137 research outputs found

    ์ž„๋ฌด ๋ถ„์„ ๋ฐ ์šด์šฉ ๋ชจ์‚ฌ๋ฅผ ํ†ตํ•œ ํ๋ธŒ์œ„์„ฑ ์ดˆ๊ธฐ์„ค๊ณ„ ์ ‘๊ทผ ๋ฐฉ๋ฒ•

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    ํ•™์œ„๋…ผ๋ฌธ (์„์‚ฌ)-- ์„œ์šธ๋Œ€ํ•™๊ต ๋Œ€ํ•™์› : ๊ธฐ๊ณ„ํ•ญ๊ณต๊ณตํ•™๋ถ€, 2013. 2. ์ •์ธ์„.๋ณธ ๋…ผ๋ฌธ์€ ํ๋ธŒ์œ„์„ฑ์„ ์œ„ํ•œ ์ดˆ๊ธฐ ์„ค๊ณ„ ์ ‘๊ทผ ๋ฐฉ๋ฒ•์„ ์ œ์‹œํ•œ๋‹ค. ํŠนํžˆ, pre-phase A์˜ ๊ธฐ์ˆ ์  ์ ํ•ฉ์„ฑ์— ์ค‘์ ์„ ๋งž์ถฐ์ ธ ์žˆ๋‹ค. Pre-phase A ๊ณผ์ •์€ ์„ฑ๊ณต์ ์ธ ์ œ์•ˆ์„œ์™€ ํ”„๋กœ์ ํŠธ๋ฅผ ์œ„ํ•ด ๋งค์šฐ ์ค‘์š”ํ•œ ๋‹จ๊ณ„์ด๋‹ค. ๊ฐ„๋‹จํ•œ ์ž„๋ฌด ๋ถ„์„ ๋ฐ ์šด์˜ ๋ชจ์‚ฌ ๋ฐฉ๋ฒ•์„ ์†Œ๊ฐœํ•˜๊ณ  ์ด๋ฅผ ๋„ํ‘œ ๊ธฐ๋ฐ˜ ์ดˆ๊ธฐ ์„ค๊ณ„ ์ ‘๊ทผ ๋ฐฉ๋ฒ•๊ณผ ์ ‘๋ชฉ์‹œํ‚ด์œผ๋กœ์จ ์ž์›์„ ๋ณด๋‹ค ํšจ์œจ์ ์œผ๋กœ ๋ถ„๋ฐฐํ•  ์ˆ˜ ์žˆ๋‹ค. ์šด์˜ ๋ชจ์‚ฌ๋ฅผ ์œ„ํ•ด ์ง€๊ตฌ ์ค‘๋ ฅ๊ตฌ๋ฐฐ, ๋Œ€๊ธฐ์˜ ๊ณต๊ธฐ์ €ํ•ญ, ํƒœ์–‘ ๋ณต์‚ฌ์••, ๊ทธ๋ฆฌ๊ณ  third body์— ์˜ํ•œ ์„ญ๋™์„ Cowells method์— ํฌํ•จ์‹œ์ผœ ์šด๋™๋ฐฉ์ •์‹์„ ์„ธ์šด๋‹ค. ์šฐ์ฃผํ™˜๊ฒฝ ๋ชจ์‚ฌ๋ฅผ ์œ„ํ•ด ํ•ญ์„ฑ ์œ„์น˜ ๋ชจ๋ธ๋ง, ํ•ญ์„ฑ ํšŒ์ „์ถ• ๋ชจ๋ธ๋ง, ์‹(่•) ๋ชจ๋ธ๋ง, ๊ทธ๋ฆฌ๊ณ  ๋Œ€๊ธฐ ๋ฐ€๋„ ๋ชจ๋ธ๋ง ๋ฐฉ๋ฒ•์„ ์†Œ๊ฐœํ•œ๋‹ค. SNUSAT-1 ์ดˆ๊ธฐ์„ค๊ณ„๋ฅผ ์œ„ํ•ด ์ œ์•ˆ๋œ ๋„ํ‘œ ๊ธฐ๋ฐ˜ ์ดˆ๊ธฐ ์„ค๊ณ„์™€ ์ตœ์ƒ์œ„ ์š”๊ตฌ์‚ฌํ•ญ์„ ํ†ตํ•ด pre-phase A ๊ธฐ์ˆ ์  ์ ํ•ฉ์„ฑ ํ‰๊ฐ€๋ฅผ ์ˆ˜ํ–‰ํ•œ๋‹ค.This study presents an initial design approach method for CubeSats. The study focuses on the pre-phase A procedure technical feasibility assessment. The pre-phase A procedure is important for a successful proposal and project. By introducing a simple mission analysis and operation simulation method and joining pre-phase A with a table based initial design approach, resources can be efficiently allocated. The study uses Cowells method with perturbing acceleration due to geopotential, atmospheric drag, solar radiation pressure, and third body. Space environment is modeled for ephemerides, rotational elements, eclipse, and atmospheric density. With initial design, using the presented basic design table, and with top-level requirements, pre-phase A procedure of technical feasibility assessment for SNUSAT-1 is performed using the introduced orbit simulation method. As a result, initial design is given for SNUSAT-1.Abstract Table of Contents List of Tables List of Figures List of Symbols 1. Introduction 1 2. Numerical Methods 3 2.1. Equation of Motion 3 2.1.1. Cowells Method 3 2.1.2. Geopotential 4 2.1.3. Atmospheric Drag 8 2.1.4. Solar Radiation Pressure 10 2.1.5. Third Body Perturbation 11 2.2. Numerical Integration 13 3. Space Environment Modeling 15 3.1. Time and Coordinate System 15 3.1.1. Time 15 3.1.2. Coordinate 16 3.1.3. Initialization 18 3.2. Ephemerides 18 3.3. Rotation Elements 24 3.4. Shadow 27 3.5. Atmospheric Model 29 4. Initial CubeSat Design 33 4.1. Structure 33 4.2. Thermal 34 4.3. Onboard Data Handling 34 4.4. Telemetry, Tracking, and Command 35 4.5. Attitude Determination and Control 36 4.6. Electrical Power Subsystem 37 5. Application on SNUSAT-1 39 5.1. Top-Level Requirements 39 5.1.1. Space Segment Requirements 39 5.1.2. Ground Segment Requirements 40 5.1.3. Launch Segment Requirements 40 5.2. Initial Design Approach 41 5.3. Feasibility Assessment 44 5.3.1. Lifetime 45 5.3.2. Link Analysis 45 5.3.3. Power 46 6. Conclusion 52 References 54 Abstract in Korean 56Maste

