Design and Implementation about Xiame Finance Bureau Integrated Information Platform of Centralized Treasury Payment System

随着我市社会经济的发展，财政收支规模日益庞大，手工录入财政数据，使用电子表格进行统计分析等传统手段，已远不能满足财政资金管理科学化、精细化的要求。特别是2004年推行财政资金国库集中支付改革以来，旧的工作方式已远不能适应现代公共财政管理的要求。因此，近年来我局陆续开发上线预算编制系统、指标管理系统、非税收入管理系统、税收收入分析系统、国库集中支付系统等，优化、细化了财政资金管理，加强了对财政资金使用的监督。 论文首先介绍我国及我市财政国库集中支付的现状，描述了国库集中支付的相关概念，分析数据质量存在的问题，提出解决问题的方法。 其次，主要通过介绍J2EE平台，讨论系统各组件以J2EE为平台...With the social economy development in our country, the financial revenue and expenditure scale becomes larger and larger, what traditional means about manual input of financial data, using a spreadsheet for statistical analysis,already cannot satisfy the requirements of financial scientific management. Especially in 2004,it carry out the reform about centralized treasury payment of Finance capita...学位：工程硕士院系专业：软件学院_工程硕士(软件工程)学号：X201023056

李如龙先生语言学研究体系述要

李如龙的学术研究涵盖了语言学的多个领域。他的研究,首先从方言学入手,对闽语、客赣语、粤语以及北方方言都有全面的调查研究。在占有大量语言事实的基础上,通过古今串联、南北贯通、书口比较,他对词汇学、文字学、汉语的特征做出了独具特色的研究。对于语言使用中的问题,也绝不回避,他的研究对社会语言学、语言教育、语言规划、文化语言学、地名学等多个学科也具有启发意义

Precipitated Phase of Titanium Alloy with Adding Nd Elements

通过粉末冶金方法(冷等静压-真空烧结)制备钛合金Ti-6Al-4V-2Cr-1Nd, 经过固溶-时效热处理后, 利用光学显微镜(OM)、; X射线衍射仪(XRD)和透射电镜(TEM)分析合金的微观组织、 物相的组成及析出相的形核特点, 研究添加稀土元素Nd对析出相的影响。; 实验结果表明,在添加1%Nd(质量分数)元素后, 钛合金组织得到了明显细化;通过合金细化成核理论分析发现, 添加稀土元素Nd后,; 固溶时效中Nd_2O_3可以作为形核的基础, 促进形核, 所以稀土Nd元素可以有效促进非均匀形核, 主要析出相Nd_2O_3有利于晶粒的细化,; 是有效的形核剂;在高分辨透射电镜下对离子减薄后的试样进行观察,通过对合金的形貌和析出物进行傅里叶变换(FFT)和反傅里叶变换(IFFT)分析,; 得到清晰的原子排列图, 发现析出相Nd_2O_3与基体alpha-Ti之间存在平行相界面, 经分析为半共格界面。Titanium alloy Ti-6Al-4V-2Cr-1Nd prepared by powder metallurgy method; (cold isostatic pressing and vacuum sintering) was researched. The; microstructure, phase composition and precipitated phase nucleation; process were analyzed by optical microscope (OM), X-ray diffraction; (XRD) and transmission electron microscope (TEM) after solution and; aging treatment. The effect of adding rare earth element Nd to the; titanium alloy on its precipitated phase was studied. The experimental; results showed that the microstructure refinement effect was obvious; after adding rare earth element 1%Nd (mass fraction); based on the; analysis of alloy refining nucleation theory, it was found that after; adding Nd, Nd_2O_3 could serve as the basis of nucleation because of its; high energy, promoting nucleation, there fore Nd could promote the; heterogeneous nucleation effectively, the main precipitation phase; Nd_2O_3 was beneficial to refining crystalline grains and it was; effective nucleating agents. Through high resolution observation of ion; thinning sample, and the morphology of the alloy precipitates were; analyzed by fast Fourier transform (FFT) and inverse fast Fourier; transformation (IFFT). It was found that there was parallel interface; between precipitated phase Nd_2O_3 and matrix alpha-Ti, and it was; semi-coherent interface shown by analysis.河南省重大科技专项项

Effects of Nd element addition on microstructure refinement of Ti-6Al-4V-2Cr alloy

