Z-十八碳-9-烯-丙磺酰胺对糖尿病认知功能障碍小鼠学习记忆功能的影响

探索新化合物Z-十八碳-9-烯-丙磺酰胺（N15）对糖尿病认知功能障碍（DACD）小鼠学习记忆功能的作用及机制。采用链脲佐菌素（STZ）连续小剂量腹腔注射以及高脂高糖加STZ诱导2型糖尿病小鼠模型,N15(50和100mg·kg-1·d-1)连续灌胃给药6周,于给药末期进行跳台、避暗以及Morris水迷宫测试以评价小鼠学习记忆功能;对海马内葡萄糖和乳酸水平进行测定;通过realtimePCR测定海马内突触成长相关蛋白-43（GAP-43）、突触素（SYN）、脑源性生长因子（BDNF）和神经营养因子-3（NT-3）m RNA的表达。结果表明,N15可显著改善模型小鼠学习记忆能力,降低海马内葡萄糖和乳酸含量,显著上调海马内GAP-43、SYN、BDNF和NT-3 m RNA表达水平。上述结果表明,新型化合物N15具有改善糖尿病认知功能障碍的作用,其机制可能与增加海马内突触生长相关因子和神经营养因子表达相关。福建省教育厅资助项目(JAT160583

Study of the Simulation of Marine Atmospheric Exposure with Lab Accelerated Test of Marine Coating Systems

通过两年海洋大气环境暴露试验、盐雾/紫外冷凝老化交替试验和氙灯老化试验,对比聚氨酯涂料、丙烯酸涂料涂层的色差和失光率,研究了3种试验对涂层表观性能的影响,发现紫外/冷凝老化加速试验对海洋大气暴露试验有很好的模拟性。The simulation of marine atmospheric exposure with lab accelerated test was studied.The lab accelerated test methods were UV-condensation and salt-fog alternant test and Xenon-Arc exposure test.The marine coating systems based on polyurethane and acrylic were compared in color difference and rate of losing gloss.The result showed that UV-condensation and salt-fog alternant test can better simulate the marine atmospheric environment than the Xenon-Arc exposure test

Anxiety，depression and insomnia in pregnant women during the COVID － 19 epidemic in Beijing

目的:评估新冠肺炎流行期间孕妇的焦虑抑郁症状与睡眠问题及其相关因素。方法:2020年2月28日-4月26日,通过网络问卷平台调查北京四家助产机构就诊的885例孕妇的焦虑抑郁症状及睡眠问题。采用广泛焦虑量表(GAD-7)评估焦虑症状,采用患者健康问卷抑郁症状群量表(PHQ-9)评估抑郁症状,采用失眠严重程度指数量表(ISI)评估失眠症状。结果:本样本中焦虑症状、抑郁症状及失眠症状检出率分别为12.2%,24.6%和13.6%。缺少照顾(OR=1.73)、有分娩担忧(OR=3.95)及心理弹性差(OR=4.57)是焦虑症状的危险因素;家庭收入高(OR=1.94)、有分娩担忧(OR=2.39)及心理弹性差(OR=3.04)是抑郁症状的危险因素;除已婚外其他婚姻状况(OR=4.95)、孕周较长(13～27周,OR=2.03;28周及以上,OR=2.13)、有躯体疾病史(OR=1.77)、存在分娩担忧(OR=2.78)及心理弹性差(OR=1.67)是失眠症状危险因素。结论:新冠肺炎流行期间北京市孕妇焦虑症状、抑郁症状及失眠症状常见,尤其是存在分娩担忧及心理弹性差的孕妇。</p

Study on Correlation between Marine Environmental Test and Accelerated Tests in Laboratory for Ship Coatings——Coating Systems for Marine Atmosphere

采用光泽-色泽仪、涂膜粉化率测定仪、fdIr,SEM及AfM等现代测试分析手段,对海洋大气区7种常用舰船涂料体系在实际海洋环境暴露试验以及室内人工加速老化及腐蚀试验前后的涂层性能变化进行了对比分析,并结合厦门地区的气象环境谱探索了实验室加速试验与实际海洋大气暴露试验的相关性。Seven ship coating systems were exposed in marine atmospheric environment and accelerated weathering tests in lab.Some modern analyses,such as gloss and color measurement,coat chalk rating,precise thickness meter,FDIR,SEM,AFM were applied to characterize the properties of the coating systems.The results of performance change before and after exposure were compared.The weather environmental spectrum of Xiamen area was also combined for discussion of the correlation between marine environmental exposure tests and accelerated weathering tests in lab