    ์•ผ๊ฐ„ ๋ณด๊ด‘์‹œ ๊ด‘๋„์™€ ์ฃผ๊ธฐ์— ๋”ฐ๋ฅธ ์ƒ์œก๊ณผ ๊ด‘ํ•ฉ์„ฑ ๋ฐ˜์‘

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    ํ•™์œ„๋…ผ๋ฌธ (์„์‚ฌ)-- ์„œ์šธ๋Œ€ํ•™๊ต ๋Œ€ํ•™์› : ๋†์—…์ƒ๋ช…๊ณผํ•™๋Œ€ํ•™ ์‹๋ฌผ์ƒ์‚ฐ๊ณผํ•™๋ถ€, 2018. 2. ๊น€๊ธฐ์„ .These studies were conducted to investigate the influence of supplemental lighting timing in a day (Expt. 1), and to determine how the duration and light intensity during nighttime supplemental lighting (NSL) influence the growth and photosynthesis of the Cymbidium plants (Expt. 2). Nine-month-old Cymbidium Yang Guifei and Wine Shower plants were treated with three different supplemental lighting timings: from 22:00 to 02:00 HR (middle of the night, MN)from 17:00 to 21:00 HR (day extension, DE)and from 07:00 to 09:00 HR plus from 17:00 to19:00 HR (day extension which was divided into two sections, 1/2DE), and with non-supplemental lighting (8/16 hshort day, SD) for 4 months. All of the supplemental lighting treatments were provided by 100% red LEDs (peak at 640 and 660 nm) with 150 ยตmolm-2s-1 and 800 ยตmolmol-1 of CO2 was supplied during nighttime. In both cultivars, pseudobulb diameter under supplemental lighting treatments (MN, DE, and 1/2DE) appeared to be greater irrespective of supplemental lighting timings than under SD. Photosynthetic assimilation rate (An) also showed the similar response as growth. These results indicate that supplemental lighting timing application is not required for promoting growth and photosynthesis in these two Cymbidium plants. Furthermore, to accelerate growth and photosynthesis of Cymbidium plants, it is related with the total light integral. Thus, in Expt.2, 2-month-old Cymbidium plants with the same cultivar in Expt. 1 were used to determine how NSL duration and light intensity, which affects NSL light integral, influence growth and photosynthesis. Plants were treated with five NSL durations of 2, 4, 6, 8, and 16 h and three light intensities of 10, 100, and 200 ยตmolm-2s-1 for 4 months, which provided 13 NSL light integrals ranging from 0 to 11.52 molm-2d-1. After 4 months of NSL treatment, plants in all treatments were then grown in the same ambient photoperiod to identify the residual effects on subsequent growth. In both cultivars, pseudobulb diameter, number of leaves, leaf width, and biomass accumulation significantly increased as NSL duration and light intensity increased. In case of pseudobulb diameter, it increased by 33% and 43% in Yang Guifei and Wine Shower, respectively, as NSL light integral increased from 0 to 11.52 molโˆ™m-2โˆ™d-1. However, relative chlorophyll content (SPAD value) significantly decreased in Yang Guifei by increasing NSL light integral during NSL treatment but, it recovered after the treatments ended. An during NSL treatment was promoted according to the increase of NSL duration and light intensity in both cultivars. Also, daily An was increased with increasing NSL light integral and showed positive correlation with pseudobulb diameter. These experiments indicate that supplemental lighting during nighttime with high light integral accelerates growth with greater photosynthetic assimilation rate.INTRODUCTION 1 LITERATURE REVIEW 3 Characteristics of Cymbidium 3 Pseudobulb of Cymbidium 3 Growth Affected by Supplemental Lighting 4 MATERIALS AND METHODS 5 Supplemental Lighting Timing in a Day (Experiment 1) 5 Duration and Intensity of Supplemental Lighting during Nighttime (Experiment 2) 10 RESULTS AND DISCUSSION 15 Supplemental Lighting Timing in a Day (Experiment 1) 15 Duration and Intensity of Supplemental Lighting during Nighttime (Experiment 2) 24 LITERATURE CITED 42 ABSTRACT IN KOREAN 49Maste

    Estimation of Punching Shear on UHPC Slab

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    ํ•™์œ„๋…ผ๋ฌธ (์„์‚ฌ)-- ์„œ์šธ๋Œ€ํ•™๊ต ๋Œ€ํ•™์› : ๊ฑด์ถ•ํ•™๊ณผ, 2015. 2. ํ™์„ฑ๊ฑธ.Nowadays, UHPC (High Performance Fiber Reinforced Concrete) is used widely with its remarkable performance, such as strength, ductility and durability. Due to the fibers in the UHPC which can control the tensile crack, the punching shear capacity of UHPC is higher than that of the conventional concrete, but the structural behavior of UHPC has not been determined completely. In this study, the data were analyzed for confirming the feasibility of the existing equations. In the preliminary study, the punching shear data of fiber-reinforced concrete slabs were analyzed for understanding the fiber effect. By analyzing experimental data, the equation that calculates the concrete, reinforcement and the fiber separately shows more accurate results. However, the method has problem that the coefficients for each terms are usually determined by experimental results. Therefore the relationship between the deformation based on material properties and the punching shear strength should be examined. In this paper, seven slabs with different thickness and fiber volume ratio were tested. In direct tension test, the crack width does not show the relationship according to the fiber volume ratio, but the tensile strength was increasing as the fiber volume ratio was increasing up to 1%. For the fiber content, 1% and 1.5% UHPC do not have big differences in tension test and punching shear test. However, the ratio of tensile strength and the punching shear strength was not proportional. The design tensile strength seems more proportional to the punching shear strength. It is assumed for the reason of un-proportional relationship between the direct tensile strength and punching shear strength that the un-unified crack width and the fibers directivity difficult to control. The thicker slab thickness causes the increment of the punching shear strength with decrement of deformation capacity. The UHPC flat plate shows the wider punching shear area than the conventional concrete. The gentler strut angle for UHPC slab can be assumed in further study for UHPC failure mode. The punching shear strength equations tend to overestimate the thin slabs. From observing the deformation curve and the failure section, it is insisted that the thin slabs have flexural failure behavior. Due to the flexural behavior of the thin slabs, it could not resist the punching load as much as predicted. The minimum slab thickness should be proposed thicker than 40mm. By analyzing the test data, the JSCE code shows the least standard deviation, but it overestimates the punching shear strength. K-UHPC code results are close to the experimental value. However, the study for finding the relationship between the stress and the material property should be performed with effort to reduce the variance.Abstract Contents List of Tables List of Figures Chapter 1. Introduction 1.1 General 1.2 Advantage and Disadvantage of Using UHPC 1.3 Research Strategy and Thesis Outline Chapter 2. Literature Review 8 2.1 ACI code 2.2 K-UHPC code 2.3 Fib Model Code 2010 2.4 KCI code 2012 2.5 Swamy and Ali (1979) 2.6 Narayanan and Darwish (1987) 2.7 Shaaban and Gesunds equation (1994) 2.8 AFGC Code for Ultra High Performance Concrete 2.9 JSCE Chapter 3. Preliminary Analysis 3.1 Summary of preliminary analysis procedures 3.2 Tendency Analysis for Fiber Volume Ratio 3.3 Tendency Analysis for Compressive Strength of Concrete 3.4 Comparison of the Predicted Results and the Experimental Results Chapter 4. Materials and Testing 4.1 Fabrication 4.1.1 K-UHPC 4.1.2 Compression Test 4.1.3 Tension Test 4.2 Test Setting 4.2.1 Specimen Fabrication 4.2.2 Boundary Condition 4.3 Specimen Plan 4.4 Experimental Setup 4.4.1 Frame 4.4.2 Loading 4.4.3 Measurement Plan Chapter 5. Test Results and Analysis 5.1 Summary of the objectives of this experiment 5.2 Failure Mechanism 5.2.1 General 5.2.2 Punching Shear Strength and Displacement 5.2.3 Relationship between the tensile strength and the punching shear strength 5.2.4 Relationship between the load and deflection 5.3 Failure Behavior 5.3.1 Strain Distribution according to the fiber volume ratio 5.3.2 Strain Distribution according to the slab thickness 5.3.3 Failure Section 5.4 Flexural Capacity 5.5 Punching Shear Capacity Chapter 6. Conclusion References ์ดˆ ๋กMaste

