Decision Support System for Urbanization of the Northern Part of the Volga-Akhtuba Floodplain (Russia) on the Basis of Interdisciplinary Computer Modeling

There is a computer decision support system (CDSS) for urbanization of the northern part of the Volga-Akhtuba floodplain. This system includes subsystems of cognitive and game-theoretic analysis, geoinformation and hydrodynamic simulations. The paper presents the cognitive graph, two-level and three-level models of hierarchical games for the cases of uncontrolled and controlled development of the problem situation. We described the quantitative analysis of the effects of different strategies for the spatial distribution of the urbanized territories. For this reason we conducted the territory zoning according to the level of negative consequences of urbanization for various agents. In addition, we found an analytical solution for games with the linear dependence of the average flooded area on the urbanized area. We numerically computed a game equilibrium for dependences derived from the imitational geoinformation and hydrodynamic modeling of flooding. As the result, we showed that the transition to the three-level management system and the implementation of an optimal urbanization strategy minimize its negative consequences.Comment: 14 pages, 5 figures; Conference: Creativity in Intelligent Technologies and Data Science. CIT&DS 201

Domain and Geometry Agnostic CNNs for Left Atrium Segmentation in 3D Ultrasound

Segmentation of the left atrium and deriving its size can help to predict and detect various cardiovascular conditions. Automation of this process in 3D Ultrasound image data is desirable, since manual delineations are time-consuming, challenging and observer-dependent. Convolutional neural networks have made improvements in computer vision and in medical image analysis. They have successfully been applied to segmentation tasks and were extended to work on volumetric data. In this paper we introduce a combined deep-learning based approach on volumetric segmentation in Ultrasound acquisitions with incorporation of prior knowledge about left atrial shape and imaging device. The results show, that including a shape prior helps the domain adaptation and the accuracy of segmentation is further increased with adversarial learning

Ozone sensors based on layered SAW devices with InOx/SiNx/36°YX LiTaO3 structure

Monitoring of air-quality it is a major task nowadays as the emission of pollutant gases increases particularly in urban areas. Ozone (O<sub>3</sub>) is a significant toxic pollutant and presents health risks. We have developed ozone sensors using a surface acoustic wave (SAW) based devices. The sensors structure consists of a lithium tantalate piezoelectric (LiTaO<sub>3</sub>) substrate with silicon nitride (SiN<sub>x</sub>) intermediate layer deposited by R.F. magnetron sputtering and e-beam evaporation techniques. A 100 nm thin film of indium oxide (InO<sub>x</sub>) deposited by R.F. magnetron sputtering provides the selectivity towards O<sub>3</sub>. This paper presents a comparative study of the sensors performance in terms of response time, recovery time and response magnitude as a function of operational temperature. Exceptionally large frequency shift as high as 56 kHz was observed for O<sub>3</sub> concentrations as low as 50 parts per billion (ppb) in air. Microstructural characterization of the InO<sub>x</sub> thin films by atomic force microscopy (AFM) is also presented

Characterization of a new pathway that activates lumisterol <i>in vivo</i> to biologically active hydroxylumisterols

Abstract Using LC/qTOF-MS we detected lumisterol, 20-hydroxylumisterol, 22-hydroxylumisterol, 24-hydroxylumisterol, 20,22-dihydroxylumisterol, pregnalumisterol, 17-hydroxypregnalumisterol and 17,20-dihydroxypregnalumisterol in human serum and epidermis, and the porcine adrenal gland. The hydroxylumisterols inhibited proliferation of human skin cells in a cell type-dependent fashion with predominant effects on epidermal keratinocytes. They also inhibited melanoma proliferation in both monolayer and soft agar. 20-Hydroxylumisterol stimulated the expression of several genes, including those associated with keratinocyte differentiation and antioxidative responses, while inhibiting the expression of others including RORA and RORC. Molecular modeling and studies on VDRE-transcriptional activity excludes action through the genomic site of the VDR. However, their favorable interactions with the A-pocket in conjunction with VDR translocation studies suggest they may act on this non-genomic VDR site. Inhibition of RORα and RORγ transactivation activities in a Tet-on CHO cell reporter system, RORα co-activator assays and inhibition of (RORE)-LUC reporter activity in skin cells, in conjunction with molecular modeling, identified RORα and RORγ as excellent receptor candidates for the hydroxylumisterols. Thus, we have discovered a new biologically relevant, lumisterogenic pathway, the metabolites of which display biological activity. This opens a new area of endocrine research on the effects of the hydroxylumisterols on different pathways in different cells and the mechanisms involved

