Double beta decay of 100Mo^{100}Mo: the deformed limit

The double beta decay of $^{100}Mo$ to the ground state and excited states of $^{100}Ru$ is analysed in the context of the pseudo SU(3) scheme. The results of this deformed limit are compared with the vibrational one based on the QRPA formalism. Consistency between the deformed limit and the experimental information is found for various $\beta\beta$ transitions, although, in this approximation some energies and B(E2) intensities cannot reproduced.Comment: 16 pages, revtex, no figures. Submmitted to Phys. Rev.

Learning, Prediction and Planning with Approximate Forward Models

The capacity to build internal representations of the world provides an agent with the opportunity to use them to act in its surroundings more appropriately. These internal representations may capture complex associations and keep track of the state of the agent and the environment. One of the most striking aspects of this phenomenon is that the agent may manipulate these internal representations to consider the distant future, and to formulate plans likely to lead to beneficial outcomes. Our treatment in this thesis considers this particular class of agents referred to as model-based. The behaviour of these agents is not only contingent upon the current sensory stream and their memory, but also based on hypothetical future sensory streams that are produced from potential sequences of actions. Throughout this thesis, there are two main themes that we explore and that are fundamental for advancing our understanding of model-based agents. The first is the agent's uncertainty about its environment and how it influences its decision-making. There are multiple aspects one could investigate about this relation. We analyse two specific scenarios. The first illustrates how it is possible to harness the agent's uncertainty to devise error-correction schemes. In the second, a probability distribution that defines the agent's current model is used to derive intrinsic utility signals to guide behaviour. The other main theme that permeates this thesis is the question of what are the aspects of the external world that should be stored and represented by an internal model? This question has important consequences for the design of learning objectives. As we will see in this thesis, we start with perhaps the most conceptually intuitive way to frame a learning objective for acquiring a world model. Namely, the assumption that the agent must be able to predict as accurately as possible its future observations. From this starting point, we progress towards learning objectives that introduce additional prediction targets or constraints to aim for a compressed and more essential representation of an observation. This theme concludes by trying to gain some perspective on whether it is possible, and even desirable, to attempt to have an internal model that tries to map the external observations, as we start to consider information-theoretic notions of relevance. Our results show that these design choices can have a profound effect on performance, even when the planning machinery is identical, and demonstrate the importance of building world models aligned with the agent's behavioural objectives

Classical mappings of the symplectic model and their application to the theory of large-amplitude collective motion

We study the algebra Sp(n,R) of the symplectic model, in particular for the cases n=1,2,3, in a new way. Starting from the Poisson-bracket realization we derive a set of partial differential equations for the generators as functions of classical canonical variables. We obtain a solution to these equations that represents the classical limit of a boson mapping of the algebra. The relationship to the collective dynamics is formulated as a theorem that associates the mapping with an exact solution of the time-dependent Hartree approximation. This solution determines a decoupled classical symplectic manifold, thus satisfying the criteria that define an exactly solvable model in the theory of large amplitude collective motion. The models thus obtained also provide a test of methods for constructing an approximately decoupled manifold in fully realistic cases. We show that an algorithm developed in one of our earlier works reproduces the main results of the theorem.Comment: 23 pages, LaTeX using REVTeX 3.

Factores determinantes en la selecci?n de vivienda social en el Per? : evidencia de un estudio en Chincha

Este estudio tuvo por objetivo determinar atributos m?s importantes que el comprador de vivienda social tiene en cuenta al momento de optar por una vivienda a fin de que las diferentes entidades privadas y no privadas las puedan tomar en cuenta al momento de realizar los dise?os de sus proyectos inmobiliarios de vivienda social. La hip?tesis planteada es que existe un grupo de factores que son determinantes en el momento de la decisi?n de compra de la vivienda social en nuestro pa?s. Adicionalmente se busca determinar el orden de importancia o preferencia entre estos factores