采用冷等静压–真空烧结法制备Ti-6Al-4V-2Cr-1Nd合金,然后进行固溶及时效热处理,通过实验与最小错配度理论计算,研究Nd元素对该合金组织细化的影响,并分析细化机理。结果表明,添加1%(质量分数)的稀土元素Nd后,析出相Nd2O3能有效促进晶粒细化。二维错配度的计算结果证明析出相Nd2O3是有效的形核剂,可促进非均匀形核,增加形核率,从而使晶粒细化。通过对合金试样薄区进行高分辨率观察,发现另一种絮状的、非常细小的、弥散分布的Nd2Ti4O11相,由于其界面错配度较低,也可作为非均匀形核的核心,促进形核,起到细化晶粒的作用。Titanium alloy Ti-6Al-4V-2Cr-1Nd is made by the cold isostatic pressing and vacuum sintering, then the solution and aging heat treatment was carried on the prepared of titanium alloy, the effect of Nd elements on the microstructure refinement and the refinement mechanism were researched and analyzed through the experiment and theory calculation of minimum mismatch degree. The results show that the main precipitation phase Nd_2O_3 can effectively promote the grain refinement after adding rare earth element 1% Nd(mass fraction). The two-dimensional mismatch degree calculation results proved that the precipitated phase Nd2O3 is the effective nucleating agents that can promote the heterogeneous nucleation and increase the nucleation rate, thus promote the grain refinement. Through the high resolution observation of thin area in the sample, another precipitated phase Nd2Ti4O11 is found, which is flocculent, dispersed and very small. Because of the low degree of interface mismatch, Nd2Ti4O11 can also be used as the core of heterogeneous nucleation and promote nucleation, which means it can also play a role in grain refinement.河南省重大科技专项(102105000007

动作电位参数作为区分狗心室肌三种细胞的可行性研究

应用细胞膜片钳技术测定狗心室肌细胞的电生理特征、动作电位(AP)以及收缩的参数,并用统计学方法评价所测量的参数是否可将心内、外膜及中层(M)细胞有效地区分开。结果:获取52个混合的有3种心肌细胞的AP,以AP穹隆的高度以及AP切迹的膜电位水平和穹隆上升的速度将其分三组细胞。以穹隆的膜电位水平能有效区分心外膜与其他两种细胞(P0.05)。以AP时程(APD)可以有效区分M细胞与其他两种细胞(P0.05)。尖峰切迹时间以及收缩参数均不能有效区分三种心室肌细胞(P>0.05)。结论:狗心室单个细胞AP的一些参数,可以作为辨别心内、外膜,M细胞的依据

Establishment of a nude mouse model of glioma orthotopic xenograft with double-fluorescent labeling

目的建立一种稳定、可实时监测的胶质瘤原位移植瘤裸鼠模型。方法用带有荧光素酶（luciferase-Luc）和绿色荧光蛋白（green fluorescent protein-GFP）基因的慢病毒感染U251神经胶质瘤细胞,流式细胞仪筛选稳定表达GFP-Luc荧光的细胞系,并通过CCK-8实验、细胞周期实验、Transwell肿瘤迁移及侵袭实验等评价荧光细胞的增殖、迁移和侵袭能力是否改变;将细胞接种至裸鼠大脑尾状核,建立胶质瘤原位移植瘤模型,利用小鼠活体成像系统监测脑内肿瘤的生长情况,并通过石蜡切片,HE染色评价细胞在裸鼠脑内的病理特征及成瘤能力。结果成功构建稳定表达GFP荧光和luciferase荧光的U251胶质瘤细胞系及动物模型,慢病毒整合并未改变细胞的增殖、迁移及侵袭能力;模型生长周期适中,成瘤率高,瘤体在颅内生长稳定,HE切片符合人胶质瘤特征。结论双荧光标记的胶质瘤细胞相比于传统细胞更有利于胶质瘤动物模型的实验研究;U251-GFP-Luc胶质瘤细胞裸鼠模型,其肿瘤生长和病理特性与人胶质瘤相似,且可实时观察肿瘤生长,可作为胶质瘤实验研究的理想动物模型。Objective To establish a stable and real-time monitorable nude mouse model of orthotopic glioma xenograft. Methods U251 glioma cell line was infected by a leutiviral vector containing green fluorescent protein （GFP） and luciferase （Luc） gene. Ceils stably expressing fluorescence of GFP and Luc were sorted by flow cytometry. CCK-8 test and Transwell tumor invasion and migration assay were used to compare the biological features between the ceils stably expressing GFP-Luc fluorescence and cells without fluorescence. Then the ceils were implanted intracranially in the right caudate nucleus of athymic BaIb/c nude mice to establish the tumor model. The growth of intracerebral tumor was monitored over time by a bioluminescence imaging （BLI） system. Hematoxylin-eosin （HE） staining was used to evaluatethe histopathological features and tumorigenicity of the transplanted glioma cells in the brain of nude mice. Results U251 glioma cell line with stably expressing GFP-Luc fluorescence and the corresponding orthotopic xenograft model were successfully established. There was no statistically significant difference in the proliferation, invasion and migration abilities between the cells with stably expressing GFP-Luc fluorescence and the control cells. This model showed a high tumor formation rate and stable tumor growth, and takes a moderate time to establish this model. Conclusions Compared with the traditional glioma cells, GFP-Luc-transfected human glioma cells are more feasible for the studies of glioma in vivo. The tumor growth and pathological characteristics in this U251-GFP-Luc glioma model are similar to human glioma, and the growth of this tumor can be real-time monitored. It can be used as an ideal animal model for experimental studies of glioma.国家自然科学基金（编号：30970733）

