Physical activity and cancer prevention: a review of current evidence and biological mechanisms

Objective. The main aim of this paper is to review the evidence available from the date of PubMed?s inception to May 2011 for a link between cancer and physical activity (PA) in both animal models and humans. Methods. We decided to select studies that comply with the scheme proposed by the American College of Sports Medicine/ American Heart Association (ACSM/AHA) that distinguish occupational physical activity (OPA) and leisure-time physical activity (LT-PA), further classified in three levels of intensity (low, moderate and heavy) based on the Metabolic Equivalent of Task (MET) index. Results. Considering animal models, there was strong evidence for an inverse association between voluntary wheel exercise and the risk of colon and breast cancer. Regarding human studies, we identified the following main results: 1) colorectum: LT-PA provided an overall colon risk reduction of 13-14%; 2) breast: significant reduction in the frequency of post-menopausal (PMP) cancers in women that practiced heavy and moderate LT-PA; 3) prostate: heavy OPA and LT-PA seemed to reduce the risk of advanced prostate cancers; 4) endometrium: strong protective effect of heavy/moderate LT-PA among overweight/ obese women; 5) lung: inverse relationship between heavy LT-PA and lung cancer in former or current smokers across all histologies. Conclusion. Increased LT-PA is associated with cancer prevention in several organs, but strong biases, such as body mass index (BMI), gender and age, make it difficult to assess which aspects of PA contribute most strongly to the reduced risk. Furthermore, we found few studies that indicated a protective role for OPA in cancer prevention when compared with LT-PA

Screening of endocrine organ-specific humoral autoimmunity in 47,XXY Klinefelter's syndrome reveals a significant increase in diabetes-specific immunoreactivity in comparison with healthy control men.

The aim of this study was to evaluate the frequency of humoral endocrine organ-specific autoimmunity in 47,XXY Klinefelter’s syndrome (KS) by investigating the autoantibody profile specific to type 1 diabetes (T1DM), Addison’s disease (AD), Hashimoto thyroiditis (HT), and autoimmune chronic atrophic gastritis (AG). Sixty-one adult Caucasian 47,XXY KS patients were tested for autoantibodies specific to T1DM (Insulin Abs, GAD Abs, IA-2 Abs, Znt8 Abs), HT (TPO Abs), AD (21-OH Abs), and AG (APC Abs). Thirty-five of these patients were not undergoing testosterone replacement therapy TRT (Group 1) and the remaining 26 patients started TRT before the beginning of the study (Group 2). KS autoantibody frequencies were compared to those found in 122 control men. Six of 61 KS patients (9.8 %) were positive for at least one endocrine autoantibody, compared to 6.5 % of controls. Interestingly, KS endocrine immunoreactivity was directed primarily against diabetes-specific autoantigens (8.2 %), with a significantly higher frequency than in controls (p = 0.016). Two KS patients (3.3 %) were TPO Ab positive, whereas no patients were positive for AD- and AG-related autoantigens. The autoantibody endocrine profile of untreated and treated KS patients was not significantly different. Our findings demonstrate for the first time that endocrine humoral immunoreactivity is not rare in KS patients and that it is more frequently directed against type 1 diabetes-related autoantigens, thus suggesting the importance of screening for organ-specific autoimmunity in clinical practice. Follow-up studies are needed to establish if autoantibody-positive KS patients will develop clinical T1D

Thermal luminosity degeneracy of magnetized neutron stars with and without hyperon cores