APRENDIZAJE SERVICIO COMO ESTRATEGIA PARA LA INTEGRACI 3N DE PERSONAS CON DISCAPACIDAD A LAS ACTIVIDADES AGR\ucdCOLAS

El prop\uf3sito fue analizar el aprendizaje servicio como estrategia para la integraci\uf3n de personas con discapacidad a las actividades agr\uedcolas. Desde el servicio comunitario estudiantil del Decanato de Agronom\ueda se desarrollan proyectos diversos donde destaca la atenci\uf3n a personas con discapacidad. Tal es el caso, del proyecto realizado en el Peque\uf1o Cottolengo Don Orione, instituci\uf3n sin fines de lucro que de forma gratuita presta servicio y atenci\uf3n integral a m\ue1s de 130 personas con diversidad funcional, con bajas posibilidades de independencia para el trabajo y carentes de un n\ufacleo familiar. El objetivo del proyecto del servicio comunitario fue desarrollar actividades agr\uedcolas para la producci\uf3n de alimentos y ornamentales en sus instalaciones. De \ue9ste se deriva el presente estudio con un abordaje cualitativo de investigaci\uf3n-acci\uf3n participativa siendo un m\ue9todo sistem\ue1tico e intencional de indagaci\uf3n para reflexionar y actuar sobre los problemas derivados de la realidad. El an\ue1lisis de la informaci\uf3n se presenta en tres contextos: (a) los resultados del proyecto: veinticinco (25) miembros del personal capacitado, treinta y cinco (35) j\uf3venes y adultos residentes, capacitados e incorporados a labor terapia, tres (3) hect\ue1reas de superficie incorporada a la producci\uf3n y tres (3) estructuras protegidas usadas eficazmente. (b) sistematizaci\uf3n de la experiencia de los estudiantes, quienes manifestaron que trabajar con personas con diversidad funcional agudiza su sentido de la justicia, tolerancia, amistad y humildad; (c) la opini\uf3n del personal, donde destacan que las actividades agr\uedcolas para la incorporaci\uf3n de los j\uf3venes con discapacidad fomentaron la motivaci\uf3n, habilidades, destrezas, mejoraron el estado de \ue1nimo de los participantes, la integraci\uf3n social y laboral. En consecuencia, el aprendizaje servicio demuestra su importancia en la incorporaci\uf3n de las personas con discapacidad a las labores agr\uedcolas. Palabras claves: personas con discapacidad, aprendizaje servicio, actividades agr\uedcolas. Abstract The purpose was to analyze service learning as a strategy for integration of people with impairments to agricultural activities. From student community service of \u93Decanato de agronom\ueda\u94 (Agronomy Deanship), diverse projects are developed where attention to persons with impairments in highlighted. This is the case of the project developed in \u93Peque\uf1o Cottolengo Don Orione\u94a non-profit organization that provides free of charge service and attention to over 130 persons with dysfunctional diversity, with low possibilities of independence for work and no family. Main objective of this community service research was to develop agricultural activities for food and ornament production in their facilities. This leads to the present research with a qualitative approach of \u93investigaci\uf3n-acci\uf3n participative\u94 (Participative research-action) being an international and systematic method for inquire and reflect about the problems derived in reality. Analysis of information is presented in three contexts: (a)results of project: twenty five (25) members of trained staff, thirty five (35) young and adult residents, trained and incorporated to therapy labor, three (3) hectares of land incorporated to production and three (3) protected structures used efficiently. (b) systematization of experience of students who manifested that working with people with functional diversity sharpens their sense of justice , tolerance, friendship and humility; (c) Staff opinion, where agricultural activities for incorporation of young men and women with an impairment are emphasized fomented motivation, capabilities, they improved the mood of participants, social and labor integration. In consequence, service learning shows its importance in the incorporation of persons with impairments to agricultural labors. Keywords: persons with impairments, service learning, agricultural activities. <br

Secado de forraje con el horno microondas: efecto sobre el an\ue1lisis de calidad

