43 research outputs found
ํจ๊ณผ์ ์ฐ๋ถ์กฐ์ง ์ฌ๊ฑด์ ์ํ ๋์ข ์ง๋ฐฉ๊ธฐ์ง ๋ฐ ์์ฐํ๋ง๊ทธ๋ค์ ํจ์ ํด๋ฆฌ(๋ฝํฑ-์ฝ-๊ธ๋ฆฌ์ฝ์ฐ) ๋ฏธ๋ฆฝ๊ตฌ๋ฅผ ์ด์ฉํ ์ง๋ฐฉ์ด์์
ํ์๋
ผ๋ฌธ(๋ฐ์ฌ) -- ์์ธ๋ํ๊ต๋ํ์ : ์๊ณผ๋ํ ์ํ๊ณผ, 2022. 8. ์ด์ ์ฐฌ.Autologous fat grafting is one of the most common procedures used in plastic surgery to correct soft tissue deficiency or depression deformity. However, its clinical outcomes are often suboptimal, and lack of metabolic and architectural support at recipient sites affects fat graft survival leading to complications such as cyst formation and calcification. Extracellular matrix (ECM)-based scaffolds, such as allograft adipose matrix (AAM) and poly (lactic-co-glycolic acid) (PLGA), have shown exceptional clinical promise as regenerative scaffolds. AAM is composed of the extracellular matrices of adipose tissue through decellularization. Additionally, PLGA is one of the most commonly used biopolymers owing to its biodegradability for tissue regenerations. Magnesium hydroxide (MH), an alkaline ceramic, has attracted attention as a potential additive to improve biocompatibility. Magnesium hydroxide (MH) could neutralize the acidic microenvironment induced by the acidic decomposed products of PLGA, thereby suppressing undesirable inflammatory reactions. We attempted to combine fat graft with injectable regenerative scaffolds: natural (AAM) and synthetic (PLGA/MH microspheres). We investigated the volume changes and viability of injected fat graft in relation to the effects of biomaterials. In this study, a comparison of the volume retention effect and angiogenic ability in vivo between autologous fat grafting, injectable natural (AAM), and synthetic (PLGA/MH microsphere) biomaterials will provide a reasonable basis for fat grafting. And by using PLGA/MH microsphere, we could overcome the disadvantages of conventional PLGA scaffolds and effectively improve fat retention rate with complex biological functions.1. Introduction 1
2. Materials and Methods 5
Materials 5
Fabrication of the PLGA microspheres 5
Scaffold characterization and in vitro degradation test 6
Cell cytotoxicity assay 6
In vitro wound healing assay 7
Quantitative real-time PCR 7
Fat preparation 8
Allograft adipose matrix preparation 8
Animal study 8
Histological analysis 9
Statistical analysis 10
3. Results and Discussion 10
Scaffold fabrication and characterization 10
In vitro biocompatibility and anti-inflammatory effect of scaffold 11
Wound healing and angiogenic effect of the scaffold 14
Volume retention effect of the scaffold for fat grafting survival 15
In vivo evaluation of the scaffold for fat grafting survival 17
4. Conclusions 19
References 21
Abstract 26
Acknowledgements 28๋ฐ
A Study on Development of Hydrographic Data Measurement and Analysis System Based on ENC
The data resulted from hydrographical survey are very important for both marine research institute and dredgers. These data include information about depths, tides and currents, quality of the bottom and so on. It is very difficult to get those data easily since the task to get those data costs a great deal of money and efforts.
This study proposed a method to develop a hydrographic survey and analysis system. In order to make the system low-costed, the proposed method includes an electronic navigational chart (ENC) and single-beam echo sounder. ENC is useful tools to display the locations and the soundings of surveyed area, and the single-beam echo sounder was adopted due to its low price and high accuracy characteristics.
This study shows the results of survey carried out by the proposed system, and also verifies its effectiveness in both accuracy and cost.
With the proposed system, there are advantages for users to get and check the submarine topographic data simultaneously. And also the system has several advantages so as that the persons concerned dredging works understand and learn easily how to operate and use the system, how to deal with and how to analyze the surveyed data.์ 1์ฅ ์๋ก = 1
1.1 ์ฐ๊ตฌ ๋ฐฐ๊ฒฝ ๋ฐ ๋ชฉ์ = 1
1.2 ๋
ผ๋ฌธ ๊ตฌ์ฑ = 4
์ 2์ฅ ํด์ ์์ฌ์ ๋ณด ์์คํ
ํํฉ ๋ฐ ๋ถ์ = 5
2.1 ํด์ ์์ฌ์ ๋ณด ์์คํ
์ ์ ์ = 5
2.2 ํด์ ์์ฌ์ ๋ณด ์์คํ
์ ํํฉ = 6
2.2.1 ๋จ๋น์ํฅ์ธก์ฌ๊ธฐ (Single Beam Echo Sounder) = 6
2.2.2 ์ธก๋ฉด์ฃผ์ฌ์ํํ์ง๊ธฐ (Side Scan Sonar) = 7
2.2.3 ๋ฉํฐ๋น ์ํฅ ์ธก์ฌ๊ธฐ (Multi Beam Echo Sounder) = 9
2.2.4 ํ ํด์ ์์ฌ์ ๋ณด ์์คํ
์ ํ๊ฐ = 11
2.3 ํด์ ์์ฌ์ ๋ณด์์คํ
์ ๊ฐ์ ๋ฐฉ์ = 14
์ 3์ฅ ENC๊ธฐ๋ฐ์ ํด์ ์์ฌ์ ๋ณด ๊ณ์ธก ๋ฐ ๋ถ์ ์์คํ
๊ฐ๋ฐ = 16
3.1 ์์คํ
์ ๊ฐ์ ๋ฐ ๊ตฌ์ฑ = 16
3.1.1 ๊ฐ์ = 16
3.1.2 H/W ๊ตฌ์ฑ = 18
3.1.3 S/W์ ๊ตฌ์ฑ = 28
3.2 ์์คํ
๊ฐ๋ฐ ๋ด์ฉ = 33
3.2.1 ENC๊ธฐ๋ฐ์ ํด์ ์์ฌ์ ๋ณด ๊ณ์ธก S/W ๊ฐ๋ฐ = 33
3.2.2 ENC๊ธฐ๋ฐ์ ํด์ ์์ฌ์ ๋ณด ๋ถ์ S/W ๊ฐ๋ฐ = 44
3.3 ์คํ ๋ฐ ๊ณ ์ฐฐ = 53
3.3.1 ํ์ฅ ์คํ ๊ฐ์ = 53
3.3.2 ํ์ฅ ์คํ ๋ด์ฉ = 54
3.3.3 ํ์ฅ ์คํ ๊ฒฐ๊ณผ ๋ฐ ํ๊ฐ = 58
์ 4์ฅ ๊ฒฐ๋ก = 62
4.1 ์ฐ๊ตฌ์ ๊ฒฐ๊ณผ = 62
4.2 ์์คํ
์ ํฅํ ์ฐ๊ตฌ๋ฐฉํฅ = 64
์ฐธ๊ณ ๋ฌธํ = 6
Implementation and Analysis of Graphic User Interface Systems for Shipbuilding Modeling & Simulation Environment
This paper describes the development of graphic user interface (GUI) systems for the visualization of graphical results of engineering analyses or performance.
