225 research outputs found
Hardness Transitions of Star Colouring and Restricted Star Colouring
We study how the complexity of the graph colouring problems star colouring
and restricted star colouring vary with the maximum degree of the graph.
Restricted star colouring (in short, rs colouring) is a variant of star
colouring. For , a -colouring of a graph is a function
such that for every edge of
. A -colouring of is called a -star colouring of if there is
no path in with and . A -colouring of
is called a -rs colouring of if there is no path in with
. For , the problem -STAR COLOURABILITY
takes a graph as input and asks whether admits a -star colouring.
The problem -RS COLOURABILITY is defined similarly. Recently, Brause et al.
(Electron. J. Comb., 2022) investigated the complexity of 3-star colouring with
respect to the graph diameter. We study the complexity of -star colouring
and -rs colouring with respect to the maximum degree for all . For
, let us denote the least integer such that -STAR COLOURABILITY
(resp. -RS COLOURABILITY) is NP-complete for graphs of maximum degree by
(resp. ).
We prove that for and , -STAR COLOURABILITY is NP-complete
for graphs of maximum degree . We also show that -RS COLOURABILITY is
NP-complete for planar 3-regular graphs of girth 5 and -RS COLOURABILITY is
NP-complete for triangle-free graphs of maximum degree for .
Using these results, we prove the following: (i) for and ,
-STAR COLOURABILITY is NP-complete for -regular graphs if and only if
; and (ii) for , -RS COLOURABILITY is NP-complete
for -regular graphs if and only if
FLUKA Monte Carlo for Basic Dosimetric Studies of Dual Energy Medical Linear Accelerator
General purpose Monte Carlo code for simulation of particle transport is used to study the basic dosimetric parameters like percentage depth dose and dose profiles and compared with the experimental measurements from commercial dual energy medical linear accelerator. Varian Clinac iX medical linear accelerator with dual energy photon beams (6 and 15 MV) is simulated using FLUKA. FLAIR is used to visualize and edit the geometry. Experimental measurements are taken for 100 cm source-to-surface (SSD) in 50 × 50 × 50 cm3 PTW water phantom using 0.12 cc cylindrical ionization chamber. Percentage depth dose for standard square field sizes and dose profiles for various depths are studied in detail. The analysis was carried out using ROOT (a DATA analysis frame work developed at CERN) system. Simulation result shows good agreement in percentage depth dose and beam profiles with the experimental measurements for Varian Clinac iX dual energy medical linear accelerator
FLUKA Monte Carlo for Basic Dosimetric Studies of Dual Energy Medical Linear Accelerator
General purpose Monte Carlo code for simulation of particle transport is used to study the basic dosimetric parameters like percentage depth dose and dose profiles and compared with the experimental measurements from commercial dual energy medical linear accelerator. Varian Clinac iX medical linear accelerator with dual energy photon beams (6 and 15 MV) is simulated using FLUKA. FLAIR is used to visualize and edit the geometry. Experimental measurements are taken for 100 cm source-to-surface (SSD) in 50 × 50 × 50 cm3PTW water phantom using 0.12 cc cylindrical ionization chamber. Percentage depth dose for standard square field sizes and dose profiles for various depths are studied in detail. The analysis was carried out using ROOT (a DATA analysis frame work developed at CERN) system. Simulation result shows good agreement in percentage depth dose and beam profiles with the experimental measurements for Varian Clinac iX dual energy medical linear accelerator
Transcriptomic responses of the heart and brain to anoxia in the Western Painted turtle
Painted turtles are the most anoxia-tolerant tetrapods known, capable of surviving without oxygen for more than four months at 3°C and 30 hours at 20°C. To investigate the transcriptomic basis of this ability, we used RNA-seq to quantify mRNA expression in the painted turtle ventricle and telencephalon after 24 hours of anoxia at 19°C. Reads were obtained from 22,174 different genes, 13,236 of which were compared statistically between treatments for each tissue. Total tissue RNA contents decreased by 16% in telencephalon and 53% in ventricle. The telencephalon and ventricle showed ≥ 2x expression (increased expression) in 19 and 23 genes, respectively, while only four genes in ventricle showed ≤ 0.5x changes (decreased expression). When treatment effects were compared between anoxic and normoxic conditions in the two tissue types, 31 genes were increased (≥ 2x change) and 2 were decreased (≤ 0.5x change). Most of the effected genes were immediate early genes and transcription factors that regulate cellular growth and development; changes that would seem to promote transcriptional, translational, and metabolic arrest. No genes related to ion channels, synaptic transmission, cardiac contractility or excitation-contraction coupling changed. The generalized expression pattern in telencephalon and across tissues, but not in ventricle, correlated with the predicted metabolic cost of transcription, with the shortest genes and those with the fewest exons showing the largest increases in expression
Knowledge, Attitude and Practice towards Self-Medications in a Rural Community
Background: The consumption of drugs without consulting healthcare professional regardless of side effects and duration of therapy is known as self-medication. This study was conducted to analyze the practice of self-medication and knowledge about the medicines among the common people of rural areas.
Methods: 6 months Study was carried out by collecting the data with the help of questionnaire and thereby collecting their answers. The data was analyzed statistically in terms of actual numbers and percentage.
Results: As an outcome of our survey, majority of the population were unaware about proper usage of medicines. The survey also shows that NSAIDs are the most consumed medicines. 72.11% stop taking medications without the advice or without informing healthcare provider. 77.56% believe medication without prescription will help them.
Conclusion: The survey that most of the common population in the rural areas don’t know about the indication for which they are taking medication and the study also emphasizes the unawareness of common population towards proper usage of medication. Elderly people are on polypharmacy due to multiple and inter current diseases, with their improper use due to lack of knowledge of correct dose, side effects, and interactions would bring serious implications. Community pharmacists should get continuous education and repeated training programs because they are easy accessible to the common population. A proper statutory drug control must be implemented, rationally restricting the availability of drugs to the public. Self-medication is an area where governments and health authorities need to ensure that it is done in a responsible manner, ensuring that safe drugs are made available over the counter and the consumer is given adequate information about the use of drugs and when to consult a doctor.
Keywords: Self-medication, irrational use, prevalence, pharmacist, drugs
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