Presentación atípica del patrón electrocardiográfico de Wellens asociado con lesión de bifurcación coronaria

We present a patient who was admitted to the emergency room due to unstable angina, with an initial electrocardiogram without signs of acute ischemia and a favorable clinical evolution. During hospitalization, she developed the Wellens electrocardiographic pattern, noted in the literature as an infrequent, poorly identified finding and with an ominous prognosis. This electrocardiographic pattern is described in precordial derivatives, suggesting a significant lesion of a principal epicardial artery; our patient had similar electrocardiographic alterations in the high lateral leads, in whom the coronary bifurcation lesion not previously described in this scenario was confirmed.Presentamos el caso de una paciente que ingresó a emergencia por angina inestable, con electrocardiograma inicial sin signos de isquemia aguda y evolución clínica favorable. Durante la hospitalización desarrolló el patrón electrocardiográfico de Wellens, señalado en la literatura como un hallazgo infrecuente, poco identificado y de pronóstico ominoso. Este patrón electrocardiográfico se detalla en derivadas precordiales, sugiriendo una lesión significativa de una arteria epicárdica principal; la paciente tuvo alteraciones electrocardiográficas similares en las derivadas laterales altas, en quien se confirmó el compromiso de bifurcación coronaria no descrita previamente en este escenario

New heterobimetallic ferrocenyl derivatives are promising antitrypanosomal agents

In the search for a more effective chemotherapy for the treatment of Chagas’ disease and human African trypanosomiasis, caused by Trypanosoma cruzi and Trypanosoma brucei parasites, respectively, the use of organometallic compounds may be a promising strategy. In this work, eight new heterobimetallic compounds are described including four 5-nitrofuryl containing thiosemicarbazones as bioactive ligands (HL1–HL4) and dppf = 1,1′-bis(diphenylphosphino) ferrocene as an organometallic co-ligand. Complexes of the formula [MII(L)(dppf)](PF6) with M = Pd or Pt were synthesized and fully characterized in the solid state and in solution, including the determination of the molecular structure of four of them by single crystal X-ray diffraction methods. Most compounds showed activity in the low micromolar or submicromolar range against both parasites, with the platinum compounds being more active than the palladium analogues. Activity was significantly increased by generation of the M-dppf compounds (3–24 fold increase with respect to free ligands HL for T. cruzi and up to 99 fold increase with respect to HL for T. brucei). The inclusion of the organometallic co-ligand also led to lower toxicity in mammalian cells and higher selectivity towards both parasites when compared to the free HL compounds. The complexes interact with DNA and affect the redox metabolism of the parasites. Furthermore, the most active and selective compound of the new series showed no in vivo toxicity in zebrafish embryos.Instituto de Física La Plat

Expressions of Multiple Neuronal Dynamics during Sensorimotor Learning in the Motor Cortex of Behaving Monkeys

Previous studies support the notion that sensorimotor learning involves multiple processes. We investigated the neuronal basis of these processes by recording single-unit activity in motor cortex of non-human primates (Macaca fascicularis), during adaptation to force-field perturbations. Perturbed trials (reaching to one direction) were practiced along with unperturbed trials (to other directions). The number of perturbed trials relative to the unperturbed ones was either low or high, in two separate practice schedules. Unsurprisingly, practice under high-rate resulted in faster learning with more pronounced generalization, as compared to the low-rate practice. However, generalization and retention of behavioral and neuronal effects following practice in high-rate were less stable; namely, the faster learning was forgotten faster. We examined two subgroups of cells and showed that, during learning, the changes in firing-rate in one subgroup depended on the number of practiced trials, but not on time. In contrast, changes in the second subgroup depended on time and practice; the changes in firing-rate, following the same number of perturbed trials, were larger under high-rate than low-rate learning. After learning, the neuronal changes gradually decayed. In the first subgroup, the decay pace did not depend on the practice rate, whereas in the second subgroup, the decay pace was greater following high-rate practice. This group shows neuronal representation that mirrors the behavioral performance, evolving faster but also decaying faster at learning under high-rate, as compared to low-rate. The results suggest that the stability of a new learned skill and its neuronal representation are affected by the acquisition schedule.United States-Israel Binational Science FoundationIsrael Science FoundationIda Baruch FundRosetrees Trus