The objectives were to utilize a microwave oven (HM) to determine dry matter (MS) and evaluate its effect on dry matter (MS), organic matter content (MO), in vitro organic matter digestibility (DIVMO), brute protein (PB), acid detergent fiber (FDA), and acid-detergent insoluble nitrogen (NIDA). We utilized the forage species: Medicago sativa L., Trifolium repens L., Trifolium pratense L. and Thinopyrum ponticum Barkw. &amp; D.R. Dewey, and mixtures of: M. sativa-Dactylis glomerata L., Festuca arundinacea Schreb.-T.repens-D. glomerata, and Lolium perenne L.-T. repens. The experimental design was a factorial complete randomized block. We compared drying time (Ts) and quality parameters on stove method (T1), HM at 900 W (T2), and HM at 900 and 400 W (T3), by ANDEVA and Duncan Test (p 64 0,05). In T2 and T3, Ts ranged from 6 to 8 min (T. pratense and Th. ponticum, respectively), compared to 48 h for T1. The MS value did not show differences between treatments for M. sativa, T. pratense, M. sativa-D. glomerata, and L. perenne-T. repens, but there were differences for the other forages between T2 or T3 with T1, which could be explained by the forages phenological stage. Differences between treatments were found for FDA (T. repens), DIVMO and PB (Th. ponticum), and PB and MO (L. perenne-T. repens). The use of the microwave oven allows a quick and consistent MS determination, along with a reliable forage quality standard evaluation.Los objetivos de este experimento fueron utilizar el horno microondas (HM) para determinar materia seca (MS) y evaluar su efecto sobre el valor de materia org\ue1nica (MO), digestibilidad in vitro de la MO (DIVMO), prote\uedna bruta (PB), fibra detergente \ue1cido (FDA) y nitr\uf3geno insoluble en detergente \ue1cido (NIDA). Se utilizaron forrajes puros: Medicago sativa L., Trifolium repens L., Trifolium pratense L. y Thinopyrum ponticum Barkw. &amp; Dewey, y en mezclas: M. sativa-Dactylis glomerata L., Festuca arundinacea Schreb.-T. repens-D. glomerata, y Lolium perenne L.-T. repens. El dise\ue3o experimental usado fue bloques completamente aleatorizados con arreglo factorial de tratamientos. Se compar\uf3 el tiempo de secado (Ts) y los par\ue1metros de calidad entre: Estufa (T1), HM a 900 W (T2), y HM a 900 y 400 W (T3), mediante ANDEVA y Test de Duncan (p 64 0,05). Para T2 y T3, Ts vari\uf3 entre 6 a 8 min (T. pratense y Th. ponticum respectivamente), siendo en T1, 48 h. La MS no difiri\uf3 entre tratamientos para M. sativa, T. pratense, M. sativa-D. glomerata y L. perenne-T. repens, pero si en el resto de los forrajes entre T2 \uf3 T3 con T1; esto se podr\ueda asociar al estado fenol\uf3gico del material forrajero al momento del corte. Respecto a los par\ue1metros de calidad evaluados se observaron diferencias en FDA en T. repens, DIVMO y PB en Th. ponticum, y PB y MO en L. perenne-T. repens. El uso del HM permite obtener r\ue1pida y confiablemente la MS del forraje sin modificar sustancialmente sus par\ue1metros de calidad

Durvalumab plus tremelimumab for the treatment of advanced neuroendocrine neoplasms of gastroenteropancreatic and lung origin

Single immune checkpoint blockade has shown limited activity in patients with neuroendocrine neoplasms (NENs). Here the authors report the results of a phase II clinical trial of durvalumab (anti-PD-L1) and tremelimumab (anti CTLA-4) in patients with advanced NENs of gastroenteropancreatic and lung origin. Single immune checkpoint blockade in advanced neuroendocrine neoplasms (NENs) shows limited efficacy; dual checkpoint blockade may improve treatment activity. Dune (NCT03095274) is a non-randomized controlled multicohort phase II clinical trial evaluating durvalumab plus tremelimumab activity and safety in advanced NENs. This study included 123 patients presenting between 2017 and 2019 with typical/atypical lung carcinoids (Cohort 1), G1/2 gastrointestinal (Cohort 2), G1/2 pancreatic (Cohort 3) and G3 gastroenteropancreatic (GEP) (Cohort 4) NENs; who progressed to standard therapies. Patients received 1500 mg durvalumab and 75 mg tremelimumab for up to 13 and 4 cycles (every 4 weeks), respectively. The primary objective was the 9-month clinical benefit rate (CBR) for cohorts 1-3 and 9-month overall survival (OS) rate for Cohort 4. Secondary endpoints included objective response rate, duration of response, progression-free survival according to irRECIST, overall survival, and safety. Correlation of PD-L1 expression with efficacy was exploratory. The 9-month CBR was 25.9%/35.5%/25% for Cohorts 1, 2, and 3 respectively. The 9-month OS rate for Cohort 4 was 36.1%, surpassing the futility threshold. Benefit in Cohort 4 was observed regardless of differentiation and Ki67 levels. PD-L1 combined scores did not correlate with treatment activity. Safety profile was consistent with that of prior studies. In conclusion, durvalumab plus tremelimumab is safe in NENs and shows modest survival benefit in G3 GEP-NENs; with one-third of these patients experiencing a prolonged OS