Exploring the Biological Response to Superhydrophobic/Superhydrophilic Surfaces

医用不锈钢、金属钛及其合金的表面改性及材料的生物学响应是生物材料研究领域的热点之一。针对当前国内外在医用材料表面改性、润湿性调控及生物系统对材料的生物学响应等重要科学问题和关键技术，本论文工作旨在构筑具有特殊润湿性（超亲水和超疏水）的纳米二氧化钛@不锈钢表面，并进一步探讨生物材料表面的润湿性、化学成分、表面形貌等性质对材料与生物体系的相互作用的影响，包括材料表面蛋白吸附、细胞粘附及血小板粘附等行为。 本论文的主要研究内容有：a)在不锈钢基底表面构筑超亲水、超疏水的二氧化钛（TiO2）纳米管，并研究材料的耐蚀性及血小板的粘附反应；b)利用超亲水-超疏水微图案技术高通量考察超疏水表面的空气膜对蛋...Surface modification of stainless steel, Ti and Ti based alloy has been developed for better biocompatibility in the past several decades. At the mean time, understanding the basic mechanism underlying the biological responds to biomaterials is of considerable scientific utility in designing biomaterials and assessing biocompatibility. This thesis research focus on some scientific and technical ke...学位：理学博士院系专业：化学化工学院_物理化学(含化学物理)学号：2052010015366

On the Intellectual Property Protection for Idea

一个好的创意具有巨大的经济价值，这已经在现代信息社会里得到无数次的论证。创意在很多领域都得以广泛应用，特别是在广告、时装设计、艺术创作、影视娱乐等行业中，人们对可商业化的创意的追逐更是到了无以复加的地步。为了充分发挥创意的巨大经济价值，需要配套的硬件设施、创意人才、法律政策等各方面要素的全方位联动。其中，法律能否对创意进行恰当的界定、能否为创意提供充足的事后救济，直接关系到创意提供者的创造积极性以及创意产业的发展，甚至影响创新型社会的构建进程。 本文首先解析了创意的基本内涵，从创意的概念、特征和典型类型入手，分析它与思想、内容和表达的关系，将创意界定为具有新颖性、可实施性和尚待实施性的思想观...A good idea makes great economic value, which has been proven by many times in the modern information society. Good ideas have been widely used in many areas, especially in advertising, fashion design, art, film and entertainment industry. The idea itself (such as the advertising scheme, the business scheme, the script outline of the story) is much more valuable than the expression of the idea (su...学位：法学硕士院系专业：法学院法律系_民商法学(含劳动法学、社会保障法学)学号：1292007115020

纳米金簇复合丝素薄膜的性能及其在生物成像中的应用

具有荧光性能的丝素薄膜可用于生物体内外实时的、无损伤的生物成像,为直观监测体内生物材料及其化学环境的变化提供了新思路。采用浇铸法制备纳米金簇复合丝素薄膜,研究了纳米金簇、甘油和制备过程中pH值对纳米金簇复合丝素薄膜结构和性能的影响。结果表明:纳米金簇和甘油的加入都会提高纳米金簇复合丝素薄膜β-折叠和结晶度,从而提高其断裂强度;在碱性条件下制备的纳米金簇复合丝素薄膜在680nm处可发射较强荧光;细胞能在制备的薄膜上正常黏附和生长,实现薄膜和细胞同时荧光成像。国家自然科学基金资助项目(51773171,U1405226)福建省科技厅自然科学基金资助项目(2017J06019)高等学校学科创新引智计划资助项目(B16029)厦门大学校长基金资助项目(20720160088,20720150218

广西少数民族预科生数学学习习惯的调查研究

学生的数学学习习惯是影响其数学学习的重要因素之一。调查发现,预科生在数学学习中的课前预习、课中交流、课后反思的习惯较差;数学学习习惯在性别、文理科以及学习层次上有一定的差异。研究少数民族预科生的数学学习习惯,将有利于对其进行有效的指导和培养。广西少数民族预科教育基地专项基金项目“民族预科生数学学习习惯的调查研究”(项目编号:2014YKYB10