Mortality and cause of death in Abuth, Zaria: 1999-2005

Background: Accurate mortality statistics are needed for policy formulation,implementation and monitoring of health intervention that are aimed at improving the health status of the people. Mortality level is one of the indicators of the quality of life and status of health of a population. However, accurate collection, collation, analysis and interpretation of such data is poorly organised in developing nations, including Nigeria leading to a gap in health policy formulation, implementation and monitoring. Therefore, policies and strategies for disease prevention are based on empirical evidence rather than on data primarily collected to formulate disease specific interventions.Though, hospital data have inherent deficiency in its use to design prevention. However, when accurately generated and adequately managed would provide both qualitative and quantitative information on morbidity and mortality if not for the entire society at least for a segment of the population utilizing it. We implemented a system of death certification to determine causes and pattern of mortality in Ahmadu Bello University Teaching Hospital, Zaria Methods: From May 1999 to November 2005, all case folders of deceased patients were retrieved from the central library of health information management department of the hospital; case folders of deceased patients are required to have in them a completed IFMCCD(International Form of Medical Certification of Cause of Death). All case folders of deceased patients after relevant information were extracted by the staff of health management information department, were passed on to the staff of department of Community Medicine directly involved in this study. The completed cause of death certificates received in the department of Community Medicine (between May 1999 and November 2005), were examined. Coding rules were employed to select the appropriate code for those certificates that were incorrectly completed. The underlying cause of death as identified from the correctly completed IFMCCDS is coded according to ICD-10.Results: For the period under study, there were 4019 deaths: 2212 males and 1807 females. Total of 2914 (72.5%) deaths were certified, using the IFMCCD of which 1641 of them were males and 1273 females and formed the basis of this analysis. Coverage rates ranges from 56.2% in 2001 to 85% in 1999. The proportion of garbage codes ranges from 0% to 2.4% while the three leading causes of death are HIV infection, road traffic accident (RTA), and cardiovascular diseases among the ten. The time-trend of the leading causes of death show RTA maintaining steady upward climb while malaria, septicemia, PEM, sepsis in the neonatal period shows unsteady fluctuation. Conclusion: This study assessed the pattern of mortality and causes of death in ABU Teaching Hospital, Zaria; it also provided information on leading causes of death

Socially sensitive lactation: Exploring the social context of breastfeeding

Many women report difficulties with breastfeeding and do not maintain the practice for as long as intended. Although psychologists and other researchers have explored some of the difficulties they experience, fuller exploration of the relational contexts in which breastfeeding takes place is warranted to enable more in-depth analysis of the challenges these pose for breastfeeding women. The present paper is based on qualitative data collected from 22 first-time breastfeeding mothers through two phases of interviews and audio-diaries which explored how the participants experienced their relationships with significant others and the wider social context of breastfeeding in the first five weeks postpartum. Using a thematic analysis informed by symbolic interactionism, we develop the overarching theme of ‘Practising socially sensitive lactation’ which captures how participants felt the need to manage tensions between breastfeeding and their perceptions of the needs, expectations and comfort of others. We argue that breastfeeding remains a problematic social act, despite its agreed importance for child health. Whilst acknowledging the limitations of our sample and analytic approach, we suggest ways in which perinatal and public health interventions can take more effective account of the social challenges of breastfeeding in order to facilitate the health and psychological well-being of mothers and their infants

Climate instability and tipping points in the Late Devonian: Detection of the Hangenberg Event in an open oceanic island arc in the Central Asian Orogenic Belt

