Contribution of local atomic arrangements and electronic structure to high electrical resistivity in the Al_{82.6-x}Re_{17.4}Si_x (7≼x≼12) 1/1-1/1-1/1 approximant

Electrical resistivity of Al_{82.6-x}Re_{17.4}Si_x (7≼x≼12) 1/1-1/1-1/1 approximants was discussed in terms of their electronic structure near the Fermi level and the local atomic arrangements. Strong composition dependence of the electrical resistivity was observed for these 1/1-1/1/-1/1 approximants; samples with x=7, 9, and 12 show the Boltzmann-type electrical resistivity, while the others possess behaviors expected for system under the weak-localization.We found that the weak localization effect in the electrical resistivity, which is one of the characteristics of the corresponding Al-based quasicrystals, appears only when a condition of very low density of states with imperfections in the periodicity is satisfied. The Boltzmann-type behavior, on the other hand, takes place when one of the two factors, the very low density of states or the imperfection in the periodicity, is absent from the structure of the 1/1-1/1-1/1 approximant.journal articl

<Original Article> Surgical Management of Atherosclerotic Aneurysms of the Distal Aortic Arch Using a Temporary Bypass Graft Method

We report a unique method for the repair of atherosclerotic aneurysms of the distal aortic arch and the surgical results of this method. During the past 10 years, 34 patients have undergone repair of distal aortic arch aneurysms using temporary bypass graft at our institution; 31 elective procedures and 3 emergency procedures were performed. During aortic occlusion, distal perfusion was maintained through a temporary bypass which was usually created between the right axillary artery and the left external iliac artery. In 31 patients, aneurysms were repaired via left thoracotomy at the 4th intercostal space, and in the remaining 3 patients, a median sternotomy wifh left thoracotomy was used to approach the aneurysm because the aneurysm was in proximity to the orifice of the left common carotid artery. The aortic aneurysm was repaired by tube grafting in 29 patients, and by patch grafting in 5 patients. The mean ratio of lower extremity blood pressure to radial artery pressure during aortic occlusion was 0.69 (SE 0.19) in patients with temporary bypass using low porosity woven 14 mm Dacron grafts, and 0.86 (SE 0.09) in patients with the bypass using 16 mm knitted Dacron grafts (p<0.05). Postoperative complications included thalamic bleeding in 1 patient, pneumonia in 5 patients, acute renal failure in 1 patient, and paraplegia in 2 patients. Early surgical mortality within 30 postoperative days was 2.9% (n=1) and in-hospital mortality was 8.8% (n=3). The cause of early postoperative death was graft infection subsequent to postoperative pneumonia. The surgical results from temporary bypass grafts are comparable to results obtained with cardiopulmonary bypass reported in the recent Japanese literature.journal articl

第01号

一般雑誌記事 / Articlearticl

Improved measurement of CP-violation parameters sin⁡2ϕ1 and |λ|, B meson lifetimes, and B0-B̅0 mixing parameter Δmd

journal articl

Performance Evaluation of a Dynamic Resolution Control Scheme for Video Traffic in Media-Synchronized Multimedia Communications

This paper studies a congestion control scheme in integrated variable bit-rate video, audio and data (e. g. , image or text) communications, where each video stream is synchronized with the corresponding audio stream. When the audio and video streams are output, media synchronization control is performed. To avoid congestion, we employ a dynamic video resolution control scheme which dynamically changes the video encoding rate according to the network loads. By simulation, the paper evaluates the performance of the scheme in terms of throughput, loss rate, average delay, and mean square error of synchronization. Numerical results show the effectiveness of the scheme.application/pdfjournal articl

医療関連死における死因究明制度の現状と展望 ―いわゆる“医療事故調”に関する法律上の諸問題 民主党案(患者支援法案と原因究明制度案）と厚生労働省案（医療安全調査委員会設置法案（仮称）大綱案・自民党案）等の検討―

application/pdf田中利幸教授退職記念号departmental bulletin pape

DataSheet1_Path4Drug: Data Science Workflow for Identification of Tissue-Specific Biological Pathways Modulated by Toxic Drugs.ZIP

The early prediction of drug adverse effects is of great interest to pharmaceutical research, as toxicity is one of the leading reasons for drug attrition. Understanding the cell signaling and regulatory pathways affected by a drug candidate is crucial to the study of drug toxicity. In this study, we present a computational technique that employs the propagation of drug-protein interactions to connect compounds to biological pathways. Target profiles for drugs were built by retrieving drug target proteins from public repositories such as ChEMBL, DrugBank, IUPHAR, PharmGKB, and TTD. Subsequent enrichment test of the protein pool using Reactome revealed potential pathways affected by the drugs. Furthermore, an optional tissue filter utilizing the Human Protein Atlas was applied to identify tissue-specific pathways. The analysis pipeline was implemented in an open-source KNIME workflow called Path4Drug to allow automated data retrieval and reconstruction for any given drug present in ChEMBL. The pipeline was applied to withdrawn drugs and cardio- and hepatotoxic drugs with black box warnings to identify biochemical pathways they affect and to find pathways that can be potentially connected to the toxic events. To complement this approach, drugs used in cardiac therapy without any record of toxicity were also analyzed. The results provide already known associations as well as a large amount of additional potential connections. Consequently, our approach can link drugs to biological pathways by leveraging big data available in public resources. The developed tool is openly available and modifiable to support other systems biology analyses.</p

Additional file 2 of KNIME workflow for retrieving causal drug and protein interactions, building networks, and performing topological enrichment analysis demonstrated by a DILI case study

Additional file 2: CHEMBL mode of action annotation

Additional file 10 of KNIME workflow for retrieving causal drug and protein interactions, building networks, and performing topological enrichment analysis demonstrated by a DILI case study

Additional file 10: Skimmed data from DrugBank for the workflow

Additional file 11 of KNIME workflow for retrieving causal drug and protein interactions, building networks, and performing topological enrichment analysis demonstrated by a DILI case study

Additional file 11: Downloaded data from the SIGNOR database