『宣教卿記』天正三年六月〜一二月記

departmental bulletin pape

var. foliaceum

Symphyotrichum foliaceum (Lindley ex De Candolle) G.L. Nesom var. foliaceumAster foliaceusroad shoulder, junction of Old Wilmington Road and Rt. 100, Whitingham 2.3 miles north of Jacksonville lin

Histological features from an autopsy from a 29 yr old male thalassaemia patient who died of congestive cardiac failure

<p><b>Copyright information:</b></p><p>Taken from "The heart in transfusion dependent homozygous thalassaemia today – prediction, prevention and management"</p><p></p><p>European Journal of Haematology 2008;80(2):93-106.</p><p>Published online Jan 2008</p><p>PMCID:PMC2253710.</p><p>© 2008 The Authors Journal compilation © 2008 Blackwell Munksgaard</p> Histology shows individual myocyte hypertrophy with multiple deposits of brown granular material within the cytoplasm of the myocytes. These granules stain positive with Prussian blue, confirming heavy myocardial iron deposition

A 30 yr old female thalassaemia patient 2-D four chamber view with the presence of an apical thrombus

<p><b>Copyright information:</b></p><p>Taken from "The heart in transfusion dependent homozygous thalassaemia today – prediction, prevention and management"</p><p></p><p>European Journal of Haematology 2008;80(2):93-106.</p><p>Published online Jan 2008</p><p>PMCID:PMC2253710.</p><p>© 2008 The Authors Journal compilation © 2008 Blackwell Munksgaard</p

Changes in Serum Levels of Myokines and Wnt-Antagonists after an Ultramarathon Race

<div><p>Background</p><p>Regular physical activities have a positive effect on the muscular skeletal system but overstrenuous exercise may be different. Transiently suppressed bone formation and increased bone resorption after participation in a 246-km ultradistance race has been demonstrated.</p><p>Purpose</p><p>The aim of this study was to analyze effects of the Spartathlon race on novel musculoskeletal markers.</p><p>Methods</p><p>Venous blood samples were obtained before and immediately after the race from 19 participants of the Spartathlon. From 9 runners who were available 3 days after the start blood was drawn for a third time. Serum levels of myostatin, an inhibitor of myogenic differentiation, and its opponent follistatin as well as sclerostin and dickkopf-1, both of them inhibitors of the wnt signaling pathway, and markers of bone turnover were determined.</p><p>Results</p><p>Serum levels of myostatin were significantly higher after the race. Serum follistatin only showed a transient increase. Sclerostin levels did not significantly differ before and after the race, whereas dickkopf-1 levels were significantly decreased. At follow-up a decrement of sclerostin and dickkopf-1 levels was seen. Serum cathepsin K levels did not change.</p><p>Conclusion</p><p>The increase of serum levels of myostatin appears to reflect muscle catabolic processes induced by overstrenuous exercise. After the short-term uncoupling of bone turnover participation in an ultradistance race seems to initiate a long-term positive effect on bone indicated by the low-level inhibition of the Wnt/β-catenin signaling pathway.</p></div

Serum levels of P1NP, CTX, and cathepsin K on the day before the start of the race, within 15 minutes after finishing the race, and three days after the start; median [quartiles].

<p>^a: significant change after finish compared to before the start.</p><p>Serum levels of P1NP, CTX, and cathepsin K on the day before the start of the race, within 15 minutes after finishing the race, and three days after the start; median [quartiles].</p

Serum levels of myostatin, follistatin, sclerostin, DKK-1, P1NP, CTX, and cathepsin K on the day before the start of the race as well as within 15 minutes after finishing the race; median [quartiles].

<p>Serum levels of myostatin, follistatin, sclerostin, DKK-1, P1NP, CTX, and cathepsin K on the day before the start of the race as well as within 15 minutes after finishing the race; median [quartiles].</p