Three representative computer graphic libraries, OpenGL, OpenCASCADE, and OpenGL Performer, are selected based on their performance and functionalities. Those libraries are integrated to Microsoft Foundation Class (MFC) to form a graphic window frame. Advantages and disadvantages of each GUI system are discussed to suggest a way to choose an appropriate graphic library suitable to a specific visualization purpose.
The performance of the constructed GUI systems are analyzed with respect to their rendering capability. A complicated geometric model and its sub models are adopted for rendering with the standard data formats such as IGES, STEP, as well as other formats used in popular CAD systems. The results of rendering performance verifies the known capability of the graphic libraries.1.์ ๋ก 1
1.1 ์ฐ๊ตฌ ๋ฐฐ๊ฒฝ 2
1.2 ์ฐ๊ตฌ ๋ชฉ์ 2
1.3 ์ฐ๊ตฌ ๋ด์ฉ 2
2.๊ทธ๋ํฝ ๋ผ์ด๋ธ๋ฌ๋ฆฌ ๋ฐ API 3
2.1 OpenGL 3
2.1.1 OpenGL์ ๊ตฌ์ฑ 3
2.1.2 OpenGL API 4
2.2 OpenCASCADE 7
2.2.1 OpenCASCADE์ ๊ตฌ์ฑ 7
2.2.2 OpenCASCADE API 8
2.3 OpenGL Performer 11
3. ๊ทธ๋ํฝ ๋ผ์ด๋ธ๋ฌ๋ฆฌ ๊ธฐ๋ฐ GUI ์์คํ
๊ตฌํ 13
3.1 Microsoft Foundation Class 13
3.2 OpenGL ๊ธฐ๋ฐ GUI ์์คํ
14
3.2.1 OpenGL ๊ธฐ๋ฐ GUI ์์คํ
๊ตฌ์ฑ 14
3.2.2 WGL 14
3.2.3 PIXELFORMATEDSCRITOR 15
3.2.4 ํ์ 16
3.3 OpenCASCADE ๊ธฐ๋ฐ GUI ์์คํ
18
3.3.1 OpenCASCADE ๊ธฐ๋ฐ GUI ์์คํ
๊ตฌ์ฑ 18
3.3.2 OpenCASCADE ๊ธฐ๋ฐ GUI ์์คํ
์ ๊ธฐ๋ณธ์ ์ธ ํ๋ ์ ๊ตฌ์ฑ 19
3.4 OpenGL Performer ๊ธฐ๋ฐ GUI ์์คํ
20
3.4.1 OpenGL Performer ๊ธฐ๋ฐ GUI ์์คํ
๊ตฌ์ฑ 20
3.4.2 OpenGL Performer ๊ธฐ๋ฐ ๋ ๋๋ง ๊ตฌ์ฑ 20
3.4.3 OpenGL Performer ๊ธฐ๋ฐ GUI ์์คํ
ํ๋ ์ 22
3.5 GUI ์์คํ
์ ๋น๊ต ๋ฐ ๋ถ์ 24
4. GUI ์์คํ
๋ ๋๋ง ์ฑ๋ฅ ํ
์คํธ 26
4.1 ํ
์คํ
ํ๋ซํผ ์ธํ
27
4.2 GUI ์์คํ
๋ ๋๋ง ์ฑ๋ฅ ํ
์คํธ 27
4.2.1 OpenGL ๊ธฐ๋ฐ GUI ์์คํ
๋ ๋๋ง ์ฑ๋ฅ ํ
์คํธ 33
4.2.2 OpenGL Performer ๊ธฐ๋ฐ GUI ์์คํ
๋ ๋๋ง ์ฑ๋ฅ ํ
์คํธ 33
4.2.3 OpenGL ๊ธฐ๋ฐ GUI ์์คํ
๊ณผ OpenGL Performer ๊ธฐ๋ฐ GUI ์์คํ
์ ... 34
5. ๊ฒฐ ๋ก 36
์ฐธ ๊ณ ๋ฌธ ํ 3
Cognitive dysfunction after valvular heart surgery
์ํ๊ณผ/์์ฌ[ํ๊ธ]์ฐ๊ตฌ๋ฐฐ๊ฒฝ: ์ฌ์ฅ ์์ ํ์ ์ ๊ฒฝํ์ ์ฅ์ ๋ ์์ง๊น์ง๋ ๊ทธ ๋ฐ์๋น๋๊ฐ ๋์ผ๋ฉฐ ์์ ํ ํ๋ณต์ฅ์ ์ ๊ฐ์ฅ ์ค์ํ ์์ธ์ด๋ค. ๋ณธ ์ฐ๊ตฌ์์๋ ํ๋ง์งํ์ผ๋ก ์ฌ์ฅ ์์ ์ ๋ฐ๋ ํ์์์ ํ๋ง์์ ํ ์ธ์ง๊ธฐ๋ฅ ์ฅ์ ์ ๋ฐ์๋น๋๋ฅผ ์์๋ณด๊ณ , ์์ ์ค ๋์ฐ์ํฌํ๋์ ๋ณํ์ ์์ ํ ์ธ์ง๊ธฐ๋ฅ์ฅ์ ์ ์ฐ๊ด์ฑ์ ์์๋ณด๊ณ ์ ํ์๋ค.๋์ ๋ฐ ๋ฐฉ๋ฒ: ์ฌ์ฅ ํ๋ง์์ ์ด ๊ณํ๋ 69๋ช
์ ๋์์ผ๋ก ์ฐ๊ตฌ๋ฅผ ์งํํ์๋ค. ์ธ์ง๊ธฐ๋ฅ ๋ณํ๋ MMSE (mini-mental state exam), Trail-Making Test (Part A)์ Grooved Pegboard Test์ 3๊ฐ์ง ์ธ์ง๊ธฐ๋ฅ ๊ฒ์ฌ๋ฅผ ์์ 1์ผ ์ ๊ณผ ์์ 7์ผ ํ ์ํํ์ฌ ์ธก์ ํ์์ผ๋ฉฐ, ์์ ์ ์ธก์ ์น ๋ณด๋ค ์์ 7์ผ ํ ์ธก์ ์น๊ฐ 20% ์ด์ ๋๋น ์ง ๊ฒฝ์ฐ๋ฅผ ์ธ์ง๊ธฐ๋ฅ์ฅ์ ๋ก ์ ์ํ์๋ค. ํ์ญํ ๋ณ์ ์ธก์ ๋ฐ ๋๋งฅํ ๊ฐ์ค ๋ถ์์ ํ์ฌ ๊ธฐ๋กํ์์ผ๋ฉฐ ๋์ฐ์ํฌํ๋๊ฐ 50% ์ดํ, 40% ์ดํ๋ก ๋จ์ด์ง ๊ธฐ๊ฐ ๋๋ ๋ง์ทจ ์ ๋ ์งํ ์ธก์ ์น์ 80% ์ดํ๋ก ๋จ์ด์ง ๊ธฐ๊ฐ์ ์ธก์ ํ์ฌ ๊ธฐ๋กํ์๋ค.๊ฒฐ๊ณผ: ์์ ํ ์ธ์ง๊ธฐ๋ฅ์ ์ฅ์ ๋ Trail-Making Test (Part A)์์ 8๋ช
, Grooved Pegboard Test์์ 4๋ช
, ๋ ๊ฒ์ฌ ๋ชจ๋์์ 2๋ช
์ ํ์๊ฐ ์ฅ์ ๋ฅผ ๋ํ๋ด์ด ์ด 14๋ช
(24%)์ ํ์์์ ๋ํ๋ฌ๋ค. MMSE ๊ฒ์ฌ์์ ์์ ์ ๋ณด๋ค 20%์ด์ ๋๋น ์ง ํ์๋ ์์๋ค. ๋์ฐ์ํฌํ๋๊ฐ ์ ์ํ ์์ค ์ดํ๋ก ๊ฐ์ํ ๋น๋์ ๊ธฐ๊ฐ ๋ชจ๋ ์ธ์ง๊ธฐ๋ฅ ์ฅ์ ๊ฐ ๋ํ๋์ง ์์ ๊ตฐ๊ณผ ๋ํ๋ ๊ตฐ ๊ฐ์ ์ ์ํ ์ฐจ์ด๋ ์์๋ค.๊ฒฐ๋ก : ์ฌ์ฅํ๋ง ์์ ํ ์ธ์ง๊ธฐ๋ฅ์ฅ์ ์ ๋ฐ์๋น๋๋ ๊ณผ๊ฑฐ ๊ด์๋๋งฅ์ฐํ์ ์ ์ํ ๋ฐ๋ ํ์๋ค์์ ๋ณด๊ณ ๋ ๊ฒ์ ๋นํ์ฌ ๋ฎ์์ผ๋ฉฐ, ๋์ฐ์ํฌํ๋๋ ์ธ์ง๊ธฐ๋ฅ์ฅ์ ์ ๋ฐ์๊ณผ ๋ฐ์ ํ ์๊ด๊ด๊ณ๊ฐ ์๋ ๊ฒ์ผ๋ก ๊ด์ฐฐ๋์๋ค.
