92 research outputs found
Development of Field-based Creativity Competency Scales for College Graduates
๋ณธ ์ฐ๊ตฌ๋ ๊ธฐ์
ํ์ฅ์์ ์๊ตฌํ๋ ๋์กธ ์ ์
์ฌ์์ ์ฐฝ์์ฑ ์์ธ์ ๋์ถํ๊ณ ์ด๋ฅผ ํ์ฉํ ์ธก์ ๋๊ตฌ๋ฅผ ๊ฐ๋ฐํ๊ธฐ ์ํ ๋ชฉ์ ์ผ๋ก ์ค์๋์๋ค. ์ต๊ทผ ๊ธฐ์
๋ค์ ์ ์
์ฌ์์ ์ฐฝ์์ฑ์ ์ ๋ฐ์ ์ฃผ์ ์งํ๋ก ๊ฐ์กฐํ๊ณ ์์ผ๋ ๊ตฌ์ฒด์ ์ผ๋ก ์ฐฝ์์ฑ์ด ์ด๋ค ์์ธ์ ์๋ฏธํ๋ฉฐ ํ๊ฐ์ ์งํ๊ฐ ๋ฌด์์ธ์ง๋ฅผ ์ค๋ช
ํ๋ ๊ฒ์ ๋ชจํธํ๋ค. ๋ฐ๋ผ์ ๋ณธ ์ฐ๊ตฌ์์๋ ์ ํ์ฐ๊ตฌ์์ ๋ค๋ฃจ์ด์ง ์ง๋ฌด ์ํฉ์์์ ์ฐฝ์์ฑ์ ๊ฐ๋
๊ณผ ์์ธ๋ค์ ๊ฒํ ํ์ฌ ํ์ฅ์์ ์๊ตฌ๋๋ ์ฐฝ์์ฑ ์์๋ฅผ ๋์ถํ์์ผ๋ฉฐ ์ด๋ฅผ ํ๊ณ ๋ฐ ํ์ฅ ์ ๋ฌธ๊ฐ์ ํ๋น๋ ํ์ ๊ณผ์ ์ ๊ฑฐ์ณ ์ ์
์ฌ์์ ์ฐฝ์์ฑ ์ธก์ ๋๊ตฌ์ ์ต์ข
์์ธ๊ณผ ์งํ๋ฅผ ์ ์ ํ์๋ค. ๋ณธ ๊ฐ๋ฐ ๋๊ตฌ์ ๋ชจํ์ ๊ฒ์ฆํ๊ธฐ ์ํด ์
์ฌ 1๋
๋ฏธ๋ง์ ๋์กธ ์ ์
์ฌ์ 290๋ช
์ ๋์์ผ๋ก ํด๋น ๋๋ฃ ๋ฐ ์์ฌ 3์ธ์ ์ฌ๋ก๋ฅผ ๋ถ์ํ์์ผ๋ฉฐ, ์ต์ข
์ ์ผ๋ก ์ฐฝ์ ์ญ๋์ 2์์ธ(์ฐฝ์์ ์ฌ๋ฆฌ์์, ์ฐฝ์์ ์ฌ๊ณ ์ ์ฐ๋ฌผ)๊ณผ ์ด 13๊ฐ์ ์ธก์ ๋ฌธํญ์ด ๋์ถ๋์๋ค. ๋ณธ ์ฐ๊ตฌ์์ ๊ฐ๋ฐ๋ ๋์กธ ์ ์
์ฌ์์ ์ฐฝ์์ฑ ์ธก์ ๋๊ตฌ๋ ์กฐ์ง์ ์ค๋ฌด ํ์ฅ์์ ํฉ์๋ ์์๋ก ๊ตฌ์ฑ๋์์ผ๋ฉฐ ์ด๋ฅผ ์ค์ ๋์กธ ์ทจ์
์๋ฅผ ํตํด ๊ฒ์ฆํ์๋ค๋ ๋ฐ์ ์์๊ฐ ์๋ค. ๋ง์ง๋ง์ผ๋ก ๋ณธ ์ฐ๊ตฌ์ ๊ฒฐ๊ณผ๋ฅผ ํ ๋๋ก ๋
ผ์์ ํ๊ณ์ ์ ์ ์ํ์๋ค.This study aims to derive the factors that compose creativity which is required of college graduates by companies, and to develop a model to measure such creativity. The derived components were reviewed and validated by experts from both academia and field in order to select the factors and indicators to be used for developing a measurement model. Survey was conducted on 290 college graduates who had less than 1 year experience in companies. As a result, 2 factors (creative psychological resource, creative thinking and performance) were derived and 13 questions were developed for the model aimed at measuring creativity. The measurement model developed in this study is meaningful as it is composed of factors which were agreed upon by the field and validated by actual experiences of new recruits, and is therefore highly likely to be used in the field
A Study on Disseminated Intravascular Coagulation
Infusing 150 units of thrombin per animal into the ear vein of rabbits for one hour, coagulatiort
studies-platelet counts, fibrinogen concentration,
prothrombin time and partial thromboplastin time
were performed on the arterial blood from aorta
and the venous blood from inferior vena cava, renal
vein and portal vein at one hour and two hours
respecti vely following infusion.
