Temperature dependent asymmetry of the nonlocal spin-injection resistance: evidence for spin non-conserving interface scattering

We report nonlocal spin injection and detection experiments on mesoscopic Co-Al2O3-Cu spin valves. We have observed a temperature dependent asymmetry in the nonlocal resistance between parallel and antiparallel configurations of the magnetic injector and detector. This strongly supports the existence of a nonequilibrium resistance that depends on the relative orientation of the detector magnetization and the nonequilibrium magnetization in the normal metal providing evidence for increasing interface spin scattering with temperature.Comment: 5 pages, 4 figures, accepted for publication in PRL, minor corrections (affiliation, acknowledgements, typo

Dinosaur footprints and other Ichnofauna from the Cretaceous Kem Kem Beds of Morocco

We describe an extensive ichnofossil assemblage from the likely Cenomanian-age 'lower' and 'upper' units of the 'Kem Kem beds' in southeastern Morocco. In the lower unit, trace fossils include narrow vertical burrows in cross-bedded sandstones and borings in dinosaur bone, with the latter identified as the insect ichnotaxon Cubiculum ornatus. In the upper unit, several horizons preserve abundant footprints from theropod dinosaurs. Sauropod and ornithischian footprints are much rarer, similar to the record for fossil bone and teeth in the Kem Kem assemblage. The upper unit also preserves a variety of invertebrate traces including Conichnus (the resting trace of a sea-anemone), Scolicia (a gastropod trace), Beaconites (a probable annelid burrow), and subvertical burrows likely created by crabs for residence and detrital feeding on a tidal flat. The ichnofossil assemblage from the Upper Cretaceous Kem Kem beds contributes evidence for a transition from predominantly terrestrial to marine deposition. Body fossil and ichnofossil records together provide a detailed view of faunal diversity and local conditions within a fluvial and deltaic depositional setting on the northwestern coast of Africa toward the end of the Cretaceous

Bifidobacterial Dominance of the Gut in Early Life and Acquisition of Antimicrobial Resistance.

Bifidobacterium species are important commensals capable of dominating the infant gut microbiome, in part by producing acids that suppress growth of other taxa. Bifidobacterium species are less prone to possessing antimicrobial resistance (AMR) genes (ARGs) than other taxa that may colonize infants. Given that AMR is a growing public health crisis and ARGs are present in the gut microbiome of humans from early life, this study examines the correlation between a Bifidobacterium-dominated infant gut microbiome and AMR levels, measured by a culture-independent metagenomic approach both in early life and as infants become toddlers. In general, Bifidobacterium dominance is associated with a significant reduction in AMR in a Bangladeshi cohort, both in the number of acquired AMR genes present and in the abundance of AMR genes. However, by year 2, Bangladeshi infants had no significant differences in AMR related to their early-life Bifidobacterium levels. A generalized linear model including all infants in a previously published Swedish cohort found a significant negative association between log-transformed total AMR and Bifidobacterium levels, thus confirming the relationship between Bifidobacterium levels and AMR. In both cohorts, there was no change between early-life and later-life AMR abundance in high-Bifidobacterium infants but a significant reduction in AMR abundance in low-Bifidobacterium infants. These results support the hypothesis that early Bifidobacterium dominance of the infant gut microbiome may help reduce colonization by taxa containing ARGs.IMPORTANCE Infants are vulnerable to an array of infectious diseases, and as the gut microbiome may serve as a reservoir of AMR for pathogens, reducing the levels of AMR in infants is important to infant health. This study demonstrates that high levels of Bifidobacterium are associated with reduced levels of AMR in early life and suggests that probiotic interventions to increase infant Bifidobacterium levels have the potential to reduce AMR in infants. However, this effect is not sustained at year 2 of age in Bangladeshi infants, underscoring the need for more detailed studies of the biogeography and timing of infant AMR acquisition

Structural and functional conservation of key domains in InsP3 and ryanodine receptors.

Inositol-1,4,5-trisphosphate receptors (InsP(3)Rs) and ryanodine receptors (RyRs) are tetrameric intracellular Ca(2+) channels. In each of these receptor families, the pore, which is formed by carboxy-terminal transmembrane domains, is regulated by signals that are detected by large cytosolic structures. InsP(3)R gating is initiated by InsP(3) binding to the InsP(3)-binding core (IBC, residues 224-604 of InsP(3)R1) and it requires the suppressor domain (SD, residues 1-223 of InsP(3)R1). Here we present structures of the amino-terminal region (NT, residues 1-604) of rat InsP(3)R1 with (3.6 Å) and without (3.0 Å) InsP(3) bound. The arrangement of the three NT domains, SD, IBC-β and IBC-α, identifies two discrete interfaces (α and β) between the IBC and SD. Similar interfaces occur between equivalent domains (A, B and C) in RyR1 (ref. 9). The orientations of the three domains when docked into a tetrameric structure of InsP(3)R and of the ABC domains docked into RyR are remarkably similar. The importance of the α-interface for activation of InsP(3)R and RyR is confirmed by mutagenesis and, for RyR, by disease-causing mutations. Binding of InsP(3) causes partial closure of the clam-like IBC, disrupting the β-interface and pulling the SD towards the IBC. This reorients an exposed SD loop ('hotspot' (HS) loop) that is essential for InsP(3)R activation. The loop is conserved in RyR and includes mutations that are associated with malignant hyperthermia and central core disease. The HS loop interacts with an adjacent NT, suggesting that activation re-arranges inter-subunit interactions. The A domain of RyR functionally replaced the SD in full-length InsP(3)R, and an InsP(3)R in which its C-terminal transmembrane region was replaced by that from RyR1 was gated by InsP(3) and blocked by ryanodine. Activation mechanisms are conserved between InsP(3)R and RyR. Allosteric modulation of two similar domain interfaces within an N-terminal subunit reorients the first domain (SD or A domain), allowing it, through interactions of the second domain of an adjacent subunit (IBC-β or B domain), to gate the pore