[์๋ฌธ]Background: Postoperative cognitive dysfunction commonly develops after cardiac surgery and often persists after several years. Unlike in congenital heart surgery or coronary artery bypass surgery, little has been studied about the cognitive dysfunction in valvular hear surgery. Cerebral oximetry noninvasively measures regional cerebral oxygen saturation (rSO2) and a number of studies have demonstrated a significant correlation between changes in intraoperative rSO2 values and postoperative cognitive dysfunction. We, therefore, investigated the incidence of early postoperative cognitive dysfunction and its relationship with intraoperative rSO2 values in patients undergoing valvular heart surgery.Method: Sixty-nine patients undergoing elective valvular heart surgery without preexisting neurological disease were enrolled. Neurocognitive evaluation was performed with Mini-Mental State Exam (MMSE), Trail-Making Test (Part A), and Grooved Pegboard Test at 1 day before surgery and 7th postoperative day. Cognitive dysfunction was defined as 20% decrease in individual test scores compared to preoperative scores. During surgery, rSO2 was continuously monitored and the incidence and duration of decrease in rSO2 values were recorded as follows; 1) decrease in absolute rSO2 values to less than 50% and 2) 40% and 3) a 20% decrease compared to baseline value, which are regarded as clinically significant.Results: Fourteen patients (24%), 8 at Trail-Making Test (Part A), 4 at Grooved Pegboard Test, and 2 at both tests, demonstrated postoperative cognitive dysfunction. However, no one showed dysfunction at MMSE. The incidence and duration of decrease in rSO2 values below the predefined 3 cutoff values were not associated with the incidence of cognitive dysfunction. In addition, they were also similar between patients with and without cognitive dysfunction.Conclusion: The incidence of postoperative cognitive dysfunction in valvular heart surgery was about 20% in this study, which was lower than the values previously reported in coronary artery bypass graft surgery. Changes in rSO2 during surgery was not predictive for postoperative cognitive performance in patients undergoing valvular heart surgery.ope
์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋ ๋์ ํจ๊ณผ ์ฐ๊ตฌ
ํ์๋
ผ๋ฌธ (์์ฌ)-- ์์ธ๋ํ๊ต ํ์ ๋ํ์ : ๊ณต๊ธฐ์
์ ์ฑ
ํ๊ณผ, 2015. 8. ๊ถ์ผ์
.์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋๋ ๋ฐ์ฃผ์์ ๊ณ์ฝํ๋ ์๊ธ์ธ์ด 2์ธ ์ด์์ธ ๊ณต๋๋๊ธ์ ๋์ ์ผ์ข
์ผ๋ก์, ์ข
ํฉ๊ฑด์ค์
์ฒด์ ์ ๋ฌธ๊ฑด์ค์
์ฒด๊ฐ ์ปจ์์์์ ๊ตฌ์ฑํด ์๋๊ธ๊ณ์ฝ์๋ก ํจ๊ป ์ฐธ์ฌํ๋ ๊ณ์ฝ ๋ฐฉ์์ด๋ค. ์ ๋ถ๋ ์ด ์ ๋๊ฐ ํ๋๊ธ ๋ณํ์ ๊ทผ๋ณธ์ ์ธ ํด๊ฒฐ๋ฐฉ์์ผ๋ก์ ํ์งํฅ์๊ณผ ์์ฅ์ฐธ์ฌ์์ ์์ํ๋ ฅ์ ํจ๊ณผ์ ์ผ ๊ฒ์ผ๋ก ๊ธฐ๋ํ๊ณ ์ ๊ทน์ ์ผ๋ก ํ๋์ํ ์ค์ด๋ค. ๊ทธ๋ฌ๋ ์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋๋ฅผ ๋๋ฌ์ผ ์ด๊ฒฌ์ ๋งค์ฐ ๋ถ๋ถํ ์ค์ ์ด๋ค. ์ ๋ถ์ ์ ๋ฌธ๊ฑด์ค์
๊ณ๋ ์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋๊ฐ ๊ฑด์ค์ฐ์
์ ๋ฐ์ ์ ์ ๋ํ๊ณ ์?ํ๋๊ธ์๊ฐ์ ๋ถ๊ณต์ ๊ฑฐ๋๋ฅผ ํด์์์ผ ์ฃผ๋ ์ ๋๋ผ๊ณ ์ฃผ์ฅํ๋ ๋ฐ๋ฉด ์ข
ํฉ๊ฑด์ค์
๊ณ๋ ๊ฑด์คํ์ฅ์์ ์ฃผ๊ณ์ฝ์์ ์๊ณต๊ด๋ฆฌ์ ๋ํ ์กฐ์ ๊ถํ์ด ์ฝํ๋๊ณ ์ ๊ธฐ์ ํ๋ ฅ์ ๊ธฐ์ดํ ๊ณต์ฌ ์ํ์ด ๊ณค๋ํ์ฌ ์คํจ๊ฐ ์๋ค๋ ์
์ฅ์ ๊ฒฌ์งํ๊ณ ์๋ค. ๋ณธ ์ฐ๊ตฌ๋ ์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋์ ๋์
์ ๋ฐ๋ฅธ ํจ๊ณผ๋ฅผ ์ค์ฆ์ ์ผ๋ก ๋ถ์ํด๋ณด๊ณ ์ ํ์๋ค. ์ด๋ฅผ ์ํ์ฌ ์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋ ๋์
์ฌ๋ถ๋ฅผ ๋
๋ฆฝ๋ณ์๋ก, ์ฒด๋ถ๋น๋, ๊ณต์ฌํ์ง, ํ๋๊ธ์ ์ ํฌ๋ช
์ฑ, ์กฐ์ง๊ตฌ์ฑ ํจ์จ์ฑ์ ์ข
์๋ณ์๋ก ์ค์ ํ์์ผ๋ฉฐ ๋ถ์ ๊ฒฐ๊ณผ๋ ์๋์ ๊ฐ๋ค.