The same observation was also performed on the
rabbits injected prior to thrombin infusion with a
controlled doses of heparin, persantin, epsilon aminocaproic
acid (EACA), histamine and norepinephrine
respectively.
The results are summerized as follows:
1. Thrombin infused rabbits exhibited not only
prolongation of prothrom1:Jin time and partial thromboplastin
time, but marked decrease in fibrinogen
concentration and platelets counts particulary in
the venous blood from renal vein and the arterial
blood from aorta.
2. Injection of heprain, EACA and persantin
prior to thrombin infusion inhibited the above
effects of thrombin on coagulation factors.
3. Injection of histamine and norepinephrine inje
ction prior to thrombin infusion aggravated the
effect of thrombin on platelet counts in the thrombin
infused rabbits.
4. Heparin exerted marked influence on the venous
blood from renal vein, persantin on the venous
blood from portal vein and histamine on the venous
blood from inferior vena cava
Clinical effects of mindfulness meditation and cognitive behavioral therapy standardized for insomnia A protocol for a systematic review and meta-analysis
Introduction: This systematic review protocol describes the methods that will be used to evaluate the efficacy and safety of mindfulness meditation and cognitive behavioral therapy programs as a psychological intervention for insomnia disorders.Methods and analysis: We will search the following 11 electronic databases without language or publication status restrictions: MEDLINE, the Cochrane Central Register of Controlled Trials, EMBASE, Allied and Complementary Medicine Database, Cumulative Index to Nursing and Allied Health Literature, and PsycARTICLES, Furthermore, we will also search 5 Korean-language databases (Oriental Medicine Advanced Searching Integrated System, Korean studies Information Service System, Research Information Service System, Korean Medical Database, and Korea Citation Index). The study selection and data extraction will be performed independently by 2 authors. The study quality