Synthesis and Solution Properties of Polyacrylamide Containing Sulfobetaine Groups

用丙烯酰胺(AM)、n,n-二甲基丙烯酰胺(dMAM)、[3-(甲基乙烯酰胺)丙基]二甲基-(3-磺酸)铵(dMMPPS)和[2-(甲基丙烯酰基氧基)乙基]二甲基-(3-磺酸丙基)氢氧化铵(dMAPS)单体通过氧化还原引发剂引发自由基聚合合成AM-dMMPPS、AM-dMAM-dMMPPS、AM-dMAPS和AM-dMAM-dMAPS 4种两性离子共聚物,并对两性离子聚合物进行表征和性能评价.研究结果表明,实验合成的4种共聚物AM-dMMPPS、AM-dMAMdMMPPS、AM-dMAPS和AM-dMAM-dMAPS都有增黏、抗盐、耐温的效果.在相同的反应条件下,在合成的共聚物中,AM-dMMPPS增黏、抗盐、耐温的效果最佳,其比浓黏度达36.8,dl/g.Four kinds of zwitterionic copolymers(AM-DMMPPS,AM-DMAM-DMMPPS,AM-DMAPS and AMDMAM-DMAPS) were synthesized by free radical copolymerization of acrylamide(AM), N, Ndimethylacrylamide(DMAM),[3-(methacryloylamino)propyl]dimethyl(3-sulfopropyl) ammonium hydroxide inner salt(DMMPPS)and [2-(Methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide(DMAPS).The copolymers were characterized and their solution properties were evaluated.The results show that the existence of the copolymers enhances the viscosity of the aqueous solution and the copolymers exhibit favorable salt resistant and thermal stable properties.At the same condition of copolymerization,in all synthesized copolymers,the AMDMMPPS copolymer has the most excellent properties of aqueous thickening and heat and salt resistant effect,and the highest reduced viscosity of the copolymer solution is 36.8,dL/g.国家自然科学基金资助项目(20876108

3种B族链球菌筛查方法在孕晚期筛查中的应用

目的比较3种B族链球菌(GBS)的筛查方法在孕晚期孕妇GBS筛查中的临床应用价值。方法收集2017年9月至12月在厦门市妇幼保健院产科门诊产检的35～37孕周孕妇阴道/直肠拭子样本1 027例,用GBS运送增菌...厦门市第二批青年创新创业人才项目(2015-A-03

Preparation and evaluation of insulin thiolated hyaluronic acid nanoparticles in vitro

目的制备胰岛素巯基化透明质酸纳米粒(InSulIn THIOlATEd HyAlurOnIC ACId nAnOPArTIClES,InS-HA-CyS-nPS),考察纳米粒的理化性质。方法以合成的具有生物黏附性质的巯基化透明质酸作为载体,采用超声乳化法制备纳米粒,考察其外观、粒径、zETA电位、包封率、载药量,并进行其冻干制剂的冻干保护剂筛选。结果制备的InS-HA-CyS-nPS粒径均一,外观圆整;平均粒径为(178.5±0.8)nM,PdI为(0.214±0.013),zETA电位为-(38.47±0.46)MV,超滤离心法测定载药纳米粒的包封率为(48.85±0.66)%,载药量为(4.79±0.13)%;选择10%的甘露醇为冻干保护剂,复溶后得到具有蓝色乳光的粒径均一的纳米粒混悬液。结论巯基化透明质酸纳米粒是蛋白多肽类药物口服给药的潜在载体,为下一步研究胰岛素纳米粒在大鼠体内药效、药动学研究提供前提和基础。Objective To prepare insulin thiolated hyaluronic acid nanoparticles( Ins-HA-Cys-NPs) and study its physicochemical properties.Methods The Ins-HA-Cys-NPs was prepared by ultrasonic emulsifying method,and the properties of nanoparticles including morphology,mean diameter,Zeta potential,entrapment efficiency and drug loading efficiency were studied,as well as the cryoprotectant selection.Results The prepared nanoparticles was round in appearance and the mean diameter was( 178.5 ± 0.8) nm,the polydispersity index was( 0.214 ± 0.013) and the Zeta potential was-( 38.47 ± 0.46) mV,while the entrapment efficiency was( 48.85 ± 0.66) %,drug loading efficiency was( 4.79 ± 0.13) %; 10%mannitol as cryoprotectant provided uniform and well dispersed suspension of nanoparticles with blue opalescence after redispersion.Conclusion The thiolated hyaluronic acid nanoparticles may be used as the carrier for oral drug delivery system of insulin,and it provides a basis for studies on rats in vivo.福建省自然科学基金(2012J05159

