Synthesis and Spectroscopic Study of Naphtholic and Phenolic Azo Dyes

Azo dyes are extremely important in variety of industries for variety of technical purposes. Hence, a series of naphtholic azo dyes 1-9 were synthesized via diazotization of substituted aniline derivatives followed by azo coupling with 2-naphthol. In similar manner, diazotization followed by azo coupling with phenol afforded phenolic azo dyes 10-17 in excellent yields. The chemical structures of all synthesized compounds were confirmed using analytical data and spectroscopic technique which include Uv-visible, IR, Mass spectra, 1H- and 13C-NMR

Approaches to Economic Empowerment of Rural Women for Climate Change Mitigation and Adaptation: Implications for Policy

There are several ways of promoting women’s economic participation while also counteracting climate change. One approach in the field of climate mitigation is the promotion of renewable energies that help avoid greenhouse gas emissions. The potential of rural women as agents of change for climate mitigation and adaptation remains untapped: Their extensive theoretical and practical knowledge of the environment and resource conservation is not given due consideration. In terms of economic participation, they are not paid for the environmental services that they already provide (example, reforestation). The potential contribution of rural women to climate mitigation by being part of the economic cycle is not sufficiently exploited. The economic empowerment of women through climate mitigation and adaptation fosters economic growth and socioeconomic development, reduces poverty, keeps environmental problems in check, and increases the potential for adaptation, which is to the benefit of both women and men. Enhancing the economic empowerment of women is a catalyst for development, which helps boost a country’s economic growth, promotes the socioeconomic development not only of women, but of the entire population, and helps reduce poverty. It is observed that less attention is paid to the potential that lies in the combination of climate mitigation/ adaptation and the economic empowerment of rural women. Yet mitigation or adaptation activities offer opportunities to advance the economic empowerment of women. In particular, this applies to work that is already being undertaken by women or activities in which women could assume a leading role. In developing countries, for instance, women frequently play a major role in the reforestation and afforestation of cleared land and in forest conservation, yet they have hardly ever benefited from these environmental services. The paper addresses the economic empowerment of rural women through climate change mitigation and adaptation. The study recommends that measures to promote the economic participation of women can be integrated into climate mitigation and adaptation initiatives. In order for rural women to play an economic role, an institutional, legal and political framework is required that enables and/or makes it easier for rural women to hold their own in the market. Concrete, promising project measures at the local level should therefore be combined with advisory services at the political level related to climate change and the economic empowerment of women, with a view to initiating structural reformÂ

Approaches to Economic Empowerment of Rural Women for Climate Change Mitigation and Adaptation: Implications for Policy

There are several ways of promoting women’s economic participation while also counteracting climate change. One approach in the field of climate mitigation is the promotion of renewable energies that help avoid greenhouse gas emissions. The potential of rural women as agents of change for climate mitigation and adaptation remains untapped: Their extensive theoretical and practical knowledge of the environment and resource conservation is not given due consideration. In terms of economic participation, they are not paid for the environmental services that they already provide (example, reforestation). The potential contribution of rural women to climate mitigation by being part of the economic cycle is not sufficiently exploited. The economic empowerment of women through climate mitigation and adaptation fosters economic growth and socioeconomic development, reduces poverty, keeps environmental problems in check, and increases the potential for adaptation, which is to the benefit of both women and men. Enhancing the economic empowerment of women is a catalyst for development, which helps boost a country’s economic growth, promotes the socioeconomic development not only of women, but of the entire population, and helps reduce poverty. It is observed that less attention is paid to the potential that lies in the combination of climate mitigation/ adaptation and the economic empowerment of rural women. Yet mitigation or adaptation activities offer opportunities to advance the economic empowerment of women. In particular, this applies to work that is already being undertaken by women or activities in which women could assume a leading role. In developing countries, for instance, women frequently play a major role in the reforestation and afforestation of cleared land and in forest conservation, yet they have hardly ever benefited from these environmental services. The paper addresses the economic empowerment of rural women through climate change mitigation and adaptation. The study recommends that measures to promote the economic participation of women can be integrated into climate mitigation and adaptation initiatives. In order for rural women to play an economic role, an institutional, legal and political framework is required that enables and/or makes it easier for rural women to hold their own in the market. Concrete, promising project measures at the local level should therefore be combined with advisory services at the political level related to climate change and the economic empowerment of women, with a view to initiating structural reformÂ

Nasal carriage of methicillin resistant Staphylococcus aureus among medical students of a private institution in Ilishan-Remo, Ogun State, Nigeria

