Effect of edaravone on cerebral edema and lipid peroxidation in rats of cerebral hemorrhage

目的探讨依达拉奉对大鼠脑出血后脑水肿及脑组织氧化损害的影响。方法选取健康雄性清洁的SD大鼠150只,随机分为假手术组、对照组、治疗组,每组50只,分别于术后0.5、1、2、3、4 d 5个时间点对每组中不同10只进行观察。采用立体定向自体血注入法制作大鼠脑出血模型,检测3组并比较各时间点血肿周围脑组织含水量变化、丙二醛(MDA)含量变化及超氧化物歧化酶活力情况。结果假手术组和治疗组术后1~4 d各时间点血肿周围脑组织含水量均显著低于对照组(P<0.05);对照组在术后2d脑水肿达到最高值;假手术组、治疗组术后0.5~4 d各时间点血肿周围脑组织MDA含量均显著低于对照组(P<0.05);假手术组、治疗组术后0.5~4 d各时间点血肿周围脑组织SOD活力均显著高于对照组(P<0.05)。结论依达拉奉能明显改善脑出血大鼠血肿周围脑组织水肿,减轻脑出血大鼠脑组织氧化损害。Objective To discusse the effect of edaravone for brain tissue oxidative damage after cerebral hemorrhage through observing the hemorrhage rats back edema and the change of lipid peroxidation. Methods 150 healthy and clean male SD rats,were randomly divided to sham operation group,control group,treatment group,50 cases in each group,each group choose five time points,post operative 0. 5 day,1 day,2 days,3 days,4 days,observed different 10 rats at each time point. The intracerebral hemorrhage model was made by using the method of stereotactic autologous blood injection. The changes of water content,the content of MDA and the activity of superoxide dismutase were monitored in three groups at different time points. Results Surrounding the hematoma in the brain tissue around the hematoma after intracerebral hemorrhage in sham operation group,treatment group of postoperative day 1-4 days each time hematoma surrounding brain tissue water content was significantly lower than that in control group( P <0. 05); Control group after 2 days of cerebral edema and reached the highest value; Sham operation group and treatment group of postoperative half of the day to 4 days each time the content of MDA were significantly lower than in control group( P < 0. 05); Sham operation group and treatment group postoperative half of the day to 4 days each time the brain tissue SOD activity was significantly higher than control group( P < 0. 05). Conclusion The effect is obvious that edaravone for cerebral hemorrhage rats brain tissue around hematoma edema,reduce cerebral hemorrhage rat tissue oxidative damage.福建省医学创新课题项目(2015-1-85

An Analysis on the Sharing of Universities High-quality Courses resourses in China——Based on A Case Study of the Major International Economy and Trade

科技飞速发展，将人类带入网络时代，同时也进入知识经济时代，为知识和网络的结合提供一种可能的契机。教育领域如何把握和应对网络时代的机遇和挑战，成为值得深思的一个问题。麻省理工学院应时代之需，将共享的观念传到大江南北。结合我国国情，因经济发展不均衡使得优质高等教育资源分布不均衡的现象由来已久，尤其是“985”和“211”院校与一般院校之间优质课程资源分配不均。现从以往的重视高等教育的数量走向高等教育质量的21世纪，合作已经成为时代发展的主旋律，而在这种合作的主导下，将优质高等教育资源“静止”状态使之“活化”起来，并让其能够充分发挥应有的价值是当前教育应该重视的。 基于时代背景，借鉴麻省理工学院的...The rapid development of technology brings people not only into the network era but also into the knowledge economy times. It provides a possible chance for the combination of knowledge and network. It is worth pondering the issue faced by educators: how to grasp and reply to the opportunities and challenges in the network era. To meet the need of times, Massachusetts Institute of Technology (MIT)...学位：教育学硕士院系专业：教育研究院_高等教育学学号：2572012115172

Clinical analysis of ZhongTon gAn combined with mecobalamin in treatment of primary trigeminal neuralgia in menopausal women

