Comparative genetic resistance to Ascaridia galli infections of 4 different commercial layer-lines

1. The objective of the study was to compare the establishment and effect of Ascaridia galli infections in 4 different layer-lines. 2. A total of 160 birds comprising 4 different commercial layer-lines, ISA Brown, New Hampshire, Skalborg and a cross of New Hampshire(NH) and Skalborg (Sk), were infected with A. galli eggs. The birds were examined for the presence of parasite eggs and parasites at weeks 3, 6 and 9 post infection (pi). 3. At week 6 pi the chickens of the NH line harboured more larvae compared with the three other lines. The Sk line chickens excreted more A. galli eggs throughout the study compared with the other lines. Female worms in the Sk line were more fecund than the worms in the other lines. Male and female worms recovered from the Sk line at week 9 pi were longer. Male worms recovered from the NH line 6 weeks pi were shorter than male worms from the other lines. Female worms recovered from the NH line were shorter than the female worms from the ISA line and the Sk line. No differences were seen in weight gain among the 4 lines. 4. The results suggest that genetic factors are involved in the establishment and survival of A. galli in the intestine of layers. Further studies are needed to elucidate the genetic mechanisms behind the observed parasitological findings

The Estimation of the Effective Centre of Mass Energy in q-qbar-gamma Events from DELPHI

The photon radiation in the initial state lowers the energy available for the e$^+$e$^-$ collisions; this effect is particularly important at LEP2 energies (above the mass of the Z boson). Being aligned to the beam direction, such initial state radiation is mostly undetected. This article describes the procedure used by the DELPHI experiment at LEP to estimate the effective centre-of-mass energy in hadronic events collected at energies above the Z peak. Typical resolutions ranging from 2 to 3 GeV on the effective center-of-mass energy are achieved, depending on the event topology.Comment: 12 pages, 6 figure

A Second Large Subglacial Impact Crater in Northwest Greenland?

Following the discovery of the Hiawatha impact crater beneath the northwest margin of the Greenland Ice Sheet, we explored satellite and aerogeophysical data in search of additional such craters. Here we report the discovery of a possible second subglacial impact crater that is 36.5 km wide and 183 km southeast of the Hiawatha impact crater. Although buried by 2 km of ice, the structure's rim induces a conspicuously circular surface expression, it possesses a central uplift and it causes a negative gravity anomaly. The existence of two closely-spaced and similarlysized complex craters raises the possibility that they formed during related impact events. However, the second structure's morphology is shallower, its overlying ice is conformal and older, and such an event can be explained by chance. We conclude that the identified structure is very likely an impact crater, but it is unlikely to be a twin of the Hiawatha impact crater

Spinal degeneration is associated with lumbar multifidus morphology in secondary care patients with low back or leg pain

Associations between multifidus muscle morphology and degenerative pathologies have been implied in patients with non-specific low back pain, but it is unknown how these are influenced by pathology severity, number, or distribution. MRI measures of pure multifidus muscle cross-sectional area (CSA) were acquired from 522 patients presenting with low back and/or leg symptoms in an outpatient clinic. We explored cross-sectional associations between the presence, distribution, and/or severity of lumbar degenerative pathologies (individually and in aggregate) and muscle outcomes in multivariable analyses (beta coefficients [95% CI]). We identified associations between lower pure multifidus muscle CSA and disc degeneration (at two or more levels): − 4.51 [− 6.72; − 2.3], Modic 2 changes: − 4.06 [− 6.09; − 2.04], endplate defects: − 2.74 [− 4.58; − 0.91], facet arthrosis: − 4.02 [− 6.26; − 1.78], disc herniations: − 3.66 [− 5.8; − 1.52], and when > 5 pathologies were present: − 6.77 [− 9.76; − 3.77], with the last supporting a potential dose–response relationship between number of spinal pathologies and multifidus morphology. Our findings could hypothetically indicate that these spinal and muscle findings: (1) are part of the same degenerative process, (2) result from prior injury or other common antecedent events, or (3) have a directional relationship. Future longitudinal studies are needed to further examine the complex nature of these relationships

The chemosensory systems of Vibrio cholerae

Vibrio cholerae, the causative agent of the acute diarrheal disease cholera, is able to thrive in diverse habitats such as natural water bodies and inside human hosts. To ensure their survival, these bacteria rely on chemosensory pathways to sense and respond to changing environmental conditions. These pathways constitute a highly sophisticated cellular control system in Bacteria and Archaea. Reflecting the complex life cycle of V. cholerae, this organism has three different chemosensory pathways that together contain over 50 proteins expressed under different environmental conditions. Only one of them is known to control motility, while the function of the other two remains to be discovered. Here, we provide an overview of the chemosensory systems in V. cholerae and the advances toward understanding their structure and function.Microbial Biotechnolog

Robust Bayesian Pitch Tracking Based on the Harmonic Model

Fundamental frequency is one of the most important characteristics of speech and audio signals. Harmonic model-based fundamental frequency estimators offer a higher estimation accuracy and robustness against noise than the widely used autocorrelation-based methods. However, the traditional harmonic model-based estimators do not take the temporal smoothness of the fundamental frequency, the model order, and the voicing into account as they process each data segment independently. In this paper, a fully Bayesian fundamental frequency tracking algorithm based on the harmonic model and a first-order Markov process model is proposed. Smoothness priors are imposed on the fundamental frequencies, model orders, and voicing using first-order Markov process models. Using these Markov models, fundamental frequency estimation and voicing detection errors can be reduced. Using the harmonic model, the proposed fundamental frequency tracker has an improved robustness to noise. An analytical form of the likelihood function, which can be computed efficiently, is derived. Compared to the state-of-the-art neural network and nonparametric approaches, the proposed fundamental frequency tracking algorithm has superior performance in almost all investigated scenarios, especially in noisy conditions. For example, under 0 dB white Gaussian noise, the proposed algorithm reduces the mean absolute errors and gross errors by 15% and 20% on the Keele pitch database and 36% and 26% on sustained /a/ sounds from a database of Parkinson's disease voices. A MATLAB version of the proposed algorithm is made freely available for reproduction of the results. 1 1An implementation of the proposed algorithm using MATLAB may be found in https://tinyurl.com/yxn4a543