Protective Effects of Carvedilol and Vitamin C against Azithromycin-Induced Cardiotoxicity in Rats via Decreasing ROS, IL1- β

The Food and Drug Administration recently warned of the fatal cardiovascular risks of azithromycin in humans. In addition, a recently published study documented azithromycin-induced cardiotoxicity in rats. This study aimed to justify the exact cardiovascular events accompanying azithromycin administration in rats, focusing on electrocardiographic, biochemical, and histopathological changes. In addition, the underlying mechanisms were studied regarding reactive oxygen species production, cytokine release, and apoptotic cell-death. Finally, the supposed protective effects of both carvedilol and vitamin C were assessed. Four groups of rats were used: (1) control, (2) azithromycin, (3) azithromycin + carvedilol, and (4) azithromycin + vitamin C. Azithromycin resulted in marked atrophy of cardiac muscle fibers and electrocardiographic segment alteration. It increased the heart rate, lactate dehydrogenase, creatine phosphokinase, malondialdehyde, nitric oxide, interleukin-1 beta (IL1-β), tumor necrosis factor alpha (TNF-α), nuclear factor kappa beta (NF-κB), and caspase-3. It decreased reduced glutathione, glutathione peroxidase, and superoxide dismutase. Carvedilol and vitamin C prevented most of the azithromycin-induced electrocardiographic and histopathological changes. Carvedilol and vitamin C decreased lactate dehydrogenase, malondialdehyde, IL1-β, TNF-α, NF-κB, and caspase-3. Both agents increased glutathione peroxidase. This study shows that both carvedilol and vitamin C protect against azithromycin-induced cardiotoxicity through antioxidant, immunomodulatory, and antiapoptotic mechanisms

Thermodynamic Parameters of the Uncatalyzed Redox Reaction Between Potassium Peroxydisulphate and D(+)Glucose

The uncatalyzed redox reaction between potassium peroxydisulphate and D(+) glucose was  studied titremetically . The progress of the reaction was followed by examining the concentration of potassium peroxydisulphate in the reaction mixture at different time intervals by iodometric titration method. Thermodynamic parameters, activation energy (Ea), frequency factor (A), entropy change (?S) and the free energy change (?G) of the uncatalyzed redox reaction were evaluated from the values of the fractional order rate constants ko at different temperatures. Keywords: Uncatalyzed redox reaction, thermodynamic parameters, D(+)glucose, Potassium peroxydisulphate

The effect of dividend payments and firm’s attributes on earnings quality: empirical evidence from Egypt

This empirical study aims mainly to investigate the effect of both dividend payments (DP) and five firm's attributes (firm size, firm leverage, firm performance, legal form and audit quality) on earnings quality (EQ) of the most active listed firms in Egypt. A sample of 552 firm-year observations during four years from 2014 to 2017 was used. Hierarchical Multiple Regression (HMR) was used to regress the six independent variables on firms’ EQ through the absence of firms’ earnings management (EM), which was estimated through discretionary accruals (DAC). Main results show that there is some divergence in EM practices over the four years and might suggest that EM by listed firms in Egypt exists especially in the first two years (2014 and 2015); how¬ever, relatively lower EM practices are found in the last two years (2016 and 2017). Correlation results show a number of significant relationships between the EM and three independent variables (firm leverage, legal form and audit quality). HMR results are in line with the results obtained via Pearson correlation

Nanocrystalline Na0.1V2O5.nH2Oxerogel Thin Film for Gas Sensing

Nanocrystalline thin film of Na0.1V2O5.nH2O xerogel obtained by sol-gel synthesis was used as a gas sensor. Gas sensing properties of different gases such as hydrogen, petroleum and humidity were investigated. Applying XRD and TEM the size of the nanocrystals is found to be 7.5 nm. SEM shows a highly porous structure with submicron meter-sized voids present throughout the sample. FTIR measurement shows different chemical groups identifying the obtained series of gels. The sample was n-type semiconductor according to the thermoelectric power and electrical conductivity. It can be seen that the sensor response curves from 130°C to 150°C show a rapid increase in sensitivity for all types of gas injection, low response values for heating period and the rapid high response values for cooling period. This result may suggest that this material is able to act as gas sensor during the heating and cooling process