目的：探讨肿痛安联合甲钴胺治疗更年期女性原发性三叉神经痛（primary trigeminal neuralgia,PTN）的临床疗效。方法：选择45至60岁PTN更年期女性患者108例,采用随机分组,随机分入实验组和对照组,运用双盲对照研究。实验组54例治疗给予肿痛安＋甲钴胺,对照组54例治疗给予卡马西平。运用视觉模拟评分（visual analogue scale,VAS）对患者疼痛进行观察。统计8周治疗周期内患者疼痛改善情况、更年期躯体症状缓解情况,以及用药期间各组用药发生不良反应发生情况。治疗满一年后随访,进一步统计两组治疗方法的长期疗效。结果：实验组与对照组用药后与用药前比较,VAS值均显著下降（P〈0.05）;实验组与对照组用药后1、2、4周同时间节点内相互比较,VAS值差异无显著性（P〉0.05）。一年后随访治疗有效率比较：实验组总有效率（90.74%）,明显高于对照组（61.11%）,差异有显著性（P〈0.01）。实验组治疗8周后16项更年期躯体症状均有明显改善,与治疗前比较均有显著性差异（P〈0.01）,对照组未见明显更年期躯体症状缓解现象。实验组治疗期间不良反应（3.70%）低于对照组（24.07%）,两者间差异有显著性（P〈0.05）。结论：肿痛安联用甲钴胺在治疗PTN更年期女性患者时具有显著的疼痛缓解效果,虽其短期疗效与卡马西平治疗组不具有明显统计学差异,但能有效缓解更年期躯体症状,使其长期疼痛缓解效果明显高于卡马西平,且并发症少。Objective： To investigate the clinical efficacy of ZhongTongAn combined with mecobalamin the treatment of menopausal women with primary trigeminal neuralgia. Methods： 108 cases of primary trigeminal neuralgia women in the 45 to 60 years old were selected, randomly divided into two groups for double blind control study. Experimental group（54 case） was given ZhongTongAn combined with mecobalamin and the control group （54 case）was given carbamazepine. Visual analogue scale （VAS） was used to observe the pain of patients. During the 8 weeks of treatment, the improvement of pain, the remission of climacteric symptoms, and the adverse drug reactions occurred in each group were observed Long-term efficacy of the each treatment were statistics after one year follow-up. Results： Compared with before treatment and after treatment, both groups have significant decrease in visual analogue scale （VAS） values （P~0.05）. There was no significant VAS difference between the experimental group and the control group in the same time point （P ~0.05）. Compare with the total efficiency between the two groups after one year, the total effective rate of the experimental group （90.74%） was obviously higher than the control groups （61.11%）, P〈 0.01. After eight weeks of treatment the experimental group has significantly improve in 16 factors of somatic symptoms, compared with before treatment was significantly different （P 〈0.01）. In the control group, there was no obviously relief of somatic symptoms. Adverse reactions in the experimental group（3.70%） were lower than those in the control group（24.07%）, the difference is significant （P〈0.05）. Conclusion： ZhongTongAn combined with Mecobalamin in the treatment of menopausal women with primary trigeminal neuralgia with significant pain relief effect. Its short-term efficacy has no obvious statistical difference with carbamazepinetreatment and can effectively relieve menopausal symptoms, so that the long-term pain relief effect is s

The Exploration on Tsuda Umeko' s Thoughts on Higher Education of Women

津田梅子是日本近代著名教育家,曾于1900年创办日本第一所私立女子高等教育机构——女子英学塾(今津田塾大学)。津田梅子提出的女子高等教育目标是:培养经济上独立、具有专门知识、品性高尚、体质健全的全面发展的女性人才。并有针对性地以英语教育为主要教学内容,通过导师制、寄宿制等适合日本女性的教育方法等途径来实现该教育目标。虽然自明治以来日本女子教育思想一直以“良妻贤母“主义为主导,但以津田塾大学为依托的女子自立的教育思想却独树一帜,引导着人们对女子教育问题的不懈思考。Tsuda Umeko,a famous female Japanese educator,initialed Women's English Institute(now the Tsuda University) which was then the first private women's higher education institute in Japan.She stated that the aim for women's higher education should be focused on cultivating girls into all-round women which including independent on themselves economically,having special skills,being of grace characters and healthy.She also put up ways of realizing the aims,such as learning English,tutorial teaching method,and boarding system which was suitable for Japanese women at that time.Although the thoughts of cultivating girls to be "a good wife and loving mother" has been taken a mainstream in history of women's education in Japan since Meiji Period,women should depend on themselves by receiving higher education which hold on by Tsuda University has been reminded people of thinking women's education deeply

Analysis of polybrominated diphenyl ethers(PBDEs) and polybromodiphenyls(PBBs) in halobios in marine organisms

