Territorialidad y desarrollo local : el rol de la fundación para el desarrollo de Cañada de Gómez

La presente tesina pretende realizar un abordaje teórico previo, que permita esclarecer conceptos claves para la comprensión total del trabajo, tales como desarrollo local, globalización, descentralización, y territorialidad. La revisión bibliográfica pretende favorecer la comprensión integral del fenómeno objeto de estudio, en post de avanzar hacia el estudio de caso. El objetivo de este trabajo se concentra en analizar el desarrollo local de Cañada de Gómez, comprendido bajo el accionar de la Fundación para el Desarrollo de Cañada de Gómez (FUDECA).Fil: Travaglino, Luciano. Universidad Nacional de Rosario. Facultad de Ciencia Política y Relaciones Internacionales; Argentin

Suppressive effects of ethanolic extracts from propolis and its main botanical origin on dioxin toxicity

Suppressive effects of ethanolic extracts prepared from propolis group 12 and its main botanical origin (leaf bud of Bacchads dracunculifolia) on transformation of the aryl hydrocarbon receptor (AhR), the initial action of dioxin toxicity, were investigated. It was found that suppressive effects of propolis on AhR transformation were relatively higher than those of resins of its botanical origin in cell-free system and in Hepa-1c1c7 cells. When the composition of chemical ingredients was measured, propolis contained slightly higher amounts of flavonoid aglycones as compared with its botanical origin with the same characteristics. Moreover, antiradical activity, one of the typical biological activities of flavonoids, in propolis was also slightly higher than that in its botanical origin. These results indicate that not only propolis but also its botanical origin contains high amounts of flavonoid aglycones and that both of them are useful dietary sources for flavonoids with a potency to prevent dioxin toxicity.5326103061030

Antiproliferation of human prostate cancer cells by ethanolic extracts of Brazilian propolis and its botanical origin

Propolis is a resinous substance collected by bees (Apis mellifera) from various tree buds which they then use to coat hive parts and to seal cracks and crevices in the hive. Propolis, a known ancient folk medicine, has been extensively used in diet to improve health and to prevent disease. In the present study, we have evaluated the effects of ethanolic extracts of Brazilian propolis group 12 and bud resins of botanical origin (B. dracunculifolia), and propolis group 3 on proliferation of metastasis (DU145 and PC-3) and primary malignant tumor (RC58T/h/SA#4)-derived human prostate cancer cells. The strongest inhibition was observed in propolis group 3 (sample #3) extracts whereas moderate growth inhibition was observed in human prostate epithelial cells. In the RC58T/h/SA#4 cells, resins of botanical origin of propolis group 12 (sample #1) and propolis group 12 (sample #2) induced growth inhibition that was associated with S phase arrest whereas propolis group 3 (sample #3) induced growth inhibition that was associated with G2 arrest. The mechanisms of cell cycle effects of propolis were investigated. The resins of botanical origin of propolis group 12 and propolis group 12 showed similar inhibition of cyclin D1, CDK4 and cyclin B1 expression. Propolis group 3 showed higher induction of p21 expression but no inhibition of cyclin D1, CDK4 and cyclin B1 expression. The results obtained here demonstrate that the Brazilian propolis extracts have significant inhibitory effect on proliferation of human prostate cancer cells. Inhibition was achieved through regulation of protein expression of cyclin D1, B1 and cyclin dependent kinase (CDK) as well as p21. Our results indicate that the Brazilian propolis extracts show promise as chemotherapeutic agents as well as preventive agents against prostate cancer.O TEXTO COMPLETO DESTE ARTIGO, ESTARÁ DISPONÍVEL À PARTIR DE FEVEREIRO DE 2015.31360160