Dietary Conjugated Linoleic Acid and Hepatic Steatosis: Species-Specific Effects on Liver and Adipose Lipid Metabolism and Gene Expression

Objective. To summarize the recent studies on effect of conjugated linoleic acid (CLA) on hepatic steatosis and hepatic and adipose lipid metabolism highlighting the potential regulatory mechanisms. Methods. Sixty-four published experiments were summarized in which trans-10, cis-12 CLA was fed either alone or in combination with other CLA isomers to mice, rats, hamsters, and humans were compared. Summary and Conclusions. Dietary trans-10, cis-12 CLA induces a severe hepatic steatosis in mice with a more muted response in other species. Regardless of species, when hepatic steatosis was present, a concurrent decrease in body adiposity was observed, suggesting that hepatic lipid accumulation is a result of uptake of mobilized fatty acids (FA) from adipose tissue and the liver's inability to sufficiently increase FA oxidation and export of synthesized triglycerides. The potential role of liver FA composition, insulin secretion and sensitivity, adipokine, and inflammatory responses are discussed as potential mechanisms behind CLA-induced hepatic steatosis

Probable Donor-Derived Human Adenovirus Type 34 Infection in 2 Kidney Transplant Recipients From the Same Donor.

Human adenovirus type 34 (HAdV-34) infection is a recognized cause of transplant-associated hemorrhagic cystitis and, in rare cases, tubulointerstitial nephritis. The source of such infections is often difficult to assess, that is, whether acquired as a primary infection, exposure to a pathogen in the transplanted organ, or reactivation of an endogenous latent infection. We present here 2 cases of likely transplant-acquired HAdV-34 infection from the same organ donor, manifesting as tubulointerstitial nephritis in 1

6R instrumented spatial linkages for anatomical joint motion measurement—part 2: calibration

The six-revolute-joint instrumented spatial linkage (6R ISL ) Introduction As with any measuring system, an instrumented spatial linkage (ISL) must be tested and calibrated before it can be used with confidence. This paper details the calibration technique developed for improving the measurement resolution of a 6R ISL-a serial ISL design where the links are interconnected by six revolute joints. With a 6R ISL, determination of anatomical joint position is based upon a mathematical function that approximates what is actually occurring with the physical model. The independent variables of this function are six voltages, each relating to a different linkage joint angle; the dependent variables are the six anatomical position parameters. In measuring the anatomical joint position of one bony coordinate frame relative to the other, this function contains twenty-four fixed mechanical parameters and generally twelve additional fixed electrical parameters that relate linkage joint angles to the voltages output by the devices that monitor the linkage joints, typically potentiometers The goal of the calibration procedure is to adjust the nominal mechanical and electrical parameters of the ISL to optimize the accuracy of the ISL within the calibration space. Although tolerances of the electrical devices are variable and cannot be completely calibrated out, Sommer and Miller [7] have demonstrated that the adjustment of the mechanical and electrical parameters can greatly improve positional measurement accuracy. They used a Levenberg-Marquardt algorithm to refine typically nineteen of the fixed ISL parameters. Their algorithm attempted to minimize the squared difference between known and calculated sets of three Euler angles and three orthogonal translations that related one linkage end to the other. The objective function was nonweighted and used centimeters and radians as the units in measuring translation and rotation, respectively. The value of this procedure depends on the accuracy and range of the "known" calibration data. Most calibration devices referenced in the literatur

Topological Defects and Interactions in Nematic Emulsions

Inverse nematic emulsions in which surfactant-coated water droplets are dispersed in a nematic host fluid have distinctive properties that set them apart from dispersions of two isotropic fluids or of nematic droplets in an isotropic fluid. We present a comprehensive theoretical study of the distortions produced in the nematic host by the dispersed droplets and of solvent mediated dipolar interactions between droplets that lead to their experimentally observed chaining. A single droplet in a nematic host acts like a macroscopic hedgehog defect. Global boundary conditions force the nucleation of compensating topological defects in the nematic host. Using variational techniques, we show that in the lowest energy configuration, a single water droplet draws a single hedgehog out of the nematic host to form a tightly bound dipole. Configurations in which the water droplet is encircled by a disclination ring have higher energy. The droplet-dipole induces distortions in the nematic host that lead to an effective dipole-dipole interaction between droplets and hence to chaining.Comment: 17 double column pages prepared by RevTex, 15 eps figures included in text, 2 gif figures for Fig. 1

The changing ethnic profiles of Scotland and Glasgow, and the implications for population health

Oral presentation abstract

Does wage rank affect employees' well-being?

How do workers make wage comparisons? Both an experimental study and an analysis of 16,000 British employees are reported. Satisfaction and well-being levels are shown to depend on more than simple relative pay. They depend upon the ordinal rank of an individual's wage within a comparison group. “Rank” itself thus seems to matter to human beings. Moreover, consistent with psychological theory, quits in a workplace are correlated with pay distribution skewness

Increasingly Diverse: the Changing Ethnic Profiles of Scotland and Glasgow and the Implications for Population Health

Scotland’s population has become increasingly ethnically diverse. The aim of this study was to better understand future changes to the ethnic profile of the population and the implications for population health. The literature regarding ethnicity and health, particularly in the Scottish context, was reviewed alongside analyses of past trends and new future projections (2011–2031) of the size of the non-White ethnic minority population in Scotland and Glasgow (Scotland’s largest and most ethnically diverse city). The literature emphasises that the relationships between ethnicity, socioeconomic position (SEP) and health are extremely complex. In Scotland this complexity is arguably enhanced, given the different, less disadvantaged, SEP profile of many ethnic minority groups compared with those in other countries. Although indicators of overall health status have been shown to be better among many non-White ethnic minority groups compared with the White Scottish population, such analyses mask varying risks of particular diseases among different groups. This complexity extends to understanding the underlying causes of these differences, including the ‘healthy migrant’ effect, ‘acculturation’, and the impact of different types and measures of SEP. The proportion of the population belonging to a non-White ethnic group increased four-fold in both Scotland and Glasgow between 1991 and 2011. New projections suggest that by 2031, around 20% of Glasgow’s total population (and 25% of children) will belong to a non-White minority group. Given this, there is a clear need for policy-makers and service-planners to seek to understand the implications of these changes to the Scottish population