Primary Research of Antidiabetic and Antihypertensive Drugs Target by PPAR and synthesis of key intermediate in carbapenem antibiotics

摘要本论文的主要工作是化学合成药物的研发，其中包括：以PPAR为靶点的糖尿病高血压药物的初步研究；碳青霉烯类抗生素重要中间体(3S,4S,5R)-4-环丙基氧代甲基-3-(1'-羟基乙基)-2β-内酰胺的合成及其改进；抗艾滋病药物利托那韦中间体5-羟甲基噻唑的合成及其工业化路线的改进。1.以PPAR为靶点的糖尿病高血压药物的初步研究：通过文献调研，设计了化合物Ⅰ,期望其能够通过激活PPAR来达到降血糖和降血压的双重功效。同时，设计了一条相对较简单的合成路线，从对苯二酚出发，经六步反应合成了此化合物，总产率10.1%。2.(3S,4S,5R)-4-环丙基氧代甲基-3-(1'-羟基乙基)-2β-内...Researching and developing chemosynthetical drugs is the primary work of this thesis, including: a. primary research of antidiabetic and antihypertensive drugs target by PPAR; b. synthesis and industrialized improve of (1’R,3S,4S)-4-(Cyclo- propylcarbonyloxy)-3-(1-hydroxyethyl)azetidin-2-one which is the key intermedate in carbapenem antibiotics; c. synthesis and industrialized improve of 5-hydrox...学位：理学硕士院系专业：化学化工学院化学系_化学生物学学号：20042504

基于基函数展开的函数型数据聚类方法

文章在一个一般性的框架下研究了利用基函数展开进行函数型数据聚类的问题。在这个框架之下,大量传统的聚类方法都可以直接应用到函数型数据分析。另外,我们将PEArSOn相似系数引入函数型数据聚类分析,解决了欧式距离无法刻画曲线之间形态差异的问题

拟穴青蟹抗菌肽Crustin新变体的表达特性与抗菌功能

Crustins是一类较早发现并广泛分布在甲壳动物中且富含半胱氨酸的阳离子抗菌肽,能够参与抗细菌的免疫应答。从拟穴青蟹（Scylla paramamosain）中克隆获得Crustin基因,命名为SpCrus1a,其cDNA序列全长744 bp,开放阅读框编码113个氨基酸,成熟肽分子量10.03 kDa,等电点8.30。表达分析结果发现其转录本主要存在于鳃、卵巢、上皮组织中,脂多糖刺激后SpCrus1a会上调表达。体外合成SpCrus1a的第29～47位氨基酸进行抗菌活性实验发现,其对革兰氏阳性菌具有较强的抗菌活性,对被测的革兰氏阴性菌抗菌活性较弱或无抗菌活性。合成肽Sp Crus1a29-47能够在较短时间内杀死绝大多数的金黄色葡萄球菌,2 h内杀死全部的金黄色葡萄球菌。扫描电镜发现合成肽Sp Crus1a29-47可造成金黄色葡萄球菌表面结构崎岖不平,高浓度Sp Crus1a29-47造成细菌的大量死亡。上述结果表明,SpCrus1a是抗菌肽Crustins的新变体。国家自然科学基金(U205123,31172438);;厦门南方海洋研究中心科技项目(14PYY050SF03

Design and Implementation of Intelligent Home Control System Based on Android and Arduino