    ์ฝ”์›Œํ‚น ์ŠคํŽ˜์ด์Šค์™€ ์ฐฝ์กฐ์„ฑ์— ๋Œ€ํ•œ ์—ฐ๊ตฌ

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    ํ•™์œ„๋…ผ๋ฌธ (์„์‚ฌ)-- ์„œ์šธ๋Œ€ํ•™๊ต ๋Œ€ํ•™์› : ๊ณต๊ณผ๋Œ€ํ•™ ๊ฑด์„คํ™˜๊ฒฝ๊ณตํ•™๋ถ€, 2019. 2. ์ •์ฐฝ๋ฌด.IT๋ถ„์•ผ๋Š” ์šฐ๋ฆฌ๋‚˜๋ผ์˜ ์ „์ฒด ์ค‘์†Œ๊ธฐ์—… R&D์ง€์› ์ค‘ ๊ฐ€์žฅ ํฐ ๋ถ€๋ฌธ์„ ์ฐจ์ง€ํ•œ๋‹ค. ๋”๋ถˆ์–ด ๋ฒค์ฒ˜ ์ƒํƒœ๊ณ„ํ™œ์„ฑํ™”๋ฅผ ์œ„ํ•œ ๊ฐ„์ ‘์ง€์›์ •์ฑ… ๋˜ํ•œ ํ™•๋Œ€๋˜๊ณ  ์žˆ๋‹ค. ์ด๋Š”, ์šฐ๋ฆฌ๋‚˜๋ผ์˜ ๋ฒค์ฒ˜์ •์ฑ…์˜ ์„ฑ๊ณผ๊ฐ€ IT๊ธฐ์—…์˜ ์„ฑ๊ณผ์™€ ๊ทผ์ ‘ํ•œ ๊ด€๋ จ์ด ์žˆ๋‹ค๊ณ  ๋ณผ ์ˆ˜ ์žˆ๋‹ค. ์šฐ๋ฆฌ๋‚˜๋ผ๋Š” ๋„์‹ฌ ์ค‘์—์„œ๋„ ํ…Œํ—ค๋ž€๋กœ๊ฐ€ IT ๋ถ„์•ผ์˜ ์ค‘์†Œโ€ข๋ฒค์ฒ˜๊ธฐ์—…์˜ ๋ฉ”์นด๋กœ ๋Œ€ํ‘œ์ ์ด๋ฉฐ, ํ…Œํ—ค๋ž€๋กœ์˜ IT ๋ถ„์•ผ์˜ ์ค‘์†Œโ€ข๋ฒค์ฒ˜๊ธฐ์—…์ด ๋ชจ์—ฌ์„œ ์ผํ•˜๋Š” ๊ณณ์ธ Coworking Space(์ดํ•˜ CWS) ๋˜ํ•œ ๋ฒค์ฒ˜์ •์ฑ…์— ๋ชป์ง€ ์•Š์€ ๊ธ‰์„ฑ์žฅ์„ ์ด๋ฃจ๊ณ  ์žˆ๋‹ค. 2015๋…„ 2๊ณณ ๋ฟ ์ด๋˜ ์„œ์šธ์˜ CWS๊ฐ€ 2018๋…„ 5์›” ๊ธฐ์ค€ 51๊ณณ์œผ๋กœ ๋Š˜์–ด๋‚ฌ๋‹ค. 25.5๋ฐฐ์ด๋‹ค. ์„œ์šธ ๋Œ€ํ˜•๊ฑด๋ฌผ์˜ ๊ณต์‹ค๋ฅ ์ด ์œ„์›Œํฌ(Wework)์™€ ํŒจ์ŠคํŠธํŒŒ์ด๋ธŒ(FastFive) ๋“ฑ์˜ ๋Œ€ํ˜• CWS๋•๋ถ„์— ํ•ด์†Œ๋˜์—ˆ๋‹ค๋Š” ์˜๊ฒฌ๋„ ์žˆ๋‹ค. CWS๋Š” ๊ณ„์†ํ•ด์„œ ์„ฑ์žฅ์„ธ๋ฅผ ๋ณด์ด๋ฉฐ๋„์‹œ์˜ ๊ณต์‹ค๋ฅ  ๋ฌธ์ œ๋ฅผ ์–ด๋Š ์ •๋„๊นŒ์ง€ ํ•ด๊ฒฐํ•ด์ค„ ๊ฒƒ์ด๋‹ค. ํ•˜์ง€๋งŒ, CWS์— ์ž…์ฃผํ•˜๊ฒŒ ๋˜๋Š” ์šฐ๋ฆฌ๋‚˜๋ผ์˜ ์ค‘์†Œโ€ข๋ฒค์ฒ˜๊ธฐ์—… ๋˜ํ•œ CWS์˜ ์„ฑ์žฅ๊ณผ ๋น„๋ก€ํ•˜๊ฒŒ ์„ฑ์žฅํ•˜๊ณ  ์žˆ์„๊นŒ? CWS๋“ค์ด ๊ณตํ†ต์ ์œผ๋กœ ์ถ”๊ตฌํ•˜๋Š” ๊ทธ๋“ค์˜ ์ •์ฒด์„ฑ์„ ํ‚ค์›Œ๋“œ๋กœ ๋‚˜ํƒ€๋‚ด์ž๋ฉด, ์ฐฝ์กฐ์„ฑ, ์•„์ด๋””์–ด ๊ณต์œ , ์ง€์‹ ๊ณต์œ , ๋„คํŠธ์›Œํ‚น ๋“ฑ์ด ์žˆ๋‹ค. ๋‹ค์‹œ ๋งํ•ด, CWS๋Š” ์ปค๋ฎค๋‹ˆํ‹ฐ๋ฅผ ํ†ตํ•ด์„œ ์ฐฝ์กฐ์  ์•„์ด๋””์–ด์™€ ์ง€์‹์„ ๊ณต์œ ํ•˜๋ฉฐ ํ•จ๊ป˜ ์„ฑ์žฅํ•  ์ˆ˜ ์žˆ๋Š” ๊ธฐํšŒ๋ฅผ ์ œ๊ณตํ•˜๋Š” ์žฅ์†Œ์ด๋‹ค. ์œ„์›Œํฌ๋Š” ๊ธฐ์—…๋“ค์˜ ์ฐฝ์˜์„ฑ์„ ์ตœ๋Œ€ํ•œ ๋Œ์–ด๋‚ผ ์ˆ˜ ์žˆ๋Š” ํ™”์žฅ์‹ค ๊ฐœ์ˆ˜, ์˜คํ”ผ์Šค ์œ„์น˜, ์ฝ˜ํผ๋Ÿฐ์Šค๋ฃธ ๊ฐœ์ˆ˜๊นŒ์ง€ ๋น…๋ฐ์ดํ„ฐ๋ฅผ ํ™œ์šฉํ•ด ์ ์šฉํ•˜๊ณ  ์žˆ์œผ๋ฉฐ, ๊ตฌ์„ฑ์›๋“ค์ด ์ž์—ฐ์Šค๋Ÿฝ๊ฒŒ ๋ถ€๋”ชํžˆ๋ฉด์„œ ๋Œ€ํ™”๋ฅผ ๋‚˜๋ˆŒ ์ˆ˜ ์žˆ๋Š” ๋‚ด๋ถ€์„ค๊ณ„๋ฅผ ํ•œ๋‹ค. ๋ฏธ๊ตญ์˜ ๋‰ด์š•, ์‹œ์นด๊ณ , LA์— ์œ„์น˜ํ•œ ์œ„์›Œํฌ ์ž…์ฃผํ•œ ์Šคํƒ€ํŠธ์—…์˜ ์ƒ์กด๋ฅ ์ด ๋” ๋†’๋‹ค๋Š” ๋ณด๊ณ ๋Š” ๊ตฌ์„ฑ์›์˜ ์„ฑ์žฅ์— ์œ„์›Œํฌ๊ฐ€ ๋„์›€์ด ๋˜์—ˆ๋‹ค๋Š” ์˜๊ฒฌ์„ ๋’ท๋ฐ›์นจํ•œ๋‹ค. ๋˜ํ•œ, ๋ฏธ๊ตญ์˜ CWS ๊ตฌ์„ฑ์›๋“ค์˜ 84%๋Š” CWS์ž…์ฃผ ์ดํ›„, engagment'์™€ 'motivation'์ด ์ปค์กŒ๋‹ค๋Š” ๊ธ์ •์ ์ธ ๋‹ต๋ณ€์„ ํ•œ ์„ค๋ฌธ๊ฒฐ๊ณผ๋„ ์žˆ๋‹ค. ๊ทธ๋Ÿฌ๋‚˜, ์šฐ๋ฆฌ๋‚˜๋ผ์˜ ๊ฒฝ์šฐ๋Š” ๋‹ค๋ฅด๋‹ค. ๊ตญ๋‚ด CWS์˜ ๊ตฌ์„ฑ์›์„ ๋Œ€์ƒ์œผ๋กœ ํ•œ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด CWS๊ตฌ์„ฑ์›์˜ 59.8%๊ฐ€ ์ปค๋ฎค๋‹ˆํ‹ฐ๋‚˜ ๋„คํŠธ์›Œํ‚น์— ์ฐธ์—ฌํ•˜์ง€ ์•Š๋‹ค๊ณ  ๋ฐํ˜”๊ณ , ์ฐธ์—ฌํ•˜์ง€ ์•Š๋Š” ์ด์œ ์— ๋Œ€ํ•œ ์‘๋‹ต์€ ๋„คํŠธ์›Œํ‚น์„ ํ•ด๋„ ์‹ค์ œ๋กœ ๋„์›€์ด ๋˜์ง€ ์•Š์Œ(29.5%), ๋„คํŠธ์›Œํ‚น์˜ ํ•„์š”์„ฑ์„ ๋Š๋ผ์ง€ ๋ชปํ•จ(19.3%)๊ฐ€ ๊ฐ€์žฅ ๋งŽ์•˜๋‹ค. ์ด๋Š” ์šฐ๋ฆฌ๋‚˜๋ผ์˜ CWS์—์„œ๋Š” ์•„์ง๊นŒ์ง€ ๊ทธ ์ •์ฒด์„ฑ์ด ์ œ๋Œ€๋กœ ์‹คํ˜„๋˜๋Š”์ง€์— ๋Œ€ํ•œ ์˜๋ฌธ์„ ์ค€๋‹ค. ์ œ 4์ฐจ ์‚ฐ์—…ํ˜๋ช…์—์„œ ์•ž์„œ ๋‚˜๊ฐ€๊ธฐ ์œ„ํ•œ ํ•„์ˆ˜์กฐ๊ฑด์ธ IT์‚ฐ์—…์˜ ๋ฐœ์ „์ด CWS์— ๋งค์ผ ์ถœ๊ทผํ•˜๋Š” ๊ตฌ์„ฑ์›๋“ค์—๊ฒŒ ๋‹ฌ๋ ธ๋‹ค. ๊ทธ๋“ค์ด ๋งŒ๋“ค์–ด ๋‚˜๊ฐˆ ๋ฏธ๋ž˜์˜ ๋Œ€ํ•œ๋ฏผ๊ตญ์˜ ๊ฒฝ์Ÿ๋ ฅ์„ ๋‹ค์ง€๊ธฐ ์œ„ํ•ด ๋„์‹œ๋Š” ์–ด๋–ค CWS๋ฅผ ์ง€ํ–ฅํ•ด์•ผ ํ• ์ง€์— ๋Œ€ํ•œ ์ž‘์€ ์—ฐ๊ตฌ๋ฅผ ์ง„ํ–‰ํ•˜์˜€๋‹ค. ๋ณธ ์—ฐ๊ตฌ๋Š” ํ…Œํ—ค๋ž€๋กœ CWS ๊ตฌ์„ฑ์›์˜ ์ฐฝ์กฐ์„ฑ(Creativity)์— ๋Œ€ํ•œ ์—ฐ๊ตฌ์ด๋‹ค. ๊ตฌ์กฐ๋ฐฉ์ •์‹์„ ํ†ตํ•ด ๊ตฌ์„ฑ์›์˜ ์ฐฝ์กฐ์„ฑ์— ์˜ํ–ฅ์˜ ์ •๋„๋ฅผ ํŒ€ ์ฐจ์›, ๊ฐœ์ธ ์ฐจ์›์—์„œ ์•Œ์•„๋‚ธ๋‹ค. ๋˜ํ•œ, CWS์˜ ๊ตฌ์„ฑ์š”์†Œ ์ค‘ ํ•˜๋‚˜์ธ ์ „๋ฌธ๊ฐ€ ์ง‘๋‹จ์˜ ์ง‘์ ๋„๊ฐ€ ์ฐจ์ด๊ฐ€ ๋‚˜๋Š” ๋‘ CWS๋ฅผ ๋น„๊ตํ•˜์—ฌ, ์ „๋ฌธ๊ฐ€ ์ง‘๋‹จ ์ง‘์ ๋„๊ฐ€ ์ฐฝ์กฐ์„ฑ์— ์˜ํ–ฅ์„ ์ฃผ๋Š”์ง€๋ฅผ ํ‰๊ฐ€ํ•œ๋‹ค. Creativity์— ์˜ํ–ฅ์„ ์ฃผ๋Š” ์ž ์žฌ๋ณ€์ˆ˜๋Š” ๋„ค ๊ฐ€์ง€๋กœ ๊ตฌ์„ฑ๋˜์–ด ์žˆ์œผ๋ฉฐ, ํŒ€ ์ฐจ์›์˜ ์ž ์žฌ๋ณ€์ˆ˜๋Š” Intrateam Competition๊ณผ Intrateam Collaboration ์ด ์žˆ๋‹ค. Creativity์— ์˜ํ–ฅ์„ ์ฃผ๋Š” ๊ฐœ์ธ ์ฐจ์›์˜ ์ž ์žฌ๋ณ€์ˆ˜๋Š” Intrinsic Motivation๊ณผ Extrinsic Motivation์ด ์žˆ๋‹ค. ํŒ€ ์ฐจ์›์˜ ์ž ์žฌ๋ณ€์ˆ˜์™€ Creativity์— ๋Œ€ํ•œ ๋ถ„์„์€ ๊ฐœ์ธ ์ฐจ์›์— ๋Œ€ํ•œ ์ž ์žฌ๋ณ€์ˆ˜๋ฅผ ํ†ต์ œํ•œ ํ›„ ์ง„ํ–‰ํ•˜์˜€๋‹ค. ๋˜ํ•œ, ํŒ€ ์ฐจ์›์˜ ์ž ์žฌ๋ณ€์ˆ˜ ๋‘ ๊ฐ€์ง€๋Š” ๊ฐœ์ธ์ฐจ์›์˜ ์ž ์žฌ ๋ณ€์ˆ˜ ๋‘ ๊ฐ€์ง€์— ์˜ํ–ฅ์„ ์ฃผ๋Š” ๊ด€๊ณ„๋กœ ๋ชจํ˜•์ด ์„ค์ •๋˜์—ˆ๋‹ค. ์—ฐ๊ตฌ์˜ ๊ฒฐ๊ณผ๋Š” ํŒ€ ์ฐจ์›์˜ ์ž ์žฌ ๋ณ€์ˆ˜ 2๊ฐ€์ง€์™€ ๊ฐœ์ธ ์ฐจ์›์˜ ์ž ์žฌ๋ณ€์ˆ˜ 2๊ฐ€์ง€ ๋ชจ๋‘ Creativity์— ์œ ์˜๋ฏธํ•œ ์ •์ (+) ์˜ํ–ฅ๋ ฅ์„ ์ฃผ๋Š” ๊ฒƒ์œผ๋กœ ํŒŒ์•…์ด ๋˜์—ˆ๋‹ค. ์ด๋Š”, ํŒ€ ๋‚ด๋ถ€์— ๊ฒฝ์Ÿ์  ํ™˜๊ฒฝ์ด ๋†’์„์ˆ˜๋ก, ํŒ€ ๋‚ด๋ถ€ ํ˜‘๋ ฅ์  ํ™˜๊ฒฝ์ด ๋†’์„์ˆ˜๋ก, ๊ฐœ์ธ์˜ ์™ธ๋ถ€์  ๋™๊ธฐ๋ถ€์—ฌ๊ฐ€ ํด์ˆ˜๋ก, ๊ทธ๋ฆฌ๊ณ  ๊ฐœ์ธ์˜ ๋‚ด๋ถ€์  ๋™๊ธฐ๋ถ€์—ฌ๊ฐ€ ํด์ˆ˜๋ก ์ฐฝ์กฐ์„ฑ์ด ์ปค์ง„๋‹ค๋Š” ๊ฒƒ์„ ์˜๋ฏธํ•œ๋‹ค. ๋˜ํ•œ, ํŒ€ ๋‚ด๋ถ€์— ๊ฒฝ์Ÿ์  ํ™˜๊ฒฝ์ด ๋†’์„์ˆ˜๋ก ๊ฐœ์ธ์˜ ์™ธ์  ๋™๊ธฐ๋ถ€์—ฌ์™€ ๋‚ด์  ๋™๊ธฐ๋ถ€์—ฌ๊ฐ€ ์ปค์ง์„ ์˜๋ฏธํ•œ๋‹ค. ์กฐ์ ˆํšจ๊ณผ๋ฅผ ํ†ตํ•˜์—ฌ ์œ„์›Œํฌ์™€ ๋…ผ์Šค, ๋‘ ์ง‘๋‹จ์ด ์—ฐ๊ตฌ์˜ ๋ชจํ˜•์— ์–ด๋–ค ์ฐจ์ด๋ฅผ ๋‚˜ํƒ€๋‚ด๋Š”๊ฐ€์— ๋Œ€ํ•˜์—ฌ ์‚ดํŽด๋ณด๋ฉด, ์ฒซ์งธ, ์œ„์›Œํฌ ์ง‘๋‹จ์˜ ํŒ€ ๋‚ด๋ถ€์˜ ํ˜‘๋ ฅ์  ํ™˜๊ฒฝ์ด ๋†’์„์ˆ˜๋ก ๋‚ด์  ๋™๊ธฐ๋ถ€์—ฌ๊ฐ€ ์ปค์ง€๋Š” ์˜ํ–ฅ์„ ๋ณด์ธ ๋ฐ˜๋ฉด, ๋…ผ์Šค ์ง‘๋‹จ์—์„œ๋Š” ์œ ํšจํ•œ ์˜ํ–ฅ์„ ๋ณด์ด์ง€ ์•Š์•˜๋‹ค. ํ˜‘์—…์€ ๋‹ค๋ฅธ ํŒ€ ๊ตฌ์„ฑ์›๊ณผ ๊ณต๋™ ๋ชฉํ‘œ๋ฅผ ๋‹ฌ์„ฑํ•˜๊ธฐ ์œ„ํ•œ ๋…ธ๋ ฅ์ด๋ฉฐ, ์˜๋„์ ์ธ ์ง€์‹์˜ ๊ณต์œ ์ด๋ฉฐ, ๊ตฌ์„ฑ์›๊ฐ„์— ์ด๋Ÿฌํ•œ ์ƒํ˜ธ์ž‘์šฉ์€ ์œ ๋Œ€๊ด€๊ณ„์— ๋งŒ์กฑํ•  ์ˆ˜ ์žˆ๋Š” ๋‚ด์  ๋™๊ธฐ๋ถ€์—ฌ๋กœ ์—ฐ๊ฒฐ๋œ๋‹ค. ์ด๋Š” ์œ„์›Œํฌ์˜ ๊ตฌ์„ฑ์›๋“ค์ด ํŒ€ ๋‚ด๋ถ€์ ์œผ๋กœ ํ˜‘์—…์œผ๋กœ ์ธํ•œ ๋‚ด์  ๋™๊ธฐ๋ถ€์—ฌ์— ๋Œ€ํ•œ ์˜ํ–ฅ์ด ๋” ํ™œ๋ฐœํ•˜๊ฒŒ ์ด๋ฃจ์–ด์ง„๋‹ค๊ณ  ํ•  ์ˆ˜ ์žˆ๋‹ค. ๋˜ ๋‹ค๋ฅธ ์œ„์›Œํฌ ์ง‘๋‹จ์— ๋Œ€ํ•œ ์กฐ์ ˆํšจ๊ณผ๋กœ๋Š” ํŒ€ ๋‚ด๋ถ€์  ๊ฒฝ์Ÿ์ ์ธ ํ™˜๊ฒฝ๊ณผ ๊ฐœ์ธ์˜ ๋‚ด์žฌ์  ๋™๊ธฐ๋ถ€์—ฌ์˜ ์œ ์˜๋งˆํ•œ ๋ถ€์ (-)์˜ํ–ฅ์ด๋‹ค. ์ด๋Š”, ๋ณธ๋ž˜์˜ ๊ฐ€์„ค๊ณผ ๋Œ€๋ฆฝ๋˜๋Š” ๊ฒฐ๊ณผ์ด๋ฉฐ, ๋ชจํ˜•์˜ ๊ฒฐ๊ณผ์™€๋„ ๋Œ€๋ฆฝ๋œ๋‹ค. ์œ„์›Œํฌ ์ง‘๋‹จ์˜ ์ด์™€ ๊ฐ™์€ ๊ฒฐ๊ณผ์— ๋Œ€ํ•ด์„œ๋Š” ์ข€ ๋” ์ƒ์„ธํ•œ ์—ฐ๊ตฌ๊ฐ€ ํ•„์š”ํ•˜๋‹ค. ๋…ผ์Šค ์ง‘๋‹จ์˜ ๊ฒฝ์šฐ, ์œ ์˜๋ฏธํ•œ ์กฐ์ ˆํšจ๊ณผ์˜ ๊ฒฐ๊ณผ๋Š” ํ•œ ๊ฐ€์ง€๋กœ ๋‚˜ํƒ€๋‚ฌ์œผ๋ฉฐ, ์ด๋Š” ๋‚ด์  ๋™๊ธฐ๋ถ€์—ฌ๊ฐ€ ์ฐฝ์กฐ์„ฑ์„ ๋†’์ธ๋‹ค๋Š” ๊ฒƒ์ด๋‹ค. ๋…ผ์Šค ์ง‘๋‹จ์€ Curation์„ ํ†ตํ•ด ๋ฉด์ ‘์— ํ†ต๊ณผ ํ•œ ๊ตฌ์„ฑ์›๋“ค๋งŒ์ด ์ง‘๋‹จ์— ์†ํ•  ์ˆ˜ ์žˆ๋‹ค. ํ•ด๋‹น ๋ฉด์ ‘์˜ ๋‚ด์šฉ์€ ๊ธฐ๋ณธ์‚ฌํ•ญ ๋ฐ ํ•™๋ ฅ ๊ฒฝ๋ ฅ ๋ฟ๋งŒ ์•„๋‹ˆ๋ผ, ์–ด๋–ค ๊ฟˆ์„ ๊ฐ€์ง€๊ณ  ์žˆ๋Š”์ง€, ์ธ์ƒ์—์„œ ์ค‘์š”ํ•˜๊ฒŒ ์ƒ๊ฐํ•˜๋Š” ๊ฐ€์น˜๊ฐ€ ๋ฌด์—‡์ธ์ง€ ๋“ฑ ๊ฐœ์ธ์˜ ์ฒ ํ•™๊ณผ ๊ฐ€์น˜๊ด€ ๋Œ€ํ•œ ๊ฒƒ์œผ๋กœ ์ด๋ฃจ์–ด์ ธ ์žˆ๋Š” ๊ฒƒ๋“ค๋กœ ๊ตฌ์„ฑ๋˜์–ด ์žˆ๋‹ค. ๋…ผ์Šค์˜ ๋ฉด์ ‘์„ ํ†ต๊ณผํ•œ ๊ตฌ์„ฑ์›๋“ค์ด ๋” ํ™•๊ณ ํ•œ ๋‚ด์  ๋™๊ธฐ๋ถ€์—ฌ์™€ ์ฐฝ์กฐ์„ฑ์˜ ์ •(+)์˜ ์—ฐ๊ฒฐ๊ณ ๋ฆฌ๋ฅผ ๋งŒ๋“ค์—ˆ์„ ๊ฒƒ์ด๋ผ๊ณ  ์ถ”์ธกํ•ด๋ณธ๋‹ค. ๋ณธ ์—ฐ๊ตฌ๋Š” ๊ตญ๋‚ด ๋„์‹ฌ์—์„œ ๊ธ‰์„ฑ์žฅํ•˜๊ณ  ์žˆ๋Š” ์ฝ”์›Œํ‚น์ŠคํŽ˜์ด์Šค๊ฐ€ ์ฐฝ์กฐ๊ฒฝ์ œ๋ฅผ ์ด๋Œ์–ด๊ฐˆ IT์‚ฐ์—…, ํŠนํžˆ ์Šคํƒ€ํŠธ์—…์˜ ๋ฐœ์ „์„ ์œ„ํ•ด ๊ฐ–์ถ”์–ด์•ผ ํ•  ์š”์†Œ์— ๋Œ€ํ•ด ์•Œ์•„๋ณด๊ณ ์ž ํ•˜์˜€๋‹ค๋Š” ๊ฒƒ์— ๊ทธ ์˜์˜๊ฐ€ ์žˆ๋‹ค. CWS ๊ตฌ์„ฑ์›๋“ค์˜ ์ฐฝ์กฐ์„ฑ์„ ํ‚ค์šฐ๊ธฐ ์œ„ํ•ด ์œ„์›Œํฌ์™€ ๊ฐ™์€ ๋Œ€ํ˜• CWS๊ณต๊ฐ„์€ ํ˜‘๋ ฅ์ƒ˜ํ”Œ์‚ฌ์ด์ฆˆ๋Š” ๊ตฌ์กฐ๋ฐฉ์ •์‹์— ํ†ต์ƒ์ ์œผ๋กœ ํ•„์š”ํ•œ ์ƒ˜ํ”Œ์‚ฌ์ด์ฆˆ์ธ 200๊ฐœ์— ๋ฏธ์น˜์ง€ ๋ชปํ•˜์ง€๋งŒ ์™œ๋„์™€ ์ฒจ๋„๋ฅผ ํ†ตํ•ด ์ •๊ทœ๋ถ„ํฌ๋ฅผ ๋”ฐ๋ฅด๋Š” ๊ฒƒ์„ ํ™•์ธํ•จ์œผ๋กœ์„œ ๋ชจํ˜•์˜ ํƒ€๋‹น์„ฑ์„ ์ž…์ฆํ•˜์˜€์ง€๋งŒ, ๋” ํฐ ์ƒ˜ํ”Œ์‚ฌ์ด์ฆˆ๋กœ ๋ณด๋‹ค ๋ช…ํ™•ํ•œ ๊ฒฐ๊ณผ๋ฅผ ๋„์ถœ ํ•  ์ˆ˜ ์žˆ์„ ๊ฒƒ์œผ๋กœ ๊ธฐ๋Œ€ํ•œ๋‹ค. ๋˜ํ•œ, ์ „๋ฌธ๊ฐ€์˜ ์ง์ ‘๋„ ์ง€์ˆ˜์— ๋Œ€ํ•œ ๋ถ€์žฌ๋กœ, ์ „๋ฌธ๊ฐ€์˜ ์ง์ ‘๋„์— ๋”ฐ๋ฅธ ๋‘ ์ง‘๋‹จ๊ฐ„์˜ ๋น„๊ต์—ฐ๊ตฌ๋ฅผ ์ƒ์„ธํžˆ ์ง„ํ–‰ํ•˜์ง€ ๋ชปํ•˜์˜€๋‹ค. ํ–ฅํ›„ ์ „๋ฌธ๊ฐ€์˜ ์ง์ ‘๋„ ์ง€์ˆ˜๋ฅผ ๋ฐœ์ „์‹œํ‚จ ํ›„, ํ•ด๋‹น ์ง€์ˆ˜์— ๋”ฐ๋ฅธ ์ฐฝ์กฐ์„ฑ์— ๋Œ€ํ•œ ์—ฐ๊ตฌ๋ฅผ ํ†ตํ•ด ์ฐฝ์กฐ๊ฒฝ์ œ๋ฅผ ์œ„ํ•œ CWS์— ๋Œ€ํ•ด ์ƒ์„ธํžˆ ๊ทœ๋ช…ํ•˜๊ธธ ๊ธฐ๋Œ€ํ•œ๋‹ค. ๋ณธ ์—ฐ๊ตฌ๋Š” ์„ธ๊ณ„์ ์œผ๋กœ ๋ธ”๋ก์ฒด์ธ ์ปค๋ฎค๋‹ˆํ‹ฐ๋ฅผ ๊ธฐ์ดˆ๋กœ ํ•œ CWS๊ฐ€ ์ƒ๊ฒจ๋‚จ์— ๋”ฐ๋ผ ์ง„ํ–‰๋˜์—ˆ๋‹ค. ๋ธ”๋ก์ฒด์ธ ๋ฟ๋งŒ ์•„๋‹ˆ๋ผ, ์ธ๊ณต์ง€๋Šฅ, ์˜ˆ์ˆ , ๋“ฑ ๋‹ค์–‘ํ•œ ์‚ฐ์—…์ฒด์˜ ์ปค๋ฎค๋‹ˆํ‹ฐ๋ฅผ ์œ„ํ•ด ์ƒ๊ฒจ๋‚˜๋Š” CWS์— ๋Œ€ํ•œ ์—ฐ๊ตฌ๋„ ์ง„ํ–‰๋˜๊ธธ ๊ธฐ๋Œ€ํ•œ๋‹ค.์ œ 1์žฅ ์„œ๋ก  1 1.1 ์—ฐ๊ตฌ์˜ ๋ฐฐ๊ฒฝ ๋ฐ ๋ชฉ์  1 1.2 ์—ฐ๊ตฌ์˜ ๋ฒ”์œ„ 2 ์ œ 2์žฅ ์ฐฝ์กฐ์„ฑ(Creativity) 4 2.1 ์ฐฝ์กฐ์„ฑ ์ •์˜ ๊ด€๋ จ ์ด๋ก  4 2.2 ์ฐฝ์กฐ์„ฑ ๊ด€๋ จ ์„ ํ–‰์—ฐ๊ตฌ๋ฅผ ํ†ตํ•œ ๊ฐ€์„ค ์„ค์ • 5 ์ œ 3์žฅ ์ฝ”์›Œํ‚น์ŠคํŽ˜์ด์Šค(CWS) 10 3.1 CWS์ •์˜ ๊ด€๋ จ ์ด๋ก  10 3.2 CWS๊ด€๋ จ ์„ ํ–‰์—ฐ๊ตฌ๋ฅผ ํ†ตํ•œ ๊ฐ€์„ค ์„ค์ • 12 ์ œ 4์žฅ ๋ถ„์„๊ฒฐ๊ณผ 14 4.2 ๋ณ€์ˆ˜๋“ค์˜ ํƒ์ƒ‰์  ์š”์ธ๋ถ„์„ 16 4.3 ๋ณ€์ˆ˜๋“ค์˜ ํ™•์ธ์  ์š”์ธ๋ถ„์„ ๊ฒฐ๊ณผ 18 4.4 ํŒ๋ณ„ํƒ€๋‹น์„ฑ 21 4.5 ์ „์ฒด ์—ฐ๊ตฌ๋ชจํ˜•์˜ ์ ํ•ฉ๋„ ํ‰๊ฐ€ 24 4.6 ๊ฐ„์ ‘ํšจ๊ณผ ๊ฒ€์ฆ 27 4.7 ์œ„์›Œํฌ, ๋…ผ์Šค์— ๋”ฐ๋ฅธ ์กฐ์ ˆํšจ๊ณผ ๊ฒ€์ฆ 28 ์ œ 5์žฅ ๊ฒฐ๋ก  32 5.1 ๊ฒฐ๋ก  ๋ฐ ์‹œ์‚ฌ์  32 5.2 ์—ฐ๊ตฌ์˜ ํ•œ๊ณ„ 33 ์ฐธ๊ณ ๋ฌธํ—Œ 34 ๋ถ€๋ก 44Maste