Sedimentary petrology and trace element geochemistry indicate that the Late Devonian to Early Carboniferous Heishantou Formation near Boulongour Reservoir (NW Xinjiang, China) was deposited on a steep slope, mid-latitude accreting island arc complex in an open oceanic system. Bulk 87Sr/86Sr ratios show excursion patterns that are consistent with excursions at the Devonian–Carboniferous (D–C) boundary in epicontinental margin sediments. Sedimentation rates for the Boulongour Reservoir sediments show highly variable rates that range from 0.5 cm/ky to 10 cm/ky, consistent with other Late Devonian sections and modern arc environments. Multiple whole rock geochemical proxies for anoxia and the size and distribution of pyrite framboids suggest the presence of the Hangenberg Event in the sediments associated with the D–C boundary, despite the lack of visible black shale. The presence of anoxia in an open ocean, island arc environment cannot be explained by upwelling of anoxic bottom waters at this paleolatitude, but can be explained by the global in?iction of oceanic shallow water eutrophication on to a climate system in distress

Measuring functional ability in healthy ageing: a nationwide cross-sectional survey in the Philippine older population

OBJECTIVES: To analyse the empirical support of the functional ability concept in the healthy ageing framework developed by the WHO in a sample of the Philippine older population. According to this framework, environmental factors may enhance or hinder functional ability, which is the person's ability to do what they value, broadly represented by subjective well-being. Moreover, this network of relationships may be moderated by personal characteristics such as gender. DESIGN: Cross-sectional observational study. SETTING: Philippines, general population. PARTICIPANTS: Respondents of the 2016 National Disability Prevalence Survey/Model Functioning Survey aged 50+ (N=2825). PRIMARY AND SECONDARY OUTCOME MEASURES: Latent (unobserved) measures of functional ability, environmental factors (physical environmental factors and social network and support) and subjective well-being (positive affect, negative affect and evaluative well-being) were obtained from different items from the survey questionnaire using a SEM framework. RESULTS: We found that the relationship between environmental factors and the three components of subjective well-being considered in this study was partially explained by differences in functional ability. The portion of those effects accounted for by functional ability was comparatively larger for the physical than for the social environmental factors. We found no evidences of gender differences in this network of relationships. CONCLUSIONS: These findings suggest the relevance of functional ability at explaining the relationship between environmental factors and subjective well-being in older adults. Future studies may replicate these findings longitudinally and including other relevant measures as the person's objective level of intrinsic capacity

Transplant Coordinators' Perceived Impact of Availability of Multiple Generic Immunosuppression Therapies on Patients, Workload, and Posttransplant Maintenance Therapy

Background. No studies have evaluated the impact of multiple generic immunosuppression medications on transplant coordinators (TCs) and patients. Methods. A cross-sectional, multicenter online survey of TCs managing transplant recipients' outpatient immunosuppression was undertaken to assess TCs' perceptions of the impact of multiple generic immunosuppression therapies on patients and workload. Results. Forty-six of 106 transplant centers contacted (43%) completed the survey, with usable information from 34 TCs (53% in centers performing >100 solid organ transplants annually, 82% registered nurses, and 68% with >5-year experience working with transplant patients). TCs indicated that “change in strength,� “switching from branded to generics,� “heavy pill burden,� and “switching from one generic to another� were the four most frequent reasons for patient confusion regarding immunosuppression. TCs reported increased patient confusion over the previous year for patients on generic immunosuppression therapy: 44% answered ≥3 patient calls/day regarding confusion over immunosuppression therapy. Most TCs indicated increased workload since the introduction of generic immunosuppression therapy. TCs perceived “acute rejection rates,� “rate of graft loss,� and “poor patient adherence� as the three most likely consequences of multiple generic immunosuppression therapy. Conclusion. TCs associated availability of multiple generic immunosuppression therapy with increased patient confusion and time spent addressing patient concerns

Future changes in tropical cyclone activity in the North Indian Ocean projected by high-resolution MRI-AGCMs

Open Access at publisher's web site: http://www.springerlink.com/content/b682734237171631