Central extensions of mapping class groups from characteristic classes

Tangential structures on smooth manifolds, and the extension of mapping class groups they induce, admit a natural formulation in terms of higher (stacky) differential geometry. This is the literal translation of a classical construction in differential topology to a sophisticated language, but it has the advantage of emphasizing how the whole construction naturally emerges from the basic idea of working in slice categories. We characterize, for every higher smooth stack equipped with tangential structure, the induced higher group extension of the geometric realization of its higher automor- phism stack. We show that when restricted to smooth manifolds equipped with higher degree topological structures, this produces higher extensions of homotopy types of diffeomorphism groups. Passing to the groups of connected components, we obtain abelian extensions of mapping class groups and we derive sufficient conditions for these being central. We show as a special case that this provides an elegant re-construction of Segal’s approach to $\mathbb{Z}$ -extensions of mapping class groups of surfaces that provides the anomaly cancellation of the modular functor in Chern-Simons theory. Our construction generalizes Segal’s approach to higher central extensions of mapping class groups of higher dimensional manifolds with higher tangential structures, expected to provide the analogous anomaly cancellation for higher dimensional TQFTs

A note on boundedness of operators in Grand Grand Morrey spaces

In this note we introduce grand grand Morrey spaces, in the spirit of the grand Lebesgue spaces. We prove a kind of \textit{reduction lemma} which is applicable to a variety of operators to reduce their boundedness in grand grand Morrey spaces to the corresponding boundedness in Morrey spaces. As a result of this application, we obtain the boundedness of the Hardy-Littlewood maximal operator and Calder\'on-Zygmund operators in the framework of grand grand Morrey spaces.Comment: 8 page

S-adenosylmethionine and superoxide dismutase 1 synergistically counteract Alzheimer's disease features progression in tgCRND8 mice

Recent evidence emphasizes the role of dysregulated one-carbon metabolism in Alzheimer's Disease (AD). Exploiting a nutritional B-vitamin deficiency paradigm, we have previously shown that PSEN1 and BACE1 activity is modulated by one-carbon metabolism, leading to increased amyloid production. We have also demonstrated that S-adenosylmethionine (SAM) supplementation contrasted the AD-like features, induced by B-vitamin deficiency. In the present study, we expanded these observations by investigating the effects of SAM and SOD (Superoxide dismutase) association. TgCRND8 AD mice were fed either with a control or B-vitamin deficient diet, with or without oral supplementation of SAM + SOD. We measured oxidative stress by lipid peroxidation assay, PSEN1 and BACE1 expression by Real-Time Polymerase Chain Reaction (PCR), amyloid deposition by ELISA assays and immunohistochemistry. We found that SAM + SOD supplementation prevents the exacerbation of AD-like features induced by B vitamin deficiency, showing synergistic effects compared to either SAM or SOD alone. SAM + SOD supplementation also contrasts the amyloid deposition typically observed in TgCRND8 mice. Although the mechanisms underlying the beneficial effect of exogenous SOD remain to be elucidated, our findings identify that the combination of SAM + SOD could be carefully considered as co-adjuvant of current AD therapies

Endpoint estimates and weighted norm inequalities for commutators of fractional integrals

We prove that the commutator [b, Iα], b ∈ BMO, Iα the fractional integral operator, satisfies the sharp, modular weak-type inequality f(x) tdx, where B(t) = tlog(e + t) and Ψ(t)=[tlog(e + tα/n)]n/(n−α). These commutators were first considered by Chanillo, and our result complements his. The heart of our proof consists of the pointwise inequality, M#([b, Iα]f)(x) ≤ CbBMO [Iαf(x) + Mα,Bf(x)], where M# is the sharp maximal operator, and Mα,B is a generalization of the fractional maximal operator in the scale of Orlicz spaces. Using this inequality we also prove one-weight inequalities for the commutator; to do so we prove one and two-weight norm inequalities for Mα,B which are of interest in their own right.[b, Iα]f(x

Quantum Degenerate Systems

Degenerate dynamical systems are characterized by symplectic structures whose rank is not constant throughout phase space. Their phase spaces are divided into causally disconnected, nonoverlapping regions such that there are no classical orbits connecting two different regions. Here the question of whether this classical disconnectedness survives quantization is addressed. Our conclusion is that in irreducible degenerate systems --in which the degeneracy cannot be eliminated by redefining variables in the action--, the disconnectedness is maintained in the quantum theory: there is no quantum tunnelling across degeneracy surfaces. This shows that the degeneracy surfaces are boundaries separating distinct physical systems, not only classically, but in the quantum realm as well. The relevance of this feature for gravitation and Chern-Simons theories in higher dimensions cannot be overstated.Comment: 18 pages, no figure

Kodaira-Spencer formality of products of complex manifolds

We shall say that a complex manifold $X$ is emph{Kodaira-Spencer formal} if its Kodaira-Spencer differential graded Lie algebra $A^{0,*}_X(Theta_X)$ is formal; if this happen, then the deformation theory of $X$ is completely determined by the graded Lie algebra $H^*(X,Theta_X)$ and the base space of the semiuniversal deformation is a quadratic singularity.. Determine when a complex manifold is Kodaira-Spencer formal is generally difficult and we actually know only a limited class of cases where this happen. Among such examples we have Riemann surfaces, projective spaces, holomorphic Poisson manifolds with surjective anchor map $H^*(X,Omega^1_X) o H^*(X,Theta_X)$ and every compact K"{a}hler manifold with trivial or torsion canonical bundle. In this short note we investigate the behavior of this property under finite products. Let $X,Y$ be compact complex manifolds; we prove that whenever $X$ and $Y$ are K"{a}hler, then $X imes Y$ is Kodaira-Spencer formal if and only if the same holds for $X$ and $Y$. A revisit of a classical example by Douady shows that the above result fails if the K"{a}hler assumption is droppe