assessment and evaluation of the quality of evidence for the main findings will be performed independently by 2 authors using the Cochrane tool for assessing risk of bias and predefined criteria (the Grading of Recommendations Assessment, Development, and Evaluation approach). Data synthesis and analysis will be performed using RevMan Version 5.3. Data will be synthesized by either a fixed effects or random effects model according to a heterogeneity test or the number of studies included in the meta-analysis. If any plan for documenting important protocol amendments changes, the researchers will have a revision agreement and then register the modification in the International Prospective Register of Systematic Reviews (PROSPERO).Ethics and dissemination: Ethical approval will not be required because individual patient data are not included and because this protocol is for a systematic review. The findings of this systematic review will be disseminated through conference presentations.This research was supported by the research program of the Korea Institute of Oriental Medicine (K18900)
์ด๊ธฐ์นจ์ ๋ฒ์ผ๋ก ์ ์กฐํ ์ฐ๋ฃ์ ์ง์ฉ ๊ณ ๋ถ์ฐ. ๊ณ ๋ด์ง ๋ฐฑ๊ธ์ด๋งค์ ํน์ฑ
ํ์๋
ผ๋ฌธ(์์ฌ)--์์ธ๋ํ๊ต ๋ํ์ :ํํ์๋ฌผ๊ณตํ๋ถ,2006.Maste
Development of Field-based Creativity Competency Scales for College Graduates
๋ณธ ์ฐ๊ตฌ๋ ๊ธฐ์
ํ์ฅ์์ ์๊ตฌํ๋ ๋์กธ ์ ์
์ฌ์์ ์ฐฝ์์ฑ ์์ธ์ ๋์ถํ๊ณ ์ด๋ฅผ ํ์ฉํ ์ธก์ ๋๊ตฌ๋ฅผ ๊ฐ๋ฐํ๊ธฐ ์ํ ๋ชฉ์ ์ผ๋ก ์ค์๋์๋ค. ์ต๊ทผ ๊ธฐ์
๋ค์ ์ ์
์ฌ์์ ์ฐฝ์์ฑ์ ์ ๋ฐ์ ์ฃผ์ ์งํ๋ก ๊ฐ์กฐํ๊ณ ์์ผ๋ ๊ตฌ์ฒด์ ์ผ๋ก ์ฐฝ์์ฑ์ด ์ด๋ค ์์ธ์ ์๋ฏธํ๋ฉฐ ํ๊ฐ์ ์งํ๊ฐ ๋ฌด์์ธ์ง๋ฅผ ์ค๋ช
ํ๋ ๊ฒ์ ๋ชจํธํ๋ค. ๋ฐ๋ผ์ ๋ณธ ์ฐ๊ตฌ์์๋ ์ ํ์ฐ๊ตฌ์์ ๋ค๋ฃจ์ด์ง ์ง๋ฌด ์ํฉ์์์ ์ฐฝ์์ฑ์ ๊ฐ๋
๊ณผ ์์ธ๋ค์ ๊ฒํ ํ์ฌ ํ์ฅ์์ ์๊ตฌ๋๋ ์ฐฝ์์ฑ ์์๋ฅผ ๋์ถํ์์ผ๋ฉฐ ์ด๋ฅผ ํ๊ณ ๋ฐ ํ์ฅ ์ ๋ฌธ๊ฐ์ ํ๋น๋ ํ์ ๊ณผ์ ์ ๊ฑฐ์ณ ์ ์
์ฌ์์ ์ฐฝ์์ฑ ์ธก์ ๋๊ตฌ์ ์ต์ข
์์ธ๊ณผ ์งํ๋ฅผ ์ ์ ํ์๋ค. ๋ณธ ๊ฐ๋ฐ ๋๊ตฌ์ ๋ชจํ์ ๊ฒ์ฆํ๊ธฐ ์ํด ์
์ฌ 1๋
๋ฏธ๋ง์ ๋์กธ ์ ์
์ฌ์ 290๋ช
์ ๋์์ผ๋ก ํด๋น ๋๋ฃ ๋ฐ ์์ฌ 3์ธ์ ์ฌ๋ก๋ฅผ ๋ถ์ํ์์ผ๋ฉฐ, ์ต์ข
์ ์ผ๋ก ์ฐฝ์ ์ญ๋์ 2์์ธ(์ฐฝ์์ ์ฌ๋ฆฌ์์, ์ฐฝ์์ ์ฌ๊ณ ์ ์ฐ๋ฌผ)๊ณผ ์ด 13๊ฐ์ ์ธก์ ๋ฌธํญ์ด ๋์ถ๋์๋ค. ๋ณธ ์ฐ๊ตฌ์์ ๊ฐ๋ฐ๋ ๋์กธ ์ ์
