A Chiral Spin Theory in the Framework of an Invariant Evolution Parameter Formalism

We present a formulation for the construction of first order equations which describe particles with spin, in the context of a manifestly covariant relativistic theory governed by an invariant evolution parameter; one obtains a consistent quantized formalism dealing with off-shell particles with spin. Our basic requirement is that the second order equation in the theory is of the Schr\"{o}dinger-Stueckelberg type, which exhibits features of both the Klein-Gordon and Schr\"{o}dinger equations. This requirement restricts the structure of the first order equation, in particular, to a chiral form. One thus obtains, in a natural way, a theory of chiral form for massive particles, which may contain both left and right chiralities, or just one of them. We observe that by iterating the first order system, we are able to obtain second order forms containing the transverse and longitudinal momentum relative to a time-like vector $t_{\mu}t^{\mu}=-1$ used to maintain covariance of the theory. This time-like vector coincides with the one used by Horwitz, Piron, and Reuse to obtain an invariant positive definite space-time scalar product, which permits the construction of an induced representation for states of a particle with spin. We discuss the currents and continuity equations, and show that these equations of motion and their currents are closely related to the spin and convection parts of the Gordon decomposition of the Dirac current. The transverse and longitudinal aspects of the particle are complementary, and can be treated in a unified manner using a tensor product Hilbert space. Introducing the electromagnetic field we find an equation which gives rise to the correct gyromagnetic ratio, and is fully Hermitian under the proposed scalar product. Finally, we show that the original structure of Dirac'sComment: Latex, 61 pages. Minor revisions. To be published in J. Math. Phy

Representation of Quantum Mechanical Resonances in the Lax-Phillips Hilbert Space

We discuss the quantum Lax-Phillips theory of scattering and unstable systems. In this framework, the decay of an unstable system is described by a semigroup. The spectrum of the generator of the semigroup corresponds to the singularities of the Lax-Phillips $S$-matrix. In the case of discrete (complex) spectrum of the generator of the semigroup, associated with resonances, the decay law is exactly exponential. The states corresponding to these resonances (eigenfunctions of the generator of the semigroup) lie in the Lax-Phillips Hilbert space, and therefore all physical properties of the resonant states can be computed. We show that the Lax-Phillips $S$-matrix is unitarily related to the $S$-matrix of standard scattering theory by a unitary transformation parametrized by the spectral variable $\sigma$ of the Lax-Phillips theory. Analytic continuation in $\sigma$ has some of the properties of a method developed some time ago for application to dilation analytic potentials. We work out an illustrative example using a Lee-Friedrichs model for the underlying dynamical system.Comment: Plain TeX, 26 pages. Minor revision

Thermoregulation in rats: Effects of varying duration of hypergravic fields

The effects of hypergravitational fields on the thermoregulatory system of the rat are examined. The question underlying the investigation was whether the response of the rat to the one hour cold exposure depends only upon the amplitude of the hypergravic field during the period of cold exposure or whether the response is also dependent on the amplitude and duration of the hypergravic field prior to cold exposure. One hour of cold exposure applied over the last hour of either a 1, 4, 7, 13, 19, 25, or 37 hr period of 3G evoked a decrease in core temperature (T sub c) of about 3 C. However, when rats were subjected concurrently to cold and acceleration following 8 days at 3G, they exhibited a smaller fall in T sub c, suggesting partial recovery of the acceleration induced impairment of temperature regulation. In another series of experiments, the gravitational field profile was changed in amplitude in 3 different ways. Despite the different gravitational field profiles used prior to cold, the magnitude of the fall in T sub c over the 1 hr period of cold exposure was the same in all cases. These results suggest that the thermoregulatory impairment has a rapid onset, is a manifestation of an ongoing effect of hypergravity, and is not dependent upon the prior G profile

Effect of altered gravity on temperature regulation in mammals: Investigation of gravity effect on temperature regulation in mammals

Male, Long-Evans hooded rats were instrumented for monitoring core and hypothalamic temperatures as well as shivering and nonshivering thermogenesis in response to decreased ambient temperature in order to characterize the nature of the neural controller of temperature in rats at 1G and evaluate chronic implantation techniques for the monitoring of appropriate parameters at hypergravic fields. The thermoregulatory responses of cold-exposed rats at 2G were compared to those at 1G. A computer model was developed to simulate the thermoregulatory system in the rat. Observations at 1 and 2G were extended to acceleration fields of 1.5, 3.0 and 4.0G and the computer model was modified for application to altered gravity conditions. Changes in the acceleration field resulted in inadequate heat generation rather than increased heat loss. Acceleration appears to impair the ability of the neurocontroller to appropriately integrate input signals for body temperature maintenance

Lyapunov vs. Geometrical Stability Analysis of the Kepler and the Restricted Three Body Problem

In this letter we show that although the application of standard Lyapunov analysis predicts that completely integrable Kepler motion is unstable, the geometrical analysis of Horwitz et al [1] predicts the observed stability. This seems to us to provide evidence for both the incompleteness of the standard Lyapunov analysis and the strength of the geometrical analysis. Moreover, we apply this approach to the three body problem in which the third body is restricted to move on a circle of large radius which induces an adiabatic time dependent potential on the second body. This causes the second body to move in a very interesting and intricate but periodic trajectory; however, the standard Lyapunov analysis, as well as methods based on the parametric variation of curvature associated with the Jacobi metric, incorrectly predict chaotic behavior. The geometric approach predicts the correct stable motion in this case as well.Comment: 9 pages, 14 figure

Regulatory T cells in systemic lupus erythematosus: past, present and future

Regulatory/suppressor T cells (Tregs) maintain immunologic homeo-stasis and prevent autoimmunity. In this article, past studies and recent studies of Tregs in mouse models for lupus and of human systemic lupus erythematosus are reviewed concentrating on CD4+CD25+Foxp3+ Tregs. These cells consist of thymus-derived, natural Tregs and peripherally induced Tregs that are similar phenotypically and functionally. These Tregs are decreased in young lupus-prone mice, but are present in normal numbers in mice with established disease. In humans, most workers report CD4+Tregs are decreased in subjects with active systemic lupus erythematosus, but the cells increase with treatment and clinical improvement. The role of immunogenic and tolerogenic dendritic cells in controlling Tregs is discussed, along with new strategies to normalize Treg function in systemic lupus erythematosus

Identity of mysterious CD4+CD25-Foxp3+ cells in SLE

Various abnormalities in CD4+CD25+ regulatory T cells (Tregs) in systemic lupus erythematosus (SLE) include increased Foxp3+ cells that are CD25 negative. Barring methodological technical factors, these cells could be atypical Tregs or activated non-Treg CD4+ cells that express Foxp3. Two groups have reached opposite conclusions that could possibly reflect the subjects studied. One group studied untreated new-onset SLE and suggested that these T cells were mostly CD25-Foxp3+ non-Tregs. The other group studied patients with long-standing disease and suggested that these cells are mostly dysfunctional Tregs. A third group reported increased Foxp3+CD4+CD25dim rather than CD25- cells in active SLE and these were also non-Tregs. Thus, it is likely that not all Foxp3+ T cells in SLE have protective suppressive activity