Supramolecular gels and mesoscopic structure

从介观结构角度综述了超分子凝胶晶体网络结构的形成机理、结构特性对宏观性能的影响以及超分子凝胶的设计与调控,系统总结了超分子凝胶的表征方法.超分子凝胶的性能由层级结构决定,介观结构可大幅提高材料的宏观性能,其结构与性能可以通过四个因素相关联:拓扑结构,相关长度,对称性/有序性和晶体网络间的结合力.基于对超分子凝胶的介观概念更深、更新的理解,该类材料的研究和开发将被推向新的阶段.From the perspective of mesoscale, the formation mechanism of crystal network structure of supramolecular gel, the influence of structure on macroscopic properties, and the design and control of supramolecular gels are reviewed. Crystal network is a key character of the hierarchical structure of the gel, the formations of the basic and multi-level crystal networks are based on the crystal nucleation and growth. The engineering and controlling of the gel structure can be implemented by various stimuli, such as additives, sonication, seeding, and thermodynamic driving force, which leads to a controllable performance of the gel. In addition, the methods of characterizing supramolecular gels are systematically summarized, such as, rheology, atomic force microscope, scanning tunnel microscope, scanning electron microscope,transmission electron microscope, polarizing optical microscope, X-ray diffraction, small-angle X-ray scattering, smallangle neutron scattering, nuclear magnetic resonance spectroscopy, dynamic light scattering etc. Supramolecular gel performance is determined by the hierarchy mesoscopic structures, which can significantly improve the properties of the material. Four factors can be correlated to the structure and performance of material: topology, correlation length,symmetry/ordering, and strength of association of crystal networks. According to the more in-depth understanding of mesoscopic supramolecular gels, the research and development of such a material will be pushed to a new stage.111计划(批准号:B16029);; 国家自然科学基金(批准号:21404087,U1405226 21401154);; 国家高技术研究发展计划(批准号:2011AA06Z228);; 福建省科技厅项目(批准号:2014H6022,2015J05109);; 广东省自然科学基金(批准号:2015A030310007,2014A030310005);; 中组部千人计划项目;; 厦门大学校长基金(批准号:20720160088,20720150218,20720140528)资助的课题~

Determination of Nitrate in Seawater with Valve-Free Continuous Flow Analysis

建立了一种无阀连续流动分析方法和装置,仅用一台多通道蠕动泵传送试剂和样品,无需依靠注入阀、电磁阀和定量环进行试剂或样品的选择和定量输入。样品通过; 铜-镉还原柱,将硝酸盐还原为亚硝酸盐,然后用重氮-偶氮光度法进行测定。研究结果表明,硝酸盐的线性范围为5 ~ 180 mumol; /L,方法检出限为0.27 mumol /L,对10和80 mumol; /L硝酸盐溶液连续测定11次,相对标准偏差分别为1.4%和1.3%,不同盐度的实际水样加标回收率在99.4% ~; 106.1%之间。测定结果与流动注射分析法相比,无显著性差异。与流动注射分析相比,无阀设计装置大大降低了成本,操作更加简便,有利于在普通实验室或; 现场连续监测中推广使用。本方法成功应用于厦门西港海水样品中硝酸盐的测定以及九龙江河口区的硝酸盐走航式监测。A valve-free continuous flow method and its corresponding instrument were established, with only two multi-channel pump for delivering the sample and reagent, without any injection or solenoid valves and sample loop for selecting and adding the sample or reagent. Nitrate was reduced to nitrite with Cu-Cd reductant column, and then detected with spectrophotometric detector.The proposed method was suitable for determination of nitrate at normal level in most of estuary and coastal seawaters. With the optimum parameters, the linear range and detection limit were 5-180 mu M and 0.27 mu M, respectively. The nitrate samples (10 and 80 mu M) were continually measured for 11 times, and the relative standard deviations were 1.4% and 1.3%, respectively. The recovery of real samples at different salinity was ranged from 99.4% to 106.1%. There were no significant differences in the analytical results between the proposed method and a reference method, i. e., flow injection analysis. In comparison with flow injection analysis, the method and instrument were less cost and easy to operate,and was suitable to be applied in general laboratories and field for continuous monitoring. The method was successfully applied to measure nitrate of seawater samples in Xiamen western harbor and underway monitor nitrate in the Jiulongjiang estuary.National Natural Science Foundation of China [41306090