将气相色谱-负离子化学源/质谱法(gC-nCI/MS)应用于分析海洋生物中五种多溴联苯醚(PbdES)和五种多溴联苯(PbbS)残留。样品以正己烷/丙酮(1∶1,V/V)作为提取剂,采用超声萃取法,提取液经酸性硅胶和中性硅胶层析柱净化和正己烷洗脱后,以PCb-103为内标物和gC-nCI/M的选择离子监测方式(SIM)进行定性与定量分析。平均加标回收率为82.7%~101.0%,相对标准偏差小于5.6%,方法检测限都小于0.20x10-9,PbdES的线性范围是(0.1~500)x10-9,PbbS的线性范围是(0.35~350)x10-9,相关系数都大于0.9999。所分析生物样品中PbdE-47是最主要检出目标物。A rapid method based on ultrasonic extraction was developed for the determination of five polybrominated diphenyl ethers(PBDEs) and five polybromodiphenyls(PBBs) in fish and mussel.Hexane/acetone(1/1) was used as the extraction solvent,and hexane was elution solvent,after the extraction was cleaned by the cartridge filled with silica gel and acidic silica gel,the analysis of samples was accomplished using gas chromatography with negative chemical ionization mass spectrometric detection(GC-NCI/MS) in the selected ion monitoring mode(SIM),and with PCB-103 as internal standard(IS).The average recoveries of the spiked standard samples ranged from 82.7% to 101.0% with a relative standard deviation that was less than 5.6%,and the detection limit of the method was lower than 0.20×10-9 for all PBDEs and PBBs,the range of linearity was from 0.1×10-9 to 500×10-9 for PBDEs,and 0.35×10-9 to 350×10-9 for PBBs,with determination coefficients>0.9999.PBDE-47 was the main in all studied samples

Discussion on carrying on idelogical and political education in student apartment

随着高等教育体制改革的深化,学生公寓思想政治教育工作已成为高校思想政治教育的一个重要方面,针对思想政治教育阵地的转变,指出在学生公寓开展思想政治教育的原因、方式与作用。With the deepening of structural reform in higher education, ideological and political education of students in an apartment has become an important aspect, for the changes in position, pointing out the reasons, method and role for carrying on the ideological and political education in apartment

Sistem Pendukung Keputusan Prioritas Calon Penerima Program Indonesia Pintar Pada Siswa Sekolah Menengah Pertama Menggunakan Metode Topsis

Pendidikan merupakan hal penting dalam memajukan pembangunan negara, dengan itu pemerintah membuat kebijakan wajib belajar pendidikan sembilan tahun. Namun perekonomian masyarakat yang minim sering kali mengakibatkan mereka lebih memilih bekerja sebelum menuntaskan pendidikan dasar sembilan tahun tersebut. Demi mewujudkan hal tersebut pemerintah memiliki program bantuan pendidikan PIP (Program Indonesia Pintar) yang ditujukan pada masyarakat miskin. Namun implementasinya masih terdapat banyak kendala yang mengakibatkan tidak tepat sasaran dalam pemberian program bantuan pendidikan tersebut. Oleh Karena itu, untuk mengatasi permasalahan tersebut perlu adanya sistem dalam menentukan prioritas calon penerima PIP dengan menambahkan beberapa kriteria yang lebih mendasar. Pada penelitian ini dirancang sistem pendukung keputusan menggunakan metode TOPSIS (Technique for Order Performance by Similarity to Ideal Solutions) dengan beberapa kriteria yaitu Status Aktif Siswa, Surat Keterangan Miskin, Kondisi Yatim Piatu, Gaji Orang Tua, Presentasi Absensi. Pada aplikasi ini didapatkan hasil akhir berupa perankingan prioritas siswa yang akan menerima bantuan PIP

两极化趋势下人民币汇率制度的选择

自20世纪90年代以来,汇率制度的变革出现两极化趋势,越来越多的国家选择自由浮动或完全固定的汇率制度,而“软”的钉住汇率制度正逐步被抛弃。本文在“两极论”的基础上对固定汇率制度与浮动汇率制度的取舍进行分析,并结合我国国情探讨两极化趋势下人民币汇率制度的选择

A review of inorganic solid electrolyte/electrode interface in all-solid-state lithium batteries

