New Analyses of Double-Bang Events in the Atmosphere

We use CORSIKA+Herwig simulation code to produce ultra-high energy neutrino interactions in the atmosphere. Our aim is to reproduce extensive air showers originated by extragalactic tau-neutrinos. For charged current tau-neutrino interactions in the atmosphere, beside the air shower originated from the neutrino interaction, it is expected that a tau is created and may decay before reaching the ground. That phenomenon makes possible the generation of two related extensive air showers, the so called Double-Bang event. We make an analysis of the main characteristics of Double-Bang events in the atmosphere for mean values of the parameters involved in such phenomenon, like the inelasticity and tau decay length. We discuss what may happen for the ``out of the average'' cases and conclude that it may be possible to observe this kind of event in ultra-high energy cosmic ray observatories such as Pierre Auger or Telescope Array.Comment: 17 pages, 5 figures, final version to appear in BJ

Rigorous Born Approximation and beyond for the Spin-Boson Model

Within the lowest-order Born approximation, we present an exact calculation of the time dynamics of the spin-boson model in the ohmic regime. We observe non-Markovian effects at zero temperature that scale with the system-bath coupling strength and cause qualitative changes in the evolution of coherence at intermediate times of order of the oscillation period. These changes could significantly affect the performance of these systems as qubits. In the biased case, we find a prompt loss of coherence at these intermediate times, whose decay rate is set by $\sqrt{\alpha}$, where $\alpha$ is the coupling strength to the environment. We also explore the calculation of the next order Born approximation: we show that, at the expense of very large computational complexity, interesting physical quantities can be rigorously computed at fourth order using computer algebra, presented completely in an accompanying Mathematica file. We compute the $O(\alpha)$ corrections to the long time behavior of the system density matrix; the result is identical to the reduced density matrix of the equilibrium state to the same order in $\alpha$. All these calculations indicate precision experimental tests that could confirm or refute the validity of the spin-boson model in a variety of systems.Comment: Greatly extended version of short paper cond-mat/0304118. Accompanying Mathematica notebook fop5.nb, available in Source, is an essential part of this work; it gives full details of the fourth-order Born calculation summarized in the text. fop5.nb is prepared in arXiv style (available from Wolfram Research

The Impact of Transcriptomics on the Fight against Tuberculosis: Focus on Biomarkers, BCG Vaccination, and Immunotherapy

In 1882 Robert Koch identified Mycobacterium tuberculosis as the causative agent of tuberculosis (TB), a disease as ancient as humanity. Although there has been more than 125 years of scientific effort aimed at understanding the disease, serious problems in TB persist that contribute to the estimated 1/3 of the world population infected with this pathogen. Nonetheless, during the first decade of the 21st century, there were new advances in the fight against TB. The development of high-throughput technologies is one of the major contributors to this advance, because it allows for a global vision of the biological phenomenon. This paper analyzes how transcriptomics are supporting the translation of basic research into therapies by resolving three key issues in the fight against TB: (a) the discovery of biomarkers, (b) the explanation of the variability of protection conferred by BCG vaccination, and (c) the development of new immunotherapeutic strategies to treat TB