Perspective: new insights from loss function landscapes of neural networks

Abstract: We investigate the structure of the loss function landscape for neural networks subject to dataset mislabelling, increased training set diversity, and reduced node connectivity, using various techniques developed for energy landscape exploration. The benchmarking models are classification problems for atomic geometry optimisation and hand-written digit prediction. We consider the effect of varying the size of the atomic configuration space used to generate initial geometries and find that the number of stationary points increases rapidly with the size of the training configuration space. We introduce a measure of node locality to limit network connectivity and perturb permutational weight symmetry, and examine how this parameter affects the resulting landscapes. We find that highly-reduced systems have low capacity and exhibit landscapes with very few minima. On the other hand, small amounts of reduced connectivity can enhance network expressibility and can yield more complex landscapes. Investigating the effect of deliberate classification errors in the training data, we find that the variance in testing AUC, computed over a sample of minima, grows significantly with the training error, providing new insight into the role of the variance-bias trade-off when training under noise. Finally, we illustrate how the number of local minima for networks with two and three hidden layers, but a comparable number of variable edge weights, increases significantly with the number of layers, and as the number of training data decreases. This work helps shed further light on neural network loss landscapes and provides guidance for future work on neural network training and optimisation

Insect Population Dynamics, Varietal Preference and Performance of Organic Bio-Pesticides

Abstract Organic farming prohibits use of synthetic agrochemicals and encourages use of Integrated Pest Management (IPM) methods. States in the Southeastern US generally lag behind the rest of the country in organic vegetable production partly because of high insect pressures that make it difficult to grow vegetables without pesticides. This study on summer squash (Cucurbita pepo), grown using organic management practices, was conducted at a research station located in Mills River, North Carolina. The objectives of the study were to assess insect population dynamics and to evaluate performance of three OMRI-approved bio-pesticides: Azadirachtin, Pyrethrin and Spinosad against major insect pests of three summer squash varieties (Gentry, Spineless Beauty, and Zephyr). The highest populations of leafhoppers and thrips were recorded in early and late July. Squash varieties significantly influenced the populations of leafhoppers, thrips, aphids, and cucumber beetles. Bio-pesticides performed similarly against the major insect pests of squash recorded in this study Keywords: Organic Summer Squash, Insect Pests, Bio Pesticides, Organic Farmin

The Impact of Tobacco Smoking on One Year Patient Outcomes at a Family Medicine Residency Clinic

Abstract Objectives: In Appalachia, tobacco smoking rates are significantly higher than the United States average, and many of the comorbidities that exist with tobacco are prominent. The researchers investigated the impact of tobacco smoking on patients for one year of health outcomes at our resident primary care clinic. Methods: The present study examined outpatient clinic charts and hospital records for a calendar year to determine patient self-reported tobacco rates. Patient medical comorbidities were tracked as well as rates of hospital utilization during the calendar year, and those figures were compared for a group of 90 patients who currently smoke and another group of 90 patients who have never smoked. Results: Tobacco smokers in the present study were more likely to have a history of several medical comorbidities including COPD, musculoskeletal problems, psychiatric treatment, and substance abuse issues. Additionally, tobacco smokers were more likely to have visited the emergency department and to have been admitted to the hospital during the year. Conclusions: The problem of tobacco smoking is complex and primary care clinics provide a wealth of information to investigate numerous comorbid concerns. Consistent with prior research, tobacco users in this study were at greater risk for many medical problems. Abstract Word Count: 19

Thrips Settling, Oviposition and IYSV Distribution on Onion Foliage

Thrips tabaci Lindeman (Thysanoptera: Thripidae) adult and larval settling and oviposition on onion (Allium cepa L.) foliage were investigated in relation to leaf position and leaf length at prebulb plant growth stages under controlled conditions. In the laboratory, four and six adult females of T. tabaci were released on onion plants at three-leaf stage and six- to eight-leaf stage, respectively, and thrips egg, nymph, and adult count data were collected on each of the three inner most leaves at every 2-cm leaf segment. Thrips settling and oviposition parameters were quantified during the light period on the above ground portion of onion plants from the distal end of the bulb or leaf sheath “neck” through the tips of the foliage. Results from studies confirmed that distribution of thrips adults, nymphs, and eggs were skewed toward the base of the plant. The settling distributions of thrips adults and nymphs differed slightly from the egg distribution in that oviposition occurred all the way to the tip of the leaf while adults and nymphs were typically not observed near the tip. In a field study, the foliage was divided into three equal partitions, i.e., top, middle, basal thirds, and thrips adults by species, primarily Frankliniella fusca (Hinds) and T. tabaci, were collected from each partition to determine if there was a similar bias of all adult thrips toward the base of the plant. The results suggested that adults of different species appear to segregate along leaf length. Finally, thrips oviposition on 2-cm segments and Iris yellow spot virus positive leaf segments were quantified in the field, irrespective of thrips species. Both variables demonstrated a very similar pattern of bias toward the base of the plant and were significantly correlated