Background: Nasal carriage of methicillin resistant Staphylococcus aureus (MRSA) is a major factor for its transmission especially from the health workers and medical students to their patients. There are a number of published data on the prevalence of MRSA among health workers but data on nasal colonization of medical students by MRSA are sparse in Nigeria. The objectives of this study are to determine the prevalence of nasal carriage of MRSA among medical students of the Ben Carson School of Medicine, Babcock University, Ilishan-Remo, Ogun State, Nigeria, and identify risk factors associated with this nasal carriage. Methodology: A case control study involving 100 clinical (study group) and 100 pre- clinical (control group) medical students was undertaken between March 2018 and October 2019. Structured questionnaire was administered to obtain socio-demographic information and potential risk factors. Nasal swab was collected from each student and cultured for isolation of S. aureus by standard microbiology techniques. Phenotypic MRSA was detected by the cefoxitin 30μg disk diffusion method according to the guideline of Clinical and Laboratory Standards Institute. The mecA gene was detected by conventional polymerase chain reaction (PCR) assay. Results: The prevalence of S. aureus nasal carriage among the study group was 14% (14/100) while the prevalence among the control group was 6% (6/100) (p=0.097). The prevalence of phenotypic MRSA among the study group was 4% (4/100) and 1% (1/100) among the control group (p=0.3687) while mecA gene was detected in 3 of the 4 (75%) phenotypic MRSA positive study participants and in the only (100%) phenotypic MRSA positive (1%) control group. Antibiotics usage without prescription, antibiotic treatment of common cold, and use of antibiotics in the previous one year, were significantly associated with MRSA carriage among the study group. Conclusion: Although the prevalence of nasal carriage of S. aureus and MRSA among clinical and pre-clinical medical students was not statistically significant, the risk factors identified with carriage of MRSA among the study group indicates the need for antimicrobial stewardship program to reduce carriage and transmission of MRSA by medical students. Keywords: methicillin resistant, Staphylococcus aureus, mecA gene, nasal carriage, medical student

Light-to-moderate alcohol consumption and mortality in the physicians’ health study enrollment cohort

AbstractOBJECTIVESThis study examined the relationship between light-to-moderate alcohol consumption and cause-specific mortality.BACKGROUNDPrevious studies suggest a J-shaped relation between alcohol and total mortality in men. A decrease in cardiovascular disease (CVD) mortality without a significant increase in other causes of mortality may explain the overall risk reduction at light-to-moderate levels.METHODSWe conducted a prospective cohort study of 89,299 U.S. men from the Physicians’ Health Study enrollment cohort who were 40 to 84 years old in 1982 and free of known myocardial infarction, stroke, cancer or liver disease at baseline. Usual alcohol consumption was estimated by a limited food frequency questionnaire.RESULTSThere were 3,216 deaths over 5.5 years of follow-up. We observed a U-shaped relationship between alcohol consumption and total mortality. Compared with rarely/never drinkers, consumers of 1, 2 to 4 and 5 to 6 drinks per week and 1 drink per day had significant reductions in risk of death (multivariate relative risks [RRs] of 0.74, 0.77, 0.78 and 0.82, respectively) with no overall benefit or harm detected at the ≥2 drinks per day level (RR = 0.95; 95% confidence interval (CI), 0.79 to 1.14). The relationship with CVD mortality was inverse or L-shaped with apparent risk reductions even in the highest category of ≥2 drinks per day (RR = 0.76; 95% CI, 0.57 to 1.01). We found no clear harm or benefit for total or common site-specific cancers. For remaining other cancers, there was a nonsignificant 28% increased risk for those consuming ≥2 drinks per day.CONCLUSIONSThese data support a U-shaped relation between alcohol and total mortality among light-to-moderate drinking men. The U-shaped curve may reflect an inverse association for CVD mortality, no association for common site-specific cancers and a possible positive association for less common cancers

Multicentre phase II pharmacokinetic and pharmacodynamic study of OSI-7904L in previously untreated patients with advanced gastric or gastroesophageal junction adenocarcinoma

A two-stage Simon design was used to evaluate the response rate of OSI-7904L, a liposome encapsulated thymidylate synthase inhibitor, in advanced gastric and/or gastroesophageal adenocarcinoma (A-G/GEJA), administered intravenously at 12 mg m−2 over 30 min every 21 days. Fifty patients were treated. Median age was 64 years (range 35–82), 62% were male and 89% had ECOG PS of 0/1. A total of 252 cycles were administered; median of 4 per patient (range 1–21). Twelve patients required dose reductions, mainly for skin toxicity. Investigator assessed response rate was 17.4% (95% CI 7.8–31.4) with one complete and seven partial responses in 46 evaluable patients. Twenty-one patients (42%) had stable disease. Median time to progression and survival were 12.4 and 36.9 weeks, respectively. NCI CTCAE Grade 3/4 neutropenia (14%) and thrombocytopenia (4%) were uncommon. The main G3/4 nonhaematological toxicities were skin-related 22%, stomatitis 14%, fatigue/lethargy 10%, and diarrhea 8%. Pharmacokinetic data showed high interpatient variability. Patients with higher AUC were more likely to experience G3/4 toxicity during cycle 1 while baseline homocysteine did not predict toxicity. Response did not correlate with AUC. Elevations in 2′-dU were observed indicating target inhibition. Analysis of TS genotype, TS protein and expression did not reveal any correlation with outcome. OSI-7904L has activity in A-G/GEJA similar to other active agents and an acceptable safety profile

