342 research outputs found
Artefacts of Violence of the Bronze and Copper Ages in the South of Western Siberia
In the archeological sources the facts of violent actions are expressed at several levels They can include peculiarities of burial traditions traumatic effects on paleoanthropological materials objects symbolizing weapons and images of military conflicts By now there has been quite a variety of such facts revealed on the southern territory of the Western Siberia Fig 1 for the Late Bronze and Early Iron Ages 1000 BC which require detailed consideration They encompass violence and peculiarities of burial customs traumatic effects on paleoanthropological materials cutting of heads scalping injuries images of cut heads objects symbolizing weapons pictures of military conflict
Association between benzodiazepine use with or without opioid use and all-cause mortality in the United States, 1999-2015
Importance: Although overall rates of opioid use have been plateauing, coprescriptions of benzodiazepines and opioids have increased greatly in recent years. It is unknown whether this combination is an independent risk factor for all-cause mortality as opposed to being more frequently used by persons with a baseline elevated risk of death.
Objective: To evaluate whether benzodiazepine use, with or without opioid use, is associated with increased all-cause mortality relative to the use of low-risk antidepressants.
Design, Setting, and Participants: This retrospective cohort study used a large, nationally representative US data set (the National Health and Nutrition Examination Surveys [NHANES]) from 1999 to 2015. Eight cycles of NHANES data were used, spanning 37 610 person-years of follow-up time among 5212 individuals. Statistical analysis was performed from August 24, 2019, through May 23, 2020.
Exposures: The primary exposure variable was benzodiazepine and opioid coprescriptions. Individuals taking selective serotonin reuptake inhibitors (SSRIs) served as an active comparator reference group.
Main Outcomes and Measures: All-cause mortality was obtained via linkage of NHANES to the National Death Index. Propensity scores were calculated from covariates associated with sociodemographic factors, comorbidities, and medication use for more than 1000 prescription types. Propensity score-weighted mortality hazards were calculated from Cox proportional hazards regression models.
Results: Of 5212 participants aged 20 years or older (1993 men [38.2%]; mean [SD] age, 54.8 [16.9] years) followed up for a median of 6.7 years (range, 0.2-16.8 years), 101 deaths (33.0 per 1000 person-years) occurred among those receiving cotreatment, 236 deaths (26.5 per 1000 person-years) occurred among those receiving only benzodiazepines, and 227 deaths (20.2 per 1000 person-years) occurred among SSRI recipients taking neither opioids nor benzodiazepines. After propensity score weighting, a significant increase in all-cause mortality was associated with benzodiazepine and opioid cotreatment (hazard ratio, 2.04 [95% CI, 1.65-2.52]) and benzodiazepines without opioids (hazard ratio, 1.60 [95% CI, 1.33-1.92]). Subgroup analyses revealed an increased risk of mortality for individuals receiving cotreatment who were 65 years or younger but not for those older than 65 years; similar findings were observed for those receiving benzodiazepines without opioids.
Conclusions and Relevance: This study found a significant increase in all-cause mortality associated with benzodiazepine use with or without opioid use in comparison with SSRI use. Benzodiazepine and opioid cotreatment, in particular, was associated with a 2-fold increase in all-cause mortality even after taking into account medical comorbidities and polypharmacy burden
Fitting Ranked English and Spanish Letter Frequency Distribution in U.S. and Mexican Presidential Speeches
The limited range in its abscissa of ranked letter frequency distributions
causes multiple functions to fit the observed distribution reasonably well. In
order to critically compare various functions, we apply the statistical model
selections on ten functions, using the texts of U.S. and Mexican presidential
speeches in the last 1-2 centuries. Dispite minor switching of ranking order of
certain letters during the temporal evolution for both datasets, the letter
usage is generally stable. The best fitting function, judged by either
least-square-error or by AIC/BIC model selection, is the Cocho/Beta function.
We also use a novel method to discover clusters of letters by their
observed-over-expected frequency ratios.Comment: 7 figure
A new ordering principle for the classical statistical analysis of Poisson processes with background
Inspired by the recent proposal by Feldman and Cousins of a ``unified
approach to the classical statistical analysis of small signals'' based on a
choice of ordering in Neyman's construction of classical confidence intervals,
I propose a new ordering principle for the classical statistical analysis of
Poisson processes with background which minimizes the effect on the resulting
confidence intervals of the observation of less background events than
expected. The new ordering principle is applied to the calculation of the
confidence region implied by the recent null result of the KARMEN neutrino
oscillation experiment.Comment: 16 pages including 5 figures, RevTeX. Final version published in
Phys. Rev. D 59 (1999) 05300
Neutrino Oscillations in the Framework of Three-Generation Mixings with Mass Hierarchy
We have analyzed the results of reactor and accelerator neutrino oscillation
experiments in the framework of a general model with mixing of three neutrino
fields and a neutrino mass hierarchy that can accommodate the results of the
solar neutrino experiments. It is shown that
oscillations with and amplitude
larger than are not compatible with the existing limits on
neutrino oscillations if the non-diagonal elements of the mixing matrix and are small. Thus, if the
excess of electron events recently observed in the LSND experiment is due to oscillations, the mixing in the lepton sector
is basically different from the CKM mixing of quarks. If this type of mixing is
realized in nature, the observation of
oscillations would not influence
oscillations that are being searched for in the CHORUS and NOMAD experiments.Comment: Revtex file, 13 pages + 2 figures (included). The postscript file of
text and figures is available at
http://www.to.infn.it/teorici/giunti/papers.html or
ftp://ftp.to.infn.it/pub/giunti/1995/dftt-25-95/dftt-25-95.ps.
Effects of neutrino oscillations and neutrino magnetic moments on elastic neutrino-electron scattering
We consider elastic antineutrino-electron scattering taking into account
possible effects of neutrino masses and mixing and of neutrino magnetic moments
and electric dipole moments. Having in mind antineutrinos produced in a nuclear
reactor we compute, in particular, the weak-electromagnetic interference terms
which are linear in the magnetic (electric dipole) moments and also in the
neutrino masses. We show that these terms are, however, suppressed compared to
the pure weak and electromagnetic cross section. We also comment upon the
possibility of using the electromagnetic cross section to investigate neutrino
oscillations.Comment: 12 pages, REVTEX file, no figures, submitted to Phys.Rev.
A Search for Muon-neutrino to Electron-neutrino and Muon-antineutrino to Electron-antineutrino Oscillations at NuTeV
Limits on and oscillations
are extracted using the NuTeV detector with sign-selected and
\nub_\mu beams. In \nub_\mu mode, for the case of ,
is excluded, and for
, . The NuTeV data exclude the
high end of oscillations parameters
favored by the LSND experiment without the need to assume that the oscillation
parameters for and \nub are the same. We present the most stringent
experimental limits for
oscillations in the large region.Comment: 4 pages, 3 figures. Submitted to Phys. Rev. Letters, UR-164
Neutrino mass matrix with U(2) flavor symmetry and neutrino oscillations
The three neutrino mass matrices in the model are studied
focusing on the neutrino oscillation experiments. The atmospheric neutrino
anomaly could be explained by the large oscillation.
The long baseline experiments are expected to detect signatures of the neutrino
oscillation even if the atmospheric neutrino anomaly is not due to the neutrino
oscillation. However, the model cannot solve the solar neutrino deficit while
it could be reconciled with the LSND data.Comment: 12 pages, LaTex file, to be published in PR
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