The evidence for automated grading in diabetic retinopathy screening

Peer reviewedPostprin

Longitudinal Polarization at future e+e−e^+e^- Colliders and Virtual New Physics Effects

The theoretical merits of longitudinal polarization asymmetries of electron-positron annihilation into two final fermions at future colliders are examined, using a recently proposed theoretical description. A number of interesting features, valid for searches of virtual effects of new physics, is underlined, that is reminiscent of analogous properties valid on top of $Z$ resonance. As an application to a concrete example, we consider the case of a model with triple anomalous gauge couplings and show that the additional information provided by these asymmetries would lead to a drastic reduction of the allowed domain of the relevant parameters.Comment: 18 pages and 1 figure. e-mail: [email protected]

Cross-country differences in unemployment : fiscal policy, unions, and household preferences in general equilibrium

We develop a five period overlapping generations model with individuals who differ by ability and with an imperfect labour market (union wage setting) for the individuals of lower ability. The model explains human capital formation, hours worked and unemployment within one coherent framework. Its predictions match the differences in the unemployment rate across 12 OECD countries remarkably well. A Shapley decomposition of these differences reveals an almost equal role for fiscal policy variables and union preferences. As to fiscal policy, differences in unemployment benefits play a much more important role than tax differences. Differences in households’ taste for leisure are unimportant

Note and Comment

The Tight of a Trade Union to Enforce a Boycott; Criminal Responsibility of Husband for Maliciously Slandering His Wife; The Bulk Sales Laws; The Police Power and Liberty of Contract; The Obligations Resulting from an Indorsement, In Blank, Before Delivery, of a Negotiable Instrumen

Falcon Research in Greenland, 1973

... During the summer of 1972 a research team initiated the first in-depth study of the peregrine falcon (Falco peregrinus) in West Greenland. Eight eyries (nests) of this endangered species were located in an inland sample area of 700 sq. mi. Detailed observations were taken of peregrine breeding behaviour at one eyrie. Seven of the eyries produced young, containing an average of 2.57 young per successful eyrie. This high reproductive rate indicates a healthy population, but analyses of 2 addled eggs revealed high p,p'-DDE as well as polychlorinated biphenyl (PCB) residues and eggshell fragments from 9 eggs showed a 14 per cent decrease in thickness compared with 42 eggs collected in Greenland before the introduction of DDT into the environment. ... The [1973] survey area consisted of 900 sq. mi. (2,330 sq. km.), including ice-cap, lakes, fjords, and other unsuitable habitat totalling about 150 sq. mi. (388 sq. km.). We found 10 occupied peregrine falcon nesting cliffs in the survey area in 1973. ... 9 eyries produced young. Of these 9, 7 were also successful in 1972, while another was occupied throughout the season by an aggressive pair, and at the ninth a lone female mildly defended the cliff. Of the 9 producing eyries in 1973, 1 contained 4 young, 5 contained 3 young each, 2 had 2 young each, and 1 held 1 young. This gives a total of 24 young peregrines and a production rate of 2.4 young per occupied eyrie, or 2.67 young per successful eyrie. These young were counted at advanced ages varying from 2.5 weeks to just before fledging. It is believed that all or almost all fledged. We found 1 occupied eyrie per 90 sq. mi. (233 sq. km.), or 1 successful eyrie per 100 sq. mi. (260 sq. km.). All young were banded with a metal band on the left tarsus and a red plastic band on the right. ... The colour bands signify the beginning of an international peregrine colour banding system established for quick geographical identification of banding locality. During the 2 summers, 9 gyrfalcon nesting cliffs were located in the survey area. We believe that at least 6 of the 9 locations were occupied in 1972. In 1973, 8 of the 9 cliffs were checked. Young were found at 4 sites. A fifth was observed from an aircraft and appeared to be active. Lone adults were observed at 2 other locations. Seven young gyrfalcons were banded out of 10 young found. One nest site was inaccessible and the young were not banded, accounting for the difference in number located and banded. The production rate per producing pair of gyrfalcons was 2.50 young. ... Our sample survey indicates that in 1973, as in 1972, the peregrine falcon reproduced normally in West Greenland. The slightly higher production rate in 1973 can possibly be attributed to warmer temperatures during the nesting period, as the summer of 1972 was unseasonably cool. However, the 1972 data on eggshell thinning and high DDE and PCB residues reveal that this population is precariously balanced, and severe reproductive failure threatens. Analysis of the 1973 addled egg and measurement of the additional eggshell fragments will supplement the 1972 results to provide a larger data base. ..