The dissipation of intense crustal electric currents produces high Joule heating rates in cooling neutron stars. Here it is shown that Joule heating can counterbalance fast cooling, making it difficult to infer the presence of hyperons (which accelerate cooling) from measurements of the observed thermal luminosity Lγ. Models with and without hyperon cores match Lγ of young magnetars (with poloidal-dipolar field Bdip ≳ 1014 G at the polar surface and Lγ ≳ 1034 erg s−1 at t ≲ 105 yr) as well as mature, moderately magnetized stars (with Bdip ≲ 1014 G and 1031 erg s−1 ≲ Lγ ≲ 1032 erg s−1 at t ≳ 105 yr). In magnetars, the crustal temperature is almost independent of hyperon direct Urca cooling in the core, regardless of whether the latter is suppressed or not by hyperon superfluidity. The thermal luminosities of light magnetars without hyperons and heavy magnetars with hyperons have Lγ in the same range and are almost indistinguishable. Likewise, Lγ data of neutron stars with Bdip ≲ 1014 G but with strong internal fields are not suitable to extract information about the equation of state as long as hyperons are superfluid, with maximum amplitude of the energy gaps of the order ≈1 MeV.FA is supported by The University of Melbourne through a Melbourne Research Scholarship. AM acknowledges funding from an Australian Research Council Discovery Project grant (DP170103625) and the Australian Research Council Centre of Excellence for Gravitational Wave Discovery (OzGrav) (CE170100004). DV is supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (ERC Starting Grant "IMAGINE" No. 948582, PI DV). CD is supported by the ERC Consolidator Grant “MAGNESIA” (No. 817661, PI Nanda Rea) and this work has been carried out within the framework of the doctoral program in Physics of the Universitat Autònoma de Barcelona. JAP acknowledges support by the Generalitat Valenciana (PROMETEO/2019/071), AEI grant PGC2018-095984-B-I00 and the Alexander von Humboldt Stiftung through a Humboldt Research Award

Adverse pathophysiological influence of early testosterone therapy on the testes of boys with higher grade sex chromosome aneuploidies (HGAs): a retrospective, cross-sectional study

Purpose: Higher grade aneuploidies (HGAs) of the male sex chromosomes are a rare genetic group of pathologies caused by nondisjunction meiotic events. The aim of this study was to evaluate the impact of early androgenic therapy on the testicular secretory hormone profile, and the pathophysiological implications. Patients and methods: In this cross-sectional study, 18 HGA subjects aged 6–8 years were recruited. They were divided into two groups, based on whether or not they had previously undergone testosterone therapy (group 1: 11 untreated subjects; group 2: 7 treated subjects). Serum FSH, LH, testosterone (T), inhibin B (INHB) and anti-Müllerian hormone (AMH) were determined, and auxological parameters were assessed. Five group 1 patients and four group 2 patients were treated with hCG (human chorionic gonadotropin) for inguinal cryptorchidism; their hormone profile and auxological parameters were assessed both pre- and post-hCG treatment. Results: Group 1 subjects showed significantly higher testicular volume and higher levels of AMH and INHB (p < 0.0001). Subjects who had undergone hCG therapy showed a significantly higher testicular volume, penis length (respectively, p = 0.008 and p = 0.0005 for group 1 and p = 0.04 and p = 0.001 for group 2) and T (p = 0.005 for group 1 and p = 0.004 for group 2). Conclusions: HGA patients undergoing early testosterone therapy show an earlier and persistent suppression of testicular secretory function. At this age, the testes are still responsive to stimulation with hCG. The selection of patients to be treated must be accompanied by a thorough clinical and hormonal evaluation

Magnetic dynamo caused by axions in neutron stars

The coupling between axions and photons modifies Maxwell's equations, introducing a dynamo term in the magnetic induction equation. In neutron stars, for critical values of the axion decay constant and axion mass, the magnetic dynamo mechanism increases the total magnetic energy of the star. We show that this generates substantial internal heating due to enhanced dissipation of crustal electric currents. These mechanisms would lead magnetized neutron stars to increase their magnetic energy and thermal luminosity by several orders of magnitude, in contrast to observations of thermally-emitting neutron stars. To prevent the activation of the dynamo, bounds on the allowed axion parameter space can be derived.Comment: 5 pages, 2 figures, 1 table + Supplemental Materia

Magnetic Dynamo Caused by Axions in Neutron Stars

The coupling between axions and photons modifies Maxwell’s equations, introducing a dynamo term in the magnetic induction equation. In neutron stars, for critical values of the axion decay constant and axion mass, the magnetic dynamo mechanism increases the total magnetic energy of the star. We show that this generates substantial internal heating due to enhanced dissipation of crustal electric currents. These mechanisms would lead magnetized neutron stars to increase their magnetic energy and thermal luminosity by several orders of magnitude, in contrast to observations of thermally emitting neutron stars. To prevent the activation of the dynamo, bounds on the allowed axion parameter space can be derived.F. A., P. D. L., and A. M. are supported by the Australian Research Council (ARC) Centre of Excellence for Gravitational Wave Discovery (OzGrav), through Project No. CE170100004. P. D. L. is supported through ARC Discovery Project No. DP220101610. J. A. P. acknowledges support by the Generalitat Valenciana (PROMETEO/2019/071) and AEI Grant No. PID2021-127495NB-I00