Comment on ‘A novel technique in the management of severe postpartum uterine atony bleeding: Three vertical uterine compression sutures’

[No abstract available]2-s2.0-85108382766PubMed: 3404975

Navigating the black hole: explicating layers of job search context and adaptational responses

Via a qualitative study, we introduce and elucidate 5 layers of context-related job search demands (omnibus, organizational, social, task, and personal) that are encountered by both employed and unemployed job seekers. We develop a process model to portray the mechanisms (managing mood and motivation, feedback/help seeking, and self-reflection/learning) through which these context-related demands are related to several important job search outcomes. We provide new insight into employed job seekers, showing that they report the job search as full of difficulties, obstacles, and challenges, and that some of these demands parallel those that unemployed job seekers face

From Emergency Response to Recovery: Multiple Impacts and Lessons Learned from the 2011 Van Earthquakes

On 23 October 2011, and then on 9 November 2011, two earthquakes struck the province of Van in eastern Turkey. One month after the first earthquake, between 25 November and 27 November 2011, a reconnaissance team from the Middle East Technical University, Disaster Management Implementation and Research Center (METU DMC) visited the region. The team focused on disaster management activities such as emergency relief, damage assessment, psychosocial support, and economic impacts. Field observations and personal interviews concluded that deficits in mitigation led to shortcomings in the response and rehabilitation operations in Van. Although search and rescue activities were evaluated as satisfactory, there were problems in the organization of support services, temporary accommodation, and delivery of basic needs. This paper presents a reconnaissance report outlining the observations of the interdisciplinary team in the field. It suggests some policies for improvement in the disaster management system in the future. </jats:p

P–709 Dual stimulation in-vitro-maturation (Duostim IVM) for overcoming oocyte maturation arrest, resulting in embryo transfer and livebirth

Abstract Study question Does luteal phase followed by follicular phase letrozole priming and dual oocyte retrieval for in-vitro maturation (IVM) overcome oocyte maturation arrest (OMA)? Summary answer Oocyte maturation, fertilization,embryo cryopreservation and livebirth can be achieved with letrozole priming IVM in rare cases of OMA. What is known already OMA is an intractable problem resulting in only immature oocytes being collected and to date no succesful treatment exists. Attempts to mature oocytes collected in stimulated IVF cycles with OMA have so far failed. Cases with OMA can be due to intrinsic oocyte defects, intrafollicular factors or resistance to stimulation. Study design, size, duration Six women with OMA in ≥ 2 prior stimulated IVF cycles were treated between March 2019 and December 2020. Participants/materials, setting, methods Participants had total of 18 (range 2 - 6) prior IVF cycles yielding only 166 immature oocytes. Letrozole 5mg was given days 15–18 of ovulatory cycle; SC decapeptyl 0.1mg trigger given at follicles 12 mm, 38 hours&amp;lt;OPU. After menstruation, letrozole 5mg days 3–7; SChCG 250ug when follicles=12 mm 38 hours&amp;lt;OPU. After in-vitro-maturation oocytes reaching MII were fertilized. Embryos from luteal collection were frozen and fresh embryo transfer was attempted after follicular phase collection. Main results and the role of chance Six women underwent DuoStim IVM, median (quartiles) 3.5 (0 - 9) GV and 0.5 (0 - 2) MI oocytes were collected from luteal phase OC and 0 (0 - 0) GV and 2(0 – 4.5) MI oocytes were collected from follicular phase OC. They had a total of 166 immature oocytes collected in prior IVF cycles. There were no MII oocytes at the time of collection in any cycles.0 (0 – 3.5) oocytes matured from luteal phase OC and 1 (0 – 4) from follicular phase OC. 0 (0 – 1.5) embryos were available from luteal phase and 0 (0 - 2) from follicular phase OC.Two subjects (29 and 33 years old) underwent fresh DET and the 29 year old with 2 previous failed IVF cycles achieved a livebirth (50% per ET and 16.7% per started cycle). None of the women who did not have an embryo for fresh transfer from the follicular phase collection had an embryo from the luteal phase collection. The same 29 year old has 2 luteal phase and 2 more follicular phase embryos vitrified. Limitations, reasons for caution OMA is a rare condition with a variety of etiologies. Different etiologies can require different managements. Wider implications of the findings: It may be possible to overcome OMA with letrozole IVM in rare cases. This case is the first recorded live birth. The value of dual stimulation overcoming OMA remains uncertain. Trial registration number This study is approved by the local ethical commitee of Medicana Samsun International Hospital by a Grant number of 02/05.02.2020: registration is not required due to retrospective status </jats:sec

Gerçek boş folikül sendromu oosit olgunlaşma anomalilerinin bir alt türüdür

Objective: To review the outcomes of in vitro maturation (IVM) and in vitro fertilization (IVF) in women with empty follicle syndrome (EFS). The study evaluated the genetic underpinnings of EFS by analyzing mutations. Materials and Methods: This retrospective case series involving 17 women with EFS over at least 2 IVF cycles was conducted. The study also employed whole-exome sequencing to analyze the genetic mutations. The treatment approaches included letrozole-primed IVM, follicle-stimulating hormone (FSH)-human chorionic gonadotrophin (hCG)-primed IVM, and conventional IVF. Results: The average female age was 31.5±4.6 years, and the duration of infertility was 7.3±3.5 years. Four patients underwent IVF. IVM oocyte collections yielded oocytes in 12 of 13 subjects. Of these, 75% (9/12) yielded MII oocytes after 48 h of IVM media incubation. Six subjects had fertilized embryos, resulting in a 40.9% intracytoplasmic sperm injection (ICSI) fertilization rate (9 embryos/22 MII oocytes). Genetic analysis revealed mutations in seven patients. This study demonstrated the partial efficacy of letrozole-primed IVM plus growth hormone and FSH-hCG primed IVM protocols. No pregnancies or live births were recorded after IVM. One ongoing pregnancy post-IVF and one spontaneous live birth were observed. Conclusion: Inter-cycle variabilities were observed in women with oocyte maturation abnormalities (OMAs). Almost all patients with EFS had oocytes collected during IVM following IVF. These oocytes have limited potential for maturation, fertilization, and live birth, as demonstrated by the low rates observed after IVM culture and ICSI. These conditions are observed in OMAs due to defects in the oocyte machinery. The proposed flowchart provides a comprehensive classification approach for various forms of EFS. © 2024 The Author