EFEK PENAMBAHAN SERAT POLYPROPYLENE TERHADAP KUAT TEKAN BETON PADA PERKERASAN KAKU

Rigid pavement or cement concrete pavement is a construction (pavement) with aggregate and raw materials and uses cement as a binding material. Rigid pavements have good compressive strength, but in contrast to flexural strength, this is due to their brittle nature, so when planning rigid pavements, fiber is added to the concrete mixture in the hope of increasing the elastic or flexible properties of the rigid pavement itself. This study aims to analyze the effect of adding polypropylene fibers to a mixture of rigid pavement concrete with a variation of 0.1%; 0.3%; 0.5%; 0.7%; and 1.0% by weight of cement. Control test objects without using polypropylene fiber. The number of cylindrical specimens of 15x30 cm was 30 pieces. Compressive strength test. The results showed that the compressive strength were optimum at 0.30%.Perkerasan kaku atau perkerasan beton semen adalah konstruksi (perkerasan jalan) dengan agregat dan bahan baku serta menggunakan semen sebagai bahan pengikat. Perkerasan kaku memiliki kuat tekan yang baik, namun berbeda dengan kuat lentur, hal ini dikarenakan sifatnya yang getas, sehingga pada saat merencanakan perkerasan kaku, ditambahkan serat pada campuran beton dengan harapan dapat meningkatkan sifat elastis atau lentur dari perkerasan kaku itu sendiri. Penelitian ini bertujuan menganalisis pengaruh penambahan serat polypropylene pada campuran beton perkerasan kaku dengan variasi 0,1%; 0,3%; 0,5%; 0,7%; dan 1,0% berat semen. Benda uji tanpa menggunakan serat polypropylene sebagai benda uji kontrol. Jumlah benda uji berbentuk silinder 15x30 cm sebanyak 30 buah. Uji kuat tekan Hasil penelitian menunjukkan bahwa kuat tekan optimum pada kadar serat polypropylene 0,30% terhadap berat seme

Pengaruh Kualitas Penyiar dan Program Siaran Terhadap Citra Perusahaan, Kepuasan dan Loyalitas Pendengar Radio di Kota Makassar

Radio hingga kini masih dipercaya menjadi media informasi dan komunikasi yangdigemari masyarakat karena mempunyai peran penting dalam penyebaran informasi yangseimbang dan setimpal di masyarakat. Tentu saja dalam menyampaikan informasi dibutuhkankecakapan dari seorang penyiar. Selain penyiar, program siaran juga berperan penting. Acaraatau program juga akan menentukan dalam mendukung keberhasilan finansial suatu stasiunpenyiaran radio baik melalui citra perusahaan, kepuasan maupun loyalitas pendengar.Penelitian ini bertujuan untuk mengetahui pengaruh kualitas penyiar dan program siaranterhadap citra perusahaan, kepuasan dan loyalitas pendengar. Penelitian ini dilaksanakan padapendengar radio RRI Pro 2, Venus dan Madama dengan pengumpulan data melaluikuesioner, studi pustaka dan wawancara dan dianalisis menggunakan regresi berganda danregresi sederhana melalui uji SPSS. Uji data dilakukan dengan enam hipotesis nol dan enamhipotesis alternatif. Hasil penelitian menunjukkan bahwa terdapat pengaruh yang kuat padakualitas penyiar terhadap citra perusahaan dan kepuasan pendengar. Terdapat pengaruh yangyang lemah pada kualitas penyiar terhadap loyalitas pendengar.Terdapat pengaruh yang kuatpada program siaran terhadap citra perusahaan dan kepuasan pendengar. Terdapa pengaruhyang lemah dari program siaran terhadap loyalitas pendengar.&nbsp

Mortality among patients with polymyalgia rheumatica: A retrospective cohort study.

OBJECTIVE: To determine whether a diagnosis of polymyalgia rheumatica (PMR) is associated with premature mortality. METHODS: We extracted anonymised electronic medical records of patients over the age of 40 years, who were eligible for linkage with the Office for National Statistics (ONS) Death Registration dataset, from the Clinical Practice Research Datalink from 1990-2016. Patients with PMR were individually matched by age, sex and registered General Practice with up to 5 controls without PMR. The total number and proportion of deaths and mortality rates were calculated. The mortality rate ratio (MRR), with 95% confidence interval (CI), adjusted for age, sex, region, smoking status, body mass index (BMI), and alcohol consumption, was calculated using Poisson regression. The twenty most common causes of death were tabulated. RESULTS: 18,943 patients with PMR were matched to 87,801 controls. Mean (standard deviation) follow-up after date of diagnosis was 8.0 (4.4) years in patients with PMR, and 7.9 (4.6) in controls. PMR was not associated with an increase in the risk of death (adjusted MRR 1.00 [95% CI 0.97, 1.03]) compared to matched controls. Causes of death were broadly similar between patients with PMR and controls, although patients with PMR were slightly more likely to have a vascular cause of death recorded (24% vs 23%). CONCLUSIONS: A diagnosis with PMR does not appear to increase the risk of premature death. Minor variations in cause of death were observed, but overall this study is reassuring for patients with PMR and clinicians

