Lessons From the First Comprehensive Molecular Characterization of Cell Cycle Control in Rodent Insulinoma Cell Lines

OBJECTIVE—Rodent insulinoma cell lines may serve as a model for designing continuously replicating human β-cell lines and provide clues as to the central cell cycle regulatory molecules in the β-cell

Análisis de la actividad científica de la Comunidad Autónoma de la Región de Murcia. Biomedicina 1999-2005.

An analysis of scientific activity in Biomedicine in Murcia between 1999-2005 is presented

Mechanisms of goethite dissolution in the presence of desferrioxamine B and Suwannee River fulvic acid at pH 6.5

Siderophores are Fe3+ specific low MW chelating ligands secreted by microorganisms in response to Fe stress. Low MW organic acids such as oxalate have been shown to enhance siderophore mediated dissolution of Fe3+ oxides. However, the effect of fulvic acid presence on siderophore function remains unknown. We used batch dissolution experiments to investigate Fe release from goethite in the goethite-fulvic acid desferrioxamine B (goethite-SRFA-DFOB) ternary system. Experiments were conducted at pH 6.5 while varying reagent addition sequence. FTIR and UV-Vis spectroscopy were employed to characterise the Fe-DFOB, Fe-SRFA and DFOB–SRFA complexes. Iron released from goethite in the presence of SRFA alone was below detection limit. In the presence of both SRFA and DFOB, dissolved Fe increased with reaction time, presence of the DFOB-SRFA complex, and where SRFA was introduced prior to DFOB. FTIR data show that in the ternary system, Fe3+ is complexed primarily to oxygen of the DFOB hydroxamate group, whilst the carboxylate C=O of SRFA forms an electrostatic association with the terminal NH3+ of DFOB. We propose that SRFA sorbed to goethite lowers the net positive charge of the oxide surface, thus facilitating adsorption of cationic DFOB and subsequent Fe3+ chelation and release. Furthermore, the sorbed SRFA weakens Fe-O bonds at the goethite surface, increasing the population of kinetically labile Fe. This work demonstrates the positive, though indirect role of SRFA in increasing the bioavailability of Fe3+

Optimización de la gestión y mantenimiento de elementos urbanos mediante geoposicionamiento y vinculación de base de datos interactiva al modelo de información de construcción

El artículo resumino en este póster, denominado “Optimization of the management and maintenance of urban elements through geolocation and linking of interactive database to the construction information model”, fue seleccionado y superó el proceso de revisión de INGEGRAF2019 para ser incluido en la publicación “Advances in Design Engineering” Lecture Notes in Mechanical Engineering de la editorial Springer International Publishing AG, con número de orden: 87021766, GPU/PD/PS: 3/32/457, Legal Entity Number: 1128, IU: 477172, Edition ID: 426426 y Código de la editorial 457_87021766_AUE_Cavas-Martínez_Advances in Design Engineering.BIMoPOLIS surge como una idea, basada en el desarro-llo de contenidos digitales, en el campo de la arquitectura y las infraestructuras, haciendo uso de las últimas tecnologías en los campos del levantamiento, modelado en tres dimensiones (3D), geoposicionamiento y realidad virtual y aumentada (RV) (RA), cuyo proyecto obtuvo un premio Spin-Off. El objetivo de estos contenidos digitales es su inclusión en aplicaciones que transformen la manera en la que tradicionalmente se opera en estas áreas a nivel de gestión y mantenimiento, optimizando los protocolos, en busca del concepto de Smart City. Para ello, se suele proceder levantando y geoposicionando la infraestructura en cuestión e incorporando al modelo 3D la información relevante para la realización de operaciones habituales de mantenimiento como medidas, materiales, datos de contacto de distribuidores, precios, vistas de detalle u otros indicadores de interés. La vinculación de esos datos al modelo virtual conlleva numerosas ventajas ya que, mediante el uso de una única aplicación, se pueden realizar informes de incidencias, posicionar averías, contactar con operarios y proveedores, reportar de trabajos acabados, etc., suponiendo un gran ahorro en tiempos y costes de ges-tión y comunicación en operaciones de mantenimiento. Este artículo se centra en el primer proyecto desarrollado por BIMoPOLIS, por encargado del Vicerrectorado de Smart-Campus de la Universidad de Málaga (UMA), consistente en el geoposicionamiento arbóreo y vinculación de base de datos interactiva al modelado de información de construcción de la sección principal del bulevar Louis Pasteur, ubicado en su Campus de Teatinos.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

Solvothermal synthesis and characterization of ytterbium/iron mixed oxide nanoparticles with potential functionalities for applications as multiplatform contrast agent in medical image techniques

A solvothermal route to prepare Glutathione capped hybrid ytterbium/iron oxide nanoparticles with potential applications as multiplatform contrast agent in medical image techniques has been developed. The influence of ytterbium/iron molar ratio used as precursor, as well as the degree of the autoclave filling on the structural and morphological characteristics of the obtained nanoparticles has been extensively studied. Although all nanoparticles present similar composition, with YbFeO3 being the majority phase, size and morphology of the as synthetized nanoparticles are highly influenced by the critical temperature and by the over -saturation reached during the solvothermal process. We have demonstrated that glutathione properly functionalizes the hybrid nanoparticles, increasing their colloidal stability and decreasing their cytotoxicity. Additionally, they show good imaging in magnetic resonance and X-ray computerized tomography, thereby indicating promising potential as a dual contrast agent. This work presents, for the first time, glutathione functionalized ytterbium/iron oxide nanoparticles with potential applications in Biomedicine. © 2022 Elsevier Ltd and Techna Group S.r.l