全固态锂电池有望较好地提高电池安全性并实现高的能量密度, 因此已成为二次锂电池发展的一个重要方向.; 发展具有高锂离子电导率、低电解质/电极界面阻抗及有较好应变性的固态电解质材料是全固态电池研究的重要研究课题. 如何有效构筑电解质/电极界面,; 提高界面稳定性并显著降低界面阻抗又是其中的难点之一.; 本文综述了近年来国际上比较关注的两种无机固体电解质--硫化物与石榴石(garnet)型氧化物的最新研究进展,; 重点对这两类固体电解质与正负极材料的界面特性进行总结与评述.All-solid-state lithium batteries have attracted great interest, due to; its potential to significantly improve battery safety and realize higher; energy density. A solid electrolyte with high Li-ion conductivity, a; small electrolyte/electrode (including cathode and anode interface); interfacial resistance and good strain tolerant is a key component in; all-solid-state lithium batteries. Rational design of efficient; electrolyte/electrode interfaces to improve the stability of interface; and significantly decrease the interfacial resistance is one of the key; challenges in enabling all-solid-state lithium batteries. This paper; reviews the state-of-the-art development of some solid electrolytes; which has received extensive attention, eg. sulfides and garnet type; oxides. Major issues associated with electrolyte/electrode interface of; these two type solid electrolytes are summarized and analyzed.国家自然科学基金; 国家重点基础研究发展计

The mechanism of ROS regulation of antibiotic resistance and antimicrobial lethality

抗生素的不合理使用甚至滥用,使得细菌耐药性问题日趋严重。如何解决这一难题是人类目前面临的一项巨大挑战。除开发新型抗菌药物之外,寻找新的方法以增强现有抗生素的杀菌效果也是一种切实可行的策略。近期的研究发现活性氧簇(Reactive oxygen species,ROS)在细菌耐药及抗生素杀菌方面均发挥重要作用。非致死浓度的抗生素作用下产生的ROS会通过影响Mar R(Multiple antibiotic resistance repressor)-Mar A(Multiple antibiotic resistance activator)激活药物外排泵,通过Sox R(Superoxide response transcriptional regulator)-Sox S(Superoxide response transcription factor)途径启动细菌应激保护机制以及通过促进SOS DNA损伤修复系统诱导耐药突变,从而促成抗生素耐药与耐受的形成。而致死浓度的抗生素作用产生的ROS则会参与抗生素杀菌并减少耐药菌产生。除与抗生素浓度有关外,ROS参与细菌耐药与抗生素杀菌过程还会受到一系列遗传调控因子(如Maz EF、Cpx、Sox R和Mar RAB)的影响,因此存在一定复杂性。本文综述了ROS在细菌耐药与抗生素杀菌方面的作用机制,以期为寻找新的方法以增强现有抗生素杀菌效果,解决抗生素耐药问题提供一定的借鉴和指导。Misuse and overuse of antibiotics have led to serious resistance problems that pose a grave threat to human health. How to solve the increasing antibiotic resistance problem is a huge challenge. Besides the traditional strategy of developing novel antimicrobial agents, exploring ways to enhance the lethal activity of antibiotics currently available is another feasible approach to fight against resistance. Recent studies showed that ROS plays an important role in regulat-ing both antibiotic resistance and antimicrobial lethality. ROS produced by sublethal levels of antibiotic induces antibiotic resistance through activating drug efflux pumps via Mar R(Multiple antibiotic resistance repressor)-Mar A(Multiple antibiotic resistance activator), triggers the protective function against stress via Sox R(Superoxide response transcriptional regulator)-Sox S(Superoxide response transcription factor), and promotes mutagenesis by induction of SOS system. On the contrary, ROS triggered by lethal levels of antibiotic promotes bacterial killing and suppresses resistance. In addition to the concentration of antibiotic, the role of ROS in mediating antimicrobial resistance and bacterial killing is also regulated by a series of genetic regulators(e.g. Maz EF, Cpx, Sox R, Mar RAB). Thus, how ROS contribute to antimicrobial resistance and bacterial killing is complex. In this review, we summarized the mechanism of ROS in regulating antibiotic resistance and antimicrobial lethality, which may provide references and guidance for finding new ways to enhance antimicrobial lethality of currently available antimicrobials and battling antibiotic resistance.国家自然科学基金项目(编号:81473251,81301474,31370166);; 福建省自然科学基金项目(编号:2014J01139,2015J01345)资助~