B¨acklund transformations for Cosgrove’s equation F-XVIII

In this paper we study B¨acklund transformations (BTs) for Cosgrove’s equation F-XVIII.We use the generalization of Fokas and Ablowitz method to derive BTs between F-XVIII and new fourth-order ordinary differential equations (ODEs) of Painlev´e-type. Moreover we derive auto-BT and give special solutions for F-XVIII.In this paper we study B¨acklund transformations (BTs) for Cosgrove’s equation F-XVIII.We use the generalization of Fokas and Ablowitz method to derive BTs between F-XVIII and new fourth-order ordinary differential equations (ODEs) of Painlev´e-type. Moreover we derive auto-BT and give special solutions for F-XVII

Dual buoyant/mucoadhesive macroporous polypropylene microparticles for gastric delivery of repaglinide

Preparation and characterization of dual buoyant/mucoadhesive polypropylene microparticles (MPs) loaded with repaglinide (REP) for gastric drug delivery in order to augment the weak mucoadhesion in the stomach.Porous foam powder MPs were prepared using coating polymers with variable permeability (Eudragit L100, Eudragit RSPO) alone or in combination by the soaking method. Thiolated Eudragit L100 (Eudragit L100-SH) was also synthesized and tried in an attempt to enhance the mucoadhesive properties of MPs. All formulae were characterized for their yield, flow properties, particle size, encapsulation efficiency (EE %), morphology, and drug release and its mechanistics. Possible interactions inside MPs matrix were also elucidated using FTIR study. The suitability of the selected formulae for gastroretention was evaluated by in vitro buoyancy and ex-vivo mucoadhesion studies.All REP-loaded MPs demonstrated a passable powder flow, high yield values, promising floatation and mucoadhesion. Encapsulation efficiency % values were nearly tripled upon addition of Eudragit polymers. Compared to the Eudragit free REP loaded foam powder, all formula showed more sustained release features. Eudragit L100-SH was synthesized and confirmed by FTIR. Furthermore, its incorporation, alone or in combination, exhibited a significant increase in mucoadhesion strength compared to the unmodified one.Dual buoyant/mucoadhesive MPs loaded with REP encourage planning for future in-vivo performance studies for the management of diabetes

Antibodies to Mutated Citrullinated Vimentin in Rheumatoid Arthritis: Diagnostic Value, Association with Radiological Damage and Axial Skeleton Affection

Abstract Background: Early definitive diagnosis and effective treatment are mandatory in rheumatoid arthritis (RA) as it can halt the disease progression and subsequent joints destruction. Objective: To investigate the diagnostic and prognostic value of anti-mutated citrullinated vimentin (anti-MCV) and its correlation with disease activity, peripheral and axial skeleton affection in RA patients. Patients and methods: A total of 123 patients with different rheumatic diseases were enrolled in a prospective-two year study at Ain Shams University hospital: 64 patients with RA and 59 patients with other rheumatic diseases as controls. RA patients were fulfilling the traditional and the new ACR/EULAR diagnostic criteria for RA. They have been followed up for two years. At baseline, all RA patients were subjected to: Clinical assessment of disease activity by taking full histories, general and local examination, measurement of 28 joint count of tender and swollen joints with calculation of disease activity score (DAS-28) for each patient. Complete blood count, erythrocytes sedimentation rate, C-reactive protein and rheumatoid factor titers were performed. Anti-MCV IgG immunoglobulins’ assay was performed at the study endpoint by ELISA. RA patients were then classified into; anti-MCV positive and anti-MCV negative groups for statistical comparison. Plain X-ray was performed on the peripheral joints and scored by the Simple Erosion Narrowing score (SEN-score). Magnetic Resonance Imaging (MRI) scans were carried out to 22 RA patients on cervical and lumbosacral regions. Results: Anti-MCV antibodies were found to be of high sensitivity (79.6%) and specificity (96.6%) in diagnosing RA. The area under the curve was 0.893 at 95% confidence interval (CI), confers an odds ratio of 23.5. Anti-MCV positive RA patients had significantly higher DAS-28 and SEN-scores than anti-MCV negative patients; who were found to have more benign disease with lower incidence of erosions (P , 0.05). MRI scans revealed that; 17/22 (77%) had cervical joints involvement while, 8 (36%) had lumbo-sacral joint lesions (P , 0.05), both were correlated significantly with aggressive peripheral joint disease. Conclusion: Anti-MCV antibodies are promising diagnostic and prognostic marker in RA, with high sensitivity and specificity. They may identify a subset of RA patients with aggressive early erosive disease. The axial skeleton—especially the cervical spine—could be affected in RA and this was correlated with aggressive peripheral joints’ disease. MRI scanning is a sensitive method for detecting axial skeleton involvement in RA, in attempt for better disease control and outcomes

