67 research outputs found
The convergence of the concepts of academic and inclusive excellence at research universities
Introduction. In the 21st century, there is an active involvement of universities in inclusive processes; however, against the backdrop of increasing diversity, new types of inequality arise in higher education. The processes of transformation of organisational cultures in universities and their research agenda under the influence of inclusion need to be studied.The aim of the present research was to analyse the convergence of concepts of academic and inclusive excellence in foreign universities of the world level, the impact of convergence on their missions, the values expressed in official strategies, the research agenda and the infrastructure of scientific collaborations.Methodology and research methods. The authors conducted a content analysis of three strategies of world-class University associations (the Association of American Colleges and Universities, the Association of Universities in Canada, the League of European Research Universities), nine strategies for the development of universities in the USA and Canada, the European Union, and Australia. A scientometric analysis of Web of Science metadata was performed using the VOSViewer software.Results and scientific novelty. The current research confirms the convergence of values of academic excellence and inclusion in research universities. It is revealed that the concept of inclusive excellence of the university is an enriched version of its academic excellence and denotes a set of university strategies and practices aimed at achieving the best results in training, research and services through maintaining diversity and inclusive processes. The world's leading universities are actively involved in the process of creating an inclusive friendly environment and services, which are accessible to all members of the educational process, regardless of their social status and development characteristics. When universities reach academic heights, they recognise inclusion as the next level of their development. In turn, inclusion becomes a factor in the movement of the university towards academic excellence. The key characteristics and contradictions of the convergence of the concepts of inclusive and academic excellence of universities are identified. The local models of inclusive excellence of universities and the contexts, which influence these models, are described. The gaps between educational policies and research agendas of leading universities are revealed. The clusters of international studies on inclusive processes in higher education are highlighted.Practical significance. Russian universities, which implement the federal programme for improvement of international competitiveness based on the values of academic excellence, are developing in accordance with global trends. Therefore, the model of inclusive excellence of the university can be used in practical terms to implement inclusive strategies and overcome social inequality both at the university and outside of it within the framework of a new educational initiative of Russia on academic leadership.ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅. Π XXI Π²Π΅ΠΊΠ΅, Ρ ΠΎΠ΄Π½ΠΎΠΉ ΡΡΠΎΡΠΎΠ½Ρ, Π½Π°Π±Π»ΡΠ΄Π°Π΅ΡΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΠ΅ Π²ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΠΎΠ² Π² ΠΈΠ½ΠΊΠ»ΡΠ·ΠΈΠ²Π½ΡΠ΅ ΠΏΡΠΎΡΠ΅ΡΡΡ, Ρ Π΄ΡΡΠ³ΠΎΠΉ - Π² ΡΠΈΡΡΠ΅ΠΌΠ΅ Π²ΡΡΡΠ΅Π³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Π½Π° ΡΠΎΠ½Π΅ Π½Π°ΡΠ°ΡΡΠ°ΡΡΠ΅Π³ΠΎ ΡΠ°Π·Π½ΠΎΠΎΠ±ΡΠ°Π·ΠΈΡ Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡΡ Π½ΠΎΠ²ΡΠ΅ Π²ΠΈΠ΄Ρ Π½Π΅ΡΠ°Π²Π΅Π½ΡΡΠ²Π°. ΠΡΠΎΡΠ΅ΡΡΡ ΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΠΈ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΊΡΠ»ΡΡΡΡ ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΠΎΠ² ΠΈ ΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΎΠΉ ΠΏΠΎΠ²Π΅ΡΡΠΊΠΈ ΠΏΠΎΠ΄ Π²Π»ΠΈΡΠ½ΠΈΠ΅ΠΌ ΠΈΠ½ΠΊΠ»ΡΠ·ΠΈΠΈ Π½ΡΠΆΠ΄Π°ΡΡΡΡ Π² ΠΈΠ·ΡΡΠ΅Π½ΠΈΠΈ.Π¦Π΅Π»ΡΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π½ΠΎΠ³ΠΎ Π² ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΈ ΠΈΠ·ΡΡΠΊΠ°Π½ΠΈΡ ΡΠ²Π»ΡΠ΅ΡΡΡ Π°Π½Π°Π»ΠΈΠ· ΠΊΠΎΠ½Π²Π΅ΡΠ³Π΅Π½ΡΠΈΠΈ ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΠΉ Π°ΠΊΠ°Π΄Π΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈ ΠΈΠ½ΠΊΠ»ΡΠ·ΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²Π° Π² Π·Π°ΡΡΠ±Π΅ΠΆΠ½ΡΡ
ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΠ°Ρ
ΠΌΠΈΡΠΎΠ²ΠΎΠ³ΠΎ ΡΡΠΎΠ²Π½Ρ, ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ Π²Π»ΠΈΡΠ½ΠΈΡ Π΄Π°Π½Π½ΠΎΠΉ ΠΊΠΎΠ½Π²Π΅ΡΠ³Π΅Π½ΡΠΈΠΈ Π½Π° ΠΈΡ
ΠΌΠΈΡΡΠΈΠΈ, ΡΠ΅Π½Π½ΠΎΡΡΠΈ, Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΡΠ΅ Π² ΠΎΡΠΈΡΠΈΠ°Π»ΡΠ½ΡΡ
ΡΡΡΠ°ΡΠ΅Π³ΠΈΡΡ
, Π½Π° ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΡΡ ΠΏΠΎΠ²Π΅ΡΡΠΊΡ ΠΈ ΠΈΠ½ΡΡΠ°ΡΡΡΡΠΊΡΡΡΡ Π½Π°ΡΡΠ½ΡΡ
ΠΊΠΎΠ»Π»Π°Π±ΠΎΡΠ°ΡΠΈΠΉ.ΠΠ΅ΡΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΡ, ΠΌΠ΅ΡΠΎΠ΄Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ ΠΊΠΎΠ½ΡΠ΅Π½Ρ-Π°Π½Π°Π»ΠΈΠ· ΡΡΠ΅Ρ
ΡΡΡΠ°ΡΠ΅Π³ΠΈΠΉ Π°ΡΡΠΎΡΠΈΠ°ΡΠΈΠΉ ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΠΎΠ² ΠΌΠΈΡΠΎΠ²ΠΎΠ³ΠΎ ΡΡΠΎΠ²Π½Ρ (ΠΡΡΠΎΡΠΈΠ°ΡΠΈΡ Π°ΠΌΠ΅ΡΠΈΠΊΠ°Π½ΡΠΊΠΈΡ
ΠΊΠΎΠ»Π»Π΅Π΄ΠΆΠ΅ΠΉ ΠΈ ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΠΎΠ², ΠΡΡΠΎΡΠΈΠ°ΡΠΈΡ ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΠΎΠ² ΠΠ°Π½Π°Π΄Ρ, ΠΠΈΠ³Π° Π΅Π²ΡΠΎΠΏΠ΅ΠΉΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΈΡ
ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΠΎΠ²), Π΄Π΅Π²ΡΡΠΈ ΡΡΡΠ°ΡΠ΅Π³ΠΈΠΉ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΠΎΠ² Π‘Π¨Π ΠΈ ΠΠ°Π½Π°Π΄Ρ, ΠΠ²ΡΠΎΡΠΎΡΠ·Π°, ΠΠ²ΡΡΡΠ°Π»ΠΈΠΈ. ΠΡΠΈ ΠΏΠΎΠΌΠΎΡΠΈ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠ½ΠΎΠ³ΠΎ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΡ VOSViewer ΠΎΡΡΡΠ΅ΡΡΠ²Π»Π΅Π½ Π½Π°ΡΠΊΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΌΠ΅ΡΠ°Π΄Π°Π½Π½ΡΡ
Web of Science.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈ Π½Π°ΡΡΠ½Π°Ρ Π½ΠΎΠ²ΠΈΠ·Π½Π°. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠ΄ΠΈΠ»ΠΎ ΠΊΠΎΠ½Π²Π΅ΡΠ³Π΅Π½ΡΠΈΡ ΡΠ΅Π½Π½ΠΎΡΡΠ΅ΠΉ Π°ΠΊΠ°Π΄Π΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠ΅Π²ΠΎΡΡ
ΠΎΠ΄ΡΡΠ²Π° ΠΈ ΠΈΠ½ΠΊΠ»ΡΠ·ΠΈΠΈ Π² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΈΡ
ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΠ°Ρ
. ΠΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΎ, ΡΡΠΎ ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΡ ΠΈΠ½ΠΊΠ»ΡΠ·ΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²Π° ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΠ° ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅Ρ ΡΠΎΠ±ΠΎΠΉ ΠΎΠ±ΠΎΠ³Π°ΡΠ΅Π½Π½ΡΡ Π²Π΅ΡΡΠΈΡ Π΅Π³ΠΎ Π°ΠΊΠ°Π΄Π΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²Π° ΠΈ ΠΎΠ±ΠΎΠ·Π½Π°ΡΠ°Π΅Ρ ΡΠΎΠ²ΠΎΠΊΡΠΏΠ½ΠΎΡΡΡ ΡΡΡΠ°ΡΠ΅Π³ΠΈΠΉ ΠΈ ΠΏΡΠ°ΠΊΡΠΈΠΊ Π²ΡΠ·Π°, Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΡΡ
Π½Π° Π΄ΠΎΡΡΠΈΠΆΠ΅Π½ΠΈΠ΅ Π½Π°ΠΈΠ»ΡΡΡΠΈΡ
ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² Π² ΠΎΠ±ΡΡΠ΅Π½ΠΈΠΈ, ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡΡ
ΠΈ ΡΠ΅ΡΠ²ΠΈΡΠ΅ ΡΠ΅ΡΠ΅Π· ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ ΡΠ°Π·Π½ΠΎΠΎΠ±ΡΠ°Π·ΠΈΡ ΠΈ ΠΈΠ½ΠΊΠ»ΡΠ·ΠΈΠ²Π½ΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ². ΠΠ΅Π΄ΡΡΠΈΠ΅ ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΡ ΠΌΠΈΡΠ° Π°ΠΊΡΠΈΠ²Π½ΠΎ Π²ΠΊΠ»ΡΡΠΈΠ»ΠΈΡΡ Π² ΠΏΡΠΎΡΠ΅ΡΡ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈΠ½ΠΊΠ»ΡΠ·ΠΈΠ²Π½ΠΎΠΉ Π΄ΡΡΠΆΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΡΡΠ΅Π΄Ρ ΠΈ ΡΡΠ»ΡΠ³, Π΄ΠΎΡΡΡΠΏΠ½ΡΡ
Π΄Π»Ρ Π²ΡΠ΅Ρ
ΡΡΠ±ΡΠ΅ΠΊΡΠΎΠ² ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ° Π²Π½Π΅ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΠΈΡ
ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°ΡΡΡΠ° ΠΈ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΡΠ°Π·Π²ΠΈΡΠΈΡ. ΠΠΎΠ³Π΄Π° Π²ΡΠ·Ρ Π΄ΠΎΡΡΠΈΠ³Π°ΡΡ Π°ΠΊΠ°Π΄Π΅ΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
Π²Π΅ΡΡΠΈΠ½, ΠΎΠ½ΠΈ ΠΎΡΠΎΠ·Π½Π°ΡΡ ΠΈΠ½ΠΊΠ»ΡΠ·ΠΈΡ ΠΊΠ°ΠΊ ΡΠ»Π΅Π΄ΡΡΡΠΈΠΉ ΡΡΠΎΠ²Π΅Π½Ρ ΡΠ²ΠΎΠ΅Π³ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ. Π ΡΠ²ΠΎΡ ΠΎΡΠ΅ΡΠ΅Π΄Ρ, ΠΈΠ½ΠΊΠ»ΡΠ·ΠΈΡ ΡΡΠ°Π½ΠΎΠ²ΠΈΡΡΡ ΡΠ°ΠΊΡΠΎΡΠΎΠΌ Π΄Π²ΠΈΠΆΠ΅Π½ΠΈΡ ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΠ° ΠΊ Π°ΠΊΠ°Π΄Π΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΌΡ ΡΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²Ρ. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ ΠΊΠ»ΡΡΠ΅Π²ΡΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ ΠΈ ΠΏΡΠΎΡΠΈΠ²ΠΎΡΠ΅ΡΠΈΡ ΠΊΠΎΠ½Π²Π΅ΡΠ³Π΅Π½ΡΠΈΠΈ ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΠΉ ΠΈΠ½ΠΊΠ»ΡΠ·ΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΈ Π°ΠΊΠ°Π΄Π΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²Π° ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΠΎΠ². ΠΠΏΠΈΡΠ°Π½Ρ Π»ΠΎΠΊΠ°Π»ΡΠ½ΡΠ΅ ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΈΠ½ΠΊΠ»ΡΠ·ΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²Π° ΡΡΠ΅Π±Π½ΡΡ
ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΉ Π²ΡΡΡΠ΅ΠΉ ΡΠΊΠΎΠ»Ρ ΠΈ ΠΊΠΎΠ½ΡΠ΅ΠΊΡΡΡ, Π²Π»ΠΈΡΡΡΠΈΠ΅ Π½Π° ΡΡΠΈ ΠΌΠΎΠ΄Π΅Π»ΠΈ. ΠΠ±ΠΎΠ·Π½Π°ΡΠ΅Π½Ρ ΡΠ°Π·ΡΡΠ²Ρ ΠΌΠ΅ΠΆΠ΄Ρ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΡΠΌΠΈ ΠΏΠΎΠ»ΠΈΡΠΈΠΊΠ°ΠΌΠΈ ΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΈΠΌΠΈ ΠΏΠΎΠ²Π΅ΡΡΠΊΠ°ΠΌΠΈ Π²Π΅Π΄ΡΡΠΈΡ
ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΠΎΠ². ΠΡΡΠ²Π»Π΅Π½Ρ ΠΊΠ»Π°ΡΡΠ΅ΡΡ ΠΌΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ, ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π½ΡΡ
