类泛素蛋白及其中文命名

泛素家族包括泛素及类泛素蛋白,约20种成员蛋白.近年来,泛素家族领域取得了迅猛发展,并已与生物学及医学研究的各个领域相互交叉.泛素家族介导的蛋白质降解和细胞自噬机制的发现分别于2004和2016年获得诺贝尔奖.但是,类泛素蛋白并没有统一规范的中文译名. 2018年4月9日在苏州召开的《泛素家族介导的蛋白质降解和细胞自噬》专著的编委会上,部分作者讨论了类泛素蛋白的中文命名问题,并在随后的\"泛素家族、自噬与疾病\"(Ubiquitinfamily,autophagy anddiseases)苏州会议上提出了类泛素蛋白中文翻译草案,此草案在参加该会议的国内学者及海外华人学者间取得了高度共识.冷泉港亚洲\"泛素家族、自噬与疾病\"苏州会议是由美国冷泉港实验室主办、两年一度、面向全球的英文会议.该会议在海内外华人学者中具有广泛影响,因此,参会华人学者的意见具有一定的代表性.本文介绍了10个类别的类泛素蛋白的中文命名,系统总结了它们的结构特点,并比较了参与各种类泛素化修饰的酶和它们的生物学功能.文章由45名从事该领域研究的专家合作撰写,其中包括中国工程院院士1名,相关学者4名,长江学者3名,国家杰出青年科学基金获得者18名和美国知名高校华人教授4名.他们绝大多数是参加编写即将由科学出版社出版的专著《泛素家族介导的蛋白质降解和细胞自噬》的专家

基于CPD模型的蔚州长焰煤热解特性研究

不同煤种成分的差异导致热解产物分布不同,CPD热解模型是精确预测煤热解产物分布规律的重要手段之一。采用非线性拟合方法对现有CPD模型进行修正,确定适用于蔚州长焰煤的5个化学结构参数,并通过热重实验对比分析了CPD修正模型的精确性

基于改进变分模态分解的齿轮点蚀故障诊断

针对齿轮点蚀故障特征难以提取的问题，提出了一种基于改进变分模态分解的齿轮点蚀故障诊断方法。利用经验模态分解自适应分解的特点，将各分量的能量占比作为有效分量的判断依据，并据此设定变分模态分解算法的模态个数，在此基础上，以变分模态分解分量的排列熵和最小值作为适应度函数，用遗传算法对惩罚因子进行搜索；根据所得结果设置变分模态分解参数，并对齿轮点蚀信号进行处理；筛选合适的本征模态函数进行包络调解，通过包络谱图分析齿轮点蚀故障的特征信息。对齿轮实验信号的分析表明，与现有方法相比，本文中提出的改进变分模态分解算法能够更加准确地识别出齿轮点蚀故障，在传动系统故障诊断方面具有一定实用价值

电动车两挡自动变速器敲击噪声的仿真分析

敲击噪声是变速器噪声的一种类型，由于变速器敲击噪声具有噪声级跳跃和明显的宽频带特征，与其他噪声有明显区别，故对变速器敲击噪声的研究尤为重要。以某款纯电动车两挡机械式自动变速器为研究对象，搭建变速器齿轮传动系统多体动力学模型，分析变速器挂挡齿轮和空套齿轮在运转过程中的角加速度、啮合力，理论计算分析得出产生敲击噪声最大的空套齿轮；并以此为例，结合轴承动态载荷的仿真结果，对变速器结构的振动响应进行理论计算，间接验证齿轮动力学模型的准确性，并研究阻滞力矩对敲击噪声的影响

Influence of ion source pretreatment on WC substrate surface and Ta buffer coating

研究了阳极层离子源预处理工艺对WC硬质合金基底表面粗糙度Ra和表面最大峰谷值Pv的影响,以及对后续镀制Ta缓冲涂层表面特征及膜基附着力的影响。结果表明,硬质合金基片表面粗糙度和表面最大峰谷值的增加量随基片偏压升高呈指数增加;而离子源电压对基片表面粗糙度和表面最大峰谷值影响较弱;采用离子源电压1350 V,基片偏压200 V轰击硬质合金基片15 min后镀制Ta膜,膜层表面晶粒细小均匀,表面致密性显著增加;此外,基片表面经离子源处理后,镀制的Ta缓冲层与基底的膜基结合力有较大改善,这将有利于提高后续贵金属保护涂层的附着力及抗元素扩散能力

氧化铁纳米棒的制备及在NOx消除中的应用

Synthesis of Iron Oxide Nanorods and Application in NOx Abatemen

Tandem polymer solar cells: Simulation and optimization through a multiscale scheme

