6 research outputs found

    ST段抬高型急性心肌梗死院前溶栓治疗中国专家共识

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    急性心肌梗死仍然严重威胁我国人民健康,在我国广大城乡地区,形势更为严峻[1,2]。及时救治急性心肌梗死患者,降低死亡率和保护心脏功能刻不容缓。鉴于我国的实际情况,院前溶栓治疗在大城市以外的城乡地区具有重要意义。为此,中国医师协会胸痛专业委员会及中国医学救援协会心血管急救分会专门组织有关专家制订了本共识,旨在帮助院前医疗急救人员对急性心肌梗死患者选择最佳

    Study on Relationship between the Molecular Folding and Activity of ALkaline Phosphatase From Sinonovacula Constricty in the Presence of Guanidine Hydrochloride

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    报道了缢蛏碱性磷酸酶(简称AlP)经不同浓度盐酸胍处理时酶的分子构象所发生的变化以及酶变化和失活的动力学过程。在胍中酶荧光发射峰强度下降,紫外差光谱在246nM和285nM处出现2个负峰,Cd谱中酶的α螺旋度下降,且随浓度增大,变化程度也加大。动力学研究表明,酶在0.5MOl/l、1.0MOl/l、2.0MOl/l3.0MOl/l、4.0MOl/l盐酸胍中的变性速度常数分别为3.21x10-(-4)S-(-1)、6.38x10-(-4)S-(-1)、2.17x10-(-3)S-(-1)、2.33x10-(-3)S-9-1)、5.17x10-(-3)S-(-1);而酶在相应盐酸胍中的失活速度常数分别为2.33x10-(-4)S-(-1)、3.57x10-(-4)S-(-1)、5.86x10-(-4)S-(-1)、1.14x10-(-3)S-(-1)、3.45x10-(-3)S-(-1);表现为失活与构象伸展变化基本平行。EFFect of guanidine hydrochloride (GuHcl) on the changes in molecular conFormation and activity, kinetics of denaturation and inactivation of alkaline phosphatase (ALP)From Sinonovacula constrica are reported in this essay.In the presence of guanidine, the Flu rescence emission peak of ALP decreased; On the other hand, two negative peaks merged at the wavelengths of 246 nm and 285 nm on the UV diFFerential spectra;and the αhelix degree in the circular dichroism spectra reduced.Denaturation rate constants of ALP in diFFerent concentrations of GuHCl (0.5 , 1.0 , 2.0 , 3.0, 4.0 mol/L) measured by Fluorescence were 3.21×10 ̄(-4), 6.38×10 ̄(-4) , 2.17×10 ̄(-3) , 2.33×10 ̄(-3) and 5.16×10 ̄(-3)s ̄(-1) ,respectively.Meanwhile the respective inactivation rate constants were 2.33×10 ̄(-4) , 3.57 × 10 ̄(-4), 5.86×10 ̄(-4), 1.14×10 ̄(-3) and 3.45×10 ̄(-3)s ̄(-1).Results indicate that the rates of conFormational changes of ALP in the presence of GuHCl are slightly Faster than those of inactivation, though they all Fall in the same order of magnitude.We propose to call such relationship the ″synchronous alteration type″ For rate changes in conFormation and inactivation of the same order during denaturation.国家自然科学基

    风水两相变化对黄河中游支流粗泥沙的影响

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    基于黄河中游河口-龙门区间实地考察和对1964—1989年的实测资料进行时空变化分析,结果发现:该区水力、风力变化对河流产出的粗泥沙的量和质的变化具有一定的分异控制作用,水力对河流的输沙量的变化起主导作用,而风力对粗泥沙占全沙的百分比变化起主导作用。随着降雨量的减少和风沙活动的减弱,黄河中游河流输沙量和粗沙比有不同程度的减少,输沙量减少明显,减沙比在50%~70%之间,而粗沙比的变化要小得多,减少量在10%~20%之间

    Characteristic research on the soil salinity in coastal cotton field of the Yellow River Delta

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    采用相关分析和主成分分析方法对黄河三角洲棉田试验区土壤盐分特征进行研究,结果表明,试验区土壤为中度盐渍化,且盐分呈现一定的表聚现象;土壤各层盐基离子中,阳离子以Na~+为主,阴离子以Cl~-为主,这两种离子对棉花生长的毒害作用尤为突出;土壤盐分含量与Na~+ 、SO_4~(2-)、Cl~-、Mg~(2+)、Ca~(2+)、NO_3~(2-)、HCO_3~(2-)离子含量均呈极显著正相关;Na~+、Cl~-及SO_4~(2-)是影响试验区棉田盐渍化的主要特征因子。本研究结果可为黄河三角洲地区盐渍化土地科学管理和农业可持续发展提供理论基础和实践依据。</p

    Ziprasidone versus other atypical antipsychotics for schizophrenia

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