    Improvement of Peak Cough Flow After the Application of a Mechanical In-exsufflator in Patients With Neuromuscular Disease and Pneumonia: A Pilot Study

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    OBJECTIVE: To investigate and demonstrate persistent increase of peak cough flow after mechanical in-exsufflator application, in patients with neuromuscular diseases and pneumonia. METHODS: A mechanical in-exsufflator was applied with patients in an upright or semi-upright sitting position (pressure setting, +40 and -40 cmH2O; in-exsufflation times, 2-3 and 1-2 seconds, respectively). Patients underwent five cycles, with 20-30 second intervals to prevent hyperventilation. Peak cough flow without and with assistive maneuvers, was evaluated before, and 15 and 45 minutes after mechanical in-exsufflator application. RESULTS: Peak cough flow was 92.6 L/min at baseline, and 100.4 and 100.7 L/min at 15 and 45 minutes after mechanical in-exsufflator application, respectively. Assisted peak cough flow at baseline, 15 minutes, and 45 minutes after mechanical in-exsufflator application was 170.7, 179.3, and 184.1 L/min, respectively. While peak cough flow and assisted peak cough flow increased significantly at 15 minutes after mechanical in-exsufflator application compared with baseline (p=0.030 and p=0.016), no statistical difference was observed between 15 and 45 minutes. CONCLUSION: Increased peak cough flow after mechanical in-exsufflator application persists for at least 45 minutes.ope

