Turbulent film condensation in a vertical tube in presence of non condensable gas

This paper presents the simulation of the condensation of methanol vapour in the presence of non-condensable gas in turbulent flows in a vertical tube. The liquid and gas stream are approached by two coupled turbulent boundary layer. For solving the coupled governing equations for liquid film and gas flow together with the interfacial matching conditions an implicit finite difference method is employed. The effect of the influencing parameters are studied so the effect of inlet Reynolds number, the effect of temperature gradient, mass fraction are illustrated. The numerical results demonstrate that an important concentration of no-condensable gas reduces the heat transfer coefficient and film thickness considerably. The local heat flux and film thickness increase as tube surface temperature decreases at any bulk concentration of non-condensable gas. Moreover, inlet velocity increases as film thickness decreases and heat flux increases

Two-Phase Pulsed Flow of a Non Newtonian Fluid in Pipe with Elastic Wall

K. Gueraoui Team of modelling in fluid mechanics and environment, LPT, URAC 13 Faculty of sciences, Mohamme

CANCER DU COL, DYSPLASIE, DYSPLASIE SEVERE, MICRO INVASION : CARACTERISTIQUE DE LA PRISE EN CHARGE PENDANT la grossesse ?

Approximately 30% of cervical cancers occur in women of childbearing age. In early pregnancy , it is now recommended that a new cervical cytology if the previous rise to 2 years or more , or in the absence of regular monitoring. The methods of conventional cytology smears or said liquid medium are easily achievable. Pregnancy makes available the junction area and changes of pregnancy do not reduce the diagnostic value of smears after informing the cytologist. During pregnancy colposcopy examination remains essential to assess the cytological abnormalities . If the smear shows a high-grade lesion , an ASC- H, or low - grade and ASC-US or glandular atypia (AGC) colposcopy and directed biopsy is performed. Rates dysplasia found is of course variable but to behave similarly. The aim of our work is referred to the particularities of the association of cervical cancer and pregnancy in different diagnostic and therapeutic steps.Environ 30 % des cancers du col surviennent chez des femmes en âge de procréer. En début de grossesse, il est actuellement recommandé de réaliser une nouvelle cytologie cervicale si la précédente remonte à 2 ans ou plus, ou en l’absence de suivi régulier. Les méthodes de cytologie conventionnelle dite de Papanicolaou ou en milieu liquide sont facilement réalisables. La grossesse rend accessible la zone de jonction et les modifications gravidiques ne diminuent pas la valeur diagnostique du frottis après information du cytologiste. Pendant la grossesse la colposcopie demeure l’examen indispensable pour évaluer les anomalies cytologiques. Si le frottis montre une lésion de haut grade, une ASC-H, ou de bas-grade et ASC-US ou une atypie glandulaire (AGC) on réalise une colposcopie et biopsie dirigée .Le taux de dysplasie retrouvé est bien sûr variable mais la conduite à tenir est similaire. Le but de notre travail est d’évoqué les particularités liées à l’association cancer du col et grossesse aux différentes étapes diagnostiques et thérapeutiques

Exploring Medicinal Herbs’ Therapeutic Potential and Molecular Docking Analysis for Compounds as Potential Inhibitors of Human Acetylcholinesterase in Alzheimer’s Disease Treatment

Background and Objectives: Alzheimer’s disease (AD) stands as a pervasive neurodegenerative ailment of global concern, necessitating a relentless pursuit of remedies. This study aims to furnish a comprehensive exposition, delving into the intricate mechanistic actions of medicinal herbs and phytochemicals. Furthermore, we assess the potential of these compounds in inhibiting human acetylcholinesterase through molecular docking, presenting encouraging avenues for AD therapeutics. Materials and Methods: Our approach entailed a systematic exploration of phytochemicals like curcumin, gedunin, quercetin, resveratrol, nobiletin, fisetin, and berberine, targeting their capability as human acetylcholinesterase (AChE) inhibitors, leveraging the PubChem database. Diverse bioinformatics techniques were harnessed to scrutinize molecular docking, ADMET (absorption, distribution, metabolism, excretion, and toxicity), and adherence to Lipinski’s rule of five. Results: Results notably underscored the substantial binding affinities of all ligands with specific amino acid residues within AChE. Remarkably, gedunin exhibited a superior binding affinity (−8.7 kcal/mol) compared to the reference standard. Conclusions: These outcomes accentuate the potential of these seven compounds as viable candidates for oral medication in AD treatment. Notably, both resveratrol and berberine demonstrated the capacity to traverse the blood-brain barrier (BBB), signaling their aptitude for central nervous system targeting. Consequently, these seven molecules are considered orally druggable, potentially surpassing the efficacy of the conventional drug, donepezil, in managing neurodegenerative disorders

Screening of Phytochemical, Antimicrobial, and Antioxidant Properties of <i>Juncus acutus</i> from Northeastern Morocco

Juncus acutus, acknowledged through its indigenous nomenclature “samar”, is part of the Juncaceae taxonomic lineage, bearing considerable import as a botanical reservoir harboring conceivable therapeutic attributes. Its historical precedence in traditional curative methodologies for the alleviation of infections and inflammatory conditions is notable. In the purview of Eastern traditional medicine, Juncus species seeds find application for their remedial efficacy in addressing diarrhea, while the botanical fruits are subjected to infusion processes targeting the attenuation of symptoms associated with cold manifestations. The primary objective of this study was to unravel the phytochemical composition of distinct constituents within J. acutus, specifically leaves (JALE) and roots (JARE), originating from the indigenous expanse of the Nador region in northeastern Morocco. The extraction of plant constituents was executed utilizing an ethanol-based extraction protocol. The subsequent elucidation of chemical constituents embedded within the extracts was accomplished employing analytical techniques based on high-performance liquid chromatography (HPLC). For the purpose of in vitro antioxidant evaluation, a dual approach was adopted, encompassing the radical scavenging technique employing 2,2-diphenyl-1-picrylhydrazyl (DPPH) and the total antioxidant capacity (TAC) assay. The acquired empirical data showcase substantial radical scavenging efficacy and pronounced relative antioxidant activity. Specifically, the DPPH and TAC methods yielded values of 483.45 ± 4.07 µg/mL and 54.59 ± 2.44 µg of ascorbic acid (AA)/mL, respectively, for the leaf extracts. Correspondingly, the root extracts demonstrated values of 297.03 ± 43.3 µg/mL and 65.615 ± 0.54 µg of AA/mL for the DPPH and TAC methods. In the realm of antimicrobial evaluation, the assessment of effects was undertaken through the agar well diffusion technique. The minimum inhibitory concentration, minimum bactericidal concentration, and minimum fungicidal concentration were determined for each extract. The inhibitory influence of the ethanol extracts was observed across bacterial strains including Staphylococcus aureus, Micrococcus luteus, and Pseudomonas aeruginosa, with the notable exception of Escherichia coli. However, fungal strains such as Candida glabrata and Rhodotorula glutinis exhibited comparatively lower resistance, whereas Aspergillus niger and Penicillium digitatum exhibited heightened resistance, evincing negligible antifungal activity. An anticipatory computational assessment of pharmacokinetic parameters was conducted, complemented by the application of the Pro-tox II web tool to delineate the potential toxicity profile of compounds intrinsic to the studied extracts. The culmination of these endeavors underpins the conceivable prospects of the investigated extracts as promising candidates for oral medicinal applications

GC/MS Profiling, In Vitro Antidiabetic Efficacy of <i>Origanum compactum</i> Benth. Essential Oil and In Silico Molecular Docking of Its Major Bioactive Compounds

Diabetes is a global health concern with significant implications for individuals and healthcare systems. Finding effective and safe antidiabetic agents is crucial for the management of this chronic disease. Natural products have emerged as potential alternatives to allopathic drugs, offering a vast source of bioactive compounds. In this study, we conducted an assessment of the antidiabetic potential of Origanum compactum essential oil, employing a two-pronged approach, i.e., experimental investigation and computational docking analysis. The results of gas chromatography–mass spectrometry (GC-MS) showed that thymol (54.6%), carvacrol (23.18%), and p-cymene (7.12%) were the major compounds. Experimental assessments revealed higher IC50 values (150 µg/mL for α-amylase; 120 µg/mL for α-glucosidase) of O. compactum oil, compared to the control drug acarbose. In silico analysis revealed the best binding affinity of the oil components (carvacrol and thymol) with human NADPH oxidase, while the lysosomal acid-α-glucosidase and salivary amylase also demonstrated good binding affinity towards carvacrol and thymol. Our findings highlight the translational potential of O. compactum oil-based treatment for diabetes mellitus and provide a basis for further studies on the modulation of NADPH oxidase, amylase inhibition, and α-glucosidase by antidiabetic natural products. However, further in vivo investigations are strongly required to confirm the results of in vitro antidiabetic effect of O. compactum EO

Quantifying Landscape and Social Amenities as Ecosystem Services in Rapidly Changing Peri-Urban Landscape

The peri-urban landscape is a highly dynamic area between the urban zone and the rural belt. The heterogeneous natural landscape around the cities provides several ecosystem services, but progressive urbanization affects it and results in the loss of biodiversity, greenery, and related benefits. This study attempts to quantify the social amenities associated with ecosystem services in the peri-urban landscape of the Gujrat district, in Pakistan, by using the Contingent Valuation Method (CVM) The results show that the peri-urban landscape provides amenities for the well-being of the community. Such amenities and the related recreational opportunities represent ecosystem services that are highly regarded by the residents, so much so that a significant willingness to pay can be associated with them. Therefore, this study highlights that natural areas and green areas’ landscapes must be taken into account when facing the social and economic necessity to provide for city expansion in developing countries, especially when aiming to achieve development in alignment with the Sustainable Development Goals. The ecosystem services and their evaluation are confirmed as indispensable tools for conservation and fortification of landscape development