Asymmetric oxidation of 1,3-dithianes to 1,3-dithiane 1-oxides

Oxidation of 2-(1-hydroxy-1-methylethyl)-1,3-dithiane with the Sharpless reagent has been examined under various reaction conditions. Oxidation of 2-(1-hydroxy-1-methylethyl)-1,3-dithiane with Ti(OPri)4-diethyl L-(+)-tartrate-tert-butyl hydroperoxide (1:2:1.5) in CH2Cl2 in the presence of 4 A molecular sieves gives (1S,2S)-2-(1-hydroxy-1-methylethyl)-1,3-dithiane 1-oxide with high trans selectivity and with moderate enantioselectivity. The enantioselectivity depends upon the substituent at the 2-position of the 1,3-dithiane. Oxidation of 2-(1-methoxy-1-methylethyl)- and 2-(1-acetoxy-1-methylethyl)-1,3-dithiane gives (1S,2S)-2-(1-methoxy-1-methylethyl)- and (1R,2S)-2-(1-acetoxy-1-methylethyl)-1,3-dithiane 1-oxides, respectively in >99% ee.application/pdfjournal articl

Surface reaction of CF_2 radicals for fluorocarbon film formation in SiO_2/Si selective etching process

The surface reaction of CF_2 radicals on Si and fluorocarbon films was investigated in electron cyclotron resonance (ECR) Ar and H_2 /Ar downstream plasmas employing CF_2 radical injection technique. The effects of Ar^+ ions, Ar^* metastable species and radiation from plasmas on the fluorocarbon film formation were evaluated in ECR Ar downstream plasma with CF_2 radical injection. As a result, CF_2 radicals with assistance of Ar+^ ion bombardment were found to play an important role in the fluorocarbon film formation. The adsorptive reactions of CF_2 radicals on the fluorocarbon film surface with and without Ar and H_2 /Ar plasma exposures were successfully investigated by in situ Fourier transform infrared reflection absorption spectroscopy and in situ x-ray photoelectron spectroscopy. It was found that the formation of fluorocarbon film in the plasma proceeded through the adsorptive reaction of CF_2 radicals at a high probability on the active sites formed by the bombardment of Ar^+ ions on the fluorocarbon film surface.journal articl

On the Compellation of “Haisyo" –A Study on “Haisyo" of Shinto Shrine in Wakasa-District–

In this paper, compellation of “Haisyo" of Shinto shrine is considered. As a result, this paper found the following. The “Haisyo" is hardly confirmed any place other than Wakasa-district. The “Haisyo" was confirmed at the middle of Edo period, but that is generally confirmed at after 1893 in Wakasa-district. Compellation of “Haisyo" is one of the characteristics of Shinto shrine in Wakasa-district.departmental bulletin pape

宇都宮大学の将来像

その他 / Othersothe

Improved measurement of CP-violation parameters sin⁡2ϕ1 and |λ|, B meson lifetimes, and B0-B̅0 mixing parameter Δmd

journal articl

Raindrop Detection and Removal from Long Range Trajectories

In rainy scenes, visibility can be degraded by raindrops which have adhered to the windscreen or camera lens. In order to resolve this degradation, we propose a method that automatically detects and removes adherent raindrops. The idea is to use long range trajectories to discover the motion and appearance features of raindrops locally along the trajectories. These motion and appearance features are obtained through our analysis of the trajectory behavior when encountering raindrops. These features are then transformed into a labeling problem, which the cost function can be optimized efficiently. Having detected raindrops, the removal is achieved by utilizing patches indicated, enabling the motion consistency to be preserved. Our trajectory based video completion method not only removes the raindrops but also complete the motion field, which benefits motion estimation algorithms to possibly work in rainy scenes. Experimental results on real videos show the effectiveness of the proposed method.conference pape

Systematic identification of trans eQTLs as putative drivers of known disease associations

Identifying the downstream effects of disease-associated SNPs is challenging. To help overcome this problem, we performed expression quantitative trait locus (eQTL) meta-analysis in non-transformed peripheral blood samples from 5,311 individuals with replication in 2,775 individuals. We identified and replicated trans eQTLs for 233 SNPs (reflecting 103 independent loci) that were previously associated with complex traits at genome-wide significance. Some of these SNPs affect multiple genes in trans that are known to be altered in individuals with disease: rs4917014, previously associated with systemic lupus erythematosus (SLE), altered gene expression of C1QB and five type I interferon response genes, both hallmarks of SLE. DeepSAGE RNA sequencing showed that rs4917014 strongly alters the 3′ UTR levels of IKZF1 in cis, and chromatin immunoprecipitation and sequencing analysis of the trans-regulated genes implicated IKZF1 as the causal gene. Variants associated with cholesterol metabolism and type 1 diabetes showed similar phenomena, indicating that large-scale eQTL mapping provides insight into the downstream effects of many trait-associated variants. © 2013 Nature America, Inc. All rights reserved.</p

Cell Specific eQTL Analysis without Sorting Cells

The functional consequences of trait associated SNPs are often investigated using expression quantitative trait locus (eQTL) mapping. While trait-associated variants may operate in a cell-type specific manner, eQTL datasets for such cell-types may not always be available. We performed a genome-environment interaction (GxE) meta-analysis on data from 5,683 samples to infer the cell type specificity of whole blood cis-eQTLs. We demonstrate that this method is able to predict neutrophil and lymphocyte specific cis-eQTLs and replicate these predictions in independent cell-type specific datasets. Finally, we show that SNPs associated with Crohn’s disease preferentially affect gene expression within neutrophils, including the archetypal NOD2 locus. © 2015, Public Library of Science. All rights reserved.</p

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

Type 2 diabetes (T2D) is a very common disease in humans. Here we conduct a meta-analysis of genome-wide association studies (GWAS) with ~16 million genetic variants in 62,892 T2D cases and 596,424 controls of European ancestry. We identify 139 common and 4 rare variants associated with T2D, 42 of which (39 common and 3 rare variants) are independent of the known variants. Integration of the gene expression data from blood (n = 14,115 and 2765) with the GWAS results identifies 33 putative functional genes for T2D, 3 of which were targeted by approved drugs. A further integration of DNA methylation (n = 1980) and epigenomic annotation data highlight 3 genes (CAMK1D, TP53INP1, and ATP5G1) with plausible regulatory mechanisms, whereby a genetic variant exerts an effect on T2D through epigenetic regulation of gene expression. Our study uncovers additional loci, proposes putative genetic regulatory mechanisms for T2D, and provides evidence of purifying selection for T2D-associated variants. © 2018, The Author(s).</p

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

Understanding the difference in genetic regulation of gene expression between brain and blood is important for discovering genes for brain-related traits and disorders. Here, we estimate the correlation of genetic effects at the top-associated cis-expression or -DNA methylation (DNAm) quantitative trait loci (cis-eQTLs or cis-mQTLs) between brain and blood (r b ). Using publicly available data, we find that genetic effects at the top cis-eQTLs or mQTLs are highly correlated between independent brain and blood samples (r b = 0.70 for cis-eQTLs and r ^ b = 0.78 for cis-mQTLs). Using meta-analyzed brain cis-eQTL/mQTL data (n = 526 to 1194), we identify 61 genes and 167 DNAm sites associated with four brain-related phenotypes, most of which are a subset of the discoveries (97 genes and 295 DNAm sites) using data from blood with larger sample sizes (n = 1980 to 14,115). Our results demonstrate the gain of power in gene discovery for brain-related phenotypes using blood cis-eQTL/mQTL data with large sample sizes. © 2018 The Author(s).</p