The long-term energy transition: Drivers, outcomes, and the role of the multinational enterprise

The pre-eminence of the production and consumption of nonrenewable fossil fuels is waning with the growth of renewable energy solutions. This long-term energy (LTE) transition is one of the global grand challenges, characterized by uncertain and evolving markets. Although this is a global issue, there are regional differences and non-linear trajectories that suggest that the LTE transition is a complex challenge for firms and countries. For international business scholars, questions related to the role and effect of multinational enterprises in the context of the LTE transition have opened new avenues for advancing theoretical, managerial, and policy understanding. Thus, we advance this body of research by presenting a framework that delineates important drivers and outcomes of the transition. In this way, we emphasize how MNEs both influence and are being influenced by the LTE transition. We identify theoretical perspectives that may be useful to address LTE transition challenges, and suggest avenues for future research on this global grand challenge

Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always

Melanopsin retinal ganglion cells (mRGCs) are intrinsically photosensitive RGCs deputed to non-image forming functions of the eye such as synchronization of circadian rhythms to light-dark cycle. These cells are characterized by unique electrophysiological, anatomical and biochemical properties and are usually more resistant than conventional RGCs to different insults, such as axotomy and different paradigms of stress. We also demonstrated that these cells are relatively spared compared to conventional RGCs in mitochondrial optic neuropathies (Leber's hereditary optic neuropathy and Dominant Optic Atrophy). However, these cells are affected in other neurodegenerative conditions, such as glaucoma and Alzheimer's disease. We here review the current evidences that may underlie this dichotomy. We also present our unpublished data on cell experiments demonstrating that melanopsin itself does not explain the robustness of these cells and some preliminary data on immunohistochemical assessment of mitochondria in mRGCs

Slagtekyllinger reducerede antallet af æblebladhvepse I økologisk dyrkede "Discovery" æbler

Samproduktion af fjerkræ og frugt er et emne, som er blevet diskuteret og prøvet i økologisk frugtdyrkning i Danmark. Fjerkræets skraben efter føde kan muligvis formindske populationen af skadedyr, som tilbringer en del af deres livscyklus i jorden. I økologisk forskning er meget få forsøg med kombineret vegetabilsk og animalsk produktion udført. Behovet for alternative metoder til at regulerer skadedyrspopulationerne meget efterspurgte, fordi økologisk æbleproduktion i Danmark har meget få økologiske sprøjtemidler til rådighed. Æblehvepsen (Hoplocampa testudinea) giver store udbyttetab i æbler. Æblehvepsene lægger æg under blomstring og larverne ødelægger de små frugter, der falder til jorden før modenhed. Laven overvintre og forpupper sig i jorden. Hønsefugle levede oprindeligt I skove, hvor de kunne gemme sig for rovfugle under buske og træer. Livet i en frugtplantage ligner fuglenes oprindelige miljø. Velfærden for høns og kyllinger vil derfor sandsynligvis være bedre i en frugtplantage end på de græsarealer, som de normalt har adgang til

Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on immune responses to schistosome antigens among the offspring: results of a randomised, placebo-controlled trial.

BACKGROUND: Offspring of women with schistosomiasis may exhibit immune responsiveness to schistosomes due to in utero sensitisation or trans-placental transfer of antibodies. Praziquantel treatment during pregnancy boosts maternal immune responses to schistosome antigens and reduces worm burden. Effects of praziquantel treatment during pregnancy on responses among offspring are unknown. METHODS: In a trial of anthelminthic treatment during pregnancy in Uganda (ISRCTN32849447; http://www.controlled-trials.com/ISRCTN32849447/elliott), offspring of women with Schistosoma mansoni were examined for cytokine and antibody responses to schistosome worm (SWA) and egg (SEA) antigen, in cord blood and at age one year. Relationships to maternal responses and pre-treatment infection intensities were examined, and responses were compared between the offspring of women who did, or did not receive praziquantel treatment during pregnancy. RESULTS: Of 388 S. mansoni-infected women studied, samples were obtained at age one year from 215 of their infants. Stool examination for S. mansoni eggs was negative for all infants. Cord and infant samples were characterised by very low cytokine production in response to schistosome antigens with the exception of cord IL-10 responses, which were substantial. Cord and infant cytokine responses showed no association with maternal responses. As expected, cord blood levels of immunoglobulin (Ig) G to SWA and SEA were high and correlated with maternal antibodies. However, by age one year IgG levels had waned and were hardly detectable. Praziquantel treatment during pregnancy showed no effect on cytokine responses or antibodies levels to SWA or SEA either in cord blood or at age one year, except for IgG1 to SWA, which was elevated in infants of treated mothers, reflecting maternal levels. There was some evidence that maternal infection intensity was positively associated with cord blood IL-5 and IL-13 responses to SWA, and IL-5 responses to SEA, and that this association was modified by treatment with praziquantel. CONCLUSIONS: Despite strong effects on maternal infection intensity and maternal immune responses, praziquantel treatment of infected women during pregnancy had no effect on anti-schistosome immune responses among offspring by age one year. Whether the treatment will impact upon the offspring's responses on exposure to primary schistosome infection remains to be elucidated. TRIAL REGISTRATION: ISRCTN: ISRCTN32849447