作为时下最炙手可热的移动应用端操作系统,Android以其显著的开放性、便于开发的灵活性、能够与Google应用的无缝对接性及丰富的第三方软硬件; 资源等成为智能应用系统不可或缺的组成部分;Arduino单片机系统以其开源的电子原型平台、灵活便捷的设计和丰富的传感器资源等被广泛应用。其与Ja; va和C语言相类似的基于; Wiring/Processing的语言开发环境更是受到越来越多的电子爱好者和开发者的青睐。本文以移动手机安卓系统为无线控制终端,结合Ardui; no单片机系统,设计并实验仿真了一款基于Android与Arduino的智能家居控制系统,以控制; LED灯示例,通过网络http传输控制指令到Arduino单片机系统,Arduino根据所接收到的指令,控制不同的家居电器完成所要求的工作任务。; 仿真实验表明,文章所设计方法行之有效,可以灵活的运用到日常家居电器设备,提供了一种智能家居系统设计的新思路,具有易实现,应用广的特点。As one of the most sought-after mobile application terminal operating; system, Android has become an indispensable part of the intelligent; application system, because it has the features of definite openness,; flexibility for development, perfect connection with Google applications; and abundant third party software and hardware resources and so on.; Arduino MCU system is widely used in society because of its; characteristics of open source electronic prototype platform, flexible; and convenient design, rich sensor resources, etc. Moreover, its classes; Java and C language based on Wiring/Processing development environment; are becoming more and more popular among the electronics enthusiasts and; developers. Taking the mobile phone Android system as wireless control; terminal, and combining Arduino MCU system, an intelligent home control; system based on Android and Arduino is designed and implemented in this; paper. By controlling LED lamp samples, with the network HTTP; transmission control instructions sending to the Arduino MCU system, and; according to the received instructions, Arduino can control different; household electrical appliances to complete the required tasks.; Experiments show that the methods designed in this paper can be flexibly; applied to daily household appliances, such as, home appliance control,; security equipment, etc. This paper provides a new idea for the design; of intelligent home system, which is easy to implement and widely used.2015年度"福建省高校杰出青年科研人才培育计划"项目; 2015年福建省高等学校创新创业教育改革项目;; 2016年本科高校重大教育教学改革研究项目; 2016年省级互联网实验教学示范中心项目; 2016年福建省高等学校服务产业特色专业建设项

Initial Study on Management and Operation Mode of Analysis and Test Center in Universities

国家科技发展的要求,“985“、“211“工程的投入,使各高校分析测试中心面临新的机遇与挑战;新形势下如何应对,使其在学科建设、科学研究、人才培养及高新技术开发等方面发挥重要作用,寻找能够适合测试中心可持续发展的管理和运行模式,是亟待解决的问题。文中结合厦门大学分析测试中心的实际运行经验,在分析测试中心的管理和运行模式以及如何为教学、科研发展和学科建设发挥更大的作用等方面进行探讨。With the development of science and technology,especially with the input of the "985 project" and the "211 project" to universities in China,most of the analysis and test centers in Chinese universities are facing new challenges and opportunities as well.In order to play a sustainable role in subject construction,scientific research,personnel training and high technology,analysis and test centers need to solve the problems of management and operation.Based on the practical experiences of the management and running analysis and test center in Xiamen university in the past years,this paper explores the following respects:how to set up a new management and operation mode on analysis and test center,how to promote its effectiveness to subject construction,scientific research and so on

Effect of Exogenous Nitric Oxide Donor Sodium Nitroprusside on Stomatal Movement in Leaves of Mangrove Plant Aegiceras corniculatum

探索一种用材简单、操作方便、真实性强的观察红树植物桐花树叶片气孔的制片技术,并利用该技术研究不同浓度、不同处理时间的一氧化氮(nO)供体硝普钠(SOdIuM nITrOPruSSIdE,SnP)对桐花树气孔开闭的影响,探讨了nO调控的气孔运动与外源CA2+的关系以及nO与H2O2在调节气孔运动过程中的关系。结果表明:在搅碎法、指甲油印迹法、牛皮胶印迹法三种观察气孔方法中,牛皮胶印迹法是观察气孔开度变化的最佳方法。nO能够诱导桐花树气孔快速关闭,且表现出明显的时间效应与浓度效应。nO导致的气孔关闭与CA2+的参与有密切关系,nO与H2O2存在明显的协同效应,可以促进气孔关闭。The aim of the present paper was to find out a simple and easy-to-go method to observe the stomatal movement of a mangrove plant Aegiceras corniculatum.The new method was used to study the following areas, inculing the effect of exogenous nitric oxide (NO) on the leaf stomatal movement under different concentrations and different treated time, the effect of Ca2+ in the regulation of stomatal movement induced by exogenous NO, the interactional effect between NO and H2O2 in the regulationb of stomatal movement.The results suggested that the oxhide pastern print was the best way to observe stomatal movement of A.corniculatum compared with the blender method and the nail enamel print method.The stomatal closure induced by NO was associated with Ca2+ in dose dependent manner.It was also proved that a rapid stomatal closure could be co-induced by NO and H2O2 in A.corniculatum guard cells.国家自然科学基金项目(30770192;30670317);厦门大学“新世纪优秀人才支持计划”项目(X07115);湖北民族学院博士启动基金项

