^-3 eV^2, snthetabar=1.0. A fit to the two-flavor oscillation approximation constrains |dm2bar|<3.37x10^-3 eV^2 at the 90% confidence level with snthetabar=1.0

    Rainbow domination and related problems on some classes of perfect graphs

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    Let kNk \in \mathbb{N} and let GG be a graph. A function f:V(G)2[k]f: V(G) \rightarrow 2^{[k]} is a rainbow function if, for every vertex xx with f(x)=f(x)=\emptyset, f(N(x))=[k]f(N(x)) =[k]. The rainbow domination number γkr(G)\gamma_{kr}(G) is the minimum of xV(G)f(x)\sum_{x \in V(G)} |f(x)| over all rainbow functions. We investigate the rainbow domination problem for some classes of perfect graphs

    Searches for neutrinoless double beta decay

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    Neutrinoless double beta decay is a lepton number violating process whose observation would also establish that neutrinos are their own anti-particles. There are many experimental efforts with a variety of techniques. Some (EXO, Kamland-Zen, GERDA phase I and CANDLES) started take data in 2011 and EXO has reported the first measurement of the half life for the double beta decay with two neutrinos of 136^{136}Xe. The sensitivities of the different proposals are reviewed.Comment: 8 pages, prepared for TAUP 201

    Searches for neutrinoless double beta decay

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    Neutrinoless double beta decay is a lepton number violating process whose observation would also establish that neutrinos are their own anti-particles. There are many experimental efforts with a variety of techniques. Some (EXO, Kamland-Zen, GERDA phase I and CANDLES) started take data in 2011 and EXO has reported the first measurement of the half life for the double beta decay with two neutrinos of 136^{136}Xe. The sensitivities of the different proposals are reviewed.Comment: 8 pages, prepared for TAUP 201

    Searches for neutrinoless double beta decay

    Full text link
    Neutrinoless double beta decay is a lepton number violating process whose observation would also establish that neutrinos are their own anti-particles. There are many experimental efforts with a variety of techniques. Some (EXO, Kamland-Zen, GERDA phase I and CANDLES) started take data in 2011 and EXO has reported the first measurement of the half life for the double beta decay with two neutrinos of 136^{136}Xe. The sensitivities of the different proposals are reviewed.Comment: 8 pages, prepared for TAUP 201

    Characterizing Hepatitis C Virus–Specific CD4+ T Cells Following Viral‐Vectored Vaccination, Directly Acting Antivirals, and Spontaneous Viral Cure

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    BACKGROUND AND AIMS: Induction of functional helper CD4+ T cells is the hallmark of a protective immune response against hepatitis C virus (HCV), associated with spontaneous viral clearance. Heterologous prime/boost viral vectored vaccination has demonstrated induction of broad and polyfunctional HCV-specific CD8+ T cells in healthy volunteers; however, much less is known about CD4+ T-cell subsets following vaccination. APPROACH AND RESULTS: We analyzed HCV-specific CD4+ T-cell populations using major histocompatibility complex class II tetramers in volunteers undergoing HCV vaccination with recombinant HCV adenoviral/modified vaccinia Ankara viral vectors. Peptide-specific T-cell responses were tracked over time, and functional (proliferation and cytokine secretion) and phenotypic (cell surface and intranuclear) markers were assessed using flow cytometry. These were compared to CD4+ responses in 10 human leukocyte antigen-matched persons with HCV spontaneous resolution and 21 chronically infected patients treated with directly acting antiviral (DAA) therapy. Vaccination induced tetramer-positive CD4+ T cells that were highest 1-4 weeks after boosting (mean, 0.06%). Similar frequencies were obtained for those tracked following spontaneous resolution of disease (mean, 0.04%). In addition, the cell-surface phenotype (CD28, CD127) memory subset markers and intranuclear transcription factors, as well as functional capacity of peptide-specific CD4+ T-cell responses characterized after vaccination, are comparable to those following spontaneous viral resolution. In contrast, helper responses in chronic infection were infrequently detected and poorly functional and did not consistently recover following HCV cure. CONCLUSIONS: Helper CD4+ T-cell phenotype and function following HCV viral vectored vaccination resembles "protective memory" that is observed following spontaneous clearance of HCV. DAA cure does not promote resurrection of exhausted CD4+ T-cell memory in chronic infection
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