์ฒซ์งธ, ์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋๋ ๋
ธ๋ฌด๋น, ์ฅ๋น๋น, ์์ฌ๋น ๋ฑ ๊ธฐํ ์ฒด๋ถ๋น๋๋ฅผ ์ค์ด๋ ๋ฐฉํฅ์ผ๋ก ์ํฅ์ ์ฃผ๊ณ ์๋ ๊ฒ์ผ๋ก ๋ํ๋ฌ๋ค. ์ด๋ ๋ถ๊ณ์ฝ์์ธ ์ ๋ฌธ๊ฑด์ค์
์ฒด์ ๊ณต์ฌ๋๊ธ์ด ์ ๊ธฐ ์ง๊ธ๋๋ฉด 2์ฐจ ํ๋๊ธ์์๊ฒ ์ง๊ธ๋๋ ๊ฐ์ข
๋น์ฉ๋ ์ ๊ธฐ ์ง๊ธ๋๋ ์ ์ํ ๊ณผ์ ์ด ์ผ์ด๋๊ฒ ๋๊ธฐ ๋๋ฌธ์ธ ๊ฒ์ผ๋ก ๋ถ์๋๋ค.
๋์งธ, ์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋๊ฐ ๋์
๋ ๊ฒฝ์ฐ ํ์/์ฌ์๊ณต ๋น๋๋ ์ค์ด๋ค๊ณ ๊ฑด์ค์ฐธ์ฌ์๊ฐ ๋๋ผ๋ ํ์ง์ ๋ํ ๋ง์กฑ๋๋ ๋์์ง๋ ๊ฒ์ผ๋ก ๋ํ๋ฌ๋ค. ์ด๋ ์ ๋ฌธ๊ฑด์ค์
์ฒด๊ฐ ๋ฐ์ฃผ์์ ์ง์ ๊ณ์ฝํจ์ผ๋ก์จ ํ๋๊ธ ๊ณผ์ ์์ ๋ฐ์ํ๋ ๊ณต์ฌ๋น ๊ฐ์ ์์ด ์ ์ ๊ณต์ฌ๋น๋ฅผ ํ๋ณดํ ์ ์๊ณ , ์ด๋ฅผ ํตํด ํ์ง์ด ์ข์์ง๋ค๋ ์ฃผ์ฅ์ ๋ท๋ฐ์นจํ๋ค.
์
์งธ, ์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋๊ฐ ํ๋๊ธ์ ์ ์ ํฌ๋ช
์ฑ์ ๋ฏธ์น๋ ์ํฅ์ ์ ์๋ฏธํ์ง ์์ ๊ฒ์ผ๋ก ๋ํ๋ฌ๋ค. ์ด๋ ๊ณ์ฝ ํํ์ ๊ด๊ณ์์ด ๋๋ถ๋ถ ํ๋๊ธ ์ ์ ์ด ํฌ๋ช
ํ๊ฒ ์ด๋ฃจ์ด์ง๊ธฐ ๋๋ฌธ์ผ๋ก ์ถ์ ๋๋ค.
๋ท์งธ, ์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋์ ๋์
์ ํ์ฅ ์กฐ์ง๊ตฌ์ฑ ํจ์จ์ฑ์ ์ฆ๊ฐ์ํค๋ ๊ฒ์ผ๋ก ๋ํ๋ฌ๋ค. ๋ํ ์ ๋ฌธ๊ฑด์ค์
์ฒด ์ง์์ ์
๋ฌด์ํ๋ฅ๋ ฅ๊ณผ ์
๋ฌด์์ธ/์ฑ
์์์ ์์ค, ๊ฑด์ค์ฐธ์ฌ์์ ์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋ํ ์ ์ฑ
์ดํด๋์ ์์ฉ์ฑ์ด ์ด ํจ๊ณผ๋ฅผ ์ฆ๋์ํค๋ ์กฐ์ ํจ๊ณผ๊ฐ ์๋ ๊ฒ์ผ๋ก ๋ถ์๋์๋ค.
์ด๋ฌํ ์ฐ๊ตฌ๊ฐ ๊ฐ์ง๋ ์์ฌ์ ์ ๋ค์๊ณผ ๊ฐ๋ค.
์ฒซ์งธ, ๊ตญ๋ด ์ต๋ ๊ฑด์ค ๊ณต๊ธฐ์
์ธ ํ๊ตญํ ์ง์ฃผํ๊ณต์ฌ๋ฅผ ์ฐ๊ตฌ ๋์์ผ๋ก ํจ์ผ๋ก์จ ๊ฑด์ค ํ๋๊ธ๊ณผ ๊ด๋ จํ ๋ํ์ ์ธ ๊ฑด์ค ์ ์ฑ
์ ๋ํด ์ ์ฉํ ์ฐ๊ตฌ ๊ฒฐ๊ณผ๋ฅผ ์ ์ํ์๋ค.
๋์งธ, ์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋์ ๋ํ ๊ฑด์ค์
๊ณ์ ์ฐฌ๋ฐ ์
์ฅ์ด ์๊ฐ๋ฆฌ๋ ์ํฉ์์ ์ต๋ํ ์ค๋ฆฝ์ ์ด๊ณ ๊ฐ๊ด์ ์ธ ์๊ฐ์์ ๋ถ์ํ๊ณ ์ ํ์๋ค.
์
์งธ, ๊ทธ๋์ ์ ๋๊ฐ์ ์ด๋ ์ฌ๋ก๋ถ์ ์์ฃผ์ ์ฐ๊ตฌ์์ ๋ฒ์ด๋ ํต๊ณ๋ถ์์ ํตํ ๊ณผํ์ ๋ฐฉ๋ฒ์ผ๋ก ์ ๋์ ํจ๊ณผ๋ฅผ ์ค์ฆ์ ์ผ๋ก ๋ถ์ํ๊ณ ์ ํ์๋ค.
