Hot Quark Matter with an Axial Chemical Potential

We analyze the phase diagram of hot quark matter in presence of an axial chemical potential, $\mu_5$. The latter is introduced to mimic the chirality transitions induced, in hot Quantum Chromodynamics, by the strong sphaleron configurations. In particular, we study the curvature of the critical line at small $\mu_5$, the effects of a finite quark mass and of a vector interaction. Moreover, we build the mixed phase at the first order phase transition line, and draw the phase diagram in the chiral density and temperature plane. We finally compute the full topological susceptibility in presence of a background of topological charge.Comment: 12 pages, 7 figures. Few references added, short discussion included. Final version appearing on Phys. Rev.

LCA DI MATERIALI ISOLANTI IN CALCECANAPULO PER EDILIZIA SOSTENIBILE

La necessita\u300 di ridurre le emissioni derivanti dal settore dell\u2019edilizia ha portato alla ricerca di soluzioni per migliorare la sostenibilita\u300 e la performance energetica degli edifici. Una soluzione efficace e\u300 l\u2019utilizzo di mate- riali isolanti di origine naturale. Il calcecanapulo e\u300 un biocomposito ottenuto dalla miscela di una fibra natura- le (canapulo) e di un legante (calce) con ottime capacita\u300 isolanti e igrometriche. L\u2019obiettivo dello studio e\u300 quello di valutare la sostenibilita\u300 in termini di Life Cycle Assessment di tre diverse miscele del biocomposito prodotte dall\u2019azienda italiana Equilibrium: Natural Beton 200 (con un rapporto calce canapa 1:1), Natural Be- ton 300 (con rapporto 2:1) e Biomattone (2:1). L\u2019approccio dello studio e\u300 \u201cdalla culla al cancello\u201d. Per tutte le miscele la fase di produzione della calce e della canapa risultano essere quelle con impatti maggiori. Gli im- patti derivanti dal trasporto della calce possono essere ridotti cambiando il sito di approvviggionamento

Pacific circulation response to eastern Arctic sea ice reduction in seasonal forecast simulations

Recent studies point to the sensitivity of mid-latitude winter climate to Arctic sea ice variability. However, there remain contradictory results in terms of character and timing of Northern Hemisphere large-scale circulation features to Arctic sea ice changes. This study assesses the impact of realistic late autumn eastern Arctic sea ice anomalies on atmospheric wintertime circulation at mid-latitudes, pointing to a hidden potential for seasonal predictability. ​Using a dynamical seasonal prediction system, an ensemble of seasonal forecast simulations of 23 historical winter seasons is run with reduced November sea ice cover in the Barents-Kara Seas, and is compared to the respective control seasonal hindcast simulations set. ​A non energy-conserving approach is adopted for achieving the desired sea ice loss, with artificial heat being added conditionally to the ocean surface heat fluxes so as to inhibit the formation of sea ice during November. Our results point to a robust atmospheric circulation response in the North Pacific sector, similar to previous findings on the multidecadal timescale. Specifically, an anticyclonic anomaly at upper and lower levels is identified over the eastern midlatitude North Pacific, leading to dry conditions over the North American southwest coast. The responses are related to a re-organization (weakening) of west-Pacific tropical convection and interactions with the tropical Hadley circulation. ​A possible interaction of the poleward-shifted Pacific eddy-driven jet stream and the Hadley cell is discussed​. ​The winter circulation response in the Euro-Atlantic sector is ephemeral in character and statistically significant in January only, corroborating previous findings of an intermittent and non-stationary Arctic sea ice-NAO link during boreal winter. These results ​aid our understanding of the seasonal impacts of reduced eastern Arctic sea ice on the midlatitude atmospheric circulation with implications for seasonal predictability in wintertime

Gender differences in vaccine therapy: where are we in Covid-19 pandemic?

