Evaluation of the Effectiveness of Sugammadex for Teophylline/Aminophylline Intoxication: an Experimental Study

Previous studies have shown that cyclodextrins bind to various drugs. The hypothesis of our study is to determine whether sugammadex could bind to teophylline and delayed the toxicity of that drug. Twenty eight Wistar rats were infused with teophylline at 15 mg/kg/min (24 mg/mL). Five mins after the start of infusion animals were treated with a bolus of either 16 mg/kg (S16), 100 mg/kg (S100), or 1000 mg/kg (S1000) sugammadex. The control group infusion did not contain sugammadex. Heart rate, electrocardiography, and respiratory rate were monitored. The primary endpoint was time to asystole. Teophylline infusion continued until the animals arrested. The asystole time for the S16 group was significantly longer compared to those for the control group (p < 0.05). Mean lethal dose of teophylline 90.44 +/- 27.58 mg/kg in the saline-treated rats. On the other hand, mean lethal dose of teophylline 128.54 +/- 24.03 mg/kg in the S16 group (p < 0.05). Mean lethal dose of teophylline in the S16 group, was significantly higher than control group (p < 0.05). We found 16 mg/kg sugammadex significantly delayed teophylline toxicity, and raises mean lethal dose of teophylline in a rat model of teophylline toxicity. Further research must be conducted on the interaction between teophylline and sugammadex