Intrapreneurial self-capital training: a case study of an Italian university student

This chapter presents a case study which describes the application of the Intrapreneurial Self-Capital Training with a final-year postgraduate female biology student, Erica. The chapter presents an overview of theory that is relevant to the world of work and the conceptual dimensions of intrapreneurial self capital (ISC). Training for ISC aims to assist young people to identify their personal strengths in terms of intrapreneurship and career adaptability. A qualitative instrument, the Life Adaptability Qualitative Assessment (LAQuA) was administered before and after the training to detect meaningful changes in the participant’s narratives about career adaptability and enhanced reflexivity. The LAQuA coding system revealed enhancements to the participant’s awareness about her personal intrapreneurial resources and career adaptability. The relevance of ISC to employability and career services in education contexts is discussed along with recommendations for research into ISC training

Slow-roll Inflation for Generalized Two-Field Lagrangians

We study the slow-roll regime of two field inflation, in which the two fields are also coupled through their kinetic terms. Such Lagrangians are motivated by particle physics and by scalar-tensor theories studied in the Einstein frame. We compute the power spectra of adiabatic and isocurvature perturbations on large scales to first order in the slow-roll parameters. We discuss the relevance of the extra coupling terms for the amplitude and indexes of the power spectra. Beyond the consistency condition which involves the amplitude of gravitational waves, additional relations may be found in particular models based on such Lagrangians: as an example, we find an additional general consistency condition in implicit form for Brans-Dicke theory in the Einstein frame.Comment: 17 pages, 1 figure, accepted for publication in Phys. Rev.

A Source Identification Problem for the Electrical Activity of Brain During Hand Movement

A field source reconstruction of the dipoles modeling the activated area of the brain, while a subject performs the task of the voluntary motion of the hand, is solved. Experimental data resulting from fMRI are used for constraining the position of the equivalent dipole

CT-based tumour response criteria compared after combined treatment for liver metastases of colorectal cancer

open6noPurpose: The aim of this analysis is to compare different tumour response criteria (TRC) after chemotherapy combined with bevacizumab in liver metastases from colorectal cancer (mCRC) to ascertain the best early prognostic indicator of response. Methods and Materials: 103 target liver metastases from 65 mCRC patients treated with chemoterapy plus bevacizumab were examined at the Istituto Oncologico Veneto IOV-IRCSS (March 2008-January 2013). All patients had baseline CT and at least one follow-up scan. Tumour response was retrospectively analyzed by two radiologists using RECIST1.1, modified Choi, and Chun morphologic criteria. Tumour response, classified as good (complete or partial response) or poor (stable or progressive disease), was compared with progression-free survival (PFS) at first follow-up (t1) and time of best response. Interobserver agreement and concordance between TRC were measured. Results: At t1, 32.31% showed a good response according to RECIST1.1 (median PFS 11.1), 84.62% according to Choi (median PFS 10.8). These percentages rose to 49.23% (median PFS 12.1) and 87.69% (median PFS 10.8), respectively, at the time of best response. According to Chun, 67.69% showed a good response at the time of best response (median PFS 10.8). The Choi criteria detected a higher proportion of good responders at t1, showing a better correlation with PFS; all methods correlated with PFS at the time of best response. Conclusion: The Choi criteria proved more consistent in the early detection of response in mCRC treated with chemotherapy plus bevacizumab, underscoring the importance of using these criteria in the early assessment of response to combined treatment.openopenVarotto, A.; Di Grazia, L.; Aliberti, C.; Bergamo, F.; Nardin, M.; Pomerri, F.Varotto, A.; Di Grazia, L.; Aliberti, C.; Bergamo, F.; Nardin, M.; Pomerri, Fabi

Testing complete positivity

We study the modified dynamical evolution of the neutral kaon system under the condition of complete positivity. The accuracy of the data from planned future experiments is expected to be sufficiently precise to test such a hypothesis.Comment: 12 pages, latex, no figures, to appear in Mod. Phys. Lett.

Genotoxicity assessment of piperitenone oxide: an in vitro and in silico evaluation

Piperitenone oxide, a natural flavouring agent also known as rotundifolone, has been studied for the genotoxicity assessment by an integrated in vitro and in silico experimental approach, including the bacterial reverse mutation assay, the micronucleus test, the comet assay and the computational prediction by Toxtree and VEGA tools. Under our experimental conditions, the monoterpene showed to induce both point mutations (i.e. frameshift, base-substitution and/or oxidative damage) and DNA damage (i.e. clastogenic or aneuploidic damage, or single-strand breaks). Computational prediction for piperitenone oxide agreed with the toxicological data, and highlighted the presence of the epoxide function and the α,β-unsaturated carbonyl as possible structural alerts for DNA damage. However, improving the toxicological libraries for natural occurring compounds is required in order to favour the applicability of in silico models to the toxicological predictions. Further in vivo evaluations are strictly needed in order to evaluate the role of the bioavailability of the substance and the metabolic fate on its genotoxicity profile. To the best of our knowledge, these data represent the first evaluation of the genotoxicity for this flavour compound and suggest the need of further studies to assess the safety of piperitenone oxide as either flavour or fragrance chemicals

The Impact of Exogenous Shocks on Business Models and Business Relationships: An Empirical Analysis of the Italian Music Industry

Purpose: Scholars have been increasingly interested in understanding business models. However, little attention has been paid to how business models change in reaction to exogenous circumstances and how business relationships alter be-cause of business model changes. This paper investigates how the business model paradigm of the Italian music industry altered in response to two major exogenous influences that impacted the sector: the digital revolution and the COVID-19 pandemic. Design/methodology/approach: As the purpose of this study is to investigate phenomena in a real-world setting, qualitative research methodology has been selected as the most appropriate one. It was decided to conduct sixteen semi-structured interviews with professionals active in the Italian music business, selected through a combination of snowball and convenience sampling. Findings: The empirical findings indicate that the digital revolution and COVID-19 pushed Italian music companies to revise their business models by either reducing or adding the number of linkages to the existing ones. This was done in order for the companies to remain competitive in an environment that is constantly changing and to outcompete rivals. Originality/value: Few studies have evaluated how business relationships alter in response to the many business models emerging in the music industry due to external causes. This research is one of the first to examine music companies’ reactions to exogenous events such as crises or disruptive advances that affect the competitive landscap