城乡链接与农民合作

2009-2010 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Synthesis and Evaluation of Copolymers for EOR

随着社会经济的高度发展，人们对石油的需求量不断增加，而其储量不断减少。目前油气田开发的任务就是尽可能经济、合理地提高地下油气的采出程度，即提高石油采收率（EOR，Enhancedoilrecovery）。随着油田的进一步开发，开采难度会逐步增大。本文即着眼于现在石油工业最关心的问题——如何提高采收率，主要研究提高石油采收率用共聚物的合成及性能分析。 实验以不同单体比例和引发剂量下，合成了中间产物苯乙烯-马来酸酐共聚物，以四氢呋喃为溶剂在不同条件下合成苯乙烯-马来酸酐-十八胺共聚物。将合成的共聚物作油溶性稠油降粘剂，测试了所制备的样品对稠油的降粘效果，考察降粘剂添加量及测试温度对降粘效果的影响...With the rapid development of the social economy, the demand for oil is growing while the current oil resources are exhausting. How to improve production of the oil well as economically and reasonably as possible is the the primary aim of the oil resources development. This is usually referred to enhanced oil recovery (EOR) technology. With the further development of the oil field, the difficulty ...学位：工学硕士院系专业：化学化工学院_化学工程学号：2062010115143

Exploration of a New Practical Teaching System for Mathematics and Applied Mathematics Specialty in University for Nationalities

针对民族院校数学与应用数学本科专业(简称"数本专业")新形势下的专业定位、人才培养目标及生源结构变化,从2005年起,笔者对教学计划做出重大调整,修改了原有实践模块,提出专业主干课实践教学与其它实践环节并重的实践教学新模式,重构数本专业实践教学新体系.经过实践表明,该专业实践教学新体系的实施对提高学生的知识应用能力和创新能力起着较大的促进作用.As professional orientation, personnel training target and enrollment are changed in the new situation of university for nationalities＇ undergraduate education in mathematics and applied mathematics （short as ＂mathematics major＂）. Since 2005, we have made a significant adjustment to the teaching plan, and modify old practice module, which puts forward to a new culturing model of making the practical teach- ing in professional courses equal to other aspects, reconstructs a new system of teaching practice for mathematics major. In prove to the practice, this system plays a great part in improving the students＇abilities of application of knowledge and creativity.“十一五”新世纪广西高等教育教改工程项目(桂教高教[2006]194号

一例链状化合物的热致和光致价态互变现象(英文)

用溶液扩散法合成了一例价态互变聚合物[CoⅡ(3,5-DBsq)2(dpg)]·(3,5-H2DBcat)2 (1) (其中 3,5-DBsq = 3,5-二叔丁基半醌, 3,5-H2DBcat = 3,5-二叔丁基邻苯二酚, dpg = 内消旋-α, β-二(4-吡啶基)乙二醇), 通过单晶衍射法等确定了其结构. 化合物 1 利用 3,5-H2DBsq 电活性配体和 dpg 桥联配体, 沿 b 轴方向形成了锯齿状的一维链, 这些链在 bc 平面内堆积形成了二维层状结构, 层状结构又进一步沿着 a 轴方向堆积, 形成的孔道被游离的3,5-H2DBcat 分子占据. 磁性测试表明了该化合物具有温度依赖的价态互变行为, 其行为表现出有趣的压力效应和光效应

Characterization of Carbon Deposits on W/MCM-22-based Catalysts for Dehydro-aromatization of CH_4 in Absence of O_2

