37 research outputs found
Diseño aerodinámico de un túnel de viento de bajas velocidades
This paper aims to develop the aerodynamical design and the geometric detrmination of a low veñocities wind tunnel. Was elected an Eiffel type open wind tunnel, according to the required conditions in the test chamber, such as the area and maximum air velocity in the test section; we propose the constructive layout with the tunnel elements and the geometry of them. We performe calculations to determine the flow veloctiy, the cross section and the aerodynamical losses in the characteristic sections of the instalation. We determine the required fan power and it’s selection according to the local market conditions.El presente trabajo tiene como objetivo desarrollar el diseño aerodinámico y la determinación de las características geométricas de un túnel de viento de baja velocidad. Fue elegido un túnel de viento abierto de tipo Eiffel, de acuerdo a las condiciones requeridas en la cámara de prueba, tales como el área de la sección de ensayo y la velocidad máxima del aire en esta zona; se propone el esquema constructivo con los elementos que conforman el túnel y la geometría de los mismos. Son efectuados los cálculos aerodinámicos para determinar la velocidad, el área de paso y las pérdidas aerodinámicas en las secciones características de la instalación. Se determina la potencia necesaria del ventilador y su selección de acuerdo a las condiciones del mercado nacional
An Explanatory Case Study on Teachers’ Attitudes Toward the Inclusion of Students with Special Needs in Rural Philippine Classrooms
This explanatory case study examined nine elementary teachers’ attitudes toward inclusive education in Odiongan North District, Romblon, between January and June 2025. Guided by the Social Model of Disability, Contact Theory, and the Theory of Planned Behavior, the study employed semi-structured, expert-validated focus group discussions, which were thematically analyzed to reveal four interrelated themes: moral and pedagogical motivations; contextual influences; gaps in formal professional development; and lived experiences. Insights informed a seven-module Inclusive Teaching Empowerment Series (ITES) addressing legal frameworks, differentiated instruction, co-teaching, reflective practice, and digital microlearning. The study highlights the need for sustained, context-responsive capacity building, leadership support, and resource allocation in rural, multigrade settings. Recommendations include integrating ITES into DepEd Learning Action Cells and formal peer-led workshops to scale inclusive practices
Photoacoustic methodologies for thermal diffusivity measurements for highly opaque single-layered materials
The analytical solution for the one-dimensional heat diffusion problem, involving a harmonic heat source in a single layer, is used to provide of photoacoustic self-normalized methodologies for thermal diffusivity measurements for highly opaque materials. The self-normalized procedure involves the photoacoustic phase lag between the rear and front configurations. Three methodologies are described; two of them involving linear fits in the photoacoustic thermally thick and thermally thin regimes. Comparison between the theoretical normalized equations and the corresponding normalized experimental data allows for the development of criteria on the selection of an appropriate modulation frequency range where a reliable analysis can be done
Photoacoustic methodologies for thermal diffusivity measurements for highly opaque single-layered materials
Selecting indicators to monitor outcomes across projects and multiple restoration programs in the Gulf of Mexico
ESTUDIO FITOQUÍMICO DE Echinopsis peruviana
El cactus “San Pedro Macho” (Echinopsis peruviana o también conocido como Trichocereus peruviana) debe en parte su nombre y su importancia a su similaridad, tanto taxonómica como en su contenido de alcaloides, con el muy conocido cactus “San Pedro Hembra” (Echinopsis pachanoi) o comúnmente denominado “San Pedro”, el cual es la especie más importante entre las plantas empleadas en Medicina Tradicional (MT) en el norte del Perú. Este trabajo fitoquímico de la especie Echinopsis peruviana cultivada en Perú comprende el análisis cualitativo de sus metabolitos secundarios, la cuantificación total de alcaloides y el aislamiento del alcaloide mescalina como su sal, el sulfato dihidratado, a partir de la corteza de los tallos del cactus E. peruviana. Las técnicas ESI-MS; RMN 1H, 13C; IR; UV; análisis porcentual de elementos y Cromatografía en Capa Fina (CCF) fueron empleadas para caracterizar al compuesto aislado.</jats:p
Fluorescence Polarization Assay for Small Molecule Screening of FK506 Biosynthesized in 96-Well Microtiter Plates
Diseño aerodinámico de un túnel de viento de bajas velocidades
El presente trabajo tiene como objetivo desarrollar el diseño aerodinámico y la determinación de las características geométricas de un túnel de viento de baja velocidad. Fue elegido un túnel de viento abierto de tipo Eiffel, de acuerdo a las condiciones requeridas en la cámara de prueba, tales como el área de la sección de ensayo y la velocidad máxima del aire en esta zona; se propone el esquema constructivo con los elementos que conforman el túnel y la geometría de los mismos. Son efectuados los cálculos aerodinámicos para determinar la velocidad, el área de paso y las pérdidas aerodinámicas en las secciones características de la instalación. Se determina la potencia necesaria del ventilador y su selección de acuerdo a las condiciones del mercado nacional.</jats:p
High-Titer Production of the Fungal Anhydrotetracycline, TAN-1612, in Engineered Yeasts
Antibiotic
resistance is a growing global health threat, demanding
urgent responses. Tetracyclines, a widely used antibiotic class, are
increasingly succumbing to antibiotic resistance; generating novel
analogues is therefore a top priority for public health. Fungal tetracyclines
provide structural and enzymatic diversity for novel tetracycline
analogue production in tractable heterologous hosts, like yeasts,
to combat antibiotic-resistant pathogens. Here, we successfully engineered Saccharomyces cerevisiae (baker’s yeast) and Saccharomyces boulardii (probiotic yeast) to produce
the nonantibiotic fungal anhydrotetracycline, TAN-1612, in synthetic
defined medianecessary for clean purificationsthrough
heterologously expressing TAN-1612 genes mined from the fungus, Aspergillus niger ATCC 1015. This was accomplished
via (i) a promoter library-based combinatorial pathway optimization
of the biosynthetic TAN-1612 genes coexpressed with a putative TAN-1612
efflux pump, reducing TAN-1612 toxicity in yeasts while simultaneously
increasing supernatant titers and (ii) the development of a medium-throughput
UV–visible spectrophotometric assay that facilitates TAN-1612
combinatorial library screening. Through this multipronged approach,
we optimized TAN-1612 production, yielding an over 450-fold increase
compared to previously reported S. cerevisiae yields. TAN-1612 is an important tetracycline analogue precursor,
and we thus present the first step toward generating novel tetracycline
analogue therapeutics to combat current and emerging antibiotic resistance.
We also report the first heterologous production of a fungal polyketide,
like TAN-1612, in the probiotic S. boulardii. This highlights that engineered S. boulardii can biosynthesize complex natural products like tetracyclines, setting
the stage to equip probiotic yeasts with synthetic therapeutic functionalities
to generate living therapeutics or biocontrol agents for clinical
and agricultural applications