Improving irrigation efficiency will be insufficient to meet future water demand in the Nile Basin

The Nile River Basin covers an area of approximately 3.2 million km2 and is shared by 11 countries. Rapid population growth is expected in the region. The irrigation requirements of Nile riparian countries of existing (6.4 million ha) and additional planned (3.8 million ha, 2050) irrigation schemes were calculated, and the likely water savings through improved irrigation efficiency were evaluated. We applied SPARE:WATER to calculate irrigation demands on the basis of the well-known FAO56 Crop Irrigation Guidelines. Egypt (67 km3 yr-1) and Sudan (19 km3 yr-1) consume the highest share of the 84 km3 yr-1 total (2011). Assuming today’s poor irrigation infrastructure, the total consumption was predicted to increase to 123 km3 yr-1 (2050), an amount far exceeding the total annual yield of the Nile Basin. Therefore, a key challenge for water resources management in the Nile Basin is balancing the increasing irrigation water demand basin-wide with the available water supply. We found that water savings from improved irrigation technology will not be able to meet the additional needs of planned areas. Under a theoretical scenario of maximum possible efficiency, the deficit would still be 5 km3 yr-1. For more likely efficiency improvement scenarios, the deficit ranged between 23 and 29 km3 yr-1. Our results suggest that that improving irrigation efficiency may substantially contribute to decreasing water stress on the Nile system but would not completely meet the demand. Study Region: The Nile River Basin covers an area of approximately 3.2 million km2 and is shared by 11 countries. Rapid population growth is expected in the region. Study Focus: Record population growth is expected for the study region. Therefore, the irrigation requirements of Nile riparian countries of existing (6.4 million ha) and additional planned (3.8 million ha, 2050) irrigation schemes were calculated, and likely water savings through improved irrigation efficiency were evaluated. We applied a spatial decision support system (SPARE:WATER) to calculate the irrigation demands on the basis of the well-known FAO56 Crop Irrigation Guidelines. New Hydrological Insights for the Region: Egypt (67 km3yr-1) and Sudan (19 km3yr-1) consume the highest share of 84 km3yr-1 (2011). Assuming today’s poor irrigation infrastructure, the total demand were predicted to increase to 123 km3yr-1 (2050), an amount far exceeding the total annual yield of the Nile Basin. Therefore, a key challenge for water resources management in the Nile Basin is balancing the increasing irrigation water demand and available water supply. We found that water savings from improved irrigation technology will not be able to meet the additional needs of planned areas. Under a theoretical scenario of maximum possible efficiency, the deficit would still be 5 km3yr-1. For more likely efficiency improvement scenarios, the deficit ranges between 23 and 29 km3yr-1. Our results suggest that improving irrigation efficiency may substantially contribute to decreasing water stress on the Nile system but would not completely meet the demand