Vaccination is one of the greatest achievements of public health. Vaccination programs have contributed to the decline in mortality and morbidity of various infectious diseases. This review aims to investigate the impact of sex/gender on the vaccine acceptance, responses, and outcomes. The studies were identified by using PubMed, until 30th June 2020. The search was performed by using the following keywords: SARS-CoV-2, Covid-19, gender, sex, vaccine, adverse reaction. Clinical trials, retrospective and prospective studies were included. Studies written in languages other than English were excluded. Three authors (TC, EB and IA) reviewed all study abstracts. Studies were included if gender differences in response to vaccination trials were reported. All selected studies were qualitatively analyzed. Innate recognition and response to viruses, as well as, adaptive immune responses during viral infections, differ between females and males. Unfortunately, a majority of vaccine trials have focused on healthy people, with ages between 18 to 65 years, excluding the elderly, pregnant women, post-menopausal female and children. In conclusion, it is apparent that the design of vaccines and vaccine strategies should be sex-specific, to reduce adverse reactions in females and increase immunogenicity in males. It should be mandatory to examine sex-related variables in pre-clinical and clinical vaccine trials, such as their crucial role for successful prevention of pandemic Covid-19

Inter-comparison of relative stopping power estimation models for proton therapy

Theoretical stopping power values were inter-compared for the Bichsel, Janni, ICRU and Schneider relative stopping power (RSP) estimation models, for a variety of tissues and tissue substitute materials taken from the literature. The RSPs of eleven plastic tissue substitutes were measured using Bragg peak shift measurements in water in order to establish a gold standard of RSP values specific to our centre's proton beam characteristics. The theoretical tissue substitute RSP values were computed based on literature compositions to assess the four different computation approaches. The Bichsel/Janni/ICRU approaches led to mean errors in the RSP of  −0.1/+0.7/−0.8%, respectively. Errors when using the Schneider approach, with I-values from the Bichsel, Janni and ICRU sources, followed the same pattern but were generally larger. Following this, the mean elemental ionisation energies were optimized until the differences between theoretical RSP values matched measurements. Failing to use optimized I-values when applying the Schneider technique to 72 human tissues could introduce errors in the RSP of up to  −1.7/+1.1/−0.4% when using Bichsel/Janni/ICRU I-values, respectively. As such, it may be necessary to introduce an additional step in the current stoichiometric calibration procedure in which tissue insert RSPs are measured in a proton beam. Elemental I-values can then optimized to match these measurements, reducing the uncertainty when calculating human tissue RSPs

Successful private–public funding of paediatric medicines research: lessons from the EU programme to fund research into off-patent medicines

The European Paediatric Regulation mandated the European Commission to fund research on off-patent medicines with demonstrated therapeutic interest for children. Responding to this mandate, five FP7 project calls were launched and 20 projects were granted. This paper aims to detail the funded projects and their preliminary results. Publicly available sources have been consulted and a descriptive analysis has been performed. Twenty Research Consortia including 246 partners in 29 European and non-European countries were created (involving 129 universities or public funded research organisations, 51 private companies with 40 SMEs, 7 patient associations). The funded projects investigate 24 medicines, covering 10 therapeutic areas in all paediatric age groups. In response to the Paediatric Regulation and to apply for a Paediatric Use Marketing Authorisation, 15 Paediatric Investigation Plans have been granted by the EMAPaediatric Committee, including 71 studies of whom 29 paediatric clinical trials, leading to a total of 7,300 children to be recruited in more than 380 investigational centres. Conclusion: Notwithstanding the EU contribution for each study is lower than similar publicly funded projects, and also considering the complexity of paediatric research, these projects are performing high-quality research and are progressing towards the increase of new paediatric medicines on the market. Private–public partnerships have been effectively implemented, providing a good example for future collaborative actions. Since these projects cover a limited number of offpatent drugs and many unmet therapeutic needs in paediatrics remain, it is crucial foreseeing new similar initiatives in forthcoming European funding programmes

Emergency Department as an epidemiological observatory of Human Mobility: the experience of the Moroccan population