IL-18BP重组蛋白对TNF-α诱导的人脐静脉内皮细胞的作用研究

目的探讨人重组白细胞介素-18结合蛋白(rhIL-18BP)对肿瘤坏死因子(TNF-α)诱导的内皮细胞炎症、凋亡的影响。方法体外培养人脐静脉内皮细胞(HUVECs),用20 ng/ml的TNF-α和不同质量浓度的rhIL-18BP孵育相应时间,提取mRNA并用PCR及实时定量PCR检测细胞因子(IL-6、IL-8)、黏附分子(ICAM-1、VCAM-1)的mRNA表达;ELISA法检测细胞上清液中细胞因子(IL-6、IL-8)、可溶性黏附分子(sICAM-1、sVCAM-1)的蛋白含量;流式细胞术检测细胞凋亡的变化。结果 1)IL-18BP可以抑制TNF-α诱导的人脐静脉内皮细胞中炎症因子的表达;2)IL-18BP能抑制TNF-α诱导的HUVECs的凋亡。结论 rhIL-18BP对TNF-α诱导的内皮炎症反应有抑制作用,并可以抑制TNF-α诱导的内皮细胞凋亡

Study of the effect of Strong-bone granules on the differentiation of ROS1728 osteoblasts with silenced ER expression

目的探讨健骨颗粒对成骨细胞中ERalpha介导的TERT信号通路的调控作用。方法采用雌激素受体拮抗剂ICI182780(Faslodex)阻断成; 骨细胞中雌激素受体alpha(ERalpha)的表达,建立ER抑制的大鼠成骨细胞株ROS1728细胞模型,采用酶联免疫吸附法(ELISA)检测成; 骨细胞液中碱性磷酸酶(alkaline phosphatase,ALP) 、骨钙素(osteocalcin,BGP); 、Ⅰ型胶原(collagen I,Col Ⅰ)的含量。采用实时荧光定量SYBR; GREEN法检测ERE、ERalpha、c-MYCmRNA的表达。采用Western Blot检测TERT、ERalpha、c-; MYC蛋白的表达。结果ELISA法检测结果显示:随着干预时间的延长,培养液中的ALP、BGP、ColⅠ的含量逐渐上升。其中对照组3种信号因子的含; 量最高血,雌激素组次之,健骨颗粒组再次之,模型组最低,各组比较差异有统计学意义(P < 0.05),; 4组TERT、ERalpha、c-MYCmRNA及蛋白表达量情况以对照组的蛋白表达含量最高,雌激素组次之,健骨颗粒组再次之,模型组最低。各组比较; 均有统计学意义(P < 0.05); 。结论雌激素介导TERT信号通路及其相关因子与成骨细胞分化的关系密切,而补肾健脾中药健骨颗粒可通过雌激素介导TERT信号通路促进成骨细胞分化。Objective To investigate the effect of Strong-bone granules on the; regulation of TERT signaling pathway mediated by ER alpha in; osteoblasts. Methods The estrogen receptor antagonist ICI182780; (Faslodex) was used to inhibit the expression of ER in osteoblasts and; to establish the ER-silenced model of rat osteoblast cell line ROS1728.; Serum ALP,BGP,and Col I were determined using enzyme-linked; immunosorbent assay. The mRNA expression of ERE,ERalpha,and c-MYC was; determined using real time quantitative SYBR GREEN assay. The protein; expression of ERE,ERalpha,and c-MYC was detected using Western blotting.; Results The results of ELISA showed that the content of ALP,BGP,and Col; in the culture medium increased gradually with the prolonging of; intervention time. The levels were the highest in the control group,then; followed in estrogen group,Strong-bone granules group,and the model; group,and the difference among the groups was significant (P < 0.05).; The mRNA and protein expression of TERT,ER alpha,and c-MYC was the; highest in the control group,then followed in estrogen group,Strong-bone; granules group,and the model group,and the difference among the groups; was significant (P < 0.05). Conclusion The estrogen mediated TERT; signaling pathway and its related factors are closely related to the; differentiation of osteoblasts. Strong-bone granules promote osteoblast; differentiation through estrogen mediated TERT signaling pathway.国家自然科学基金; 福建省卫生厅中医课题; 福州市卫生系统科技项