Association of Body Mass Index and Extreme Obesity With Long-Term Outcomes Following Percutaneous Coronary Intervention

Background: Previous studies have reported a protective effect of obesity compared with normal body mass index (BMI) in patients undergoing percutaneous coronary intervention (PCI). However, it is unclear whether this effect extends to the extremely obese. In this large multicenter registry‐based study, we sought to examine the relationship between BMI and long‐term clinical outcomes following PCI, and in particular to evaluate the association between extreme obesity and long‐term survival after PCI. Methods and Results: This cohort study included 25 413 patients who underwent PCI between January 1, 2005 and June 30, 2017, who were prospectively enrolled in the Melbourne Interventional Group registry. Patients were stratified by World Health Organization–defined BMI categories. The primary end point was National Death Index–linked mortality. The median length of follow‐up was 4.4 years (interquartile range 2.0‐7.6 years). Of the study cohort, 24.8% had normal BMI (18.5‐24.9 kg/m2), and 3.3% were extremely obese (BMI ≥40 kg/m2). Patients with greater degrees of obesity were younger and included a higher proportion of diabetics (P<0.001). After adjustment for age and comorbidities, a J‐shaped association was observed between different BMI categories and adjusted hazard ratio (HR) for long‐term mortality (normal BMI, HR 1.00 [ref]; overweight, HR 0.85, 95% CI 0.78‐0.93, P<0.001; mild obesity, HR 0.85, 95% CI 0.76‐0.94, P=0.002; moderate obesity, HR 0.95, 95% CI 0.80‐1.12, P=0.54; extreme obesity HR 1.33, 95% CI 1.07‐1.65, P=0.01). Conclusions: An obesity paradox is still apparent in contemporary practice, with elevated BMI up to 35 kg/m2 associated with reduced long‐term mortality after PCI. However, this protective effect appears not to extend to patients with extreme obesity

Volume-Level Calibrations for Partially-filled Liquid Process and Storage Vessels: Metering for Complex Geometries

Process vessels utilized for liquids and liquid-phase processes are important in the chemical process industries as they are employed for a number of purposes which include use as reservoirs, surge tanks, transportation tankers and as reactors. It is therefore often desired to have real-time data about the liquid volume and level especially for partially-filled vessels. While obtaining volume-level data for filled tanks for common geometries are simple tasks, this is not so for partially-filled vessels with complex geometries. This paper therefore sets out to develop a useful theoretical tool which can assist process engineers with the task of calibrating process tanks for these complex yet widely-used geometries. The paper presents a mathematical analysis of these geometries and develops equations and charts which could be used to estimate tank volumes from given depth of liquid for any geometry of partially-filled process vessel. The paper also develops a useful methodology which can assist in the design and sizing of process vessels using the developed charts. The paper is unique in that it utilized a normalization technique in the mathematical analyses of the partially-filled process vessels. Fractional volume and fractional depth were introduced as key variables in addition to dimensionless geometric parameters

Chemistry and pharmacological diversity of benzothiazepine Excellent pathway to drug discovery

In this era of sporadic advancement in science and technology, a substantial amount of intervention is being set in motion to reduce health-related diseases. Discoveries from researchers have pinpointed the usefulness of heterocyclic compounds, amongst which benzothiazepine (BTZ) derivatives have been syn- thesized for their various pharmacological activities. This also contributes to their undeniable application in therapeutic medicine for the development of efficacious drugs. BTZs are compounds with a benzene ring fused with a thiazepine ring. This work contains several methods that have been used to synthesize 1,3-, 1,4-, 1,5-, and 4-1-benzothiazepine derivatives. In addition, up-to-date information about the crucial pharmacological activities of BTZ derivatives has been reviewed in this present study to appreciate their druggable potential in therapeutic medicine for drug development. Drug design and development have further been simplified with the implementation of computer aided approaches to predict biological interactions which can help in the design of several derivatives. Hence, the structural activity relationship (SAR), ADMET and the molecular docking studies of BTZ derivatives were discussed to further establish their interactions and safety in biological systems. This present work aims to expound on the reported chemistry and pharmacological propensity of BTZ moiety in relation to other relevant moieties to validate their potential as excellent pharmacophores in drug design and development