Neoadjuvant chemotherapy versus primary surgery in advanced ovarian carcinoma

BACKGROUND: Patients with advanced ovarian cancer should be treated by radical debulking surgery aiming at complete tumor resection. Unfortunately about 70% of the patients present with advanced disease, when optimal debulking can not be obtained, and therefore these patients gain little benefit from surgery. Neoadjuvant chemotherapy (NACT) has been proposed as a novel therapeutic approach in such cases. In this study, we report our results with primary surgery or neoadjuvant chemotherapy as treatment modalities in the specific indication of operable patients with advanced ovarian carcinoma (no medical contraindication to debulking surgery). PATIENTS AND METHODS: A total of 59 patients with stage III or IV epithelial ovarian carcinomas were evaluated between 1998 and 2003. All patients were submitted to surgical exploration aiming to evaluate tumor resectability. Neoadjuvant chemotherapy was given (in 27 patients) where optimal cytoreduction was not feasible. Conversely primary debulking surgery was performed when we considered that optimal cytoreduction could be achieved by the standard surgery (32 patients). RESULTS: Optimal cytoreduction was higher in the NACT group (72.2%) than the conventional group (62.4%), though not statistically significant (P = 0.5). More important was the finding that parameters of surgical aggressiveness (blood loss rates, ICU stay and total hospital stay) were significantly lower in NACT group than the conventional group. The median overall survival time was 28 months in the conventional group and 25 months in NACT group with a P value of 0.5. The median disease free survival was 19 months in the conventional group and 21 months in NACT group (P = 0.4). In multivariate analysis, the pathologic type and degree of debulking were found to affect the disease free survival significantly. Overall survival was not affected by any of the study parameters. CONCLUSION: Primary chemotherapy followed by interval debulking surgery in select group of patients doesn't appear to worsen the prognosis, but it permits a less aggressive surgery to be performed

Characterization of quaternary chalcogenide As-Ge-Te-Si thin films

Investigated in this paper is the effect of replacement of Te by Si on the optical gap and some other physical operation parameters of quaternary chalcogenide As₃₀Ge₁₀Te₆₀₋xSix (where x = 0, 5, 10, 12 and 20 at.%) thin films. Thin films with the thickness 100-200 nm of As₃₀Ge₁₀Te₆₀₋xSix were prepared using thermal evaporation of bulk samples. Increasing Si content was found to affect the average heat of atomization, average coordination number, number of constraints and cohesive energy of the As₃₀Ge₁₀Te₆₀₋xSix alloys. Optical absorption is due to allowed non-direct transition, and the energy gap increases with increasing Si content. The chemical bond approach has been applied successfully to interpret the increase in the optical gap with increasing silicon content

Chemical Profile of Cyperus laevigatus and Its Protective Effects against Thioacetamide-Induced Hepatorenal Toxicity in Rats

Cyperus species represent a group of cosmopolitan plants used in folk medicine to treat several diseases. In the current study, the phytochemical profile of Cyperus laevigatus ethanolic extract (CLEE) was assessed using UPLC-QTOF–MS/MS. The protective effect of CLEE at 50 and 100 mg /kg body weight (b.w.) was evaluated on hepatorenal injuries induced by thioacetamide (100 mg/kg) via investigation of the extract’s effects on oxidative stress, inflammatory markers and histopathological changes in the liver and kidney. UPLC-QTOF–MS/MS analysis of CLEE resulted in the identification of 94 compounds, including organic and phenolic acids, flavones, aurones, and fatty acids. CLEE improved the antioxidant status in the liver and kidney, as manifested by enhancement of reduced glutathione (GSH) and coenzyme Q10 (CoQ10), in addition to the reduction in malondialdehyde (MDA), nitric oxide (NO), and 8-hydroxy-2′-deoxyguanosine (8OHdG). Moreover, CLEE positively affected oxidative stress parameters in plasma and thwarted the depletion of hepatorenal ATP content by thioacetamide (TAA). Furthermore, treatment of rats with CLEE alleviated the significant increase in plasma liver enzymes, kidney function parameters, and inflammatory markers. The protective effect of CLEE was confirmed by a histopathological study of the liver and kidney. Our results proposed that CLEE may reduce TAA-hepatorenal toxicity via its antioxidant and anti-inflammatory properties suppressing oxidative stress

Chemical Profiling of Significant Antioxidant and Phytotoxic Microwave-Extracted Essential Oil from Araucaria heterophylla Resin