Atomic segregation at twin boundaries in a Mg-Ag alloy

Segregation of solute atoms at twin boundaries (TBs) plays a critical role in mechanical properties and thermal stability of magnesium alloys. Here, segregation structures at {10 (1) over bar1}, {10 (1) over bar2} and {10 (1) over bar3} TBs are characterized in a Mg-Ag alloy by means of the atomic resolution high-angle annular dark-field technique based on scanning transmission electron microscopy. Of particular finding is the unique complex segregation at {10 (1) over bar3} TBs, where Ag atoms occupy both substitutional and interstitial sites. By contrast, Ag atoms only substitutionally segregate at {10 (1) over bar1} and {10 (1) over bar2} TBs. Calculation simulation of segregation energy and three-dimensional structure of TBs helps understanding of hybrid segregation. (C) 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved

Discussion on construction and laboratory qualification verification of public testing platform

随着国家教育的创新发展以及“985工程“、“211工程“的建设,各高校迎来前所未有的机遇与挑战,这种形势下,部分高校的公共检测平台建设受到了学校领导的重视而发展迅速,也呈现出各自的特点和成效。结合厦门大学公共检测平台的实际运行经验,对平台的构建、运行及参加实验室资质认定等方面遇到的问题进行探讨。With the innovation development of national education and construction of the"985 Project"and the"211 Project," universities are confronted with new opportunities and challenges.Under this situation,many universities's public testing platforms have already developed quickly and shown their own features and effects.Based on the experience of the public testing platform in Xiamen University,problems of construction,operation and laboratory qualification verification are discussed

The Phylogeny Tree Reconstruction Based on the Usage Frequencyof Codons and Corresponding Complementary Codons

为了更深入地了解密码子与互补密码子使用相关的内涵,70个单细胞和多细胞生物被更进一步的分析。结果得到70种细胞生物具有较高的相关系数平均值(0.5101,标准差是0.1389),表明密码子与其互补密码子使用间确实存在正的使用相关联系,进一步地支持了以前的结果。此外,通过对70个单细胞和多细胞生物在基于密码子与互补密码子使用频率差异,以及配对频率的高低信息的分析基础上,绘制进化树,得到的进化树与传统的进化树非常接近。The hypothesis that a codon bias usage is identical to its complementary codon usage preference has been investigated by using the relationship analysis of codons vs their complementary ones among 70 organisms. Significantly positive usage correlations between codons and their complementary ones were found and its implication in biology was also analyzed. The codoncomplementary codon tree was further built, which fairly exhibited the evolutionary relationship of these organisms. The results not only demonstrated the validity of our hypothesis,but also manifested the usefulness of correlation analysis in studying on codon usage pattern and molecular evolutionary mechanisms of organism.ThisworkwassupportedbyagrantfromtheNationalNaturalScienceFoundationofChina(No.60305001)andagrantfromtheScienceandTechnologyMinistryofChina(PreliminaryStudyonFunctionalGenomeSystematics)(No.2001CCA01400)

Study on laser lift-off of GaN material in low pressure

为了研究低压环境对激光剥离的影响,利用准分子激光剥离系统和真空腔对gAn/蓝宝石样品分别在低压下和常压下进行多脉冲激光照射,之后用台阶仪测量样品的分解深度,得知相比常压环境,低压下gAn分解深度在脉冲次数为10次、20次、30次时分别增加了为10.2%,19.0%,24.3%,之后结合gAn材料分解过程和脉冲激光照射gAn/蓝宝石结构过程进行理论分析得到相应低压和常压下的gAn材料的理论分解深度,得到与实验一致的趋势。证明了低压环境能提高激光剥离速率。In order to study the effects of low-pressure environment on laser lift-off process,the experiment that a GaN/sapphire sample was irradiated by an excimer laser lift-off system in different pressure was carried out,and then the decomposition depth of the sample was measured with a profilometer.The results show that the decomposition depth of GaN in low pressure is increased by 10.2%,19.0% and 24.3% which corresponds to the number of pulses of 10,20 and 30.One-dimensional heat flow model of GaN/sapphire structure irradiated by laser was established.The temperature field in GaN was calculated and analyzed.The decomposition depth of GaN in different pressure was obtained.The theoretical calculation result is consistent with the experimental result.It indicates that the efficiency of laser lift-off in low pressure environment is higher than that in ordinary pressureenvironment.国家自然科学基金(11104230