์ฌ์์ ์ฐฝ์์ฑ ์ธก์ ๋๊ตฌ๋ ์กฐ์ง์ ์ค๋ฌด ํ์ฅ์์ ํฉ์๋ ์์๋ก ๊ตฌ์ฑ๋์์ผ๋ฉฐ ์ด๋ฅผ ์ค์ ๋์กธ ์ทจ์
์๋ฅผ ํตํด ๊ฒ์ฆํ์๋ค๋ ๋ฐ์ ์์๊ฐ ์๋ค. ๋ง์ง๋ง์ผ๋ก ๋ณธ ์ฐ๊ตฌ์ ๊ฒฐ๊ณผ๋ฅผ ํ ๋๋ก ๋
ผ์์ ํ๊ณ์ ์ ์ ์ํ์๋ค.This study aims to derive the factors that compose creativity which is required of college graduates by companies, and to develop a model to measure such creativity. The derived components were reviewed and validated by experts from both academia and field in order to select the factors and indicators to be used for developing a measurement model. Survey was conducted on 290 college graduates who had less than 1 year experience in companies. As a result, 2 factors (creative psychological resource, creative thinking and performance) were derived and 13 questions were developed for the model aimed at measuring creativity. The measurement model developed in this study is meaningful as it is composed of factors which were greed upon by the field and validated by actual experiences of new recruits, and is therefore highly likely to be used in the field
The Relationships between School Life Adaptation and Parental Empathy Perceived by Specialized High School Male Students: The Mediating Effects of Self-Encouragement
๋ณธ ์ฐ๊ตฌ์ ๋ชฉ์ ์ ํน์ฑํ๊ณ ๋จํ์์ด ์ง๊ฐํ ๋ถ๋ชจ์ ๊ณต๊ฐ๋ฅ๋ ฅ์ด ํ๊ต์ํ์ ์ ๊ฐ์ ๊ด๊ณ์์ ์๊ธฐ๊ฒฉ๋ ค์ ๋งค๊ฐํจ๊ณผ๊ฐ ์๋์ง ํ์ํ๊ณ ์ ํ๋ ๊ฒ์ด๋ค. ์ด๋ฅผ ์ํด ์์ธ์ ์์นํ ํน์ฑํ๊ณ ๋จํ์ 252๋ช
์ ๋์์ผ๋ก ์ค๋ฌธ์ ์ค์ํ์๋ค. ๋ณธ ์ฐ๊ตฌ์ ํต๊ณ์ฒ๋ฆฌ๋ SPSS 22.0 ํ๋ก๊ทธ๋จ์ ์ฌ์ฉํ์๊ณ ๊ฐ ๋ณ์ธ๋ค ๊ฐ์ ๊ด๊ณ๋ฅผ ํ์ธํ๊ธฐ ์ํ์ฌ ์๊ด๋ถ์์ ์ค์ํ์์ผ๋ฉฐ Baron๊ณผ Kenny(1986)๋ฐฉ์์ ํตํด ๋งค๊ฐํจ๊ณผ๋ฅผ ๊ฒ์ฆํ์๋ค. ์ฐ๊ตฌ๊ฒฐ๊ณผ ์ฒซ์งธ, ๋ถ๋ชจ์ ๊ณต๊ฐ๋ฅ๋ ฅ, ํ๊ต์ํ์ ์, ์๊ธฐ๊ฒฉ๋ ค์์ ๊ด๊ณ๋ ์ ์๋ฏธํ ์๊ด๊ด๊ณ๊ฐ ์๋ ๊ฒ์ผ๋ก ๋ํ๋ฌ๋ค. ๋์งธ, ๋ถ๋ชจ์ ๊ณต๊ฐ๋ฅ๋ ฅ๊ณผ ํ๊ต์ํ์ ์ ๊ฐ์ ๊ด๊ณ์์ ์๊ธฐ๊ฒฉ๋ ค๋ ๋ถ๋ถ๋งค๊ฐ ํ๋ ๊ฒ์ผ๋ก ๋ํ๋ฌ๋ค. ํ๊ต์ํ์ ์ ํ์์์ธ๋ณ๋ก ์ดํด๋ณด๋ฉด, ๋ถ๋ชจ์ ๊ณต๊ฐ๋ฅ๋ ฅ๊ณผ ํ์
์ ์ ์๊ณผ์ ๊ด๊ณ์์ ์๊ธฐ๊ฒฉ๋ ค๋ ์์ ๋งค๊ฐ ํ๋ ๊ฒ์ผ๋ก ๋ํ๋ฌ๊ณ , ๋ถ๋ชจ์ ๊ณต๊ฐ๋ฅ๋ ฅ๊ณผ ์ฌํ์ ์ ์ ๋ฐ ์ ์์ ์ ์๊ณผ์ ๊ด๊ณ์์ ์๊ธฐ๊ฒฉ๋ ค๋ ๋ถ๋ถ๋งค๊ฐ ํ๋ ๊ฒ์ผ๋ก ๋ํ๋ฌ๋ค. ์ด๋ฌํ ์ฐ๊ตฌ ๊ฒฐ๊ณผ๋ฅผ ํ ๋๋ก ๋ณธ ์ฐ๊ตฌ์ ์์์ ์ ํ์ ์ ์ ์ํ๊ณ ํ์ ์ฐ๊ตฌ๋ฅผ ์ํ ์ ์ธ์ ๋ํด ๋