    Precise Pulmonary Function Evaluation and Management of a Patient With Freeman-Sheldon Syndrome Associated With Recurrent Pneumonia and Chronic Respiratory Insufficiency

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    Freeman-Sheldon syndrome (FSS) is a rare distal arthrogryposis syndrome. There are few reports on the respiratory insufficiency of FSS. Additionally, there is no detailed information on pulmonary functional evaluation. A 17-year-old male patient with FSS developed respiratory failure, leading him to be admitted to hospital several times for evaluation and treatment. Of those times he was admitted, two were due to pneumonia. His pulmonary functions were indicative of a restrictive lung disease potentially caused by severe scoliosis. After a non-invasive ventilatorwas applied correctly to the patient, pulmonary hypertension was normalized. His pulmonary function has been maintained for 13 years. Since receiving proper respiratory care, which includes assisted coughing methods, the patient has not developed pneumonia. It is important to properly evaluate the pulmonary function of patients who have FSS and scoliosis to eliminate the risk of long-term respiratory complications.ope

    A new histone deacetylase inhibitor improves liver fibrosis in BDL rats through suppression of hepatic stellate cells

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    BACKGROUND AND PURPOSE: Activation of hepatic stellate cells (HSCs) is a crucial step in the pathogenesis of hepatic fibrosis. Histone deacetylase (HDAC) is an attractive target in liver fibrosis because it plays a key role in gene expression and cell differentiation. We have developed a HDAC inhibitor, N-hydroxy-7-(2-naphthylthio)heptanomide (HNHA), and investigated the anti-fibrotic activity of HNHAโ€…in vitro and in vivo. EXPERIMENTAL APPROACH: We investigated the anti-fibrotic effect of HNHA on mouse and human HSC activation in vitro and in the liver of bile duct-ligated (BDL) rats in vivo using cell proliferation assays, cell cycle analysis, biochemical assay, immunohistochemistry and Western blots. Liver pathology was assessed with histochemical techniques. KEY RESULTS: HNHA inhibited proliferation and arrested the cell cycle via p21 induction in HSCs. In addition, HNHA induced apoptosis of HSCs, which was correlated with reduced COX-2 expression, NF-ฮบB activation and cell death signals. HNHA restored liver function and decreased the accumulation of extracellular matrix in the liver via suppression of HSC activation in BDL rats in vivo. HNHA administration also increased survival in BDL rats. CONCLUSIONS AND IMPLICATIONS: HNHA improved liver function, suppressed liver fibrosis and increased survival of BDL rats, accompanied by reduction of cell growth, activation and survival of HSCs. These findings show that HNHA may be a potent anti-fibrosis agent against hepatic fibrosis because of its multi-targeted inhibition of HSC activity in vivo and in vitro.ope

    THE EFFECT OF TOPICAL APPLICATION WITH STEROID AND CYCLOSPORINE ON ORAL LICHEN PLANUS PATIENTS

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    The purpose of this study was comparing the effectiveness in the topical applications of cyclosporine with that of steroid, the conventional and standard drug in the treatment of oral lichen planus. 21 patients with oral lichen planus were treated with cyclosporine (n=11) or steroid (n=10) by random allocations. They were recalled 2 weeks, 4 weeks, and 8 weeks after initial treatments. In each recall, the lesion size, clinical symptoms like pain or burning sensation, and side effects were evaluated. The differences of these measurements were compared and the effects of each drug were checked. In reticulation types, steroid showed higher effectivity than cyclosporine and this difference was significant statistically. But in erythema type lesions, either drug showed no significant recovery, statistically. However, the effect of cyclosporine was thought to be more effective. The pain of the lesions was significantly decreased by cyclosporine but not by steroid. The decrease of burning sensation was more dependant upon steroid than cyclosporine, but no statistical relationship could be found. There were no clinical side effects. There was limitation to draw in conclusion due to small pool of this study group. But with the results, this suggestion could be proposed that either drug might be superior to another in effectivity in a specific lesion type or patient symptom, so selection and usage of one drug in a specific case could be better than universal application of one drug in all cases.์„œ์šธ๋Œ€ํ•™๊ต๋ณ‘์› ์ผ๋ฐ˜์—ฐ๊ตฌ๊ณผ

    ็ƒŸๅฎข ่จฑไฝ– ๆ›ธ็•ต ็ก็ฉถ

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    ํ•™์œ„๋…ผ๋ฌธ(์„์‚ฌ)--์„œ์šธ๋Œ€ํ•™๊ต ๋Œ€ํ•™์› :๊ณ ๊ณ ๋ฏธ์ˆ ์‚ฌํ•™๊ณผ ๋ฏธ์ˆ ์‚ฌํ•™์ „๊ณต,2004.Maste
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