평판 익단 간극의 누설유동에 관한 실험적 연구

학위논문(석사)--서울대학교 대학원 :기계항공공학부,2002.학위논문(석사)-

(A) study of the relationship between body image and depression in patients with vitiligo

보건간호학과/석사[한글] 본 연구는 백반증환자와 일반피부질환자, 백반중 발생전파 후, 백반증 이환부위별 신체 상의 우울정도를 파악하고, 백반증환자의 신체상과 우울과의 관계를 규명하기 위해 시도 된 상관관계 및 환자-대조 연구이다. 연구대상은 1개 대학병원 피부과에서 백반증� 37명과 일반피부질환자 37명을 편의추출 하여 74명을 대상으로 하였으며, 조사기간은 1989년 4월 17일부터 5월 13일까지의 24일간 이었다. 연구도구로는 신체상을 측정하기 위해 박정모가 개발한 신체의미측정도구를 사용 하였으며, 우울을 측정하기 위해서는 Beck의 Depression Inventory를 사용하였다. 수집된 자료를 분석하기 위하여 백반증환자와 일반피부질환자의 일반적인 특성은 실수 와 백분율, X^^2-test를 사용하였고, 백반증환자와 일반피부질환자의 신체상과 우울정도, 백반증 발생전·후와 이환부위별 신체상은 t - test를, 백반증환자의 신체상과 우울정도 와의 상관관계에 대한 가설검정은 Pearson's product correlation coefficient를 사용하 였다. 대상자의 신체상과 우울정도는 평균점수와 표준편차, 최대값, 최소값을 구하였고, 백반증환자의 신체상 및 우울정도와 일반적 특성과의 관계는 t - test, ANOVA를 사용하여 분석하였다. 본 연구의 결과는 다음과 같다. 1. 제1가설, "백반증환자의 신체상이 일반피부질환자의 신체상보다 낮을 것이다."는 지지되었다(t=6.36, P<0.01). 2. 제2가설, "백반증환자의 우울정도가 일반피부질환자의 우울정도보다 높을 것이다. "는 지지되었다(t=5.97, P<0.01). 3. 제3가설, "백반증환자의 신체상이 낮을수록 우울정도는 높을 것이다."는 기각되었 다(r=-.2244, p>0.05). 4. 제4가설, "백반증 발생이전의 신체상보다 백반증 발생이후의 신체상이 더 낮을 것 이다."는 지지되었다(t=5.51, P<0.01). 5. 제5가설, "노출부위에 이환된 백반증환자의 신체상이 비노출부위에 이환 된 백반 증환자의 신체상보다 낮을 것이다."는 지지되었다((t=4.22, P<0.01). 6. 백반증환자의 일반적 특성과 신체상과의 관계에서는 성별, 연령, 결혼상태, 종교, 학력, 경제상태, 백반증 이환기간별로 유의한 차이가 없었다. 7. 백반증환자의 일반적 특성과 우울정도와의 관계에서는 성별에서만 유의한 차이가 있었으며, 연령, 결혼상태, 종교, 학력, 겅제상태, 백반증 이환기간별로는 유의한 차이가 없었다. 이 연구의 결과를 종합해 볼 때, 백반증환자는 일반피부질환자보다 신체상이 낮고 우 울정도가 높았으며, 백반증 발생이전보다 발생이후의 신체상이 낮고, 비노출부위보다 노 출부위에 이환된 백반증환자의 신체상이 더 낮았으나, 백반증환자의 신체상과 우울정도는 관련성이 없었다. [영문] This correlational and case-control study was undertaken in order to examine if there was a difference in body image and depression between patients with vitiligo and patients with mild skin disorders, between patients with vitiligo before onset and after inset, between patients with vitiligo on body site that is visible and on a body site that is non-visible, and if there was a relationship between body image and depression in patients with vitiligo. Thirty seven patients with vitiligo and 37 patients with mild skin disorders were selected from the skin department of one university hospital for this study. The sampling used was a non-probability, convenient sampling technique. Data were collected by means of a questionnaire and the study was carried out from April 17 to May 13, 1989. The instruments used for this study were the Body Meaning Scale developed by Park and the Beck Depression Inventory by Beck. Analysis for data was done using percentages, frequencies, means, standard deviations, Pearson's product correlation coefficient, X^^2-test, t-test and ANOVA. The findings of this study were as follows: 1. The first hypothesis,"The body image score for patients with vitiligo will be lower than for those with mild skin disorder." was supported (t=6.36, p<0.01). 2. The second hypothesis, "The depression level for patients with vitiligo will be higher than for those with mild skin disorders."was supported(t=5.97, p<0.01). 3. The third hypothesis, "The lower the body image score, the higher the depression level for patients with vitiligo." was rejected(r= -.2244, P > 0.05). 4. The fourth hypothesis, "The body image score for after onset of vitiligo will be lower than for before onset."was supported(t=5.51, p<0.01). 5. The fifth hypothesis, "The body image score for vitiligo on visible body sites will be lower than for non-visible body sites." was supported(t=4.22, p<0.01). 6. There was no significant difference between demographic factors and the body image score in patients with vitiligo. 7. There was no significant difference between demographic factors except sex and the depression level in patients with vitiligo. In conclusion, the body image score for patients with vitiligo was lower than for those with mild skin disorders, the depression level for patients with vitiligo was higher than for those with mild skin disorders, and the body image score for after onset or for visible body sites for vitiligo was lower than for before onset or for non-visible sites. There was no relationship between body image and depression in patients with vitiligo.restrictio

Scaffold상에 식립한 사람치주인대섬유모세포를 통한 치주조직공학

Human periodontal ligament fibroblasts (hPDLF) are very important for curing the periodontal tissue because they can be differentiated into various cells. A tissue engineering approach using a cell-scaffold is essential for comprehending today's periodontal tissue regeneration procedure. This study examined the possibility of using an acellular dermal matrix as a scaffold for human periodontalligament fibroblast (hPDLF). The hPDLF was isolated from the middle third of the root of periodontally healthy teeth extracted for orthodontic reasons. The cells were cultured in a medium containing Dulbecco's modified Eagle medium supplemented with 10% fetal bovine serum at in humidified air with 5% . The acellular dermal matrix(ADM) was provided by the US tissue banks(USA). Second passage cells were used in this study. The hPDLF cells were cultured with the acellular dermal matrix for 2 days, and the dermal matrix cultured by the hPDLF was transferred to a new petri dish and used as the experimental group. The control group was cultured without the acellular dermal matrix, The control and experimental cells were cultured for six weeks. The hPDLF cultured on the acellular dermal matrix was observed by Transmission Electron microscopy (TEM). Electron micrography shows that the hPDLF was proliferated on the acellular dermal matrix. This study suggests that the acellular dermal matrix can be used as a scaffold for hPDLF.이 논문은 2005년 정부(교육인적자원부)의 재원으로 한국학술진흥재단의 지원을 받아 수행된 연구입니다