ผ์ํ์๋ค. This Study aims to verify the mediation effects of self-encouragement in the relationship between parental empathy and school life adaptation of specialized high school male student. Survey participants were 252 students attending specialized high school in Seoul. The research method used SPSS 22.0. Data was analyzed by Pearson’s correlation and hierarchical regression analysis was suggested by Baron & Kenny(1986). The results obtained through this research are as follows. First, the correlations among the parents’ empathy, self-encouragement, and school life adaptation was significantly related. Second, self-encouragement partially mediated the relation between parents’ empathy and school life adaptation. Specifically, self-encouragement completely mediated the relation between parents’ empathy and academic adjustment. Self-encouragement partially mediated the relation between parents’ empathy and social adjustment and affective adjustment. Lastly, implications for future studies were discussed
Structural Relationship among School Violence Experiences during the Third Grade of Middle School, Longitudinal Changes of School Violence Experiences and School Adjustment during High School Periods
๋ณธ ์ฐ๊ตฌ๋ ์คํ๊ต 3ํ๋
๋์ ๋นํ๊ฐํด, ํผํด ๋ฐ ์ฌ์ด๋ฒ๋นํ ๊ฐํด๊ฒฝํ๊ณผ ๊ณ ๋ฑํ๊ต ์๊ธฐ์ ๋นํ๊ฐํด, ํผํด ๋ฐ ์ฌ์ด๋ฒ๋นํ ๊ฐํด๊ฒฝํ๊ณผ ํ๊ต์ํ์ ์์ ์ข
๋จ์ ๋ณํ๊ฐ์ ๊ตฌ์กฐ์ ๊ด๊ณ๋ ์ด๋ ํ๊ฐ๋ฅผ ์ดํด๋ณด๋๋ฐ ๋ชฉ์ ์ด ์๋ค. ์ฐ๊ตฌ๋์์ ํ๊ตญ์๋ยท์ฒญ์๋
์ค1ํจ๋์๋ฃ๋ก ๋นํ๊ฐํด, ํผํด๊ฒฝํ๊ณผ ์ฌ์ด๋ฒ๋นํ ๊ฐํด๊ฒฝํ์ 3์ฐจ๋
๋(์คํ๊ต 3ํ๋
)โผ6์ฐจ๋
๋(๊ณ ๋ฑํ๊ต 3ํ๋
) ์๋ฃ๋ฅผ ์ฌ์ฉํ์๊ณ , ํ๊ต์ํ์ ์์ 4์ฐจ๋
๋(๊ณ ๋ฑํ๊ต 1ํ๋
)โผ6์ฐจ๋
๋(๊ณ ๋ฑํ๊ต 3ํ๋
) ์๋ฃ๋ฅผ ์ฌ์ฉํ์๋ค. ๋ณ์ธ๋ค ๊ฐ์ ์๋์ ์ฒจ๋๋ฅผ ์ดํด๋ณธ ๊ฒฐ๊ณผ ๋นํ๋ณ์ธ์ ์๋์ ์ฒจ๋๊ฐ ์ ๊ท๋ถํฌ๊ณก์ ์ ๊ฐ์ ์์ ๋ฒ์ด๋ ๋ถ์คํธ๋ํ ๋ฐฉ๋ฒ(bootstrapping method)์ผ๋ก ๋ถ์์ ํ์๋ค. ์ฐ๊ตฌ๊ฒฐ๊ณผ ์คํ๊ต 3ํ๋
๋์ ๋นํ๊ฐํด๊ฒฝํ์ ๊ณ ๋ฑํ๊ต ๋์ ๋นํ๊ฐํด๊ฒฝํ ์ด๊ธฐ๊ฐ๊ณผ ์ฌ์ด๋ฒ๋นํ ๊ฐํด๊ฒฝํ ์ด๊ธฐ๊ฐ์ ์ํฅ์ ๋ฏธ์น๋ ๊ฒ์ผ๋ก ๋ํ๋ฌ๊ณ , ์คํ๊ต 3ํ๋
๋์ ๋นํํผํด๊ฒฝํ์ ๊ณ ๋ฑํ๊ต ๋์ ๋นํํผํด๊ฒฝํ ์ด๊ธฐ๊ฐ๊ณผ ์ ํ๋ณํ์จ, ์ฌ์ด๋ฒ๋นํ ๊ฐํด๊ฒฝํ์ ์ด๊ธฐ๊ฐ๊ณผ ์ ํ๋ณํ์จ์ ์ํฅ์ ๋ฏธ์น๋ ๊ฒ์ผ๋ก ๋ํ๋ฌ๋ค. ์คํ๊ต 3ํ๋
๋์ ์ฌ์ด๋ฒ๋นํ ๊ฐํด๊ฒฝํ์ ๊ณ ๋ฑํ๊ต ๋์ ๋นํ๊ฐํด๊ฒฝํ ์ด๊ธฐ๊ฐ, ์ฌ์ด๋ฒ๋นํ ๊ฐํด๊ฒฝํ ์ด๊ธฐ๊ฐ, ์ฌ์ด๋ฒ๋นํ ๊ฐํด๊ฒฝํ ๋ณํ์จ์ ์ํฅ์ ๋ฏธ์น๋ ๊ฒ์ผ๋ก ๋ํ๋ฌ๋ค. ๋งค๊ฐํจ๊ณผ๋ฅผ ์ดํด๋ณธ ๊ฒฐ๊ณผ ์คํ๊ต 3ํ๋