๋ท์งธ, ์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋๊ฐ ๋ฏธ์น๋ ์ํฅ์ ์์ด ์ ๋ฌธ๊ฑด์ค์
์ฒด ์ง์์ ์
๋ฌด์ํ๋ฅ๋ ฅ๊ณผ ์
๋ฌด์์ธ/์ฑ
์์์, ๊ทธ๋ฆฌ๊ณ ๊ฑด์ค ์ฐธ์ฌ์์ ์ ์ฑ
์ ๋ํ ์ดํด๋์ ์์ฉ์ฑ์ด ๋งค์ฐ ์ค์ํ๋ค๋ ์ ์ฑ
์ ์์ฌ์ ์ ๋์ถํ์๋ค.๋ชฉ ์ฐจ
์ 1 ์ฅ ์๋ก 1
์ 1 ์ ์ฐ๊ตฌ์ ๋ชฉ์ ๋ฐ ํ์์ฑ 1
์ 2 ์ ์ฐ๊ตฌ๋์ ๋ฐ ๋ฒ์ 7
์ 2 ์ฅ ์ด๋ก ์ ๋ฐฐ๊ฒฝ ๋ฐ ์ ํ์ฐ๊ตฌ 8
์ 1 ์ ์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋์ ๋ํ ์ดํด 8
1. ๊ฑด์ค์์ฐ ์ฒด๊ณ์ ํน์ง 8
2. ์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋์ ๊ฐ๋
9
3. ์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋์ ๋์
๋ฐฐ๊ฒฝ ๋ฐ ์ถ์ง๊ฒฝ๊ณผ 12
4. ์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋์ ์ฃผ์๋ด์ฉ 14
5. ์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋ ์ ํ์ฐ๊ตฌ 15
์ 2 ์ ์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋์ ๊ธฐ๋ํจ๊ณผ 18
1. ๋ถ๋ฒ, ๋ถ๊ณต์ ํ๋๊ธ ํ์ ๊ณ ์ฐฐ 18
2. ์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋ ๊ธฐ๋ํจ๊ณผ 19
์ 3 ์ ํ์ฅ ์กฐ์ง๊ตฌ์ฑ์ ํจ์จ์ฑ 20
1. ๊ฑด์ค๊ณต์ฌ ์กฐ์ง 20
2. ํํธ๋๋ง 20
3. ์ ํ์ฐ๊ตฌ 24
4. ํ์ฅ ์กฐ์ง๊ตฌ์ฑ ํจ์จ์ฑ 25
์ 4 ์ ์ ์ฑ
์ ๋ํ ์ดํด๋์ ์์ฉ์ฑ 26
1. ์ ์ฑ
์ ๋ํ ์ดํด๋ 26
2. ์์ฉ์ฑ 27
์ 3 ์ฅ ์ฐ๊ตฌ๋ฐฉ๋ฒ๋ก 28
์ 1 ์ ์ฐ๊ตฌ๋ชจํ ๋ฐ ๊ฐ์ค 28
1. ์ฐ๊ตฌ์ ๋ถ์ํ 28
2. ์ฐ๊ตฌ๊ฐ์ค ์ค์ 29
์ 2 ์ ๋ณ์์ ์กฐ์์ ์ ์ ๋ฐ ์ค๋ฌธ๊ตฌ์ฑ 31
1. ๋
๋ฆฝ๋ณ์ ์ค์ 31
2. ์ข
์๋ณ์ ์ค์ 32
3. ํต์ ๋ณ์ ์ค์ 33
4. ์กฐ์ ๋ณ์ ์ค์ 33
5. ์ค๋ฌธ์ ๊ตฌ์ฑ๊ณผ ๋ด์ฉ 34
์ 3 ์ ์กฐ์ฌ์ค๊ณ 35
์ 4 ์ฅ ์ค์ฆ๋ถ์ ๋ฐ ๊ฒฐ๊ณผํด์ 37
์ 1 ์ ํ๋ณธ์ ํน์ฑ ๋ฐ ๊ธฐ์ด๋ถ์ 37
1. ๊ธฐ์ด๋ถ์์ ๋ฐ๋ฅธ ์ผ๋ฐ์ ํน์ง 37
2. ํ๋น์ฑ ๋ฐ ์ ๋ขฐ๋ ๋ถ์ 38
3. ๋ณ์๊ฐ์ ์๊ด๊ด๊ณ ๋ถ์ 42
4. ์ฃผ์๋ณ์๋ค์ ์ฐจ์ด๋ถ์ 43
์ 2 ์ ๊ฐ์ค์ ๊ฒ์ ๋ฐ ํด์ 43
1. ์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋ฐ๋ฅธ ์ฒด๋ถ๋น๋ ์ํฅ ๋ถ์ 43
2. ์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋ฐ๋ฅธ ๊ณต์ฌํ์ง ์ํฅ ๋ถ์ 45
3. ์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋ฐ๋ฅธ ํ๋๊ธ์ ์ ํฌ๋ช
์ฑ ์ํฅ ๋ถ์ 48
4. ์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋ฐ๋ฅธ ํ์ฅ ์กฐ์ง๊ตฌ์ฑ ํจ์จ์ฑ ์ํฅ ๋ถ์ 50
5. ๊ฐ์ค ๊ฒ์ ์ ์์ฝ 53
์ 5 ์ฅ ๊ฒฐ๋ก ๋ฐ ์ ์ฑ
์ ์์ฌ์ 55
์ 1 ์ ์ฐ๊ตฌ ๊ฒฐ๊ณผ์ ์์ฝ 55
1. ์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋ฐ๋ฅธ ์ฒด๋ถ๋น๋ ๋ถ์ 56
2. ์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋ฐ๋ฅธ ๊ณต์ฌํ์ง ์ํฅ ๋ถ์ 57
3. ์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋ฐ๋ฅธ ํ๋๊ธ์ ์ ํฌ๋ช
์ฑ ์ํฅ ๋ถ์ 57
4. ์ฃผ๊ณ์ฝ์ ๊ณต๋๋๊ธ์ ๋ฐ๋ฅธ ํ์ฅ ์กฐ์ง๊ตฌ์ฑ ํจ์จ์ฑ ์ํฅ ๋ถ์ 58
์ 2 ์ ์ฐ๊ตฌ์ ์์ ๋ฐ ์์ฌ์ 59
์ 3 ์ ์ฐ๊ตฌ์ ํ๊ณ ๋ฐ ํฅํ ์ฐ๊ตฌ๋ฐฉํฅ 61
์ฐธ๊ณ ๋ฌธํ 62
Abstract 64
ํ ๋ชฉ์ฐจ
[ํ 2-1] 11
[ํ 2-2] 13
[ํ 2-3] 14
[ํ 2-4] 22
[ํ 3-1] 32
[ํ 3-2] 34
[ํ 4-1] 39
[ํ 4-2] 40
[ํ 4-3] 42
[ํ 4-4] 42
[ํ 4-5] 43
[ํ 4-6] 44
[ํ 4-7] 46
[ํ 4-8] 47
[ํ 4-9] 49
[ํ 4-10] 52
[ํ 4-11] 54
๊ทธ๋ฆผ ๋ชฉ์ฐจ
[๊ทธ๋ฆผ 2-1] 9
[๊ทธ๋ฆผ 2-2] 11
[๊ทธ๋ฆผ 3-1] 29
๋ถ๋ก ๋ชฉ์ฐจ
[๋ถ๋ก 1] โฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆ 67Maste
์์ถ ์ฑํ์์์ ๊ธํ ์ถฉ์ ๊ณผ์ ํด์
ํ์๋
ผ๋ฌธ(์์ฌ)--์์ธ๋ํ๊ต ๋ํ์ :๊ธฐ๊ณ๊ณตํ๊ณผ,1995.Maste
Relationship and mediation factors between alcohol advertising exposure and drinking behavior in Korean adolescents