Nanocrystalline Na0.1V2O5.nH2Oxerogel Thin Film for Gas Sensing

Nanocrystalline thin film of Na0.1V2O5.nH2O xerogel obtained by sol-gel synthesis was used as a gas sensor. Gas sensing properties of different gases such as hydrogen, petroleum and humidity were investigated. Applying XRD and TEM the size of the nanocrystals is found to be 7.5 nm. SEM shows a highly porous structure with submicron meter-sized voids present throughout the sample. FTIR measurement shows different chemical groups identifying the obtained series of gels. The sample was n-type semiconductor according to the thermoelectric power and electrical conductivity. It can be seen that the sensor response curves from 130°C to 150°C show a rapid increase in sensitivity for all types of gas injection, low response values for heating period and the rapid high response values for cooling period. This result may suggest that this material is able to act as gas sensor during the heating and cooling process

Improvement of drought tolerance in five different cultivars of Vicia faba with foliar application of ascorbic acid or silicon

Aim of study: To explore the role of ascorbic acid (AsA) or silicon (Si) in improving drought tolerance in five faba bean cultivars under irrigation water deficit (IWD).Area of study: The experimental farm; 30° 36′ N, 32° 16′ E, Egypt.Material and methods: Three drip irrigation regimes (WW, well-watered, 4000 m3 water ha-1; MD, moderate drought, 3000 m3 water ha-1; and SD, severe drought, 2000 m3 water ha-1) were applied to plants, which were sprayed 25, 40, and 55 days after sowing with 1.5 mM AsA or 2.0 mM Si vs distilled water as a control.Main results: Drought negatively affected physiological attributes (photosynthetic pigments, gas exchange parameters, relative water content, membrane stability index, electrolyte leakage (EL), and lipid peroxidation), which restricted plant growth and yields, and stimulated alterations in both enzymatic and non-enzymatic antioxidant activities. However, AsA or Si application mitigated drought effects on physiological attributes, improving growth, yields and water use efficiency by raising antioxidant activities and suppressing lipid peroxidation and EL in stressful cultivars. The mitigating effects of AsA and Si were more pronounced under MD.Research highlights: ‘Nubaria-2’, ‘Giza-843’, and ‘Sakha-3’ were more tolerant than ‘Giza-716’ and ‘Sakha-4’, suggesting the use of AsA or Si to ameliorate the IWD effects on stressful cultivars. Certain physiological traits exhibited positive association with growth and seed yield, demonstrating their importance in enhancing seed yield under irrigation treatments

Irrigation Practices and Their Effects on Soil Quality and Soil Characteristics in Arid Lands: A Comprehensive Geomatic Analysis

Comprehension of the long-term effects of irrigation on basic soil characteristics and quality is essential for sustainable land management and agricultural production, particularly in arid regions where water availability is limited. This study aimed to investigate long-term irrigation effects on soil quality, soil organic carbon (SOC), and nitrogen (N) stocks in the arid lands of Egypt. Seventy soil samples were collected and analyzed to determine various soil properties. A soil quality index (SQI), SOC, and N stocks were computed. ANOVA and PCA analyses were used to identify signifiant differences between alluvial soils in the southwest part of the investigated area and coastal marine soils in the northeast of the study area. The results demonstrated that most of the studied soil parameters had signifiantly greater values in alluvial compared to coastal marine soils. Long-term irrigation led to an 8.00% increase in SOC and 7.22% increase in N stocks compared to coastal marine soils production. Furthermore, a 39.53% increase was found in the SQI upon longterm irrigation practice. These results suggest that shifting from rain-fed in coastal marine areas to irrigated production systems in alluvial filds can improve soil quality, SOC, and N stocks. Therefore, further studies are required to investigate the impact of additional factors, such as irrigation method and salinity status of sub-surface soil layers, to enhance agricultural productivity and sustainable land use

THE BIDIRECTIONAL RELATIONSHIP BETWEEN HIGHER EDUCATION AND INNOVATION: EMPIRICAL EVIDENCE FROM MENA REGION

The purpose of this paper is to examine the bidirectional relationship between two sets of variables, higher education and training (eight indicators) and innovation (seven indicators), using the canonical correlation analysis (CCA). The study utilises data published by the World Economic Forum Reports for seven years (2012-2018) for a sample of 12 countries in the MENA area. CCA is used to analyse the relationship between the two sets of variables. It helps in the evaluation of the interchangeable relationships between the two sets of multiple variates. More in-depth analysis of the nature of such a relationship between the two sets of variables is provided through redundancy analysis to identify the percentage of the variance in each set that is interpreted by the other set, and the commonality analysis to determine the variance of canonical function that is due to unique or standard variables. Canonical analysis shows the causality between the two endogenous sets of variables. Also, the findings suggest that technology alone is not an antidote, while other factors might have a significant impact on innovation. Commonality analysis shows that the role of quality of management school in explaining the variation in canonical function of innovation in common with "quality of education system", "quality of math and science", "internet access", "training availability" and "staff training produce"