Instruments of RT-2 Experiment onboard CORONAS-PHOTON and their test and evaluation IV: Background Simulations using GEANT-4 Toolkit

Hard X-ray detectors in space are prone to background signals due to the ubiquitous cosmic rays and cosmic diffuse background radiation that continuously bombards the satellites which carry the detectors. In general, the background intensity depends on the space environment as well as the material surrounding the detectors. Understanding the behavior of the background noise in the detector is very important to extract the precise source information from the detector data. In this paper, we carry out Monte Carlo simulations using the GEANT-4 toolkit to estimate the prompt background noise measured with the detectors of the RT-2 Experiment onboard the CORONAS-PHOTON satellite.Comment: 21 pages, 10 figures, Accepted for publication in Experimental Astronomy (in press

SS 433: Results of a Recent Multi-wavelength Campaign

We conducted a multi-wavelength campaign in September-October, 2002, to observe SS 433. We used 45 meter sized 30 dishes of Giant Meter Radio Telescope (GMRT) for radio observation, 1.2 meter Physical Research Laboratory Infra-red telescope at Mt Abu for IR, 1 meter Telescope at the State Observatory, Nainital for Optical photometry, 2.3 meter optical telescope at the Vainu Bappu observatory for spectrum and Rossi X-ray Timing Explorer (RXTE) Target of Opportunity (TOO) observation for X-ray observations. We find sharp variations in intensity in time-scales of a few minutes in X-rays, IR and radio wavelengths. Differential photometry at the IR observation clearly indicated significant intrinsic variations in short time scales of minutes throughout the campaign. Combining results of these wavelengths, we find a signature of delay of about two days between IR and Radio. The X-ray spectrum yielded double Fe line profiles which corresponded to red and blue components of the relativistic jet. We also present the broadband spectrum averaged over the campaign duration.Comment: 17 pages 10 figures MNRAS (submitted

Lorentz-breaking effects in scalar-tensor theories of gravity

In this work, we study the effects of breaking Lorentz symmetry in scalar-tensor theories of gravity taking torsion into account. We show that a space-time with torsion interacting with a Maxwell field by means of a Chern-Simons-like term is able to explain the optical activity in syncrotron radiation emitted by cosmological distant radio sources. Without specifying the source of the dilaton-gravity, we study the dilaton-solution. We analyse the physical implications of this result in the Jordan-Fierz frame. We also analyse the effects of the Lorentz breaking in the cosmic string formation process. We obtain the solution corresponding to a cosmic string in the presence of torsion by keeping track of the effects of the Chern-Simons coupling and calculate the charge induced on this cosmic string in this framework. We also show that the resulting charged cosmic string gives us important effects concerning the background radiation.The optical activity in this case is also worked out and discussed.Comment: 10 pages, no figures, ReVTex forma

Thermally activated magnetization reversal in monoatomic magnetic chains on surfaces studied by classical atomistic spin-dynamics simulations

We analyze the spontaneous magnetization reversal of supported monoatomic chains of finite length due to thermal fluctuations via atomistic spin-dynamics simulations. Our approach is based on the integration of the Landau-Lifshitz equation of motion of a classical spin Hamiltonian at the presence of stochastic forces. The associated magnetization lifetime is found to obey an Arrhenius law with an activation barrier equal to the domain wall energy in the chain. For chains longer than one domain-wall width, the reversal is initiated by nucleation of a reversed magnetization domain primarily at the chain edge followed by a subsequent propagation of the domain wall to the other edge in a random-walk fashion. This results in a linear dependence of the lifetime on the chain length, if the magnetization correlation length is not exceeded. We studied chains of uniaxial and tri-axial anisotropy and found that a tri-axial anisotropy leads to a reduction of the magnetization lifetime due to a higher reversal attempt rate, even though the activation barrier is not changed.Comment: 2nd version contains some improvements and new Appendi

Protons in the near-lunar wake observed by the Sub-keV Atom Reflection Analyzer on board Chandrayaan-1

Significant proton fluxes were detected in the near wake region of the Moon by an ion mass spectrometer on board Chandrayaan-1. The energy of these nightside protons is slightly higher than the energy of the solar wind protons. The protons are detected close to the lunar equatorial plane at a $140^{\circ}$ solar zenith angle, i.e., ~50$^{\circ}$ behind the terminator at a height of 100 km. The protons come from just above the local horizon, and move along the magnetic field in the solar wind reference frame. We compared the observed proton flux with the predictions from analytical models of an electrostatic plasma expansion into a vacuum. The observed velocity was higher than the velocity predicted by analytical models by a factor of 2 to 3. The simple analytical models cannot explain the observed ion dynamics along the magnetic field in the vicinity of the Moon.Comment: 28 pages, 7 figure