Due to the various hazards of using synthetic chemical compounds in pharmaceutics, agriculture, and industry, scientists and researchers do their best to explore and assess new green natural compounds from natural resources with potent activity. The essential oil (EO) from the resin collected from Araucaria heterophylla Salisb. was extracted by the microwave technique and chemically characterized via GC-MS analysis. Furthermore, the extract EO was assessed for its antioxidant and phytotoxic activities. The EO has 33 compounds, mainly terpenes (98.23%), and the major compounds were α-pinene (62.57%), β-pinene (6.60%), germacrene D (5.88%), and β-caryophyllene (3.56%). The extracted EO showed substantial antioxidant activity, where it showed IC50 values of 142.42 and 118.03 mg L−1 for DPPH and ABTS, respectively. On the other hand, the EO revealed considerable phytotoxicity against the weed Chenopodium murale, where the EO showed IC50 values of 304.0, 230.1, and 147.1 mg L−1, for seed germination, seedling shoot growth, and seedling root growth, respectively. Moreover, the EO showed the same pattern of allelopathic inhibition against the weed Sonchus oleraceus, where it showed IC50 values of 295.7, 224.5, and 106.1 mg L−1, for seed germination, seedling shoot growth, and seedling root growth, respectively. The present study showed that the extraction technique affects the constituents of the EO, particularly the quantitative composition. The EO of A. heterophylla resin also revealed considerable antioxidant and phytotoxic activity against weeds. Therefore, it can be considered a promising natural resource that could be integrated into the weed management approach. However, further study is recommended for deep characterization of their authentic compounds and evaluation of their mode of action(s) on a wide spectrum of weeds

In vitro anti-inflammatory and acetylcholinesterase inhibition efficiency of plant extracts from Sinai-Egypt

Ten plant extracts were prepared and tested in in vitro assays against COX-2, COX-1 and acetylcholinesterase with evaluation of their antioxidant properties. The tested extracts exhibited varied anti COX-2 effect and they were superior to celecoxibe (inhibition percentage was 42.67% at 50 µg/mL), reference drug. Lavandula coronopifolia and Scrophularia Libanotica extracts were the efficient inhibitors (100% and 91% at 50 µg/mL respectively). Launaeaspinosa and Pulicaria undulata were the powerful AChE inhibitor (IC50 values were 16.69 and 29.06 µg/mL, respectively) followed with L. coronopifolia and S.libanotica extracts (IC50 values were 61.89 and 49.83 µg/mL, respectively) and they were efficient in scavenging superoxide radicals and metal ions, nitric oxide formation inhibition, as well as, lipid peroxide production suppression. L. coronopifolia and S. Libanotica extracts can be introduced as natural cyclooxygenase-2 inhibitors without affecting cyclooxygenase-1 whereas L. spinosa and P. undulata extracts were potent suppressor for AChE with robust antioxidant properties which suggest the possibility of using the four extracts, L. coronopifolia, S. libanotica, L. spinosa and P. undulata as natural agent in treating neurodegenerative disorder

In vitro anti-inflammatory and acetylcholinesterase inhibition efficiency of plant extracts from Sinai-Egypt

635-641Ten plant extracts were prepared and tested in in vitro assays against COX-2, COX-1 and acetylcholinesterase with evaluation of their antioxidant properties. The tested extracts exhibited varied anti COX-2 effect and they were superior to celecoxibe (inhibition percentage was 42.67% at 50 µg/mL), reference drug. Lavandula coronopifolia and Scrophularia Libanotica extracts were the efficient inhibitors (100% and 91% at 50 µg/mL respectively). Launaeaspinosa and Pulicaria undulata were the powerful AChE inhibitor (IC50 values were 16.69 and 29.06 µg/mL, respectively) followed with L. coronopifolia and S.libanotica extracts (IC50 values were 61.89 and 49.83 µg/mL, respectively) and they were efficient in scavenging superoxide radicals and metal ions, nitric oxide formation inhibition, as well as, lipid peroxide production suppression. L. coronopifolia and S. Libanotica extracts can be introduced as natural cyclooxygenase-2 inhibitors without affecting cyclooxygenase-1 whereas L. spinosa and P. undulata extracts were potent suppressor for AChE with robust antioxidant properties which suggest the possibility of using the four extracts, L. coronopifolia, S. libanotica, L. spinosa and P. undulata as natural agent in treating neurodegenerative disorder