ΠΈΠ½ΠΊΠ»ΡΠ·ΠΈΠ²Π½ΡΠΌ ΠΏΡΠΎΡΠ΅ΡΡΠ°ΠΌ Π² Π²ΡΡΡΠ΅ΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠΈ. ΠΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΡ. Π ΠΎΡΡΠΈΠΉΡΠΊΠΈΠ΅ Π²ΡΠ·Ρ, ΡΠ΅Π°Π»ΠΈΠ·ΡΡΡΠΈΠ΅ ΡΠ΅Π΄Π΅ΡΠ°Π»ΡΠ½ΡΡ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ ΠΌΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½ΠΎΠΉ ΠΊΠΎΠ½ΠΊΡΡΠ΅Π½ΡΠΎΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΠΈ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠ΅Π½Π½ΠΎΡΡΠ΅ΠΉ Π°ΠΊΠ°Π΄Π΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²Π°, ΡΠ°Π·Π²ΠΈΠ²Π°ΡΡΡΡ Π² ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΠΈΠΈ Ρ Π³Π»ΠΎΠ±Π°Π»ΡΠ½ΡΠΌΠΈ ΡΡΠ΅Π½Π΄Π°ΠΌΠΈ, ΠΏΠΎΡΡΠΎΠΌΡ ΠΌΠΎΠ΄Π΅Π»Ρ ΠΈΠ½ΠΊΠ»ΡΠ·ΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²Π° ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΠ° ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Π° Π² ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΏΠ»Π°Π½Π΅ Π΄Π»Ρ Π²Π½Π΅Π΄ΡΠ΅Π½ΠΈΡ ΠΈΠ½ΠΊΠ»ΡΠ·ΠΈΠ²Π½ΡΡ
ΡΡΡΠ°ΡΠ΅Π³ΠΈΠΉ ΠΈ ΠΏΡΠ΅ΠΎΠ΄ΠΎΠ»Π΅Π½ΠΈΡ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π½Π΅ΡΠ°Π²Π΅Π½ΡΡΠ²Π° ΠΊΠ°ΠΊ Π²Π½ΡΡΡΠΈ ΡΡΠ΅Π±Π½ΠΎΠ³ΠΎ Π·Π°Π²Π΅Π΄Π΅Π½ΠΈΡ, ΡΠ°ΠΊ ΠΈ Π·Π° Π΅Π³ΠΎ ΠΏΡΠ΅Π΄Π΅Π»Π°ΠΌΠΈ Π² ΡΠ°ΠΌΠΊΠ°Ρ
Π½ΠΎΠ²ΠΎΠΉ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΈΠ½ΠΈΡΠΈΠ°ΡΠΈΠ²Ρ Π ΠΎΡΡΠΈΠΈ ΠΏΠΎ Π°ΠΊΠ°Π΄Π΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΌΡ Π»ΠΈΠ΄Π΅ΡΡΡΠ²Ρ.The research was carried out with the financial support of the Russian Foundation for Basic Research (RFBR) in the framework of the research project No. 19-013-00373 Π βAcademic Mobility of Students with Disabilities in the Conditions of Higher Education Transformationβ.ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΎ ΠΏΡΠΈ ΡΠΈΠ½Π°Π½ΡΠΎΠ²ΠΎΠΉ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΊΠ΅ Π Π€Π€Π Π² ΡΠ°ΠΌΠΊΠ°Ρ
Π½Π°ΡΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΠ΅ΠΊΡΠ° 19-013-00373 Π Β«ΠΠΊΠ°Π΄Π΅ΠΌΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΠΎΡΡΡ ΡΡΡΠ΄Π΅Π½ΡΠΎΠ² Ρ ΠΎΠ³ΡΠ°Π½ΠΈΡΠ΅Π½Π½ΡΠΌΠΈ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡΠΌΠΈ Π·Π΄ΠΎΡΠΎΠ²ΡΡ ΠΈ ΠΈΠ½Π²Π°Π»ΠΈΠ΄Π½ΠΎΡΡΡΡ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΠΈ Π²ΡΡΡΠ΅Π³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡΒ»
Effect of ABCB1 Gene Carriage and Drug-Drug Interactions on Apixaban and Rivaroxaban Pharmacokinetics and Clinical Outcomes in Patients with Atrial Fibrillation and Deep Vein Thrombosis
Aim. To investigate the effect of ABCB1 gene carriage and interdrug interactions on apixaban pharmacokinetics and clinical outcomes in patients with atrial fibrillation and deep vein thrombosis.Material and methods. Patients hospitalized at Yudin State Clinical Hospital participated in the study. A total of 92 patients (50 patients received apixaban and 42 β rivaroxaban) with non-valvular atrial fibrillation and deep vein thrombosis were included. Genotyping was performed by real-time polymerase chain reaction. Direct oral anticoagulants concentrations were measured using an electrospray ionization mass spectrometer in positive ionization mode.Results. In our study we found that in patients carrying the CT+TT ABCB1 (rs4148738) C>T genotype encoding the carrier protein (P-gp), the plasma concentration of rivaroxaban was statistically significantly higher p= 0.026. In addition, we found that patients taking apixaban together with a CYP3A4/P-gp inhibitor were 3.5 times more likely to have hemorrhagic complications than those without inhibitors p = 0.004.Conclusion. Our study revealed that the plasma concentration of rivaroxaban was higher in patients carrying the ABCB1 (rs4148738) C>T polymorphism T allele. And patients taking apixaban together with CYP3A4/P-gp inhibitor had higher risk of hemorrhagic complications in comparison with patients not taking such drugs. Further studies are needed on the influence of pharmacogenetics and pharmacokinetics on the safety and efficacy profile of apixaban and rivaroxaban, taking into account the trend of systemic approach to optimization of anticoagulant therapy of direct oral anticoagulants based on pharmacokinetic, pharmacogenetic biomarkers
Sex peptide receptor-regulated polyandry mediates the balance of pre- and post-copulatory sexual selection in Drosophila
Polyandry prolongs sexual selection on males by forcing ejaculates to compete for fertilisation. Recent theory predicts that increasing polyandry may weaken pre-copulatory sexual selection on males and increase the relative importance of post-copulatory sexual selection, but experimental tests of this prediction are lacking. Here, we manipulate the polyandry levels in groups of Drosophila melanogaster by deletion of the female sex peptide receptor. We show that groups in which the sex-peptide-receptor is absent in females (SPR-) have higher polyandry, and β as a result β weaker pre-copulatory sexual selection on male mating success, compared to controls. Post-copulatory selection on male paternity share is relatively more important in SPR- groups, where males gain additional paternity by mating repeatedly with the same females. These results provide experimental evidence that elevated polyandry weakens pre-copulatory sexual selection on males, shifts selection to post-copulatory events, and that the sex peptide pathway can play a key role in modulating this process in Drosophil
Response of barley seedlings to water deficit and enhanced UV-B irradiation acting alone and in combination
Recombination of point defects and their interaction with the surface in the course of the clusterization of these defects in Si
The initial stages of atomic force microscope based local anodic oxidation of silicon
In this paper, the initial stages of local anodic oxidation (LAO) process initiated by AFM probe are studied on the wide (βΌ100ΞΌm) terraces of the atomic-smooth Si (111) surface when creating dense array of local oxidation points. The dependence of LAO points height on the value of voltage initiating the oxidation is found to have a pronounced step-like feature with a characteristic period of 0.7 Β± 0.1 nm. The presented analysis shows for the first time the realization of the step-layer mechanism of anodic oxide growth on the Si (111) surface
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