Obstacle avoidance using stereo vision and deep reinforcement learning in an animal-like robot

Obstacle avoidance is a fundamental behavior required to achieve safety and stability in both animals and robots. Many animals perceive and safely navigate their environment using two eyes with overlapping visual fields, allowing the use of stereopsis to compute distances to surfaces and to support collision avoidance. In this paper we develop an obstacle avoidance behavior for the biomimetic robot MiRo that combines stereo vision with deep reinforcement learning. We further show that avoidance strategies, learned for a simulated robot and environment, can be effectively transferred to a physical robot

Is there an integrative center in the vertebrate brain-stem? A robotic evaluation of a model of the reticular formation viewed as an action selection device

Neurobehavioral data from intact, decerebrate, and neonatal rats, suggests that the reticular formation provides a brainstem substrate for action selection in the vertebrate central nervous system. In this article, Kilmer, McCulloch and Blum’s (1969, 1997) landmark reticular formation model is described and re-evaluated, both in simulation and, for the first time, as a mobile robot controller. Particular model configurations are found to provide effective action selection mechanisms in a robot survival task using either simulated or physical robots. The model’s competence is dependent on the organization of afferents from model sensory systems, and a genetic algorithm search identified a class of afferent configurations which have long survival times. The results support our proposal that the reticular formation evolved to provide effective arbitration between innate behaviors and, with the forebrain basal ganglia, may constitute the integrative, ’centrencephalic’ core of vertebrate brain architecture. Additionally, the results demonstrate that the Kilmer et al. model provides an alternative form of robot controller to those usually considered in the adaptive behavior literature

Integrin-dependent control of translation: engagement of integrin alphaIIbbeta3 regulates synthesis of proteins in activated human platelets.

Integrins are widely expressed plasma membrane adhesion molecules that tether cells to matrix proteins and to one another in cell-cell interactions. Integrins also transmit outside-in signals that regulate functional responses of cells, and are known to influence gene expression by regulating transcription. In previous studies we found that platelets, which are naturally occurring anucleate cytoplasts, translate preformed mRNA transcripts when they are activated by outside-in signals. Using strategies that interrupt engagement of integrin alphaIIbbeta3 by fibrinogen and platelets deficient in this integrin, we found that alphaIIbbeta3 regulates the synthesis of B cell lymphoma 3 (Bcl-3) when platelet aggregation is induced by thrombin. We also found that synthesis of Bcl-3, which occurs via a specialized translation control pathway regulated by mammalian target of rapamycin (mTOR), is induced when platelets adhere to immobilized fibrinogen in the absence of thrombin and when integrin alphaIIbbeta3 is engaged by a conformation-altering antibody against integrin alphaIIbbeta3. Thus, outside-in signals delivered by integrin alphaIIbbeta3 are required for translation of Bcl-3 in thrombin-stimulated aggregated platelets and are sufficient to induce translation of this marker protein in the absence of thrombin. Engagement of integrin alpha2beta1 by collagen also triggered synthesis of Bcl-3. Thus, control of translation may be a general mechanism by which surface adhesion molecules regulate gene expression

Motion-Based Technical Skills Assessment in Transoesophageal Echocardiography

This paper presents a novel approach for evaluating technical skills in Transoesophageal Echocardiography (TEE). Our core assumption is that operational competency can be objectively expressed by specific motion-based measures. TEE experiments were carried out with an augmented reality simulation platform involving both novice trainees and expert radiologists. Probe motion data were collected and used to formulate various kinematic parameters. Subsequent analysis showed that statistically significant differences exist among the two groups for the majority of the metrics investigated. Experts exhibited lower completion times and higher average velocity and acceleration, attributed to their refined ability for efficient and economical probe manipulation. In addition, their navigation pattern is characterised by increased smoothness and fluidity, evaluated through the measures of dimensionless jerk and spectral arc length. Utilised as inputs to well-known clustering algorithms, the derived metrics are capable of discriminating experience levels with high accuracy (>84 %)