Effect of Lanthanum（III） 2-Ethylhexanoate on Performance of Semi-rigid Polyurethane Foam Materials

半硬质聚氨酯泡沫材料属于较新型的泡沫材料，催化剂对合成聚氨酯整皮泡沫材料的质量起到最为关键的作用，采用“络合萃取”法来制备异辛酸镧稀土，实验条件下，反应时间为30min，温度控制为70℃，氯化镧料液浓度为120g／L，氯化镧的转化率最高，可达99％以上。在全水发泡半硬质聚氨酯泡沫体系中添加异辛酸镧，结果表明：异辛酸镧的加入能明显改善泡沫的形态，泡孔尺寸更加均匀，具有更好的形态结构。Semi-rigid polyurethane foam was a new kind of foam material. The catalysts were the most important for the quality of synthesized polyurethane integral skin foam material. Lanthanum （III） 2-ethylhexanoate was prepared by complexation extraction process with reaction time of 30 min, temperature of 70 ℃ , and lanthanum chloride concentration of 120 g/L. The conversion of lanthanum chloride was the best （ more than 99% ） under above conditions. The results showed that the foam morphology was apparently improved and the cell-sizes were more uniform with the addition of lanthanum（III） 2- ethylhexanoate.广西高校人才小高地建设创新团队资助计划项目(桂教人201147号);广西自然科学基金重点项目(2011GXNSFD018015);广西高等学校优秀中青年骨干教师培养工程(桂教人201316号);广西民族大学研究生教育创新计划项目(gxun-chx2013098

Superhydrophilic/Superhydrophobic Surface Constructions on Titanium and Their Effects on Anti-bacterial Properties

生物材料植入人体后若受到细菌感染就可能导致植入手术失败，因此植入材料的抗菌性研究具有重要的意义。由于内植物感染的第一步是细菌在材料表面的贴附，植入材料的表面性质对其抗菌性有决定性的影响。本文通过电化学法在钛表面构筑一层超亲水或超疏水的表面膜层，并运用体外抗菌性试验来研究材料表面的润湿性对细菌贴附的影响，以期利用改变材料表面的润湿性达到抗菌作用。结果表明，相比超亲水表面，超疏水表面上贴附的细菌数明显减少。The microbial infection of biomaterials often causes clinic problems and sometimes even leads to the prosthesis failure. It is, therefore, important to prevent the biomaterials from bacterial contamination. This can be done by using anti-bacteria drugs. However, this method causes physiological burdens to the patients and does not always work. To stop the contamination from the just beginning is believed to be a better choice. The first step for infection is the attachment of bacteria on the material. In this work, the thin TiO2 nanotubes array films were constructed with totally different wettabilities showing either superhydrophobic or superhydrophilic. The bacterial attachment behaviors on them were evaluated. It is shown that the numbers of viable colonies on the superhydrophobic film were significantly less than those on the superhydrophilic one.国家自然科学基金资助项目（20773100）作者联系地址：1. 厦门大学 固体表面物理化学国家重点实验室，化学化工学院化学系，福建 厦门 361005 2. 中国人民解放军总医院, 北京 100853Author's Address: 1. State Key Laboratory of Physical Chemistry of Solid Surface, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, China 2. Chinese PLA General Hospital, 100853, Beijing, China通讯作者E-mail：[email protected]