We conducted a retrospective study of the accesses to the Emergency Department registered from January 2000 to December 2014 in 5 major hospitals in the Metropolitan Area of Rome. We extrapolated data relating to patients of Moroccan origin from about 5 million total accesses, so we compared with Italians data which, in the same period, came to ED. The Moroccan population is distinguished by a larger number of diagnoses belonging to the ICD-9 code of Infectious Diseases and, more precisely, to Respiratory Infectious Diseases. There are also no differences in the assignment of such diagnoses to Moroccans with Italian citizenship, and this led to think that this could play an important role in the use of the ED and moreover that enrollment to the National Health Service may reduce its inappropriate use. Regarding to Degenerative Disorders, the result of our analysis is quite emblematic, showing that the accesses to the ED is due to Cardiovascular Diseases: 6.33% of Italians' accesses against 1.81% of Moroccans and 2.36% of Moroccans with Italian citizenship. The main explanation for this difference is, obviously, due to the age of the population: about 60% of Moroccans who accessed to ED was less than 40 years old. It is interesting how, in the field of ​​Cardiovascular Diseases, Moroccans have a lower percentage of diagnosis compared to Italians for acute diseases and a greater percentage of diagnoses for chronic diseases, suggesting once again that accesses to ED for migrants often is due to the inability to use the general services of the National Health Service. In conclusion, from the point of view of the Emergency Department, Migration Medicine still has Infectious Diseases as the main reason for access. Degenerative Disorders remain a prerogative of the Italians, but we could certainly assume that the Moroccan population would develop at some point with the aging

Longitudinal Evaluation of Serum MOG-IgG and AQP4-IgG Antibodies in NMOSD by a Semiquantitative Ratiometric Method

Background and purpose: Immunoadsorption (IA) is an antibody-depleting therapy used to treat neuromyelitis optica spectrum disorder (NMOSD) associated to antiaquaporin 4 (anti-AQP4-IgG) and antimyelin oligodendrocyte glycoprotein (anti-MOG-IgG) serum autoantibodies. Our aim was to evaluate longitudinal changes of serum MOG-IgG and AQP4-IgG antibody titer and to correlate it with the clinical status. Methods: Autoantibody titer and clinical features of two MOG-IgG+/AQP4-IgG– and two AQP4-IgG+/MOG-IgG– patients with NMOSD were collected at baseline (T0), after 6 IA courses (T1), and then 2 weeks (T2) and 6 months after treatment (T3). A fluorescent ratiometric assay was used for a quantitative detection of MOG and AQP4 antibodies, based on HEK-293 cells transfected with the full-length hMOG fused to GFP or h-AQP4-M23 isoform fused to m-cherry, respectively. We defined the antibody titer as MOG quantitative ratio (MOGqr) and AQP4 quantitative ratio (AQP4qr). Results: In Case 1, the MOGqr dropped from 0.98 at T0 to 0.14 at T3, and in Case 2, it decreased from 0.96 at T0 to undetectable at T3. In Case3, the AQP4qr remained high: 0.90 at T0 and 0.92 at T3. In Case 4, the AQP4qr decreased from 0.50 at T0 to undetectable at T3. Complete recovery was found in Cases 1, 2, and 4. Conclusions: Semiquantitative ratiometric method accurately detects even slight variation of MOG-IgG and AQP4-IgG titer, suggesting it may be useful to monitor the antibody titer during the disease course and maintenance immunotherapy

DTM-based morphometry of the Palinuro seamount (Eastern Tyrrhenian Sea): Geomorphological and volcanological implications

We present a high resolution DTM of the Palinuro Seamount (PS, Tyrrhenian Sea, Italy) resulting from the processing of multibeam swath bathymetry records acquired during the second leg of the “Aeolian 2007” cruise. PS consists of several superimposed volcanoes aligned along a N100°E strike and measures 55×25 km. The western and the central sectors result from the coalescence of collapse structures (calderas) with younger volcanic cones. The eastern sector reveals a more complex and articulated structure. In the central sector, a volcanic crater with a well-preserved rim not obliterated by erosional events suggests a volcanological rejuvenation of this sector. The presence of flat surfaces on the top of the seamount may be due to the formation of marine terraces during the last sea-level lowering. Lateral collapses on the northern and southern flanks of the seamount are probably related to slope instability, as suggested by the presence of steep slopes (25–40°). The main fault affecting PS strikes N65°E and shows a right lateral component of movement. E–W and N10°E striking faults are also present. Assuming that theN100°E deep-seated fault,which is responsible for theemplacement of PS,movedwith sinistral slips, we interpret the N65°E and the N10°E faults as right-lateral (second order) shear and left-lateral (third order) shear, respectively. Due to the particular location of the Palinuro Seamount, the data presented here allow us to better understand the volcanism and the geodynamic processes of the Tyrrhenian Sea