Head-mounted accelerometry accurately detects prey capture in California sea lions

Detecting when and where animals feed is key to understanding their ecophysiology, but our ability to collect these data in marine mammals remains limited. Here, we test a tag-based accelerometry method to detect prey capture in California sea lions. From synchronized underwater video and acceleration data of two trained sea lions, we isolated a combined acceleration and Jerk pattern that reliably indicated prey capture in training datasets. We observed a stereotyped feeding motion in underwater video that included (1) mouth opening while approaching prey; (2) head deceleration to allow initial suction or prey engulfment, and (3) jaw closure. This motion (1–3) was repeated if a prey item was not initially engulfed. This stereotyped feeding motion informed a signal pattern phrase that accurately detected feeding in a training dataset. This phrase required (1) an initial heave-axis Jerk signal surpassing a threshold based on sampling rate; (2) an estimated dynamic surge-axis deceleration signal surpassing −0.7 g beginning within 0.2 s of the initial Jerk signal; and (3) an estimated dynamic surge-axis acceleration signal surpassing 1.0 g within 0.5 s of the beginning of the prior deceleration signal. We built an automated detector in MATLAB to identify and quantify these patterns. Blind tests of this detector on non-training datasets found high true-positive detection rates (91%–100%) with acceleration sampled at 50–333 Hz and low false-positive detection rates (0%–4.8%) at all sampling rates (16–333 Hz). At 32 Hz and below, true-positive detection rates decreased due to attenuation of signal detail. A detector optimized for an adult female was also accurate at 32–100 Hz when tested on an adult male’s data, suggesting the potential future use of a generalized detector in wild subjects. When tested on the same data, a published triaxial Jerk method produced high true-positive detection rates (91–100%) and low-to-moderate false-positive detection rates (15–43%) at ≥ 32 Hz. Using our detector, larger prey elicited longer prey capture duration in both animals at almost all sampling rates 32 Hz or faster. We conclude that this method can accurately detect feeding and estimate relative prey length in California sea lions

Functional characterization of the vertebrate primary ureter: Structure and ion transport mechanisms of the pronephric duct in axolotl larvae (Amphibia)

<p>Abstract</p> <p>Background</p> <p>Three kidney systems appear during vertebrate development: the pronephroi, mesonephroi and metanephroi. The pronephric duct is the first or primary ureter of these kidney systems. Its role as a key player in the induction of nephrogenic mesenchyme is well established. Here we investigate whether the duct is involved in urine modification using larvae of the freshwater amphibian <it>Ambystoma mexicanum </it>(axolotl) as model.</p> <p>Results</p> <p>We investigated structural as well as physiological properties of the pronephric duct. The key elements of our methodology were: using histology, light and transmission electron microscopy as well as confocal laser scanning microscopy on fixed tissue and applying the microperfusion technique on isolated pronephric ducts in combination with single cell microelectrode impalements. Our data show that the fully differentiated pronephric duct is composed of a single layered epithelium consisting of one cell type comparable to the principal cell of the renal collecting duct system. The cells are characterized by a prominent basolateral labyrinth and a relatively smooth apical surface with one central cilium. Cellular impalements demonstrate the presence of apical Na⁺and K⁺conductances, as well as a large K⁺conductance in the basolateral cell membrane. Immunolabeling experiments indicate heavy expression of Na⁺/K⁺-ATPase in the basolateral labyrinth.</p> <p>Conclusions</p> <p>We propose that the pronephric duct is important for the subsequent modification of urine produced by the pronephros. Our results indicate that it reabsorbs sodium and secretes potassium via channels present in the apical cell membrane with the driving force for ion movement provided by the Na⁺/K⁺pump. This is to our knowledge the first characterization of the pronephric duct, the precursor of the collecting duct system, which provides a model of cell structure and basic mechanisms for ion transport. Such information may be important in understanding the evolution of vertebrate kidney systems and human diseases associated with congenital malformations.</p