Robust output synchronization of a network of heterogeneous nonlinear agents via nonlinear regulation theory

In this paper, we consider the output synchronization problem for a network of heterogeneous diffusively-coupled nonlinear agents. Specifically, we show how the (non-identical) agents can be controlled in such a way that their outputs asymptotically track the output of a prescribed nonlinear exosystem. The problem is solved in two steps. In the first step, the problem of achieving consensus among (identical) nonlinear reference generators is addressed. In this respect, it is shown how the techniques recently developed to solve the consensus problem among linear agents can be extended to agents modeled by nonlinear d-dimensional differential equations, under the assumption that the communication graph is connected. In the second step, the theory of nonlinear output regulation is applied in a decentralized control mode, to force the output of each agent of the network to robustly track the (synchronized) output of a local reference model.Comment: Submitted to 52nd IEEE Conference on Decision and Contro

The Time of Flight System of the AMS-02 Space Experiment

The Time-of-Flight (TOF) system of the AMS detector gives the fast trigger to the read out electronics and measures velocity, direction and charge of the crossing particles. The new version of the detector (called AMS-02) will be installed on the International Space Station on March 2004. The fringing field of the AMS-02 superconducting magnet is $1.0\div2.5$ kG where the photomultiplers (PM) are installed. In order to be able to operate with this residual field, a new type of PM was chosen and the mechanical design was constrained by requiring to minimize the angle between the magnetic field vector and the PM axis. Due to strong field and to the curved light guides, the time resolution will be $150\div180$ ps, while the new electronics will allow for a better charge measurement.Comment: 5 pages, 4 figures. Proc. of 7th Int. Conf. on Adv. Tech. and Part. Phys., 15-19 October 2001,Como (Italy

Oxidative Molecular Mechanisms Underlying Liver Diseases: From Systems Biology to the Personalized Medicine

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Sistema no invasivo para medir niveles de glucosa en sangre

El objetivo de este trabajo es desarrollar los circuitos electrónicos para un sensor de niveles de glucosa en sangre. El sistema es no invasivo, por lo que elimina el pinchazo en el dedo que deben realizarse los individuos que padecen de diabetes cada vez que desean conocer su nivel de glucosa.Área: Ingeniería, Arquitectura y Tecnología

Augmented Collective Digital Twins for Self-Organising Cyber-Physical Systems

Context. Self-organising and collective computing approaches are increasingly applied to large-scale cyber-physical systems (CPS), enabling them to adapt and cooperate in dynamic environments. Also, in CPS engineering, digital twins are often leveraged to provide synchronised logical counterparts of physical entities, whereas in sensor networks the different-but-related concept of virtual device is used e.g. to abstract groups of sensors. Vision. We envision the design concept of 'augmented collective digital twin' that captures digital twins at a collective level extended with purely virtual devices. We argue that this concept can foster the engineering of self-organising CPS by providing a holistic, declarative, and integrated system view. Method. From a review and proposed taxonomy of logical devices comprehending both digital twins and virtual devices, we reinterpret a meta-model for self-organising CPSs and discuss how it can support augmented collective digital twins. We illustrate the approach in a crowd-aware navigation scenario, where virtual devices are opportunistically integrated into the system to enhance spatial coverage, improving navigation capabilities. Conclusion. By integrating physical and virtual devices, the novel notion of augmented collective digital twin paves the way to self-improving system functionality and intelligent use of resources in self-organising CPSs. Conclusion. By integrating physical and virtual devices, the novel notion of augmented collective digital twin paves the way to self-improving system functionality and intelligent use of resources in self-organising CPSs

Treatment of squamous cell carcinoma of the anal canal: A new strategies with anti-EGFR therapy and immunotherapy

The incidence of squamous cell carcinoma of the anal canal (SCAC) is increasing in both sexes but the standard treatment remains that of 20 years ago. However, interesting data have recently emerged on the use of anti-epidermal growth factor receptor (EGFR) agents and immunotherapy in advanced disease. Thus, new avenues of research are opening up that will hopefully lead to more effective therapeutic strategies. We provide an overview of the latest studies published on this tumor and discuss the possible future therapeutic options for combination therapy, anti-EGFR treatment and radiotherapy

Doping incorporation paths in catalyst-free Be-doped GaAs nanowires

The incorporation paths of Be in GaAs nanowires grown by the Ga-assisted method in molecular beam epitaxy has been investigated by electrical measurements of nanowires with different doping profiles. We find that Be atoms incorporate preferentially via the nanowire side facets, while the incorporation path through the Ga droplet is negligible. We also demonstrate that Be can diffuse into the volume of the nanowire giving an alternative incorporation path. This work is an important step towards controlled doping of nanowires and will serve as a help for designing future devices based on nanowires.Comment: 4 pages, 4 figure