๋์ ๋นํ๊ฐํด๊ฒฝํ์ ๊ณ ๋ฑํ๊ต ๋์ ๋นํ๊ฐํด๊ฒฝํ ์ด๊ธฐ๊ฐ์ ๋งค๊ฐ๋ก ํ์ฌ ํ๊ต์ํ์ ์ ์ด๊ธฐ๊ฐ์ ์ํฅ์ ๋ฏธ์น๋ ๊ฒ์ผ๋ก ๋ํ๋ฌ๊ณ , ์คํ๊ต 3ํ๋
๋์ ์ฌ์ด๋ฒ๋นํ ๊ฐํด๊ฒฝํ์ ๊ณ ๋ฑํ๊ต ๋์ ๋นํ๊ฐํด๊ฒฝํ ์ด๊ธฐ๊ฐ์ ๋งค๊ฐ๋ก ํ๊ต์ํ์ ์ ์ด๊ธฐ๊ฐ์ ์ํฅ์ ๋ฏธ์น๋ ๊ฒ์ผ๋ก ๋ํ๋ฌ๋ค. ์ด๋ฌํ ์ฐ๊ตฌ๊ฒฐ๊ณผ๋ฅผ ๋ฐํ์ผ๋ก ํ์ฌ ์ ํ์ฐ๊ตฌ์์ ๊ด๋ จ์ฑ, ๊ต์ก์ ์์, ์ฐ๊ตฌ์ ์ ํ์ ๋ฑ์ ์ ์ํ์๋ค.The purpose of the study was to investigate the structural relationships among school violence experience during the third grade of middle school, longitudinal changes of school violence experiences and school adjustment during high school periods. The subjects of the study were 1791 middle school panel data from Korean Children & Youth Panel Survey. When the researchers looked at the skewness and kurtosis of the variables, violence experience variables deviated from the assumption of the normal distribution curve so we analyzed the relationships of the variables by bootstrapping method. The results of this study showed that the experience of bullying in the third grade of middle school affected the initial level of bullying experience and cyber bullying experience in high school. The cyber bullying experience in middle school was found to affect the initial level of bullying experience and cyber bullying experience. The linear rate of change in the experience of bullying was found to affect the rate of linear change on school adjustment. As a result of the mediating effect, the experience of bullying in the third grade of junior high school affected school adjustment through the initial value of bullying experience, and cyber bullying experience of junior high school affected school adjustment by the mediation of bullying experience in high school. Based on the results of this study, the relevance to previous studies, educational implications, and limitations of the study were suggested
The significance of tissue mast cells in human bone marrow
have been observed in a wide variety of hematologic
disorders, as well as in several nonhematologic disease
states.
