To the 50th anniversary of hematology service of the Republic of Tatarstan

The article presents an overview of the development of hematology service in the Republic of Tatarstan. The well-known scientist Nikolay Konstantinovich Goryaev (1875-1943), who worked in Kazan for a long time, began to develop this direction and after passing an internship in Germany proposed an improved device for calculating the blood elements known throughout the world. Adherents of Professor Goryaev continued research in the field of hematology, a blood transfusion station was organized. Professor S.I. Sherman proposed new methods of diagnosis and treatment of B12 deficiency anemia. Professor Sh.I. Ratner studied the changes in the blood picture in diseases of the abdominal cavity. The first 15 specialized hematological beds were opened in 1968 in the hospital named “Old Clinic”. The physician who treated such patients was Rakhil Sholomovna Dashevskaya, PhD. At present, hematology service is provided by three hospitals in Kazan, hematological and therapeutical beds in Naberezhnye Chelny and Nizhnekamsk, outpatient hematology service in Zelenodolsk. In recent years, the introduction of stem cell therapy has begun, and modern combined methods of chemotherapy have been introduced

НОВЫЕ ТЕХНИЧЕСКИЕ РЕШЕНИЯ В ТЕХНОЛОГИЧЕСКОЙ ЛИНИИ ДЛЯ ПРОИЗВОДСТВА ГУМИНОВЫХ УДОБРЕНИЙ

The authors considered device and basic principles of technological line operation for complex fertilizers production on a basis of the humic ones. Its technical characteristics, analysis of the received product are given. Relevance of humic fertilizers application in the conditions of modern agriculture is opened. The most perspective of inexpensive organo-mineral fertilizers are humic (humates) and the complex fertilizers created on basis of them. Main active ingredient of such fertilizers are humic and fulvic acids. Humates, making a humus basis, influence structure of the soil well, increasing gas permeability and moisture content, reduce a soil erosion that in many respects determines its yielding potential and fertility. Their application promotes ecological improvement and a detoxication of the polluted lands, recultivation and restoration of the exhausted and infected lands. Humates absorptive radionuclides which are in the soil, pesticides, toxic substances and heavy metals in the insoluble and not acquired by plants connections and therefore provide ecological purity of production. We still have not in Russia industrial production of the specialized equipment for preparation of humic fertilizers from peat. Enterprises have to adapt for these purposes different types of processing equipment borrowed from other industries. However such equipment does not provide a necessary technological mode and reduces quality of fertilizers.Рассмотрели устройство и основные принципы работы технологической линии для производства комплексных удобрений на основе гуминовых. Привели ее технические характеристики, анализ получаемого продукта. Раскрыли актуальность использования гуминовых удобрений в условиях современного сельского хозяйства. Наиболее перспективными из недорогих органо-минеральных удобрений считаются гуминовые (гуматы) и созданные на их основе комплексные удобрения. Основные действующие вещества таких удобрений - гуминовые и фульвокислоты. Гуматы, составляя основу гумуса, благотворно влияют на структуру почвы, повышая газопроницаемость и влагосодержание, снижают эрозию почвы, что во многом определяет ее урожайный потенциал и плодородие. Их использование способствует экологическому оздоровлению и детоксикации загрязненных земель, рекультивации и восстановлению истощенных и зараженных земель. Гуматы связывают находящиеся в почве радионуклиды, пестициды, токсические вещества и тяжелые металлы в нерастворимые и не усваиваемые растениями соединения и поэтому обеспечивают экологическую чистоту продукции. В России до сих пор не существует промышленного производства специализированного оборудования для приготовления гуминовых удобрений из торфа. Предприятия вынуждены приспосабливать для этих целей различные виды технологического оборудования, позаимствованные из других отраслей промышленности. Однако такое оборудование не обеспечивает необходимого технологического режима, что снижает качество удобрений

An Experimental and Clinical Justification for Prolongation of Action of Anti-VEGF Drug in the “Wet” Form Age-related Macular Degeneration by the Introduction in the Back Subtenon Space on the Basis of Viscous Media