In this paper, polymer solar cells with a tandem structure were investigated and optimized using a multiscale simulation scheme. In the proposed multiscale simulation, multiple aspects - optical calculation, mesoscale simulation, device scale simulation and optimal power conversion efficiency searching modules - were studied together to give an optimal result. Through the simulation work, dependencies of device performance on the tandem structures were clarified by tuning the thickness, donor/acceptor weight ratio as well as the donor-acceptor distribution in both active layers of the two sub-cells. Finally, employing searching algorithms, we optimized the power conversion efficiency of the tandem polymer solar cells and located the optimal device structure parameters. With the proposed multiscale simulation strategy, poly(3-hexylthiophene)/phenyl-C61-butyric acid methyl ester and (poly[2,6- (4,4-bis-(2-ethylhexyl)-4H-cyclopenta[2,1-b;3,4-b]dithiophene)-alt-4,7-(2,1,3-benzothiadiazole)])/phenyl-C61-butyric acid methyl ester based tandem solar cells were simulated and optimized as an example. Two configurations with different sub-cell sequences in the tandem photovoltaic device were tested and compared. The comparison of the simulation results between the two configurations demonstrated that the balance between the two sub-cells is of critical importance for tandem organic photovoltaics to achieve high performance. Consistency between the optimization results and the reported experimental results proved the effectiveness of the proposed simulation scheme.</p

三单元探测器望远镜的能量刻度

介绍了３０ＭｅＶ／ｕ(４０)Ａｒ＋(５８)，(６４)Ｎｉ和(１１５)Ｉｎ反应中测得的部分实验结果，着重讨论了３０μｍＳｉ＋５００μｍＳｉ＋４ｃｍＣｓＩ（Ｔ１）探测器望远镜的能量刻度，给出了一种可靠性好、可操作性强的能量刻度方法。Some experimental results measured in 30MeV/u~40Ar+~115In reaction, as well asthe energy calibration of a telescope, consisting of 30 u m Si+ 500 u m Si+ 4cmCsI(T1), were described in this paper. A reliable and useful method of the energycalibration of three - component telescope was presented.国家自然科学基金!1923501;;中国科学院九五重大项

Aldose reductase regulates miR-200a-3p/141-3p to coordinate Keap1-Nrf2, Tgf beta 1/2, and Zeb1/2 signaling in renal mesangial cells and the renal cortex of diabetic mice

973 Program of China [2009CB941601]; National Science Foundation of China [31271239]; Fujian Provincial Department of Science and Technology [2010L0002]; 111 Project of Education of China [B06018]; Open Research Fund of the State Key Laboratory of Cellular Stress Biology, Xiamen University [SKLCSB2012KF005]; China Postdoctoral Foundation [2012M511446]Aberrant regulation in oxidative stress, fibrogenesis, and the epithelial-mesenchymal transition (EMT) in renal cells under hyperglycemic conditions contributes significantly to the onset and progression of diabetic nephropathy. The mechanisms underlying these hyperglycemia-induced dysregulations, however, have not been dearly elucidated. Herein, we report that aldose reductase is capable of regulating the expression of miR-200a-3p/141-3p negatively in renal mesangial cells. MiR-200a-3p/141-3p, in turn, act to target Keap1, Tgf beta 2, fibronectin, and Zeb2 directly and regulate Tgf beta 1 and Nrf2 indirectly under high-glucose conditions, resulting in profound dysregulations in Keap1-Nrf2, Tgf beta 1/2, and Zeb1/2 signaling. In vivo in streptozotocin-induced diabetic mice, we found that aldose reductase deficiency caused significant elevations in miR-200a-3p/141-3p in the renal cortex, which were accompanied by a significant downregulation of Keap1, Tgf beta 1/2, and fibronectin but significant upregulation of Nrf2. Moreover, in vivo administration of inhibitors of miR-200a-3p in diabetic animals significantly exacerbated cortical and glomerular fibrogenesis and increased urinary albumin excretion, tightly linking dysregulated miR-200a-3p with the development of diabetic nephropathy. Collectively, our results reveal a novel mechanism whereby hyperglycemia induces aldose reductase to regulate renal expression of miR-200a-3p/141-3p to coordinately control hyperglycemia-induced renal oxidative stress, fibrogenesis, and the EMT. Our novel findings also suggest that inhibition of aldose reductase and in vivo renal cortical restoration of miR-200a-3p/141-3p or their combination are very promising avenues for the development of therapeutic strategies or drugs against diabetic nephropathy. (C) 2013 The Authors. Published by Elsevier Inc. All rights reserved