利用TEM和XRD对积炭的甲烷无氧脱氢芳构化W/MCM 22 基催化剂及其参比样进行观测,结果显示,催化剂上的积炭主要是无定形碳,间或有为数甚少的碳纳米管或碳纤维,无可观量石墨状碳存在的 XRD证据.利用氢氟酸溶液处理积炭的W/MCM 22基催化剂试样,溶解除去沸石分子筛基催化剂组分,后用溶剂 CH2Cl2 进行萃取分离,可得不溶性和可溶性两类碳沉积物,前者占主体量,后者占总积炭量不足10%;利用FTIR、MS和1H NMR等谱学方法对积炭进行表征,结果表明,可溶性碳沉积物主要是一些分子量在523~745 范围的饱和脂肪烃高聚物,不溶性碳沉积物主要为稠环芳烃大分子.With XRD and TEM methods,the texture and structure of carbon deposits on the W/MCM-22-based catalysts for reaction of dehydro-aromatization of CH_4 in absence of O_2 (DHAM) were observed,and the results showed that those carbon deposits on the catalysts undergoing 6 h of DHAM reaction were mainly amorphous carbon,occasionally involving a small quantity of carbon nanotubes and nanofibers,and that there was no confident XRD evidence for existence of graphitized carbon.With hydrofluoric acid to immerse the used catalyst to resolve the W/MCM-22-based catalyst components,followed by extraction by CH_2Cl_2,the two types of carbon deposits,soluble and insoluble in CH_2Cl_2 solvent,were separately obtained.Using FTIR,MS,and (~1H) NMR spectroscopies,characterization of those carbon deposits were done.The results indicated that the CH_2Cl_2-soluble carbon deposits were mainly a series of polymer of saturated aliphatic hydrocarbons with molecular weight in range of 523~745,and the CH_2Cl_2-insoluble carbon deposits were mainly macromolecular compounds of condensed aromatics.国家重点基础研究规划项目“天然气、煤层气优化利用的催化基础”(G1999022400)资

体相微马达双气泡聚并驱动的界面演化机制

微纳米马达是建立微流体环境与宏观操控的桥梁,气泡微马达的驱动速度高,这一优势在实际应用中不可替代.管式气泡马达适用于复杂场景但能量转化率低,气泡驱动的Janus微球马达效率高但仅适用于气液界面附近.鉴于此,本文提出通过双气泡聚并方式驱动Janus微球马达的新体系,调和了高能量转化率与界面受限的矛盾.在实验中,借助高速摄像记录了双气泡聚并驱动微马达的-100 μs级过程,气泡聚并紧邻微球发生,通过释放的能量驱动微球显著运动,其融合过程是独特的可动曲壁受限下的气液界面演化问题.进一步结合伪势格子Boltzmann数值方法探究了气泡聚并驱动的流体动力学机制.研究结果揭示了不同时段气泡聚并的细节,给出了气泡颗粒尺寸比等因素对微球位移、初始动能转换率的影响,确认了双气泡聚并释放表面能的高效驱动机制

Interface evolution mechanism of dual-bubble coalescence driving micromotors in bulk phase

微纳米马达是建立微流体环境与宏观操控的桥梁,气泡微马达的驱动速度高,这一优势在实际应用中不可替代.管式气泡马达适用于复杂场景但能量转化率低,气泡驱动的Janus微球马达效率高但仅适用于气液界面附近.鉴于此,本文提出通过双气泡聚并方式驱动Janus微球马达的新体系,调和了高能量转化率与界面受限的矛盾.在实验中,借助高速摄像记录了双气泡聚并驱动微马达的-100 &mu;s级过程,气泡聚并紧邻微球发生,通过释放的能量驱动微球显著运动,其融合过程是独特的可动曲壁受限下的气液界面演化问题.进一步结合伪势格子Boltzmann数值方法探究了气泡聚并驱动的流体动力学机制.研究结果揭示了不同时段气泡聚并的细节,给出了气泡颗粒尺寸比等因素对微球位移、初始动能转换率的影响,确认了双气泡聚并释放表面能的高效驱动机制.</p