Purpose. Experimental-clinical substantiation of the effectiveness of subtenon injection of anti-VEGF drug on the viscous media with the purpose of strengthening and prolong of therapeutic effect in the treatment of wet form of age-related macular degeneration (AMD).Material and methods. The experimental part of the work was carried out on 10 rabbits (20 eyes). The main group of rabbits (10 eyes) were injected into the back subtenon space 0,5 ml of a 10% solution of fluorescein on the viscous mediа, which was used as a 2% solution of hydroxypropylmethylcellulose; a control (10 eyes) — without the viscous medium. After enucleation and isolation of ocular tissues in the posterior pole was performed water extraction of the dye determined the intensity of fluorescence after 3, 7, 10, 14 and 16 days after injection. In the clinical part of the work included 32 patients (34 eyes) with the wet form of AMD, to be administered anti-VEGF drug at a dose of 12,5 mg (0,5 ml) into the back subtenon space аt the same viscous media. The efficacy and safety were evaluated for 6 months.Results. As a result of the experimental study found that the length of stay in the back subtenon space of fluorescein solution of rabbit’s eye, introduced in the viscous medium to 2 times longer than without it. In a clinical study of stabilization was observed in 52,9 % of cases, improved visual function in 35,3 % of cases. Deterioration in visual functions noted in 11,8 % of cases. It was also noted improvement in photo-stress test. According OCT showed a decrease in central retinal thickness 2 times by reducing the size and volume of lesions by 30%, a significant decrease transsudativ processes in the retina in all patients, indicating that suppression of choroidal neovascularization.Conclusion: Subtenon injections of anti-VEGF drug is safe and has a positive effect in wet AMD, and its application to a viscous media has a prolonged action or property interest in any material or method mentioned

New technical solutions in technological line for humic fertilizers production

The authors considered device and basic principles of technological line operation for complex fertilizers production on a basis of the humic ones. Its technical characteristics, analysis of the received product are given. Relevance of humic fertilizers application in the conditions of modern agriculture is opened. The most perspective of inexpensive organo-mineral fertilizers are humic (humates) and the complex fertilizers created on basis of them. Main active ingredient of such fertilizers are humic and fulvic acids. Humates, making a humus basis, influence structure of the soil well, increasing gas permeability and moisture content, reduce a soil erosion that in many respects determines its yielding potential and fertility. Their application promotes ecological improvement and a detoxication of the polluted lands, recultivation and restoration of the exhausted and infected lands. Humates absorptive radionuclides which are in the soil, pesticides, toxic substances and heavy metals in the insoluble and not acquired by plants connections and therefore provide ecological purity of production. We still have not in Russia industrial production of the specialized equipment for preparation of humic fertilizers from peat. Enterprises have to adapt for these purposes different types of processing equipment borrowed from other industries. However such equipment does not provide a necessary technological mode and reduces quality of fertilizers

An Experimental and Clinical Justification for Prolongation of Action of Anti-VEGF Drug in the “Wet” Form Age-related Macular Degeneration by the Introduction in the Back Subtenon Space on the Basis of Viscous Media

Purpose. Experimental-clinical substantiation of the effectiveness of subtenon injection of anti-VEGF drug on the viscous media with the purpose of strengthening and prolong of therapeutic effect in the treatment of wet form of age-related macular degeneration (AMD).Material and methods. The experimental part of the work was carried out on 10 rabbits (20 eyes). The main group of rabbits (10 eyes) were injected into the back subtenon space 0,5 ml of a 10% solution of fluorescein on the viscous mediа, which was used as a 2% solution of hydroxypropylmethylcellulose; a control (10 eyes) — without the viscous medium. After enucleation and isolation of ocular tissues in the posterior pole was performed water extraction of the dye determined the intensity of fluorescence after 3, 7, 10, 14 and 16 days after injection. In the clinical part of the work included 32 patients (34 eyes) with the wet form of AMD, to be administered anti-VEGF drug at a dose of 12,5 mg (0,5 ml) into the back subtenon space аt the same viscous media. The efficacy and safety were evaluated for 6 months.Results. As a result of the experimental study found that the length of stay in the back subtenon space of fluorescein solution of rabbit’s eye, introduced in the viscous medium to 2 times longer than without it. In a clinical study of stabilization was observed in 52,9 % of cases, improved visual function in 35,3 % of cases. Deterioration in visual functions noted in 11,8 % of cases. It was also noted improvement in photo-stress test. According OCT showed a decrease in central retinal thickness 2 times by reducing the size and volume of lesions by 30%, a significant decrease transsudativ processes in the retina in all patients, indicating that suppression of choroidal neovascularization.Conclusion: Subtenon injections of anti-VEGF drug is safe and has a positive effect in wet AMD, and its application to a viscous media has a prolonged action or property interest in any material or method mentioned