Background and Purpose : Alcohol is a Group 1 carcinogen and addictive substances as defined by the World Health Organization's International Agency for Research on Cancer, and every year more than three million people around the world die from drinking. In addition, the harm caused by alcohol is a critical problem that accounts for more than five percent of the burden of disease and death. Recently, the World Health Organization(WHO) has emphasized as the first national implementation strategy to restrict alcohol advertising and marketing for adolescent in order to prevent the harm of drinking. In accordance with this strategy, the Korean government has promoted the improvement of alcohol advertising regulation as a priority of alcohol control policies. It is known that the harmful effect of drinking gets worse if people start drinking earlier. The result showed that the exposure of alcoholadvertising has the effect of accelerating drinking initiation and increasing alcohol consumption through a longitudinal meta-analysis. However, there was a limitation on studying alcohol advertising and youth drinking domestically, also on verifying the structural relevance of various factors on them. Furthermore, it was difficult to find a study on message empathy which has been highlighted in recent marketing communication. Consequently, in this study, we try to understand the relationship between alcohol advertising exposure and adolescent drinking behavior. The purpose of this study through the path analysis is to investigate the structural relevance whether there are mediated effects between alcohol advertising exposure and drinking behavioral factors, and alcohol advertising exposure and adolescent drinking behavior. Methods : This study analyzed online survey of 1,500 male and female students attending middle and high schools between the ages of 14 and 19 nationwide. The survey was conducted by the Korea Public Health Association as part of the Management of the Alcohol Prevention Program in the Ministry of Health and Welfare. This study examined the general characteristics of participants, alcohol advertising exposure, drinking behavior, advertisement recognition(message empathy, advertising attitude), and drinking behavioral factors(peer drinking norms, drinking attitude). In order to compare gender, descriptive statistics, chi-squared test, independent sample t-test were conducted. Multiple logistic regression analysis was performed to analyze the relationship between alcohol advertising exposure and drinking behavior. In addition, structural equation modeling(SEM) analysis was used to verify the structural relevance between alcohol advertising exposure and drinking behavior. Through the SEM, analyses for fitness and path of the model, direct andindirect effect, and moderating effect of gender were performed. Results : As a result of analyzing the relationships between exposure variables(frequency of watching alcohol advertisement, experience of three kinds of alcohol advertisements watched during the survey, and alcohol brand recall) on alcohol advertisement and drinking behavior(monthly drinking), all three exposure variables were significantly related to drinking behavior. In the first variable, frequency of watching alcohol advertisement, the odds ratio of the witness group who had watched alcohol advertising more than 10 times in the last month was 2.32 times higher(95% CI: 1.43-3.77) than the group who had not watched at all, and it was statistically significant. In the second variable, experience of three kinds of alcohol advertisements, the odds ratio of the group who had watched two kinds of advertisements was 2.00 times(95% CI:1.36-2.94), and the ration of the group who