Epidemiology of Invasive Fungal Infections in Latin America

The pathogenic role of invasive fungal infections (IFIs) has increased during the past two decades in Latin America and worldwide, and the number of patients at risk has risen dramatically. Working habits and leisure activities have also been a focus of attention by public health officials, as endemic mycoses have provoked a number of outbreaks. An extensive search of medical literature from Latin America suggests that the incidence of IFIs from both endemic and opportunistic fungi has increased. The increase in endemic mycoses is probably related to population changes (migration, tourism, and increased population growth), whereas the increase in opportunistic mycoses may be associated with the greater number of people at risk. In both cases, the early and appropriate use of diagnostic procedures has improved diagnosis and outcome

Wnt signaling in triple-negative breast cancer

Wnt signaling regulates a variety of cellular processes, including cell fate, differentiation, proliferation and stem cell pluripotency. Aberrant Wnt signaling is a hallmark of many cancers. An aggressive subtype of breast cancer, known as triple-negative breast cancer (TNBC), demonstrates dysregulation in canonical and non-canonical Wnt signaling. In this review, we summarize regulators of canonical and non-canonical Wnt signaling, as well as Wnt signaling dysfunction that mediates the progression of TNBC. We review the complex molecular nature of TNBC and the emerging therapies that are currently under investigation for the treatment of this disease

Volviéndonos mejores: necesidad de acción inmediata ante el reto de la obesidad. Una postura de profesionales de la salud.

La creciente epidemia de obesidad ha sido uno de los retos más importantes de salud pública en México durante los últimos años. Con apoyo de la Federación Mundial de Obesidad, en 2021 formamos un grupo de profesionales para identificar y resumir las acciones prioritarias en las que puede enfocarse nuestro país para hacer frente a esta epidemia. Al proceso de desarrollo y discusión de este grupo se sumaron más de 1 000 profesionales de la salud para retomar recomendaciones de documentos y guías de alto nivel previamente publicados. En conmemoración del Día Mundial de la Obesidad, en este 2022 se presenta esta postura como insumo para el desarrollo de acciones en el ámbito profesional y de los diferentes sectores, en la que se incluyen 10 recomendaciones de acción, desde la perspectiva poblacional hasta la atención individualizada, y se enfatiza en la importancia de la participación social, de las intervenciones integrales con visión centrada en la persona y de la sostenibilidad planetaria, además de mejorar la educación y las campañas de difusión, propiciar un ambiente promotor de entornos activos y blindar de conflictos de interés los esfuerzos de prevención y control. La postura hace un llamado para abordar la obesidad de manera seria, con base en la evidencia científica, oportuna e integral, con enfoque de curso de vida, de forma ética y sensible, y sin perpetuar las barreras del estigma de peso en la sociedad

Assessing paraglacial processes at Nexpayantla Gorge (Popocatépetl volcano, Central Mexico) using OSL and 14C

We evaluate the paraglacial activity in Nexpayantla, a subtropical mountainous gorge in Popocatépetl volcano (Central Mexico), fully deglaciated in the 20th century. Glacial advances are evidenced by the presence of moraines. Fluvio-glacial terraces and an alluvial megafan resulted from the gorge deglaciation. Current reworking of the glacigenic material is done by landslides and debris flows produced on the moraines and terraces. To study the different phases of mobilization of glacigenic sediment, we used an approach based on the study of the optically stimulated luminescence (OSL) signals obtained from a portable OSL (POSL) reader in samples extracted from both glacigenic and paraglacial deposits. The luminescence (POSL) results obtained at moraines increase as altitude decreases, which is expected for deglaciated valleys where the oldest moraines are located at lower elevations. We evaluate the grade of luminescence signal reset of the glacigenic sediments during the proglacial stage, and the subsequent deglaciation phases. Our results indicate that there is a marked transition between glacial and fluvially dominated processes at Nexpayantla Gorge. We find that the grade of luminescence signal resetting in the paraglacial deposits is good indicator to trace paraglacial stages and the beginning of exhaustion of the paraglacial activity in mountain areas. OSL ages confirm that the oldest fluvio-glacial terraces found at the middle sector of Nexpayantla Gorge are ~2 ka, which is also supported by an AMS 14C age. OSL dating was found challenging, since quartz grains have low sensitivity because of their volcanic origin; POSL signals, however, are in good agreement with the location and distribution of geomorphic markers. We propose that luminescence data obtained from the POSL unit can be useful to provide information about sediment mobilization in paraglacial environments during different climatic pulses – even for the case where mineral grains have low sensitivity, such as in volcanic sediments

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