The Impact of Tobacco Smoking on One Year Patient Outcomes at a Family Medicine Residency Clinic

Objectives: In Appalachia, tobacco smoking rates are significantly higher than the United States average, and many of the comorbidities that exist with tobacco are prominent. The researchers investigated the impact of tobacco smoking on patients for one year of health outcomes at our resident primary care clinic. Methods: The present study examined outpatient clinic charts and hospital records for a calendar year to determine patient self-reported tobacco rates. Patient medical comorbidities were tracked as well as rates of hospital utilization during the calendar year, and those figures were compared for a group of 90 patients who currently smoke and another group of 90 patients who have never smoked. Results: Tobacco smokers in the present study were more likely to have a history of several medical comorbidities including COPD, musculoskeletal problems, psychiatric treatment, and substance abuse issues. Additionally, tobacco smokers were more likely to have visited the emergency department and to have been admitted to the hospital during the year. Conclusions: The problem of tobacco smoking is complex and primary care clinics provide a wealth of information to investigate numerous comorbid concerns. Consistent with prior research, tobacco users in this study were at greater risk for many medical problems

Sustainability effects of next-generation intersection control for autonomous vehicles

Transportation sustainability is adversely affected by recurring traffic congestions, especially at urban intersections. Frequent vehicle deceleration and acceleration caused by stop-and-go behaviours at intersections due to congestion adversely impacts energy consumption and ambient air quality. Availability of the maturing vehicle technologies such as autonomous vehicles and Vehicle-To-Vehicle (V2V) / Vehicle-To-Infrastructure (V2I) communications provides technical feasibility to develop solutions that can reduce vehicle stops at intersections, hence enhance the sustainability of intersections. This paper presents a next-generation intersection control system for autonomous vehicles, which is named ACUTA. ACUTA employs an enhanced reservation-based control algorithm that controls autonomous vehicles’ passing sequence at an intersection. Particularly, the intersection is divided into n-by-n tiles. An intersection controller reserves certain time-space for each vehicle, and assures no conflict exists between reservations. The algorithm was modelled in microscopic traffic simulation platform VISSIM. ACUTA algorithm modelling as well as enhancement strategies to minimize vehicle intersection stops and eventually emission and energy consumption were discussed in the paper. Sustainability benefits offered by this next-generation intersection were evaluated and compared with traditional intersection control strategies. The evaluation reveals that multi-tile ACUTA reduces carbon monoxide (CO) and Particulate Matter (PM) 2.5 emissions by about 5% under low to moderate volume conditions and by about 3% under high volume condition. Meanwhile, energy consumption is reduced by about 4% under low to moderate volume conditions and by about 12% under high volume condition. Compared with four-way stop control, single-tile ACUTA reduces CO and PM 2.5 emissions as well as energy consumption by about 15% under any prevailing volume conditions. These findings validated the sustainability benefits of employing next-generation vehicle technologies in intersection traffic control. In addition, extending the ACUTA to corridor level was explored in the paper

Serum procalcitonin and CRP levels in non-alcoholic fatty liver disease: a case control study

<p>Abstract</p> <p>Background</p> <p>Both C reactive protein (CRP) and procalcitonin (PCT) are well known acute phase reactant proteins. CRP was reported to increase in metabolic syndrome and type-2 diabetes. Similarly altered level of serum PCT was found in chronic liver diseases and cirrhosis. The liver is considered the main source of CRP and a source of PCT, however, the serum PCT and CRP levels in non-alcoholic fatty liver disease (NAFLD) were not compared previously. Therefore we aimed to study the diagnostic and discriminative role of serum PCT and CRP in NAFLD.</p> <p>Methods</p> <p>Fifty NAFLD cases and 50 healthy controls were included to the study. Liver function tests were measured, body mass index was calculated, and insulin resistance was determined by using a homeostasis model assessment (HOMA-IR). Ultrasound evaluation was performed for each subject. Serum CRP was measured with nephalometric method. Serum PCT was measured with Kryptor based system.</p> <p>Results</p> <p>Serum PCT levels were similar in steatohepatitis (n 20) and simple steatosis (n 27) patients, and were not different than the control group (0.06 ± 0.01, 0.04 ± 0.01 versus 0.06 ± 0.01 ng/ml respectively). Serum CRP levels were significantly higher in simple steatosis, and steatohepatitis groups compared to healthy controls (7.5 ± 1.6 and 5.2 ± 2.5 versus 2.9 ± 0.5 mg/dl respectively p < 0.01). CRP could not differentiate steatohepatitis from simple steatosis. Beside, three patients with focal fatty liver disease had normal serum CRP levels.</p> <p>Conclusion</p> <p>Serum PCT was within normal ranges in patients with simple steatosis or steatohepatitis and has no diagnostic value. Serum CRP level was increased in NAFLD compared to controls. CRP can be used as an additional marker for diagnosis of NAFLD but it has no value in discrimination of steatohepatitis from simple steatosis.</p