Título: In primum librum Magistri Sententiarum, Disputationes grauissimae abstrusos quaestionum Theologicarum sensus enodantes

Pie de imp. tomado del colofón.Sign.: A-Z8, 2A-2D8, 2E10, A, H2, A3-A5, [ ]3.Texto a dos col. con apostillas marginales

Dilucidationum et declamationum tropologicarum in Esaiam prophetam libri quindecim : tomis tribus diuisi...: tomus primus

Sign.: A-Z\p8\s, 2A-2H\p8\s, 2I\p6\s.Error de fol., de h. 252 pasa a la 255.Texto a dos col.Port. con esc. xil real

Dilucidationum et declamationum tropologicarum in Esaiam prophetam libri quindecim : tomis tribus diuisi...: tomus tertius

Colofón.Sign.: A-X\p8\s, A-C\p8\s.Texto a dos col., rodeado del comentario.Port. con esc. xil. real

Dilucidationum et declamationum tropologicarum in Esaiam prophetam libri quindecim : tomis tribus diuisi...: tomus secundus

Sign.: A-P\p8\s, Q\p7\s.Texto a dos col.Port. con esc. xil. real

A new type of temperature driven reorientation transition in magnetic thin films

We present a new type of temperature driven spin reorientation transition (SRT) in thin films. It can occur when the lattice and the shape anisotropy favor different easy directions of the magnetization. Due to different temperature dependencies of the two contributions the effective anisotropy may change its sign and thus the direction of the magnetization as a function of temperature may change. Contrary to the well-known reorientation transition caused by competing surface and bulk anisotropy contributions the reorientation that we discuss is also found in film systems with a uniform lattice anisotropy. The results of our theoretical model study may have experimental relevance for film systems with positive lattice anisotropy, as e.g. thin iron films grown on copper.Comment: 7 pages, 4 figures, accepted for publication in EPJ

Perillaldehyde 1,2-epoxide loaded SLN-tailored mAb: production, physicochemical characterization and in vitro cytotoxicity profile in MCF-7 cell lines

We have developed a new cationic solid lipid nanoparticle (SLN) formulation, composed of Compritol ATO 888, poloxamer 188 and cetyltrimethylammonium bromide (CTAB), to load perillaldehyde 1,2-epoxide, and surface-tailored with a monoclonal antibody for site-specific targeting of human epithelial growth receptor 2 (HER2). Perillaldehyde 1,2-epoxide-loaded cationic SLN (cPa-SLN), with a mean particle size (z-Ave) of 275.31 ± 4.78 nm and polydispersity index (PI) of 0.303 ± 0.081, were produced by high shear homogenization. An encapsulation efficiency of cPa-SLN above 80% was achieved. The release of perillaldehyde 1,2-epoxide from cationic SLN followed the Korsemeyer–Peppas kinetic model, which is typically seen in nanoparticle formulations. The lipid peroxidation of cPa-SLN was assessed by the capacity to produce thiobarbituric acid-reactive substances, while the antioxidant activity was determined by the capacity to scavenge the stable radical DPPH. The surface functionalization of cPa-SLN with the antibody was done via streptavidin-biotin interaction, monitoring z-Ave, PI and ZP of the obtained assembly (cPa-SLN-SAb), as well as its stability in phosphate buffer. The effect of plain cationic SLN (c-SLN, monoterpene free), cPa-SLN and cPa-SLN-SAb onto the MCF-7 cell lines was evaluated in a concentration range from 0.01 to 0.1 mg/mL, confirming that streptavidin adsorption onto cPa-SLN-SAb improved the cell viability in comparison to the cationic cPa-SLN.The authors wish to acknowledge the financial support from CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico, from CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior), and from FAPITEC/SE (Fundação de Apoio à Pesquisa e Inovação Tecnológica do Estado de Sergipe). E.B. Souto acknowledges the sponsorship of the projects M-ERA-NET-0004/2015-PAIRED and UIDB/04469/2020, receiving support from the Portuguese Science and Technology Foundation, Ministry of Science and Education (FCT/MEC) through national funds, and co-financed by FEDER, under the Partnership Agreement PT2020.info:eu-repo/semantics/publishedVersio

Título: Viaggio da Venetia al santo Sepulchro et al monte Synai

Título tomado de colofónObra atribuida a Noè Bianco y a Niccolò da PoggibonsiTítulo en Edit16: Viaggio da Venetia al santo Sepulchro et al monte SynaiDatos de pie de imp. tomados del colofónMarca tip. en colofónNiccolo Zoppino y Vincenzo di Paolo realizaron su actividad como impresores en VeneciaSign.: A\b3-8\s, B-Q\p8\sEl v. de h. Q\b8\s en blancoLa h. A\b3\s a dos tintasLas il. son representaciones de ciudades, puertos, edificios y animales exóticos grab. xil

In vitro characterization, modelling, and antioxidant properties of Polyphenon-60 from green tea in Eudragit S100-2 chitosan microspheres

Eudragit S100-coated chitosan microspheres (S100Ch) are proposed as a new oral delivery system for green tea polyphenon-60 (PP60). PP60 is a mixture of polyphenolic compounds, known for its active role in decreasing oxidative stress and metabolic risk factors involved in diabetes and in other chronic diseases. Chitosan-PP60 microspheres prepared by an emulsion cross-linking method were coated with Eudragit S100 to ensure the release of PP60 in the terminal ileum. Different corecoat ratios of Eudragit and chitosan were tested. Optimized chitosan microspheres were obtained with a chitosan:PP60 ratio of 8:1 (Ch-PP608:1), rotation speed of 1500 rpm, and surfactant concentration of 1.0% (m/v) achieving a mean size of 7.16 µm. Their coating with the enteric polymer (S100Ch-PP60) increased the mean size significantly (51.4 µm). The in vitro modified-release of PP60 from S100Ch-PP60 was confirmed in simulated gastrointestinal conditions. Mathematical fitting models were used to characterize the release mechanism showing that both Ch-PP608:1 and S100Ch-PP60 fitted the KorsmeyersPeppas model. The antioxidant activity of PP60 was kept in glutaraldehyde-crosslinked chitosan microspheres before and after their coating, showing an IC50 of 212.3 µg/mL and 154.4 µg/mL, respectively. The potential of chitosan microspheres for the delivery of catechins was illustrated, with limited risk of cytotoxicity as shown in Caco-2 cell lines using the 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The beneficial effects of green tea and its derivatives in the management of metabolic disorders can be exploited using mucoadhesive chitosan microspheres coated with enteric polymers for colonic delivery.This research was supported by the Coordenação Aperfeiçoamento de Pessoal de Nivel Superior (CAPES), Fundação de Amparo à Pesquisa do Estado de Sergipe (FAPITEC) CHAMADA MS/CNPq/FAPITEC/SE/SES N◦ 06/2018 – PROGRAMA DE PESQUISA PARA O SUS: GESTÃO COMPARTILHADA EM SAÚDE – PPSUS SERGIPE 2017/2018, and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). This work was also financed through the projects M-ERA-NET/0004/2015-PAIRED, UIDB/04469/2020 (strategic fund) and PEst-OE/UID/AGR/04033/2019 (CITAB strategic fund), receiving support from the Portuguese Science and Technology Foundation, Ministry of Science and Education (FCT/MEC) through national funds, and co-financed by FEDER, under the Partnership Agreement PT2020. The authors acknowledge the support of the research project: Nutraceutica come supporto nutrizionale nel paziente oncologico, CUP: B83D18000140007.info:eu-repo/semantics/publishedVersio