However, the frequency and significance of this
phenomenon in the bone marrow has not yet been
accurately determined. In an attemp to define the
disorders associated with an increase in bone marrow
mast cells and to assess the relative incidence of
this finding, we examined 220 bone marrow sections
obtained at the Department of Laboratory Medicine,
Seoul National University Hospital for 7 months
from Jan. 1982 to July 1982. Mast cells were adjudged
by the metachromatic staining of their cytoplasmic
granules and counted in 20 fields under dry
high power(X 400). The 220 sections were divided
into four groups according to the mast cell counts/
HPF.
Group 1 :
Group n:
GroupM:
GroupN:
The results obtained were as follows:
1. The mast cells were irregularly dispersed
between hemopoietic cells, fat globules and around
blood vessels.
2. Mast cells were increased in 15(6.82%) out of
220 bone marrow sections.
3. There was statistically significant difference
between the groups having increased number of mast
cells and having normal number of mast cells in
celluarity (p<O. 05).
4. Of the 15 patients belonging group III (12
case) and IV (3 case), six had aplastic anemia, three
had iron deficiency anemia, and each one with
systemic lupus erythematQsus, hypersplenism, preleukemic
syndrome, FDO, systemic bacterial infection,
and malignant lymphoma without bone marrow
metastasis.
5. Of the 30 patients who had aplastic anemia,
eleven were group I. thirteen were group II, four
were group III and two were group IV.
6. None of the 44 patients with leukemia have
(AML 23, CML 9, ALL 12) increased mast cells.
7. There was no consistent relationship between
the presence of increased number of mast cells and
iron contents, and M;E ratio.
8. In group III and IV, anemia was the sole common
factor, but there was no significant relationship
between the degree of anemia and the presence of
increased number of mast cells
Application of the Buffy Coat Leucocyte Aggregation (BCLA) Test in Diagnosis of Drug Reaction
Buffy coat leucocyte aggregation (BCLA) in the
presence of a specific antigen was suggested a simple.
sensitive and highly reproducible in vitro method to
test the cell-mediated immunity to certain antigens.
The cell-mediated immune response is known to be
responsible for certain exanthematous drug reaction
and contact hypersensitivity to chemicals.
The present study was undertaken to evaluate the
BCLA test as a possible in vitro diagnostic aid to
detect the drug reactions and contact hypersensitivity
to certain chemicals. Twenty-two patients with
ampicillin drug eruption, contact dermatitis to nickel
sulfate, paraphenylenediamine, potassium dichromate
and mercuric chloride and 68 control subjects entered
this study. The method of the BCLA test was same as described by the authors elsewhere (]979). At
various concentrations of cah antigen ranging from
2. 5 X 10 to 2.5 x 10-' mg/ml, none of the patients
and the control subjects showed the BCLA.
The authors concluded that in these antigen systems
the BCLA test could not be a diagnostic method.
The possible mechanism of this negative results
was discussed
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