had watched all three kinds of advertisements was 1.57 times(95% CI: 1.00-2.46) higher thatn the group who had not watched all three advertisements, and both are statistically significant. In the third variable, alcohol brand recall, the odds ratio of the group recalling three kinds of alcohol advertisements was 1.77 times statistically significantly higher(95% CI: 1.23-2.55) than the group recalling nothing, and it was statistically significant. As a result of analyzing the structural relation between alcohol advertising exposure and drinking behavior through the SEM, alcohol advertisement had an indirect effect on drinking attitude with the path of message empathy and advertising attitude toward alcohol advertisement. Also, drinking attitude had a structural relationship that indirectly affected drinking behavior through peer drinking norms. The relationship between alcohol advertising exposure andadvertising attitude was found to be partially mediated only to male students by message empathy. At the same time, the advertising attitude was fully mediated the relations between alcohol advertising exposure and drinking attitude to both male and female students(indirect effect: male p=0.003, female p=0.002). Finally, the relationship between drinking attitude and behavior was fully mediated by peer drinking norms(indirect effect: male p=0.005, female p=0.003). Conclusion : The standards for (alcohol) advertisement from NATIONAL HEALTH PROMOTION ACT were established to protect children and youth from alcohol advertisements, including regulations on an advertising time or the degree of alcohol of advertisements. However, the results of this study indicated that alcohol advertisements were currently exposed to the youth without limitation, and there was a statistically significant relevance between alcohol advertising exposure and youth drinking behavior. In addition, with message empathy and positive attitudes toward alcohol advertising, alcohol advertisement allows young people to have positive expectations about drinking and it affects adolescents drinking behavior. Therefore, it is necessary to establish more stringent regulations on advertising contents, especially which can be easily empathized or make a positive attitude on drinking by excessively glorifying it. Lastly, relevant researches and supports are needed to protect young people and public health from aggressive marketing by alcohol industry and to support the alcohol marketing restrictions policy which is being actively discussed by the government and the National Assembly.
๋ฐฐ๊ฒฝ ๋ฐ ๋ชฉ์ : ์์ฝ์ฌ์ ์ธ๊ณ๋ณด๊ฑด๊ธฐ๊ตฌ ๊ตญ์ ์์ฐ๊ตฌ์์์ ๊ท์ ํ 1๊ตฐ ๋ฐ์๋ฌผ์ง์ด๋ฉฐ ์ค๋
๋ฌผ์ง๋ก ๋งค๋
์ ์ธ๊ณ์์ 300๋ง ๋ช
์ด์์ด ์์ฃผ๋ก ์ฌ๋งํ๊ณ ์์ฃผ๋ก ์ธํ ํํด๋ ์ง๋ณ ๋ฐ ์ฌ๋ง ๋ถ๋ด์ 5% ์ด์์ ์ฐจ์งํ๋ ์ฌ๊ฐํ ๋ฌธ์ ์ด๋ค. ์ธ๊ณ๋ณด๊ฑด๊ธฐ๊ตฌ์์๋ ์ต๊ทผ ์์ฃผํํด์๋ฐฉ์ ์ํด ์ฒญ์๋
์ ๋์์ผ๋ก ํ๋ ์ฃผ๋ฅ๊ด๊ณ ใป๋ง์ผํ
์ ์ ํํ ๊ฒ์ ์ต์ฐ์ ๊ตญ๊ฐ ์คํ์ ๋ต์ผ๋ก ๊ฐ์กฐํ๊ณ ์์ผ๋ฉฐ, ์ฐ๋ฆฌ๋๋ผ๋ ์ด์ ๋ฐ๋ผ ์ฃผ๋ฅ๊ด๊ณ ๊ท์ ๊ฐ์ ์ ์์ฃผํํด์๋ฐฉ์ ์ฑ
์ ์ต์ฐ์ ์ค์ ๊ณผ์ ๋ก ์ถ์งํ๊ณ ์๋ค. ์์ฃผ๋ ์ผ์ฐ ์์ํ ์๋ก ๊ทธ ํํด๋ ๋ ์ปค์ง๋ ๊ฒ์ผ๋ก ์ตํ ์๋ ค์ ธ ์์ผ๋ฉฐ, ์ฃผ๋ฅ๊ด๊ณ ๋
ธ์ถ์ ์ฒญ์๋
์ ์์ฃผ ์์์ ์๋น๊ธฐ๊ณ ์์ฃผ ์๋น๋ฅผ ์ฆ๊ฐ์ํค๋ ํจ๊ณผ๊ฐ ์๋ค๋ ๊ฒฐ๊ณผ๊ฐ ์ข
๋จ์ฐ๊ตฌ ๋ฉํ๋ถ์์ ํตํด ๋ฐํ์ก๋ค. ๊ทธ๋ฌ๋ ์ฃผ๋ฅ๊ด๊ณ ์ ์ฒญ์๋
์์ฃผํ๋์ ๋ํ ๊ตญ๋ด์ฐ๊ตฌ๋ ์ ํ์ ์ด๋ฉฐ, ์ด์ ๋ํ ์ฌ๋ฌ ์์ธ๋ค์ ๊ตฌ์กฐ์ ๊ด๋ จ์ฑ์ ๊ฒ์ฆํ ์ฐ๊ตฌ ์ญ์ ์ ํ์ ์ด๋ค. ๋ํ ์ต๊ทผ ๋ง์ผํ