Preparation and characterization of Posaconazole as a Nano-micelles using d-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS)

It is important to note that Posaconazole (POCZ) is a newly developed extended-spectrum triazole that belongs to BCS class II and has a solubility of less than 1µg/ml. In patients with a weakened immune system, POCZ has been shown to be effective as an antifungal treatment for invasive infections caused by candida and aspergillus species. The nano-micelles technique can be used to increase POCZ solubility. In order to increase their apparent solubility in water, nano-micelles are made by combining macromolecules that self-assemble into ordered structures capable of entrapping hydrophobic drug molecules in the interior domain. Dispersed colloidal systems, of which nano-micelles are a subset, are a large and diverse group. Composed of a phase that is itself dispersed throughout a medium (continuous phase). Surfactants form a colloidal solution when their concentration in solution is higher than their critical micelle concentration (CMC). POCZ nano-micelles are made with TPGS and tween 80. In this study, we prepared six different formulations and analyzed their particle size, polydispersity index (PDI), entrapment efficiency (EE), drug loadings (DL), saturation solubility, and in-vitro release. The drug-loaded nano-micelles of the Posaconazole formula (POCZ6) were characterized, and their properties were found to be: Particle size (90.68 nm), PDI (0.27), EE (94%), DL (10.3%), and best solubility factor (1133) are all better in the TPGS: tween80(1:5:3) ratio than in the pure drug. An in-vitro release study was conducted, and the results showed that the chosen formula POCZ6 released the entire dose of drug in 70 minutes, compared to only 23% for pure drug. Fourier transform infrared microscopy and other forms of investigation (FTIR). As can be seen from the data, there are no interactions or changes in the major peaks of Posaconazole when it is combined with polymer and surfactant

Comorbidities Associated With Attention-Deficit/Hyperactivity Disorder in Children and Adolescents at a Tertiary Care Setting

Studies have revealed high rates of neurodevelopmental and psychiatric comorbid conditions among individuals diagnosed with attention-deficit/hyperactivity disorder (ADHD). However, research on this topic in the Arab world has been limited. This study evaluates the medical, neurodevelopmental, and psychiatric comorbidities in children and adolescents diagnosed with ADHD in Dubai, United Arab Emirates (UAE). A total of 428 pediatric patients diagnosed with ADHD were included. Children and adolescents with ADHD had high rates of comorbid disorders. Twenty comorbid conditions were identified. More than 3 quarters of the study sample had at least 1 comorbid disorder. The most common comorbidity among children was autism spectrum disorder, and among adolescents was anxiety disorders. Comprehensive assessments are highly warranted to identify and manage associated comorbid conditions. Further research is needed in exploring the biopsychosocial factors contributing to the elevated rate of comorbidity in children and adolescents with ADHD

The incidence of first stroke in pregnant and non-pregnant women of childbearing age: a population-based cohort study from England

Background: Pregnant women may have an increased risk of stroke compared to non-pregnant women of similar age, but the magnitude and the timing of such risk are unclear. We examined the risk of first stroke event in women of childbearing age and compared the risk during pregnancy and in the early postpartum period to background risk outside these periods. Methods and Results: We conducted an open cohort study of 2,046,048 women aged 15-49 years between 1st April 1997 and 31th March 2014 using linked primary (Clinical Practice Research Datalink) and secondary (Hospital Episode Statistics) care records in England. Risk of first stroke was assessed by calculating the incidence rate of stroke in antepartum, peripartum (2 days before until 1 day after delivery), early (first six weeks) and late (second six weeks) postpartum periods, compared with non-pregnant time using a Poisson regression model with adjustment for maternal age, socioeconomic group and calendar time. A total of 2,511 women had a first stroke. The incidence rate of stroke was 25.0 per 100,000 person-years (95% confidence interval 24.0-26.0) in non-pregnant time. The rate was lower antepartum (10.7/100,000 person-years, 7.6-15.1), but 9-fold higher peripartum (161.1/100,000 person-years, 80.6-322.1) and 3-fold higher early postpartum (47.1/100,000 person-years, 31.3-70.9). Rates of ischaemic and haemorrhagic stroke both increased peripartum and early postpartum. Conclusions: Although the absolute risk of first stroke is low in women of childbearing age, health care professionals should be aware of a considerable increase in relative risk during the peripartum and early postpartum periods

Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction.