Effects of Nd element addition on microstructure and mechanical properties of Ti-6Al-4V-2Cr alloy

本试验采用冷等静压法及粉末冶金法制备钛合金,消除了成分偏析对合金性能的影响。在Ti-6Al-4V-2Cr中加入稀土Nd元素并进行热处理,运用光学; 显微镜、XRD和TEM对其组织和性能进行观察和分析。通过观察发现合金的组织为均匀的alpha +; beta相。运用XRD和TEM观察发现,晶界和晶内均有Nd_2O_3析出物,Nd_2O_3的出现细化了晶粒,提高了形核率,降低了晶粒尺寸。运用精; 密万能试验机进行了力学性能测试,当Nd元素含量为1%时,合金的综合力学性能最好,合金的抗拉强度提高了10.7%,伸长率提高了49.1%。The Ti-6Al-4V-2Cr-xNd alloys were prepared by the cold isostatic; pressing method and powder metallurgy with addition of Nd element,the; effect of composition segregation on properties of the titanium alloy; was eliminated,and microstructure and the properties of the alloy after; heat treatment were studied by means of optical microscope,XRD and TEM.; The results show that the microstructure of the Ti-6Al-4V-2Cr-xNd is; composed of homogeneous alpha + beta phase. Nd_2O_3 precipitates are; observed in the grain boundaries and in the grains by XRD and TEM,and it; can refine the grains,increase the nucleation rate and decrease the; grain size. The optimal mechanical properties of the alloy are obtained; when the Nd content is 1%,and the tensile strength and elongation of the; alloy increase by 10.7% and 49.1%,respectively.军工863项目; 国防973支持项

Channel Capacity Analysis of Distributed MIMO Systems in Cabin

采用自主搭建的信道测量平台测得了机舱环境下分布式MIMO系统的信道冲击响应矩阵。根据实测的信道矩阵分别计算了4种具有不同收发天线数目的分布式MIMO系统的信道容量。为了便于比较,SISO系统的信道容量也通过实测数据进行了计算。计算结果表明:在机舱环境下,采用分布式MIMO系统和采用SISO系统相比能够显著提高系统信道容量,说明分布式MIMO系统可以充分满足未来机舱内无线通信高速率数据传输的需求。With the self-built channel measurement platform,the channel matrix of in-cabin distributed MIMO system is measured.The channel capacity of 4 different distributed MIMO systems and also the channel capacity of one SISO system are calculated from the measured data.The calculation results show that as compared with one SISO system,the distributed MIMO system could significantly raise the capacity gain in the aircraft cabin environment,and thus could fully satisfy the requirements of high data-rate delivery for future in-cabin wireless communication.国家科技重大专项课题(No.2009ZX03002-002);国家重点基础研究发展规划项目资助(No.2007CB310608);国家863项目资助(No.2009AA011501);国家科技合作项目(No.2010DFB10410);清华-高通联合研究计划资助项目;长江学者和创新团队发展计划资助项目;中国博士后科学基