์ปค๋ฎค๋์ผ์ด์
์์ ๊ฐ์กฐํ๊ณ ์๋ ๊ด๊ณ ๊ณต๊ฐ์ ๋ํ ์ฃผ๋ฅ๊ด๊ณ ๊ด๋ จ ์ฐ๊ตฌ ์ญ์ ์ฐพ์๋ณด๊ธฐ ์ด๋ ค์ ๋ค. ๋ฐ๋ผ์ ๋ณธ ์ฐ๊ตฌ์์๋ ์ฃผ๋ฅ๊ด๊ณ ๋
ธ์ถ๊ณผ ์ฒญ์๋
์์ฃผํ๋์ ๊ด๋ จ์ฑ์ ํ์
ํ๊ณ , ๊ฒฝ๋ก๋ถ์์ ํตํด ์ฃผ๋ฅ๊ด๊ณ ์ ์์ฃผํ๋ ๊ด๋ จ ์์ธ๋ค์ ๊ตฌ์กฐ์ ๊ด๋ จ์ฑ์ ์์๋ณด๊ณ ์ ํ๋ค. ์ฐ๊ตฌ๋ฐฉ๋ฒ : ๋ณธ ์ฐ๊ตฌ๋ ๋ณด๊ฑด๋ณต์ง๋ถ ์์ฃผํํด์๋ฐฉ๊ด๋ฆฌ์ฌ์
์ ์ผํ์ผ๋ก ๋ํ๋ณด๊ฑดํํ์์ 2013๋
12์ 5์ผ๋ถํฐ 8์ผ๊น์ง ์ ๊ตญ 14~19์ธ ์คใป๊ณ ๋ฑํ๊ต์ ์ฌํ์ค์ธ ๋จ๋
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์ ๋์์ผ๋ก ์ค์ํ ์จ๋ผ์ธ ์ค๋ฌธ์กฐ์ฌ ์๋ฃ๋ฅผ ๋ถ์ํ์๋ค. ๋ณธ ์ฐ๊ตฌ๋ ์ฐธ์ฌ์์ ์ผ๋ฐ์ ํน์ฑ๊ณผ ์ฃผ๋ฅ๊ด๊ณ ๋
ธ์ถ, ์์ฃผ ํ๋, ๊ด๊ณ ์ธ์(๊ด๊ณ ๊ณต๊ฐ, ๊ด๊ณ ํ๋), ์์ฃผํ๋ ๊ด๋ จ์์ธ(๋๋์์ฃผ ๊ท๋ฒ, ์์ฃผํ๋)์ ํ์
ํ๊ณ ์ฑ๋ณ ๋น๊ตํ๊ธฐ ์ํด ๊ธฐ์ ํต๊ณ์ ์นด์ด์ ๊ณฑ ๊ฒ์ , ๋
๋ฆฝํ๋ณธ t ๊ฒ์ ์ ์ค์ํ์์ผ๋ฉฐ, ์ฃผ๋ฅ๊ด๊ณ ๋
ธ์ถ๊ณผ ์์ฃผํ๋์ ๊ด๋ จ์ฑ์ ๋ถ์ํ๊ธฐ ์ํด ๋ค์ค ๋ก์ง์คํฑ ํ๊ท๋ถ์์ ์ค์ํ์๋ค. ๋ํ ์ฃผ๋ฅ๊ด๊ณ ๋
ธ์ถ๊ณผ ์์ฃผํ๋ ๊ด๋ จ ์์ธ๋ค์ ๊ตฌ์กฐ์ ๊ด๋ จ์ฑ์ ๊ฒ์ฆํ๊ธฐ ์ํด ๊ตฌ์กฐ๋ฐฉ์ ์๋ชจ๋ธ์ ํตํด ๊ฒฝ๋ก ๋ถ์, ๊ฐ์ ํจ๊ณผ ๋ถ์ ๋ฑ์ ์ค์ํ์๋ค. ์ฐ๊ตฌ๊ฒฐ๊ณผ : ์ฃผ๋ฅ๊ด๊ณ ๋
ธ์ถ ๋ณ์์ธ ์ ์ฃผ๋ฅ๊ด๊ณ ๋ชฉ๊ฒฉ๋น๋, ์ค๋ฌธ ์ ์์ฒญํ ์ฃผ๋ฅ๊ด๊ณ ๋ชฉ๊ฒฉ๊ฒฝํ, ์ฃผ๋ฅ ๋ธ๋๋ ํ์๊ณผ ์์ฃผํ๋(์๊ฐ์์ฃผ ์ฌ๋ถ)์ ๊ด๋ จ์ฑ์ ๋ถ์ํ ๊ฒฐ๊ณผ, 3๊ฐ์ง ๋ณ์ ๋ชจ๋ ์์ฃผํ๋๊ณผ ์ ์ํ ๊ด๋ จ์ฑ์ด ์์๋ค. ์ ์ฃผ๋ฅ๊ด๊ณ ๋ชฉ๊ฒฉ๋น๋์์๋ ์ต๊ทผ ํ ๋ฌ๊ฐ ์ฃผ๋ฅ๊ด๊ณ ๋ฅผ ๋ณธ ์ ์ด ์๋ ๊ตฐ์ ๋นํด 10๋ฒ ์ด์ ๋ชฉ๊ฒฉ๊ตฐ์ ์ค์ฆ๋น๊ฐ 2.22๋ฐฐ(95% CI: 1.35-3.64)๋ก ํต๊ณ์ ์ผ๋ก ์ ์ํ๊ฒ ๋์๋ค. ์ฃผ๋ฅ๊ด๊ณ ๋ชฉ๊ฒฉ๊ฒฝํ์์๋ 3์ข
๋ชจ๋ ๋ชฉ๊ฒฉ ํ ์ ์ด ์๋ ๊ตฐ์ ๋นํด 2์ข
๋ชฉ๊ฒฉ๊ตฐ์ ์ค์ฆ๋น๊ฐ 1.98๋ฐฐ(95% CI: 1.33-2.95), 3์ข
๋ชจ๋ ๋ชฉ๊ฒฉํ ๊ตฐ์ ์ค์ฆ๋น๊ฐ 1.52๋ฐฐ(95% CI: 0.96-2.42)๋ก ํต๊ณ์ ์ผ๋ก ์ ์ํ๊ฒ ๋์๋ค. ์ฃผ๋ฅ ๋ธ๋๋ ํ์์์๋ ํ์ํ๋ ์ฃผ๋ฅ ๋ธ๋๋๊ฐ ์๋ ๊ตฐ์ ๋นํด 3๊ฐ ๋ชจ๋ ํ์ํ ๊ตฐ์ ์ค์ฆ๋น๊ฐ 1.76๋ฐฐ(95% CI: 1.21-2.57)๋ก ํต๊ณ์ ์ผ๋ก ์ ์ํ๊ฒ ๋์๋ค. ๊ตฌ์กฐ๋ฐฉ์ ์๋ชจ๋ธ์ ํตํด ์ฃผ๋ฅ๊ด๊ณ ๋
ธ์ถ๊ณผ ์์ฃผํ๋์ ๊ตฌ์กฐ์ ๊ด๋ จ์ฑ์ ๋ถ์ํ ๊ฒฐ๊ณผ ์ฃผ๋ฅ๊ด๊ณ ๋ ๊ด๊ณ ๋ฉ์์ง ๊ณต๊ฐ, ์ฃผ๋ฅ๊ด๊ณ ํ๋๋ฅผ ๊ฒฝ๋ก๋ก ์์ฃผํ๋์ ๊ฐ์ ์ ์ธ ์ํฅ์ ๋ฏธ์ณค๊ณ , ์์ฃผํ๋๋ ๋๋ ์์ฃผ๊ท๋ฒ์ ํตํด ์์ฃผํ๋์ ๊ฐ์ ์ ์ธ ์ํฅ์ ๋ฏธ์น๋ ๊ตฌ์กฐ์ ๊ด๊ณ๋ฅผ ๊ฐ์ง๊ณ ์์๋ค. ์ฃผ๋ฅ๊ด๊ณ ๋
ธ์ถ์ ์ฃผ๋ฅ๊ด๊ณ ํ๋์ ๊ด๊ณ ๋ฉ์์ง ๊ณต๊ฐ์ ๊ฒฝ๋ก๋ก ๋จํ์์๊ฒ๋ง ๋ถ๋ถ๋งค๊ฐ ํ์์ผ๋ฉฐ, ์ฃผ๋ฅ๊ด๊ณ ๋
ธ์ถ์ ์์ฃผํ๋์ ์ฃผ๋ฅ๊ด๊ณ ํ๋๋ฅผ ๊ฒฝ๋ก๋ก ๋จ๋
๋ชจ๋ ์์ ๋งค๊ฐ(๊ฐ์ ํจ๊ณผ ๋จ p=0.003, ์ฌ p=0.002) ํ์์ผ๋ฉฐ, ์์ฃผํ๋๋ ์์ฃผํ๋์ ๋๋ ์์ฃผ๊ท๋ฒ์ ๊ฒฝ๋ก๋ก ๋จ๋
๋ชจ๋ ์์ ๋งค๊ฐ(๊ฐ์ ํจ๊ณผ ๋จ p=0.005, ์ฌ p=0.003) ํ์๋ค. ๊ฒฐ๋ก : ์ฐ๋ฆฌ๋๋ผ๋ ์ฃผ๋ฅ๊ด๊ณ ๋ก๋ถํฐ ์ฒญ์๋
์ ๋ณดํธํ๊ธฐ ์ํด ๊ตญ๋ฏผ๊ฑด๊ฐ์ฆ์ง๋ฒ์ ์ฃผ๋ฅ๊ด๊ณ ๊ธฐ์ค์ ๋ง๋ จํ์ฌ ๊ด๊ณ ์๊ฐ๋, ์์ฝ์ฌ๋์ ๋ฑ์ ๊ท์ ํ๊ณ ์์ผ๋ ๋ณธ ์ฐ๊ตฌ๊ฒฐ๊ณผ๋ฅผ ํตํด์ ํ์ฌ ์ฃผ๋ฅ๊ด๊ณ ๋ ์ฒญ์๋
๋ค์๊ฒ ์ ํ ์์ด ๋
ธ์ถ๋๊ณ ์์์ ํ์ธํ์์ผ๋ฉฐ, ๊ด๊ณ ๋
ธ์ถ์ด ์ฒญ์๋
์์ฃผํ๋๊ณผ ํต๊ณ์ ์ผ๋ก ์ ์ํ ๊ด๋ จ์ฑ์ด ์๋ ๊ฒ์ผ๋ก ๋ํ๋ฌ๋ค. ๋ํ ์ฒญ์๋
์๊ฒ ์ฃผ๋ฅ๊ด๊ณ ๋ ๊ด๊ณ ๋ฉ์์ง ๊ณต๊ฐ๊ณผ ์ฃผ๋ฅ๊ด๊ณ ์ ๋ํ ๊ธ์ ์ ํ๋๋ฅผ ๊ฒฝ๋ก๋ก ์์ฃผ์ ๋ํ ๊ธ์ ์ ๊ธฐ๋๊ฐ์ ํ์ฑํ๊ฒ ๋์ด ์์ฃผํ๋์ ์ํฅ์ ๋ฏธ์น๋ ๊ฒ์ผ๋ก ๋ํ๋, ์ฒญ์๋
์ผ๋ก ํ์ฌ๊ธ ์ฃผ๋ฅ๊ด๊ณ ๋
ธ์ถ์ ์ ํํด์ผ ํ ๋ฟ๋ง ์๋๋ผ ๊ด๊ณ ๋ด์ฉ์ ์ฝ๊ฒ ๊ณต๊ฐํ ์ ์๊ฑฐ๋ ์์ฃผ๋ฅผ ๋ฏธํํ์ฌ ๊ธ์ ์ ํ๋๋ฅผ ํ์ฑํ๊ฒ ํ๋ ๊ด๊ณ ๋ด์ฉ์ ๋ํ ๋ณด๋ค ์๊ฒฉํ ๊ท์ ๋ง๋ จ์ด ํ์ํ ๊ฒ์ผ๋ก ์ฌ๊ฒจ์ง๋ค. ๋ํ ์ฃผ๋ฅ์
๊ณ์ ๊ณต๊ฒฉ์ ๋ง์ผํ
์ผ๋ก๋ถํฐ ์ฒญ์๋
๊ณผ ๊ตญ๋ฏผ๊ฑด๊ฐ์ ๋ณดํธํ๊ณ ํ์ฌ ์ ๋ถใป๊ตญํ์์ ํ๋ฐํ ๋
ผ์๋๊ณ ์๋ ์ฃผ๋ฅ ๋ง์ผํ
์ ํ ์ ์ฑ
์ ๊ทผ๊ฑฐ ๋ง๋ จ์ ์ํด ๊ตญ๋ด ์ฐ๊ตฌ์ ์ง์์ด ํ๋ฐํ ์ด๋ฃจ์ด์ ธ์ผ ํ๋ค.open์
Gene therapy with forkhead transcription factor inhibits neointimal hyperplasia after angioplasty by suppression of HSP70 and induction of P27
Thesis (master`s)--์์ธ๋ํ๊ต ๋ํ์ :์ํ๊ณผ ๋ด๊ณผํ์ ๊ณต,2004.Maste
๊ฐ๋ฐ์ ํ๊ตฌ์ญ ๋ด ์ํ๊ณต์ ์กฐ์ฑ๋ฐฉ์์ ๊ดํ ์ฐ๊ตฌ : ์์์ฒ ๋ฐ ์ํํต๋ก๋ก์์ ๊ธฐ๋ฅ๊ฐํ๋ฅผ ์ค์ฌ์ผ๋ก
ํ์๋
ผ๋ฌธ(์์ฌ) --์์ธ๋ํ๊ต ๋ํ์ :์ํ์กฐ๊ฒฝยท์ง์ญ์์คํ
๊ณตํ๋ถ(์ํ์กฐ๊ฒฝํ),2007.Maste