OBJECTIVES: Despite many shared risk factors and pathophysiological pathways, the risk of ischaemic heart disease (IHD) and myocardial infarction (MI) in interstitial lung disease (ILD) remains poorly understood. This lack of data could be preventing patients who may benefit from screening for these cardiovascular diseases from receiving it. METHODS: A population-based cohort study used electronic patient records from the Clinical Practice Research Datalink and linked Hospital Episode Statistics to identify 68 572 patients (11 688 ILD exposed (mean follow-up: 3.8 years); 56 884 unexposed controls (mean follow-up: 4.0 years), with 349 067 person-years of follow-up. ILD-exposed patients (pulmonary sarcoidosis (PS) or idiopathic pulmonary fibrosis (PF)) were matched (by age, sex, registered general practice and available follow-up time) to patients without ILD or IHD/MI. Rates of incident MI and IHD were estimated. HRs were modelled using multivariable Cox proportional hazards regression accounting for potential confounders. RESULTS: ILD was independently associated with IHD (HR 1.85, 95% CI 1.56 to 2.18) and MI (HR 1.74, 95% CI 1.44 to 2.11). In all disease categories, risk of both IHD and MI peaked between ages 60 and 69 years, except for the risk of MI in PS which was greatest <50 years. Men with PF were at greatest risk of IHD, while women with PF were at greatest risk of MI. CONCLUSIONS: ILD, particularly PF, is independently associated with MI and IHD after adjustment for established cardiovascular risk factors. Our results suggest clinicians should prioritise targeted assessment of cardiovascular risk in patients with ILD, particularly those aged 60-69 years. Further research is needed to understand the impact of such an approach to risk management

Duration and Magnitude of Postoperative Risk of Venous Thromboembolism after Cholecystectomy: A Population-Based Cohort Study

Background: This study aimed to identify burden and risk of VTE associated with cholecystectomy in England. Methods: An historical cohort study of cholecystectomy patients from 2001-2011 was undertaken using linked primary (Clinical Practice Research Datalink) and secondary (Hospital Episode Statistics) care data. Crude rates and adjusted hazard ratios (HRs) were calculated for risk of VTE following cholecystectomy using Cox regression.Results: 24 677 patients were identified with a rate of VTE in the first year following cholecystectomy of 2.80 per 1000 person years (95% CI 2.18-3.59). Patients aged >/=70 vs aged 30 vs BMI less than 0 had 2.4-fold increase in risk (HR 2.42, 95% CI 1.40–4.18); open vs. laparoscopic operation had 3-fold increase in risk (HR 2.94, 95% CI 1.55–5.55). Compared to general population, VTE risk was the highest in the first 30 days post-operatively with 9.9-fold risk following emergency cholecystectomy and 4.5-fold risk after inpatient cholecystectomy (HR 9.90, 95% CI 4.42–22.21; HR 4.54, 95% CI 2.85–7.21). Conclusions: Cholecystectomy is associated with a low absolute risk of VTE and we have identified high risk groups including the elderly, obese and those having open surgery

Incidence, prevalence and treatment burden of Polymyalgia Rheumatica in the UK over two decades: a population-based study

Objective Polymyalgia rheumatica (PMR) is the most common inflammatory rheumatic disease in older people. Contemporary estimates of the incidence and prevalence are lacking, and no previous study has assessed treatment patterns at a population level. This study aims to address this. Methods We extracted anonymised electronic medical records of patients over the age of 40 years from the Clinical Practice Research Datalink in the period 1990–2016. The absolute rate of PMR per 100 000 person-years was calculated and stratified by age, gender and calendar year. Incidence rate ratios were calculated using a Poisson regression model. Among persons with PMR, continuous and total duration of treatment with glucocorticoids (GC) were assessed. Results 5 364 005 patients were included who contributed 44 million person-years of follow-up. 42 125 people had an incident diagnosis of PMR during the period. The overall incidence rate of PMR was 95.9 per 100 000 (95% CI 94.9 to 96.8). The incidence of PMR was highest in women, older age groups and those living in the South of England. Incidence appears stable over time. The prevalence of PMR in 2015 was 0.85 %. The median (IQR) continuous GC treatment duration was 15.8 (7.9–31.2) months. However, around 25% of patients received more than 4 years in total of GC therapy. Conclusions The incidence rates of PMR have stabilised. This is the first population-based study to confirm that a significant number of patients with PMR receive prolonged treatment with GC, which can carry significant risks. The early identification of these patients should be a priority in future research