白金触媒とケイ素反応剤を利用する反応集積化とそれに基づく高効率的有機合成法の開発

プロジェクト番号 : A10-86一般研究 : 基礎研究textapplication/pdfresearch repor

インジウムヒドリド種の調製と利用を基軸とする環境調和型有機合成反応の開発

プロジェクト番号 : A11－92一般研究 : 基礎研究textapplication/pdfresearch repor

有機ケイ素反応剤とπ-ルイス酸性金属触媒を利用したアルキン類の連続的結合形成反応の開発

プロジェクト番号 : A09-69一般研究 : 基礎研究textapplication/pdfresearch repor

ビニルシランと白金触媒を用いる新規有機合成反応の開発《マイレビュー》

Vinylsilanes have frequently been used as carbon nucleophiles for efficient, stereospecific carbon-carbon bond formation. Their reactions occur usually at the position a to silicon. We herein report the Pt(II)-catalyzed nucleophilic addition of vinylsilanes at the b- or g-position leading to vinylation or allylation products, respectively. Under catalysis by PtCl2-2LiI, (Z)-vinylsilanes reacted with aromatic aldehydes at the position b to silicon, affording allyl silyl ethers in good to high yields. Use of MnI2 instead of LiI was effective in the vinylation of aliphatic aldehydes. We also succeeded in the one-pot vinylation of aldehydes with terminal alkynes and Et3SiH, in which PtCl2 successively catalyzed hydrosilylation of alkynes with Et3SiH and vinylation of aldehydes with the vinylsilanes formed. In contrast, under catalysis by PtCl2-2AgSbF6, the reaction of (Z)-vinylsilanes with dimethyl acetals proceeded at the g-position to give homoallylic ethers in good to high yields. When aldehydes and HC(OMe)3 were used instead of dimethyl acetals, the allylation products were obtained directly from aldehydes.textapplication/pdfdepartmental bulletin pape

Measurement of inclusive production of neutral pions from Υ(4S) decays

journal articl

Bi系高温超伝導体におけるスピン依存伝導特性

宇都宮大学博士（工学）2017text学位論文 / Thesis or Dissertationdoctoral thesi

Genotoxicity Expert Panel review: weight of evidence evaluation of the genotoxicity of glyphosate, glyphosate-based formulations, and aminomethylphosphonic acid

<p>In 2015, the International Agency for Research on Cancer (IARC) published a monograph concluding there was strong evidence for genotoxicity of glyphosate and glyphosate formulations and moderate evidence for genotoxicity of the metabolite aminomethylphosphonic acid (AMPA). These conclusions contradicted earlier extensive reviews supporting the lack of genotoxicity of glyphosate and glyphosate formulations. The IARC Monograph concluded there was strong evidence of induction of oxidative stress by glyphosate, glyphosate formulations, and AMPA. The Expert Panel reviewed the genotoxicity and oxidative stress data considered in the IARC Monograph, together with other available data not considered by IARC. The Expert Panel defined and used a weight of evidence (WoE) approach that included ranking of studies and endpoints by the strength of their linkage to events associated with carcinogenic mechanisms. Importantly, the Expert Panel concluded that there was sufficient information available from a very large number of regulatory genotoxicity studies that should have been considered by IARC. The WoE approach, the inclusion of all relevant regulatory studies, and some differences in interpretation of individual studies led to significantly different conclusions by the Expert Panel compared with the IARC Monograph. The Expert Panel concluded that glyphosate, glyphosate formulations, and AMPA do not pose a genotoxic hazard and the data do not support the IARC Monograph genotoxicity evaluation. With respect to carcinogenicity classification and mechanism, the Expert Panel concluded that evidence relating to an oxidative stress mechanism of carcinogenicity was largely unconvincing and that the data profiles were not consistent with the characteristics of genotoxic carcinogens.</p

Additional file 1: of Safety, tolerability, pharmacokinetics, and efficacy of AMG 403, a human anti-nerve growth factor monoclonal antibody, in two phase I studies with healthy volunteers and knee osteoarthritis subjects

Ethical review boards that provided approval for this study. (DOC 22 kb

面外繰り返し水平力を受ける逆L形鋼製箱形断面橋脚の耐震性能に関する解析的研究

本論文は、弾塑性有限変位解析により、面外繰り返し力を受ける逆L形鋼製箱形断面橋脚の耐震性能を評価したものである。解析は震度法設計から求められた偏心鉛直荷重と面外繰り返し荷重が作用する条件で行っている。構成則は、修正2曲面モデルを用いている。本研究ではまず、最近行われた大型模型実験と、FEM解析を比較し、その精度について検証した。次に、橋脚の耐震性能を左右する諸パラメータの影響を調べた。最後に、パラメトリック解析を通じて、偏心率の影響を考慮した係数を用いることにより、既に提案されているT形鋼製橋脚の強度と変形能の推定式から、逆L形構成橋脚の面外方向に関する強度と変形能を求める手法を提案している。Presented in this paper is numerical analysis of seismic performance of inverted L-shaped box-section steel bridge piers subjected to out-of-plane cyclic loading. The validity of the analytical model is verified by comparisons of hysterestic curves and buckling modes between the analysis and large-scale test specimens. From the analytical results, it is realized that the eccentric vertical load and cyclic loading pattern will cause a significant in-plane displacement, and in the case of inverted L-shaped piers, strength deterioration is greater than that of T-shaped piers. Furthermore, an extensive parametric analysis is performed to propose empirical formulas in order to evaluate strength and ductility of inverted L-shaped box-section steel piers.journal articl